JPS55133366A - Thiazole derivative - Google Patents
Thiazole derivativeInfo
- Publication number
- JPS55133366A JPS55133366A JP4168079A JP4168079A JPS55133366A JP S55133366 A JPS55133366 A JP S55133366A JP 4168079 A JP4168079 A JP 4168079A JP 4168079 A JP4168079 A JP 4168079A JP S55133366 A JPS55133366 A JP S55133366A
- Authority
- JP
- Japan
- Prior art keywords
- compound shown
- formula
- lower alkyl
- solvent
- phenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Abstract
NEW MATERIAL:A compound shown by the formula I [R1 and R2 are H or lower alkyl: R3 is H, lower alkyl, phenylalkyl, pyridyl, phenyl, -NR4R5 (R4 and R5 are H, lower alkyl, phenyl, etc. or R4, R5 and a linked N form a hetero ring)] and its salt.
EXAMPLE: 4-(2-Amino-4-thiazolyl)phenylacetic acid.
USE: Anti-inflammatory agents, thrombus preventive agents, and drugs for lipemia.
PROCESS: A compound shown by the formula II (X is halogen) is reacted with a compound shown by the formula III in the absence of a solvent or in the presence of a proper solvent (e.g., benzene) at room temperature to a reflux temperature of the solvent for 1W5 hours to give a compound shown by the formula I.
COPYRIGHT: (C)1980,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4168079A JPS55133366A (en) | 1979-04-05 | 1979-04-05 | Thiazole derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4168079A JPS55133366A (en) | 1979-04-05 | 1979-04-05 | Thiazole derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS55133366A true JPS55133366A (en) | 1980-10-17 |
JPS6116274B2 JPS6116274B2 (en) | 1986-04-28 |
Family
ID=12615131
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP4168079A Granted JPS55133366A (en) | 1979-04-05 | 1979-04-05 | Thiazole derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS55133366A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990011278A1 (en) * | 1989-03-24 | 1990-10-04 | The Green Cross Corporation | Thiazole compounds and applications thereof |
WO1993024472A1 (en) * | 1992-05-29 | 1993-12-09 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivative |
US5639770A (en) * | 1992-05-29 | 1997-06-17 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivatives |
US5643932A (en) * | 1990-11-30 | 1997-07-01 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
WO1998014191A1 (en) * | 1996-09-30 | 1998-04-09 | Otsuka Pharmaceutical Co., Ltd. | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion |
WO2001064674A1 (en) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
WO2003027085A3 (en) * | 2001-09-26 | 2003-12-04 | Bayer Pharmaceuticals Corp | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
-
1979
- 1979-04-05 JP JP4168079A patent/JPS55133366A/en active Granted
Cited By (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990011278A1 (en) * | 1989-03-24 | 1990-10-04 | The Green Cross Corporation | Thiazole compounds and applications thereof |
US6080764A (en) * | 1990-11-30 | 2000-06-27 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US5643932A (en) * | 1990-11-30 | 1997-07-01 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US5677319A (en) * | 1990-11-30 | 1997-10-14 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
USRE37556E1 (en) | 1990-11-30 | 2002-02-19 | Otsuka Pharmaceutical Co., Ltd. | Superoxide radical inhibitor |
US5639770A (en) * | 1992-05-29 | 1997-06-17 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivatives |
WO1993024472A1 (en) * | 1992-05-29 | 1993-12-09 | Otsuka Pharmaceutical Co., Ltd. | Thiazole derivative |
WO1998014191A1 (en) * | 1996-09-30 | 1998-04-09 | Otsuka Pharmaceutical Co., Ltd. | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion |
US8354439B2 (en) | 1996-09-30 | 2013-01-15 | Otsuka Pharmaceutical Co., Ltd. | Agent for inhibition of cytokine production and agent for inhibition of cell adhesion |
WO2001064674A1 (en) * | 2000-03-01 | 2001-09-07 | Janssen Pharmaceutica N.V. | 2,4-disubstituted thiazolyl derivatives |
JP2003525291A (en) * | 2000-03-01 | 2003-08-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 2,4-disubstituted thiazolyl derivatives |
US7105550B2 (en) | 2000-03-01 | 2006-09-12 | Christopher Love | 2,4-disubstituted thiazolyl derivatives |
US7893280B2 (en) | 2000-03-01 | 2011-02-22 | Janssen Pharmaceutica Nv | 2,4-disubstituted thiazolyl derivatives |
WO2003027085A3 (en) * | 2001-09-26 | 2003-12-04 | Bayer Pharmaceuticals Corp | 3-pyridyl or 4-isoquinolinyl thiazoles as c17,20 lyase inhibitors |
Also Published As
Publication number | Publication date |
---|---|
JPS6116274B2 (en) | 1986-04-28 |
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