YU46703B - Postupak za dobijanje hinolinskih derivata - Google Patents
Postupak za dobijanje hinolinskih derivataInfo
- Publication number
- YU46703B YU46703B YU199089A YU199089A YU46703B YU 46703 B YU46703 B YU 46703B YU 199089 A YU199089 A YU 199089A YU 199089 A YU199089 A YU 199089A YU 46703 B YU46703 B YU 46703B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- pharmaceutically acceptable
- quinoline derivatives
- procedure
- carbon atoms
- alkyl group
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Quinoline Compounds (AREA)
Abstract
POSTUPAK ZA DOBIJANJE HINOLINSKIH DERIVATA, opšte formule: u kojoj R1, R2 i R3 su isti ili različiti i svaki predstavlja atom vodonika ili nižu alkil grupu koja ima 1-5 atoma ugljenika, ili njegovog farmaceutski prihvatljivog estra ili farmaceutski prihvatljive soli ovog derivata ili njegovog estra, naznačen time, što reaguje jedinjenje formule: u kojoj X je halogenski atom, Y je atom vodonika ili niža alkil grupa koja ima 1-5 atoma ugljenika i R1, R2 i R3 su kao što je definisano napre, sa amonijakom na temperaturi od 50 do 150 C tokom 1 do 50 časova u inertnom rastvaraču takvom kao što je etanol, piridin, dimetilformamid i voda, i ako se želi, dobiveno jedinjenje se hidrolizuje i po izboru prevodi u svoju farmaceutski prihvatljivu so.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP26244187 | 1987-10-16 | ||
JP10884088 | 1988-04-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
YU199089A YU199089A (en) | 1990-04-30 |
YU46703B true YU46703B (sh) | 1994-04-05 |
Family
ID=26448650
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU192288A YU46647B (sh) | 1987-10-16 | 1988-10-14 | Postupak za dobijanje hinolinskih derivata |
YU198989A YU46684B (sh) | 1987-10-16 | 1989-10-13 | Posupak za dobijanje hinolinskog derivata |
YU199089A YU46703B (sh) | 1987-10-16 | 1989-10-13 | Postupak za dobijanje hinolinskih derivata |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
YU192288A YU46647B (sh) | 1987-10-16 | 1988-10-14 | Postupak za dobijanje hinolinskih derivata |
YU198989A YU46684B (sh) | 1987-10-16 | 1989-10-13 | Posupak za dobijanje hinolinskog derivata |
Country Status (16)
Country | Link |
---|---|
US (1) | US5013841A (sh) |
EP (1) | EP0312085B1 (sh) |
KR (1) | KR930006774B1 (sh) |
CN (1) | CN1021967C (sh) |
DE (1) | DE3880953T2 (sh) |
DK (1) | DK573788A (sh) |
ES (1) | ES2054762T3 (sh) |
FI (1) | FI884752A (sh) |
HU (1) | HU204521B (sh) |
IL (1) | IL88003A (sh) |
NO (1) | NO171016C (sh) |
NZ (1) | NZ226574A (sh) |
PH (1) | PH25530A (sh) |
PT (1) | PT88769A (sh) |
RU (2) | RU1780534C (sh) |
YU (3) | YU46647B (sh) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL88003A (en) * | 1987-10-16 | 1992-11-15 | Dainippon Pharmaceutical Co | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
US5262417A (en) * | 1988-12-06 | 1993-11-16 | The Upjohn Company | Antibacterial quinolone compounds |
ATE193890T1 (de) | 1990-04-18 | 2000-06-15 | Procter & Gamble Pharma | Antimikrobielle chinolonyl-lactame |
DE4019023A1 (de) * | 1990-06-14 | 1991-12-19 | Bayer Ag | Verfahren zur herstellung von chinolincarbonsaeuren |
TW252107B (sh) * | 1993-08-27 | 1995-07-21 | Hokuriku Pharmacetical Co Ltd | |
CA2467321A1 (en) * | 2004-05-14 | 2005-11-14 | Paul J. Santerre | Polymeric coupling agents and pharmaceutically-active polymers made therefrom |
FR2916446B1 (fr) * | 2007-05-24 | 2009-08-21 | Biocodex Sa | Nouveau procede de synthese de fluoroquinolones |
WO2019148293A1 (en) | 2018-02-02 | 2019-08-08 | Interface Biologics, Inc. | Glass formulations comprising steroid dimers and uses thereof |
JP2023524494A (ja) | 2020-05-01 | 2023-06-12 | リップル セラピューティクス コーポレーション | 眼障害を処置するためのヘテロ二量体組成物と方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3142854A1 (de) * | 1981-10-29 | 1983-05-11 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
DE3248506A1 (de) * | 1982-12-29 | 1984-07-05 | Bayer Ag, 5090 Leverkusen | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
AU594983B2 (en) * | 1985-10-29 | 1990-03-22 | Dainippon Pharmaceutical Co. Ltd. | Novel quinoline derivatives and processes for preparation thereof |
DE3542002A1 (de) * | 1985-11-28 | 1987-06-04 | Bayer Ag | 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7- (1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel |
US4668680A (en) * | 1985-12-12 | 1987-05-26 | Warner-Lambert Company | 5-amino-6,8-difluoroquinolones as antibacterial agents |
JPS62215572A (ja) * | 1986-03-17 | 1987-09-22 | Kyorin Pharmaceut Co Ltd | キノロンカルボン酸誘導体 |
EP0242789A3 (en) * | 1986-04-25 | 1990-09-05 | Dainippon Pharmaceutical Co., Ltd. | Novel quinoline derivates and processes for preparation thereof |
DE3711193A1 (de) * | 1987-04-02 | 1988-10-13 | Bayer Ag | 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate |
US5591744A (en) * | 1987-04-16 | 1997-01-07 | Otsuka Pharmaceutical Company, Limited | Benzoheterocyclic compounds |
IL88003A (en) * | 1987-10-16 | 1992-11-15 | Dainippon Pharmaceutical Co | Quinoline derivatives,their preparation and pharmaceutical compositions containing them |
-
1988
- 1988-10-11 IL IL88003A patent/IL88003A/xx unknown
- 1988-10-14 YU YU192288A patent/YU46647B/sh unknown
- 1988-10-14 DE DE88117113T patent/DE3880953T2/de not_active Expired - Fee Related
- 1988-10-14 DK DK573788A patent/DK573788A/da not_active Application Discontinuation
- 1988-10-14 NZ NZ226574A patent/NZ226574A/en unknown
- 1988-10-14 PT PT88769A patent/PT88769A/pt unknown
- 1988-10-14 FI FI884752A patent/FI884752A/fi not_active Application Discontinuation
- 1988-10-14 HU HU885296A patent/HU204521B/hu not_active IP Right Cessation
- 1988-10-14 ES ES88117113T patent/ES2054762T3/es not_active Expired - Lifetime
- 1988-10-14 PH PH37684A patent/PH25530A/en unknown
- 1988-10-14 NO NO884599A patent/NO171016C/no unknown
- 1988-10-14 EP EP88117113A patent/EP0312085B1/en not_active Expired - Lifetime
- 1988-10-15 CN CN88108434A patent/CN1021967C/zh not_active Expired - Fee Related
- 1988-10-15 KR KR1019880013470A patent/KR930006774B1/ko active IP Right Grant
-
1989
- 1989-08-04 US US07/389,900 patent/US5013841A/en not_active Expired - Fee Related
- 1989-10-13 YU YU198989A patent/YU46684B/sh unknown
- 1989-10-13 YU YU199089A patent/YU46703B/sh unknown
- 1989-10-18 RU SU894742183A patent/RU1780534C/ru active
- 1989-10-20 RU SU894742186A patent/RU1830067C/ru active
Also Published As
Publication number | Publication date |
---|---|
HUT49342A (en) | 1989-09-28 |
DK573788A (da) | 1989-04-17 |
US5013841A (en) | 1991-05-07 |
FI884752A0 (fi) | 1988-10-14 |
KR930006774B1 (ko) | 1993-07-23 |
DE3880953T2 (de) | 1993-10-14 |
KR890006620A (ko) | 1989-06-14 |
RU1780534C (ru) | 1992-12-07 |
AU2375488A (en) | 1989-04-20 |
YU198989A (en) | 1990-04-30 |
YU199089A (en) | 1990-04-30 |
AU619214B2 (en) | 1992-01-23 |
DK573788D0 (da) | 1988-10-14 |
EP0312085A3 (en) | 1990-05-30 |
NO171016B (no) | 1992-10-05 |
NO884599L (no) | 1989-04-17 |
YU46647B (sh) | 1994-01-20 |
NZ226574A (en) | 1991-07-26 |
ES2054762T3 (es) | 1994-08-16 |
IL88003A (en) | 1992-11-15 |
YU192288A (en) | 1990-04-30 |
NO171016C (no) | 1993-01-13 |
HU204521B (en) | 1992-01-28 |
EP0312085A2 (en) | 1989-04-19 |
NO884599D0 (no) | 1988-10-14 |
YU46684B (sh) | 1994-04-05 |
RU1830067C (ru) | 1993-07-23 |
CN1021967C (zh) | 1993-09-01 |
PT88769A (pt) | 1989-07-31 |
PH25530A (en) | 1991-07-24 |
CN1033996A (zh) | 1989-07-19 |
IL88003A0 (en) | 1989-06-30 |
DE3880953D1 (de) | 1993-06-17 |
FI884752A (fi) | 1989-04-17 |
EP0312085B1 (en) | 1993-05-12 |
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