YU87592A - Postupak za proizvodnju novih acilala od derivata imidazol-5-karbonskih kiselina - Google Patents

Postupak za proizvodnju novih acilala od derivata imidazol-5-karbonskih kiselina

Info

Publication number
YU87592A
YU87592A YU87592A YU87592A YU87592A YU 87592 A YU87592 A YU 87592A YU 87592 A YU87592 A YU 87592A YU 87592 A YU87592 A YU 87592A YU 87592 A YU87592 A YU 87592A
Authority
YU
Yugoslavia
Prior art keywords
formula
compound
procedure
new
acid derivatives
Prior art date
Application number
YU87592A
Other languages
English (en)
Other versions
YU48290B (sh
Inventor
D. Binder
J. Weinberger
Original Assignee
Chemisch-Pharmazeutische Forschungs Gmbh.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemisch-Pharmazeutische Forschungs Gmbh. filed Critical Chemisch-Pharmazeutische Forschungs Gmbh.
Publication of YU87592A publication Critical patent/YU87592A/sh
Publication of YU48290B publication Critical patent/YU48290B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

POSTUPAK ZA PRIPREMANJE NOVIH ACILALA OD DERIVATA IMIDAZOL-5-KARBONSKIH KISELINA, opšte formule: U kojoj R1 predstavlja eventualno alkil grupu sa pravim nizom sa 1 - 6 atoma ugljenika, R2 je vodonik, hlor, brom, jod ili CF3, a R3 je C1-C10-alkil, C3-C7-cikloalkil ili benzil grupa, kao i njihove farmaceutski prihvatljive soli, što u fazi a) jedinjenje formule u kojoj R1, R2 i R3 imaju gore navedena značenja, reaguje sa jedinjenjem formule u kojoj X predstavlja hlor, brom ili jod a --- S zaštitnu trifenilmetil grupu, a tako dobjeno jedinjenje formule u kojoj R1, R2, R3 i --- S imaju gore navedeno značenje, zagreva se u fazi b) sa nekim nižim alifatskim alkoholom pa se tako dobijeno jedinjenje formule (I) koje zbog svog amorfnog karaktera obično ne kristališe prema potrebi prevodi sa neorganskim ili organskim bazama u neku farmaceutski prihvatljivu so.
YU87592A 1991-10-04 1992-09-29 Postupak za proizvodnju novih acilala od derivata imidazol-5-karbonskih kiselina YU48290B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0198791A AT398202B (de) 1991-10-04 1991-10-04 Neue imidazolderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
YU87592A true YU87592A (sh) 1995-10-03
YU48290B YU48290B (sh) 1998-05-15

Family

ID=3525398

Family Applications (1)

Application Number Title Priority Date Filing Date
YU87592A YU48290B (sh) 1991-10-04 1992-09-29 Postupak za proizvodnju novih acilala od derivata imidazol-5-karbonskih kiselina

Country Status (22)

Country Link
US (1) US5298519A (sh)
EP (1) EP0535420A1 (sh)
JP (1) JP2544565B2 (sh)
CN (1) CN1032856C (sh)
AT (1) AT398202B (sh)
AU (1) AU649357B2 (sh)
CA (1) CA2079735A1 (sh)
CZ (1) CZ301992A3 (sh)
FI (1) FI924353A (sh)
HR (1) HRP920817A2 (sh)
HU (1) HUT62291A (sh)
IL (1) IL103329A (sh)
LV (1) LV10256B (sh)
MY (1) MY108350A (sh)
NO (1) NO923798L (sh)
NZ (1) NZ244320A (sh)
RU (1) RU2105764C1 (sh)
SI (1) SI9200240A (sh)
SK (1) SK301992A3 (sh)
TW (1) TW223073B (sh)
YU (1) YU48290B (sh)
ZA (1) ZA927205B (sh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2105939B1 (es) * 1994-08-02 1998-07-01 Uriach & Cia Sa J Nuevos pirazoles con actividad antagonista de la angiotensina ii.
CN101024643A (zh) 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用
CN101195615B (zh) * 2006-12-06 2013-03-27 深圳市信立泰资产管理有限公司 咪唑-5-羧酸衍生物的盐、制备方法及其药物组合物
AU2006351517B8 (en) * 2006-12-06 2012-01-19 Shenzhen Salubris Pharmaceuticals Co., Ltd. The salts of imidazol-5-carboxylic acid derivatives, preparation methods and use thereof
CN101214242A (zh) * 2007-01-05 2008-07-09 上海艾力斯医药科技有限公司 新的药用组合物
EP2170930B3 (en) 2007-06-04 2013-10-02 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CN101317842A (zh) * 2007-06-07 2008-12-10 上海艾力斯医药科技有限公司 一种咪唑-5-羧酸衍生物的治疗用途
CN101367795B (zh) * 2007-08-17 2012-05-02 上海艾力斯生物医药有限公司 一种咪唑-5-羧酸衍生物及其制备方法
CN101407511B (zh) * 2007-10-11 2013-01-09 上海艾力斯生物医药有限公司 一种结晶型的咪唑-5-羧酸衍生物
EP2328910B1 (en) 2008-06-04 2014-08-06 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
AU2009270833B2 (en) 2008-07-16 2015-02-19 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN103012377A (zh) * 2011-09-27 2013-04-03 江苏艾力斯生物医药有限公司 一种咪唑-5-羧酸酯的重结晶方法
AU2014235215A1 (en) 2013-03-15 2015-10-01 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
BR112015030326A2 (pt) 2013-06-05 2017-08-29 Synergy Pharmaceuticals Inc Agonistas ultrapuros de guanilato ciclase c, método de fabricar e usar os mesmos

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
AU645022B2 (en) * 1989-06-30 1994-01-06 E.I. Du Pont De Nemours And Company Fused-ring aryl substituted imidazoles
ATE113281T1 (de) * 1989-08-02 1994-11-15 Takeda Chemical Industries Ltd Pyrazol-derivate, verfahren zu deren herstellung und anwendung.
DE4132631A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Imidazolyl-propensaeurederivate
DE4132632A1 (de) * 1991-10-01 1993-04-08 Bayer Ag Substituierte imidazolyl-propensaeurederivate
DE69329982T2 (de) * 1992-06-02 2001-09-27 Sankyo Co 4-Carboxyimidazolderivate als Angiotensin-II-Antagonisten und ihre therapeutische Verwendung

Also Published As

Publication number Publication date
NO923798L (no) 1993-04-05
EP0535420A1 (de) 1993-04-07
ATA198791A (de) 1994-02-15
RU2105764C1 (ru) 1998-02-27
JPH05310731A (ja) 1993-11-22
JP2544565B2 (ja) 1996-10-16
NZ244320A (en) 1995-01-27
SI9200240A (en) 1993-06-30
US5298519A (en) 1994-03-29
MY108350A (en) 1996-09-30
CZ301992A3 (en) 1993-08-11
TW223073B (sh) 1994-05-01
HRP920817A2 (en) 1996-08-31
IL103329A0 (en) 1993-03-15
CA2079735A1 (en) 1993-04-05
LV10256B (en) 1995-04-20
CN1032856C (zh) 1996-09-25
IL103329A (en) 1996-10-31
SK301992A3 (en) 1995-10-11
HU9203149D0 (en) 1992-12-28
CN1071426A (zh) 1993-04-28
NO923798D0 (no) 1992-09-30
AT398202B (de) 1994-10-25
YU48290B (sh) 1998-05-15
LV10256A (lv) 1994-10-20
HUT62291A (en) 1993-04-28
FI924353A (fi) 1993-04-05
ZA927205B (en) 1993-03-23
AU2617692A (en) 1993-04-08
AU649357B2 (en) 1994-05-19
FI924353A0 (fi) 1992-09-29

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