JPS55133366A - Thiazole derivative - Google Patents

Thiazole derivative

Info

Publication number
JPS55133366A
JPS55133366A JP4168079A JP4168079A JPS55133366A JP S55133366 A JPS55133366 A JP S55133366A JP 4168079 A JP4168079 A JP 4168079A JP 4168079 A JP4168079 A JP 4168079A JP S55133366 A JPS55133366 A JP S55133366A
Authority
JP
Japan
Prior art keywords
compound shown
formula
lower alkyl
solvent
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP4168079A
Other languages
Japanese (ja)
Other versions
JPS6116274B2 (en
Inventor
Kiyoto Goto
Yoshiaki Tsuda
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP4168079A priority Critical patent/JPS55133366A/en
Publication of JPS55133366A publication Critical patent/JPS55133366A/en
Publication of JPS6116274B2 publication Critical patent/JPS6116274B2/ja
Granted legal-status Critical Current

Links

Abstract

NEW MATERIAL:A compound shown by the formula I [R1 and R2 are H or lower alkyl: R3 is H, lower alkyl, phenylalkyl, pyridyl, phenyl, -NR4R5 (R4 and R5 are H, lower alkyl, phenyl, etc. or R4, R5 and a linked N form a hetero ring)] and its salt.
EXAMPLE: 4-(2-Amino-4-thiazolyl)phenylacetic acid.
USE: Anti-inflammatory agents, thrombus preventive agents, and drugs for lipemia.
PROCESS: A compound shown by the formula II (X is halogen) is reacted with a compound shown by the formula III in the absence of a solvent or in the presence of a proper solvent (e.g., benzene) at room temperature to a reflux temperature of the solvent for 1W5 hours to give a compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
JP4168079A 1979-04-05 1979-04-05 Thiazole derivative Granted JPS55133366A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP4168079A JPS55133366A (en) 1979-04-05 1979-04-05 Thiazole derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP4168079A JPS55133366A (en) 1979-04-05 1979-04-05 Thiazole derivative

Publications (2)

Publication Number Publication Date
JPS55133366A true JPS55133366A (en) 1980-10-17
JPS6116274B2 JPS6116274B2 (en) 1986-04-28

Family

ID=12615131

Family Applications (1)

Application Number Title Priority Date Filing Date
JP4168079A Granted JPS55133366A (en) 1979-04-05 1979-04-05 Thiazole derivative

Country Status (1)

Country Link
JP (1) JPS55133366A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011278A1 (en) * 1989-03-24 1990-10-04 The Green Cross Corporation Thiazole compounds and applications thereof
WO1993024472A1 (en) * 1992-05-29 1993-12-09 Otsuka Pharmaceutical Co., Ltd. Thiazole derivative
US5639770A (en) * 1992-05-29 1997-06-17 Otsuka Pharmaceutical Co., Ltd. Thiazole derivatives
US5643932A (en) * 1990-11-30 1997-07-01 Otsuka Pharmaceutical Co., Ltd. Superoxide radical inhibitor
WO1998014191A1 (en) * 1996-09-30 1998-04-09 Otsuka Pharmaceutical Co., Ltd. Agent for inhibition of cytokine production and agent for inhibition of cell adhesion
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
WO2003027085A3 (en) * 2001-09-26 2003-12-04 Bayer Pharmaceuticals Corp 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1990011278A1 (en) * 1989-03-24 1990-10-04 The Green Cross Corporation Thiazole compounds and applications thereof
US6080764A (en) * 1990-11-30 2000-06-27 Otsuka Pharmaceutical Co., Ltd. Superoxide radical inhibitor
US5643932A (en) * 1990-11-30 1997-07-01 Otsuka Pharmaceutical Co., Ltd. Superoxide radical inhibitor
US5677319A (en) * 1990-11-30 1997-10-14 Otsuka Pharmaceutical Co., Ltd. Superoxide radical inhibitor
USRE37556E1 (en) 1990-11-30 2002-02-19 Otsuka Pharmaceutical Co., Ltd. Superoxide radical inhibitor
US5639770A (en) * 1992-05-29 1997-06-17 Otsuka Pharmaceutical Co., Ltd. Thiazole derivatives
WO1993024472A1 (en) * 1992-05-29 1993-12-09 Otsuka Pharmaceutical Co., Ltd. Thiazole derivative
WO1998014191A1 (en) * 1996-09-30 1998-04-09 Otsuka Pharmaceutical Co., Ltd. Agent for inhibition of cytokine production and agent for inhibition of cell adhesion
US8354439B2 (en) 1996-09-30 2013-01-15 Otsuka Pharmaceutical Co., Ltd. Agent for inhibition of cytokine production and agent for inhibition of cell adhesion
WO2001064674A1 (en) * 2000-03-01 2001-09-07 Janssen Pharmaceutica N.V. 2,4-disubstituted thiazolyl derivatives
JP2003525291A (en) * 2000-03-01 2003-08-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 2,4-disubstituted thiazolyl derivatives
US7105550B2 (en) 2000-03-01 2006-09-12 Christopher Love 2,4-disubstituted thiazolyl derivatives
US7893280B2 (en) 2000-03-01 2011-02-22 Janssen Pharmaceutica Nv 2,4-disubstituted thiazolyl derivatives
WO2003027085A3 (en) * 2001-09-26 2003-12-04 Bayer Pharmaceuticals Corp 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors

Also Published As

Publication number Publication date
JPS6116274B2 (en) 1986-04-28

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