ES458309A1 - Procedimiento de preparacion de nuevos derivados de 1,4-ben-zodioxano. - Google Patents
Procedimiento de preparacion de nuevos derivados de 1,4-ben-zodioxano.Info
- Publication number
- ES458309A1 ES458309A1 ES458309A ES458309A ES458309A1 ES 458309 A1 ES458309 A1 ES 458309A1 ES 458309 A ES458309 A ES 458309A ES 458309 A ES458309 A ES 458309A ES 458309 A1 ES458309 A1 ES 458309A1
- Authority
- ES
- Spain
- Prior art keywords
- novel
- hydrogen
- benzodioxanes
- carbon atoms
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical class C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 title abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000003276 anti-hypertensive effect Effects 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Abstract
Procedimiento de preparación de nuevos derivados de 1,4-benzodioxano de fórmula I¿: (*ver imagen I¿), en la que R¿ representa un átomo de hidrógeno, un radical alcoxi que contiene de 1 a 5 átomos de carbono, o un átomo de cloro, bromo o flúor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7612941A FR2349331A1 (fr) | 1976-04-30 | 1976-04-30 | Nouveaux derives de 2,3 dihydro a/4-(3-indolyl) 1-piperidinyl/methyl 1,4-benzodioxin-2-methanol, un procede pour leur preparation et leur application comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES458309A1 true ES458309A1 (es) | 1978-02-16 |
Family
ID=9172538
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES458309A Expired ES458309A1 (es) | 1976-04-30 | 1977-04-29 | Procedimiento de preparacion de nuevos derivados de 1,4-ben-zodioxano. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US4100291A (es) |
| JP (1) | JPS52133992A (es) |
| AU (1) | AU506408B2 (es) |
| BE (1) | BE854112A (es) |
| CA (1) | CA1095047A (es) |
| CH (1) | CH602711A5 (es) |
| DE (1) | DE2719294A1 (es) |
| DK (1) | DK187577A (es) |
| ES (1) | ES458309A1 (es) |
| FR (1) | FR2349331A1 (es) |
| GB (1) | GB1542361A (es) |
| HU (1) | HU172529B (es) |
| IL (1) | IL51974A (es) |
| LU (1) | LU77241A1 (es) |
| NL (1) | NL7704759A (es) |
| SE (1) | SE7704615L (es) |
| SU (1) | SU700063A3 (es) |
| ZA (1) | ZA772601B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2362628A1 (fr) * | 1976-08-26 | 1978-03-24 | Roussel Uclaf | Nouveaux derives du piperidyl-indole et leurs sels, procede de preparation et application a titre de medicaments |
| FR2420536A1 (fr) * | 1978-03-22 | 1979-10-19 | Roussel Uclaf | Nouveaux derives de 1,3-dihydro 3-/1-/2-(2,3-dihydro 1,4-benzodioxin-2-yl)2-hydroxyethyl/piperidin-4-yl/2h-indol-2-one, procede pour leur preparation et application comme medicaments |
| FR2444678A2 (fr) * | 1978-12-22 | 1980-07-18 | Roussel Uclaf | Nouveau procede de preparation de derives du piperidyl-indole et de leurs sels |
| DE3035403C2 (de) | 1980-09-19 | 1982-08-26 | Rütgerswerke AG, 6000 Frankfurt | Verfahren zur Herstellung von 5-Chlorindol |
| FR2533924A1 (fr) * | 1982-10-05 | 1984-04-06 | Roussel Uclaf | Nouveaux derives du 4-(1h-indol-3-yl)a-methyl piperidine-1-ethanol, leurs sels, le procede de preparation, l'application a titre de medicaments et les compositions les renfermant |
| IE58370B1 (en) * | 1985-04-10 | 1993-09-08 | Lundbeck & Co As H | Indole derivatives |
| US4742057A (en) * | 1985-12-05 | 1988-05-03 | Fujisawa Pharmaceutical Co., Ltd. | Antiallergic thiazole compounds |
| DK733788A (da) * | 1988-01-14 | 1989-07-15 | Fujisawa Pharmaceutical Co | Indolylpiperidinderivater og fremgangsmaade til fremstilling deraf |
| DE4414113A1 (de) * | 1994-04-22 | 1995-10-26 | Merck Patent Gmbh | 3-Indolylpiperidine |
| EP1070715A4 (en) * | 1998-03-19 | 2002-10-17 | Nihon Nohyaku Co Ltd | ARYLPIPERIDINE AND THEIR USE |
| AU2006306497A1 (en) * | 2005-10-24 | 2007-05-03 | Janssen Pharmaceutica, N.V. | 3-piperidin-4-yl-indole ORL-1 receptor modulators |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2193584B1 (es) * | 1972-07-28 | 1975-08-08 | Roussel Uclaf | |
| DE2322470A1 (de) * | 1973-05-04 | 1974-11-21 | Boehringer Sohn Ingelheim | Neue indolyl-piperidino-(bzw. 1,2,5,6tetrahydro-pyridyl-)butyrophenone und verfahren zu ihrer herstellung |
| US3914238A (en) * | 1974-01-18 | 1975-10-21 | Janssen Pharmaceutica Nv | 4-Aryl-{60 -(1,4-benzodioxan-2-yl)-4-hydroxy-1-piperidineethanols |
| US4039676A (en) * | 1975-06-23 | 1977-08-02 | Ciba-Geigy Corporation | 2-piperidinoalkyl-1,4-benzodioxans |
-
1976
- 1976-04-30 FR FR7612941A patent/FR2349331A1/fr active Granted
-
1977
- 1977-04-21 SE SE7704615A patent/SE7704615L/xx not_active Application Discontinuation
- 1977-04-28 JP JP4858977A patent/JPS52133992A/ja active Pending
- 1977-04-28 HU HU77RO00000925A patent/HU172529B/hu unknown
- 1977-04-28 US US05/791,927 patent/US4100291A/en not_active Expired - Lifetime
- 1977-04-28 SU SU772497909A patent/SU700063A3/ru active
- 1977-04-29 CH CH541077A patent/CH602711A5/xx not_active IP Right Cessation
- 1977-04-29 DK DK187577A patent/DK187577A/da not_active Application Discontinuation
- 1977-04-29 ES ES458309A patent/ES458309A1/es not_active Expired
- 1977-04-29 AU AU24709/77A patent/AU506408B2/en not_active Expired
- 1977-04-29 ZA ZA00772601A patent/ZA772601B/xx unknown
- 1977-04-29 CA CA277,417A patent/CA1095047A/fr not_active Expired
- 1977-04-29 NL NL7704759A patent/NL7704759A/xx not_active Application Discontinuation
- 1977-04-29 GB GB7718081A patent/GB1542361A/en not_active Expired
- 1977-04-29 IL IL51974A patent/IL51974A/xx unknown
- 1977-04-29 DE DE19772719294 patent/DE2719294A1/de not_active Withdrawn
- 1977-04-29 BE BE177137A patent/BE854112A/xx unknown
- 1977-05-03 LU LU77241A patent/LU77241A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU506408B2 (en) | 1980-01-03 |
| GB1542361A (en) | 1979-03-14 |
| NL7704759A (nl) | 1977-11-01 |
| AU2470977A (en) | 1978-11-02 |
| ZA772601B (en) | 1978-09-27 |
| IL51974A (en) | 1980-09-16 |
| JPS52133992A (en) | 1977-11-09 |
| US4100291A (en) | 1978-07-11 |
| CH602711A5 (es) | 1978-07-31 |
| SE7704615L (sv) | 1977-10-31 |
| FR2349331A1 (fr) | 1977-11-25 |
| BE854112A (fr) | 1977-10-31 |
| DE2719294A1 (de) | 1977-11-17 |
| FR2349331B1 (es) | 1978-08-25 |
| SU700063A3 (ru) | 1979-11-25 |
| IL51974A0 (en) | 1977-06-30 |
| LU77241A1 (es) | 1977-12-13 |
| CA1095047A (fr) | 1981-02-03 |
| DK187577A (da) | 1977-10-31 |
| HU172529B (hu) | 1978-09-28 |
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