ES8203845A1 - Procedimiento para preparar derivados de piridoxina - Google Patents

Procedimiento para preparar derivados de piridoxina

Info

Publication number
ES8203845A1
ES8203845A1 ES502276A ES502276A ES8203845A1 ES 8203845 A1 ES8203845 A1 ES 8203845A1 ES 502276 A ES502276 A ES 502276A ES 502276 A ES502276 A ES 502276A ES 8203845 A1 ES8203845 A1 ES 8203845A1
Authority
ES
Spain
Prior art keywords
image
methyl
radical
antiadrenergic
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES502276A
Other languages
English (en)
Other versions
ES502276A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Labaz NV
Original Assignee
Labaz NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Labaz NV filed Critical Labaz NV
Publication of ES502276A0 publication Critical patent/ES502276A0/es
Publication of ES8203845A1 publication Critical patent/ES8203845A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • C07D213/66—One oxygen atom attached in position 3 or 5 having in position 3 an oxygen atom and in each of the positions 4 and 5 a carbon atom bound to an oxygen, sulphur, or nitrogen atom, e.g. pyridoxal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE PIRIDOXINA, ASI COMO DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R R R1 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE UNA AMINA DE FORMULA H2N-R, EN LA QUE R ES LO MISMO QUE EN LA FORMULA (I), CON 3-0-(2,3-EPOXI-PROPIL)-A,A-ISOPROPILIDENOPIRIDOXOL, EN UN DISOLVENTE ORGANICO INERTE, A LA TEMPERATURA DE REFLUJO, SEGUIDA DE LA HIDROLISIS DEL CETAL OBTENIDO EN MEDIO ACIDO FUERTE PARA OBTENER EL DERIVADO DE PIRIDOXINA, EN EL QUE R1 ES HIDROGENO, Y FINALMENTE REACCION OPCIONAL DE LA BASE LIBRE CON UN ACIDO PARA OBTENER LA BASE CORRESPONDIENTE. TAMBIEN SE PUEDE CONDENSAR LA AMINA DE FORMULA H2N - R CON UNA BROMOHIDRANA DE FORMULA (II), EN LA QUE R1 ES UN RADICAL DE FORMULA R3 - NH - C = O, SIENDO R3 UN ALQUILO C1-4.
ES502276A 1980-05-19 1981-05-18 Procedimiento para preparar derivados de piridoxina Expired ES8203845A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8016516 1980-05-19

Publications (2)

Publication Number Publication Date
ES502276A0 ES502276A0 (es) 1982-04-01
ES8203845A1 true ES8203845A1 (es) 1982-04-01

Family

ID=10513518

Family Applications (1)

Application Number Title Priority Date Filing Date
ES502276A Expired ES8203845A1 (es) 1980-05-19 1981-05-18 Procedimiento para preparar derivados de piridoxina

Country Status (32)

Country Link
US (1) US4374841A (es)
EP (1) EP0040591B1 (es)
JP (1) JPS5711966A (es)
AR (1) AR226356A1 (es)
AT (1) ATE3859T1 (es)
AU (1) AU542463B2 (es)
BG (1) BG35327A3 (es)
CA (1) CA1152080A (es)
CS (1) CS223842B2 (es)
DD (1) DD159071A5 (es)
DE (1) DE3160480D1 (es)
DK (1) DK217481A (es)
EG (1) EG15890A (es)
ES (1) ES8203845A1 (es)
FI (1) FI811525L (es)
GR (1) GR82343B (es)
HU (1) HU183441B (es)
IE (1) IE51179B1 (es)
IL (1) IL62602A (es)
IN (1) IN151915B (es)
IS (1) IS1183B6 (es)
MA (1) MA19147A1 (es)
NO (1) NO811680L (es)
NZ (1) NZ196766A (es)
OA (1) OA06811A (es)
PL (1) PL129213B1 (es)
PT (1) PT72992B (es)
RO (1) RO81943A (es)
SU (1) SU1077566A3 (es)
YU (1) YU126281A (es)
ZA (1) ZA812448B (es)
ZW (1) ZW9681A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4663354A (en) * 1984-04-26 1987-05-05 Klinge Pharma Gmbh Use of etilefrin and etilefrin pivalate in the long term treatment of circulatory disorders not due to hypotonia
DE3519693A1 (de) * 1985-06-01 1987-01-02 Basf Ag Pyridin-derivate, ihre herstellung und verwendung
US6051587A (en) * 1998-04-16 2000-04-18 Medicure, Inc. Treatment of iatrogenic and age-related hypertension and pharmaceutical compositions useful therein
US6043259A (en) * 1998-07-09 2000-03-28 Medicure Inc. Treatment of cardiovascular and related pathologies
DE60023125T2 (de) 1999-03-08 2006-06-22 University Of Manitoba, Winnipeg Pyridoxal-analoge zur behandlung von störungen ausgelöst durch einen vitamin b6 mangel
AU5840200A (en) 1999-07-13 2001-01-30 Medicure Inc. Treatment of diabetes and related pathologies
WO2001013900A2 (en) 1999-08-24 2001-03-01 Medicure International Inc. Compositions for the treatment of cardiovascular diseases containing pyridoxal compounds and cardiovascular compounds
JP2003525303A (ja) 2000-02-29 2003-08-26 メディキュア インターナショナル インコーポレイテッド 心臓保護ホスホン酸塩およびマロン酸塩
US7442689B2 (en) * 2000-02-29 2008-10-28 Medicure International Inc. Cardioprotective phosphonates and malonates
JP2003528146A (ja) 2000-03-28 2003-09-24 メディキュア インターナショナル インコーポレイテッド 脳血管疾患の治療
ATE364595T1 (de) 2000-07-07 2007-07-15 Medicure Int Inc Pyridoxin- und pyridoxalanaloga als cardiovasculäre therapeutika
US6548519B1 (en) 2001-07-06 2003-04-15 Medicure International Inc. Pyridoxine and pyridoxal analogues: novel uses
US6897228B2 (en) * 2000-07-07 2005-05-24 Medicure International Inc. Pyridoxine and pyridoxal analogues: new uses
US20040121988A1 (en) * 2001-03-28 2004-06-24 Medicure International Inc. Treatment of cerebrovascular disease
JP4048166B2 (ja) * 2002-11-18 2008-02-13 三井製糖株式会社 血糖値上昇抑制剤及び体脂肪蓄積抑制剤並びに食用材料
US20040186077A1 (en) * 2003-03-17 2004-09-23 Medicure International Inc. Novel heteroaryl phosphonates as cardioprotective agents
EP1608379A1 (en) * 2003-03-27 2005-12-28 Medicure Inc. Compositions for treating angina
WO2006002549A1 (en) * 2004-07-07 2006-01-12 Medicure International Inc. Combination therapies employing platelet aggregation drugs
US20070060549A1 (en) * 2004-08-10 2007-03-15 Friesen Albert D Combination therapies employing ace inhibitors and uses thereof for the treatment of diabetic disorders
US7459468B2 (en) * 2004-10-28 2008-12-02 Medicure International, Inc. Aryl sulfonic pyridoxines as antiplatelet agents
AU2005304220A1 (en) * 2004-10-28 2006-05-18 Medicure International Inc. Dual antiplatelet/anticoagulant pyridoxine analogs
US20060094749A1 (en) * 2004-10-28 2006-05-04 Medicure International Inc. Substituted pyridoxines as anti-platelet agents
WO2007059631A1 (en) * 2005-11-28 2007-05-31 Medicure International Inc. Selected dosage for the treatment of cardiovascular and related pathologies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR207133A1 (es) * 1973-02-20 1976-09-15 Ciba Geigy Ag Procedimiento para la elaboracion de derivados de 1-piridiloxi 1-pirimidiniloxi y 1-piraziniloxi-2-hidroxi-3-amino-propano
US4115575A (en) * 1973-02-20 1978-09-19 Ciba-Geigy Corporation 2-(3-Amino-2-hydroxy-propoxy)-pyrazines
GB1485919A (en) * 1975-08-12 1977-09-14 Grindstedvaerket As Pyridine derivatives
DE2711655A1 (de) * 1977-03-17 1978-09-21 Basf Ag Pyridinyl-aminoalkylaether
US4210653A (en) * 1978-06-27 1980-07-01 Merck & Co., Inc. Pyridyloxypropanolamines

Also Published As

Publication number Publication date
AR226356A1 (es) 1982-06-30
GR82343B (es) 1984-12-13
PL129213B1 (en) 1984-04-30
EP0040591B1 (fr) 1983-06-22
DD159071A5 (de) 1983-02-16
ATE3859T1 (de) 1983-07-15
RO81943B (ro) 1983-05-30
DE3160480D1 (en) 1983-07-28
IL62602A (en) 1984-06-29
HU183441B (en) 1984-05-28
RO81943A (ro) 1983-06-01
FI811525L (fi) 1981-11-20
CA1152080A (en) 1983-08-16
EP0040591A1 (fr) 1981-11-25
PT72992A (en) 1981-06-01
ES502276A0 (es) 1982-04-01
JPS5711966A (en) 1982-01-21
IE811085L (en) 1981-11-19
ZW9681A1 (en) 1982-01-20
PT72992B (en) 1982-07-01
PL231193A1 (es) 1982-07-05
IS2631A7 (is) 1981-11-11
YU126281A (en) 1984-02-29
AU7053581A (en) 1981-11-26
ZA812448B (en) 1982-04-28
US4374841A (en) 1983-02-22
IE51179B1 (en) 1986-10-29
OA06811A (fr) 1982-12-31
MA19147A1 (fr) 1981-12-31
IS1183B6 (is) 1985-05-13
NO811680L (no) 1981-11-20
CS223842B2 (en) 1983-11-25
NZ196766A (en) 1984-02-03
IN151915B (es) 1983-09-03
IL62602A0 (en) 1981-06-29
AU542463B2 (en) 1985-02-21
BG35327A3 (en) 1984-03-15
SU1077566A3 (ru) 1984-02-29
EG15890A (en) 1987-03-30
DK217481A (da) 1981-11-20

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