JPS55108868A - Dibenzoxepin derivative - Google Patents

Dibenzoxepin derivative

Info

Publication number
JPS55108868A
JPS55108868A JP1576579A JP1576579A JPS55108868A JP S55108868 A JPS55108868 A JP S55108868A JP 1576579 A JP1576579 A JP 1576579A JP 1576579 A JP1576579 A JP 1576579A JP S55108868 A JPS55108868 A JP S55108868A
Authority
JP
Japan
Prior art keywords
formula
reacted
oxodibenz
oxepin
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP1576579A
Other languages
Japanese (ja)
Inventor
Sadakatsu Shimada
Yusuke Yukimoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Pharmaceutical Co Ltd
Original Assignee
Daiichi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Pharmaceutical Co Ltd filed Critical Daiichi Pharmaceutical Co Ltd
Priority to JP1576579A priority Critical patent/JPS55108868A/en
Publication of JPS55108868A publication Critical patent/JPS55108868A/en
Pending legal-status Critical Current

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  • Pyrane Compounds (AREA)

Abstract

NEW MATERIAL:(2, 2, 2-Trichloroethyl)-6, 11-dihydro-11-oxodibenz[b, e]oxepin formula I.
USE: Intermediate for medicines, e.g. anti-inflammatory agents.
PROCESS: A compound of formula II or its acid addition salt is reacted with nitrous acid at 0W30°C, preferably below 50°C under cooling with ice, to form a diazonium salt of formula III, which is reacted with inexpensive available vinylidene chloride in a solvent in the presence of a small amount of a copper salt, e.g. copper chloride, at 0W30°C, to give the desired compound of formula I. The resulting compound is reacted with a base in an alcohol solvent at room temperature or under heating to afford an ester, which is hydrolyzed with hydrochloric acid to form 6,11-dihydro-11- oxodibenz[b,e]oxepin-acetic acid useful as an anti-imflammatory agent readily.
COPYRIGHT: (C)1980,JPO&Japio
JP1576579A 1979-02-14 1979-02-14 Dibenzoxepin derivative Pending JPS55108868A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP1576579A JPS55108868A (en) 1979-02-14 1979-02-14 Dibenzoxepin derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1576579A JPS55108868A (en) 1979-02-14 1979-02-14 Dibenzoxepin derivative

Publications (1)

Publication Number Publication Date
JPS55108868A true JPS55108868A (en) 1980-08-21

Family

ID=11897882

Family Applications (1)

Application Number Title Priority Date Filing Date
JP1576579A Pending JPS55108868A (en) 1979-02-14 1979-02-14 Dibenzoxepin derivative

Country Status (1)

Country Link
JP (1) JPS55108868A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006120010A3 (en) * 2005-05-12 2007-01-18 Merckle Gmbh Dibenzocycloheptane compounds and pharmaceuticals containing these compounds

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006120010A3 (en) * 2005-05-12 2007-01-18 Merckle Gmbh Dibenzocycloheptane compounds and pharmaceuticals containing these compounds

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