JPS55108868A - Dibenzoxepin derivative - Google Patents
Dibenzoxepin derivativeInfo
- Publication number
- JPS55108868A JPS55108868A JP1576579A JP1576579A JPS55108868A JP S55108868 A JPS55108868 A JP S55108868A JP 1576579 A JP1576579 A JP 1576579A JP 1576579 A JP1576579 A JP 1576579A JP S55108868 A JPS55108868 A JP S55108868A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- reacted
- oxodibenz
- oxepin
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Pyrane Compounds (AREA)
Abstract
NEW MATERIAL:(2, 2, 2-Trichloroethyl)-6, 11-dihydro-11-oxodibenz[b, e]oxepin formula I.
USE: Intermediate for medicines, e.g. anti-inflammatory agents.
PROCESS: A compound of formula II or its acid addition salt is reacted with nitrous acid at 0W30°C, preferably below 50°C under cooling with ice, to form a diazonium salt of formula III, which is reacted with inexpensive available vinylidene chloride in a solvent in the presence of a small amount of a copper salt, e.g. copper chloride, at 0W30°C, to give the desired compound of formula I. The resulting compound is reacted with a base in an alcohol solvent at room temperature or under heating to afford an ester, which is hydrolyzed with hydrochloric acid to form 6,11-dihydro-11- oxodibenz[b,e]oxepin-acetic acid useful as an anti-imflammatory agent readily.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1576579A JPS55108868A (en) | 1979-02-14 | 1979-02-14 | Dibenzoxepin derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1576579A JPS55108868A (en) | 1979-02-14 | 1979-02-14 | Dibenzoxepin derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS55108868A true JPS55108868A (en) | 1980-08-21 |
Family
ID=11897882
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP1576579A Pending JPS55108868A (en) | 1979-02-14 | 1979-02-14 | Dibenzoxepin derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55108868A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006120010A3 (en) * | 2005-05-12 | 2007-01-18 | Merckle Gmbh | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds |
-
1979
- 1979-02-14 JP JP1576579A patent/JPS55108868A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006120010A3 (en) * | 2005-05-12 | 2007-01-18 | Merckle Gmbh | Dibenzocycloheptane compounds and pharmaceuticals containing these compounds |
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