JPS5724369A - Pyrimidine derivative and its preparation - Google Patents

Pyrimidine derivative and its preparation

Info

Publication number
JPS5724369A
JPS5724369A JP9904580A JP9904580A JPS5724369A JP S5724369 A JPS5724369 A JP S5724369A JP 9904580 A JP9904580 A JP 9904580A JP 9904580 A JP9904580 A JP 9904580A JP S5724369 A JPS5724369 A JP S5724369A
Authority
JP
Japan
Prior art keywords
group
fluorouracil
hetero atom
formula
pyrimidine derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP9904580A
Other languages
Japanese (ja)
Inventor
Fumio Maeda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tokyo Kinzoku Industry Co Ltd
Original Assignee
Tokyo Kinzoku Industry Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tokyo Kinzoku Industry Co Ltd filed Critical Tokyo Kinzoku Industry Co Ltd
Priority to JP9904580A priority Critical patent/JPS5724369A/en
Publication of JPS5724369A publication Critical patent/JPS5724369A/en
Pending legal-status Critical Current

Links

Abstract

NEW MATERIAL:The pyrimidine derivative of formula I [X and Y are H or group of formula II (R, R', R" and R''' are alkyl, aryl, etc.: W and W' are hetero atom or hetero atom group; V and V' are heterocyclic ring, etc.; K and K' are 0W10; l, l', m, m', n, and n' are 0W6)].
EXAMPLE: 1-(α-Acetoxyfurfuryl)-5-fluorouracil.
USE: Carcinostatic agent. The characteristic feature of the compound is the introduction of a group which can be coordinated with a polar group or metal, e.g. hetero atom, hetero atom group, hetero-cyclic ring, double bond, etc., or introduction of a crosslinkable aliphatic hydrocarbon group. It has high affinity to the cancerous tissue and low toxicity.
PROCESS: The objective compound is prepared by reacting the chloride of formula III with 5-fluorouracil (pref. 1-acetyl-5-fluorouracil or 1-alkoxycarbonyl-5-fluorouracil).
COPYRIGHT: (C)1982,JPO&Japio
JP9904580A 1980-07-19 1980-07-19 Pyrimidine derivative and its preparation Pending JPS5724369A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP9904580A JPS5724369A (en) 1980-07-19 1980-07-19 Pyrimidine derivative and its preparation

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9904580A JPS5724369A (en) 1980-07-19 1980-07-19 Pyrimidine derivative and its preparation

Publications (1)

Publication Number Publication Date
JPS5724369A true JPS5724369A (en) 1982-02-08

Family

ID=14236537

Family Applications (1)

Application Number Title Priority Date Filing Date
JP9904580A Pending JPS5724369A (en) 1980-07-19 1980-07-19 Pyrimidine derivative and its preparation

Country Status (1)

Country Link
JP (1) JPS5724369A (en)

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6069083A (en) * 1983-08-02 1985-04-19 アメリカン・サイアナミド・カンパニ− Dihydroimidazopyrrolopyridines and derivatives
JPS6087272A (en) * 1983-10-20 1985-05-16 Terumo Corp 5-fluorouracil derivative and blood platelet coagulation inhibitor containing the same
DE3524179A1 (en) * 1984-07-06 1986-01-16 Ricoh Co., Ltd., Tokio/Tokyo METHOD FOR PRODUCING POLYMER PARTICLES
JPS61215602A (en) * 1985-03-22 1986-09-25 Japan Synthetic Rubber Co Ltd Production of polymer particle
JPS6481810A (en) * 1987-09-22 1989-03-28 Kao Corp Production of fine polymer particle having uniform particle diameter
US5942292A (en) * 1996-12-20 1999-08-24 Kao Corporation Spacer for liquid crystal display and liquid crystal display made by using the same
US7732051B2 (en) 2006-07-26 2010-06-08 Jsr Corporation Polymer-coated magnetic particles comprising a 2,3-hydroxypropyl group, and probe-bonded particles
US7981512B2 (en) 2006-09-28 2011-07-19 Jsr Corporation Organic polymer-magnetic particles and process for producing same
US8703289B2 (en) 2005-11-01 2014-04-22 Jsr Corporation Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same
US8846877B2 (en) 2008-09-25 2014-09-30 Jsr Corporation Packing material for affinity chromatography
US9447232B2 (en) 2005-05-20 2016-09-20 Jsr Corporation Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same
US11320430B2 (en) 2016-12-28 2022-05-03 Jsr Corporation Magnetic particle dispersion
US11366108B2 (en) 2017-03-31 2022-06-21 Jsr Corporation Method of producing probe-bound carrier, probe-bound carrier and method of detecting or separating target substance

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198280A (en) * 1975-02-17 1976-08-30 11 * arufua ashirokishiarukiru * 55 furuororashiruruinoseizohoho
JPS5331676A (en) * 1976-09-06 1978-03-25 Mitsui Toatsu Chem Inc Uracil derivatives and their preparation
JPS54122281A (en) * 1978-03-13 1979-09-21 Mitsui Toatsu Chem Inc 5-fluorouracil derivative and its preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5198280A (en) * 1975-02-17 1976-08-30 11 * arufua ashirokishiarukiru * 55 furuororashiruruinoseizohoho
JPS5331676A (en) * 1976-09-06 1978-03-25 Mitsui Toatsu Chem Inc Uracil derivatives and their preparation
JPS54122281A (en) * 1978-03-13 1979-09-21 Mitsui Toatsu Chem Inc 5-fluorouracil derivative and its preparation

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0670054B2 (en) * 1983-08-02 1994-09-07 アメリカン・サイアナミド・カンパニ− Dihydroimidazopyrrolopyridines and their derivatives
JPS6069083A (en) * 1983-08-02 1985-04-19 アメリカン・サイアナミド・カンパニ− Dihydroimidazopyrrolopyridines and derivatives
JPH0369326B2 (en) * 1983-10-20 1991-10-31 Terumo Corp
JPS6087272A (en) * 1983-10-20 1985-05-16 Terumo Corp 5-fluorouracil derivative and blood platelet coagulation inhibitor containing the same
DE3524179A1 (en) * 1984-07-06 1986-01-16 Ricoh Co., Ltd., Tokio/Tokyo METHOD FOR PRODUCING POLYMER PARTICLES
DE3524179C2 (en) * 1984-07-06 1987-11-19 Ricoh Co., Ltd., Tokio/Tokyo, Jp
JPH0651728B2 (en) * 1985-03-22 1994-07-06 日本合成ゴム株式会社 Method for producing polymer particles
JPS61215602A (en) * 1985-03-22 1986-09-25 Japan Synthetic Rubber Co Ltd Production of polymer particle
JPH0564964B2 (en) * 1987-09-22 1993-09-16 Kao Corp
JPS6481810A (en) * 1987-09-22 1989-03-28 Kao Corp Production of fine polymer particle having uniform particle diameter
US5496897A (en) * 1987-09-22 1996-03-05 Kao Corporation Process for preparing uniformly sized, fine particles of polymer
US5942292A (en) * 1996-12-20 1999-08-24 Kao Corporation Spacer for liquid crystal display and liquid crystal display made by using the same
US9447232B2 (en) 2005-05-20 2016-09-20 Jsr Corporation Carrier polymer particle, process for producing the same, magnetic particle for specific trapping, and process for producing the same
US8703289B2 (en) 2005-11-01 2014-04-22 Jsr Corporation Organic polymer particles and process for producing the same, magnetic particles for diagnostics, carboxyl group-containing particles and process for producing the same, and probe-bound particles and process for producing the same
US7732051B2 (en) 2006-07-26 2010-06-08 Jsr Corporation Polymer-coated magnetic particles comprising a 2,3-hydroxypropyl group, and probe-bonded particles
US7981512B2 (en) 2006-09-28 2011-07-19 Jsr Corporation Organic polymer-magnetic particles and process for producing same
US8846877B2 (en) 2008-09-25 2014-09-30 Jsr Corporation Packing material for affinity chromatography
US11320430B2 (en) 2016-12-28 2022-05-03 Jsr Corporation Magnetic particle dispersion
US11366108B2 (en) 2017-03-31 2022-06-21 Jsr Corporation Method of producing probe-bound carrier, probe-bound carrier and method of detecting or separating target substance

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