YU45867B - Postupak za dobijanje derivata 3,7-diazabiciklo (3,3,1) nonana - Google Patents

Postupak za dobijanje derivata 3,7-diazabiciklo (3,3,1) nonana

Info

Publication number
YU45867B
YU45867B YU157182A YU157182A YU45867B YU 45867 B YU45867 B YU 45867B YU 157182 A YU157182 A YU 157182A YU 157182 A YU157182 A YU 157182A YU 45867 B YU45867 B YU 45867B
Authority
YU
Yugoslavia
Prior art keywords
general formula
compound
formula
group
halogen
Prior art date
Application number
YU157182A
Other languages
English (en)
Other versions
YU157182A (en
Inventor
K. Nador
G. Kraiss
K. Sinko
M. Paroczai
E. Karpati
L. Szporny
Original Assignee
Richter Gedeon Vegyeszeti Gyar Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar Rt. filed Critical Richter Gedeon Vegyeszeti Gyar Rt.
Priority to SI8211571A priority Critical patent/SI8211571A8/sl
Publication of YU157182A publication Critical patent/YU157182A/xx
Publication of YU45867B publication Critical patent/YU45867B/sh
Priority to HR920785A priority patent/HRP920785A2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

POSTUPAK ZA DOBIJANJE DERIVATA 3,7-DIAZABICIKLO (3,3,1) NONANA, opste formule: u kojoj: R1 i R2 svaki nezavisno predstavljaju C1-6alkil grupu; R3 predstavlja eterifikovanu hidroksi grupu formule -OR4, gde R4 je fenil, hlorofenil ili benzhidril grupa, ili R3 predstavlja esterifikovanu hidroksi grupu formule -O-CO-R5, gde R5 je fenil-C1-5alkil, 2-fenilvinil po izboru supstituisana sa halogenom ili sa jednom ili vise C1-4alkoksi grupom fenil koja moze biti supstituisana sa C1-4alkil grupom, fenil ili trihalometil grupom, ili jednom ili vise C1-4alkoksi grupom halogenom i/ili sa nitro grupom; difenilhidroksimetil; ksanten-9-il; naftil grupa koja je po izboru supstituisana ili heterociklicni prsten takav kao piridil, furil ili tienil, njihovih stereoizomera ili farmaceutski prihvatljivih soli sa kiselinama, naznacen time, sto u prvoj varijanti za dobivanje jedinjenja opste formule (I), gde je R3 eterifikovana hidroksi grupa formule -OR4, reaguje jedinjenje opste formule (II): gde su R1 i R2 kao sto je napred definisano, ili odgovarajuci alkoholat alkalnog metala, sa jedinjenjem opste formule (III): R4-X (III) gde R4 je kao sto je definisano napred, a X je halogen u polarnom aproticnom rastvaracu, takvom kao sto je dimetil formamid, u prisustvu jake baze na temperaturi izmedju sobne i 100°C, ili u drugoj varijanti, za dobivanje jedinjenja opste formule (I), gde R3 je esterifikovana hidroksi grupe opste formule-O- CO-R5, reaguje jedinjenje opste formule (II), sa karboksilnom kiselinom opste formule (IV) R5 - COOH (IV) gde je R5 kao sto je definisano napred ili sa njenim reaktivnim derivatom, opste formule (V): R5-CO-Z (V) gde Z je halogen ili C1-5alkoksi grupa u organskom rastvaracu takvom kao sto je haloroform ili piridin u prisustvu sredstva za vezivanje kiseline, takvog kao sto je piridin, trietilamin ili visak polaznog jedinjenja formule (II) i katalizatora takvog kao sto je alkilni metal ili alkoholat alkalnog metala, i ako se zeli vrsi se razdvajanje pojedinih izomera i/ili dobiveno jedinjenje opste formule (I) koje je slobodan baza se prevodi u svoju farmaceutski prihvatljivu adicionu so kiseline, ili se baza opste formule (I) oslobadja iz svoje soli. Prijava sadrzi jos 3 patentna zahteva.
YU157182A 1981-07-20 1982-07-19 Postupak za dobijanje derivata 3,7-diazabiciklo (3,3,1) nonana YU45867B (sh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
SI8211571A SI8211571A8 (sl) 1981-07-20 1982-07-19 Postopek za pridobivanje derivatov 3,7-diazabiciklo (3,3,1) nonanov
HR920785A HRP920785A2 (en) 1981-07-20 1992-10-01 New bicyclic compounds and a process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU812112A HU184960B (en) 1981-07-20 1981-07-20 Process for preparing new derivatives of 3,7-diazabicyclo/3.3.1/ nonane

Publications (2)

Publication Number Publication Date
YU157182A YU157182A (en) 1986-10-31
YU45867B true YU45867B (sh) 1992-09-07

Family

ID=10957812

Family Applications (1)

Application Number Title Priority Date Filing Date
YU157182A YU45867B (sh) 1981-07-20 1982-07-19 Postupak za dobijanje derivata 3,7-diazabiciklo (3,3,1) nonana

Country Status (31)

Country Link
US (1) US4451473A (sh)
JP (1) JPS5849383A (sh)
AR (1) AR230447A1 (sh)
AT (1) AT379809B (sh)
AU (1) AU552770B2 (sh)
BE (1) BE893891A (sh)
CA (1) CA1254208A (sh)
CH (1) CH653032A5 (sh)
CS (1) CS235302B2 (sh)
DD (1) DD202575A5 (sh)
DE (1) DE3226921C2 (sh)
DK (1) DK160875C (sh)
ES (2) ES514126A0 (sh)
FI (1) FI71320C (sh)
FR (1) FR2510575B1 (sh)
GB (1) GB2102801B (sh)
GR (1) GR76874B (sh)
HU (1) HU184960B (sh)
IL (1) IL66277A (sh)
IN (1) IN155994B (sh)
IT (1) IT1190920B (sh)
MX (1) MX159288A (sh)
NL (1) NL8202908A (sh)
NO (1) NO157421C (sh)
PH (1) PH18502A (sh)
PL (2) PL135814B1 (sh)
PT (1) PT75265B (sh)
SE (1) SE450704B (sh)
SU (2) SU1222197A3 (sh)
YU (1) YU45867B (sh)
ZA (1) ZA824809B (sh)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5036153A (en) * 1989-05-11 1991-07-30 Braish Tamim F Preparation of 2,5-diazabicyclo[2.2.1]heptanes and intermediates
GB9726630D0 (en) * 1997-12-18 1998-02-18 Glaxo Group Ltd Kv2.1 Antagonists
MXPA02005884A (es) 1999-12-14 2002-10-23 Neurosearch As Heteroaril-diazabicicloalcanos novedosos.
PL1731518T3 (pl) 2004-03-31 2014-11-28 Nippon Soda Co Cykliczny związek aminowy oraz środek zwalczający szkodniki
KR101006363B1 (ko) 2005-10-06 2011-01-10 닛뽕소다 가부시키가이샤 가교 고리형 아민 화합물 및 유해 생물 방제제
UA86328C2 (uk) * 2005-10-06 2009-04-10 Ниппон Сода Ко., Лтд. Циклічні амінові сполуки, засіб для боротьби зі шкідниками
EP2152670B1 (en) * 2007-04-27 2013-12-25 Actelion Pharmaceuticals Ltd. Bridged six-membered ring compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3078272A (en) * 1963-02-19 N-aza-bicyclo-alkylene-imino
DE2428792A1 (de) * 1974-06-14 1976-01-02 Knoll Ag Neue antiarrhythmika
DE2726571A1 (de) * 1977-06-13 1978-12-21 Basf Ag Neue bispidinderivate, verfahren zu deren herstellung und arzneimittel, welche diese enthalten

Also Published As

Publication number Publication date
FR2510575B1 (fr) 1986-02-07
NO157421B (no) 1987-12-07
DE3226921C2 (de) 1994-03-10
GB2102801A (en) 1983-02-09
MX159288A (es) 1989-05-12
IL66277A (en) 1985-08-30
ZA824809B (en) 1983-04-27
FI71320B (fi) 1986-09-09
ATA272382A (de) 1985-07-15
FR2510575A1 (fr) 1983-02-04
CS235302B2 (en) 1985-05-15
IT8222448A1 (it) 1984-01-19
CH653032A5 (de) 1985-12-13
PL135814B1 (en) 1985-12-31
JPS5849383A (ja) 1983-03-23
SE8204393L (sv) 1983-01-21
PT75265A (en) 1982-08-01
CA1254208A (en) 1989-05-16
SU1272990A3 (ru) 1986-11-23
IN155994B (sh) 1985-04-20
ES8401972A1 (es) 1984-01-01
AR230447A1 (es) 1984-04-30
DK160875B (da) 1991-04-29
DD202575A5 (de) 1983-09-21
IL66277A0 (en) 1982-11-30
FI71320C (fi) 1986-12-19
ES520567A0 (es) 1984-05-01
AT379809B (de) 1986-03-10
GR76874B (sh) 1984-09-04
ES8404354A1 (es) 1984-05-01
DE3226921A1 (de) 1983-02-10
SU1222197A3 (ru) 1986-03-30
FI822526L (fi) 1983-01-21
NO157421C (no) 1988-03-16
NO822485L (no) 1983-01-21
PT75265B (en) 1984-07-02
FI822526A0 (fi) 1982-07-15
DK160875C (da) 1991-10-14
ES514126A0 (es) 1984-01-01
HU184960B (en) 1984-11-28
AU8617682A (en) 1983-01-27
PL135878B1 (en) 1985-12-31
JPH0352465B2 (sh) 1991-08-12
BE893891A (fr) 1983-01-20
AU552770B2 (en) 1986-06-19
GB2102801B (en) 1985-03-27
SE450704B (sv) 1987-07-20
PL244329A1 (en) 1984-05-07
YU157182A (en) 1986-10-31
IT1190920B (it) 1988-02-24
SE8204393D0 (sv) 1982-07-19
US4451473A (en) 1984-05-29
IT8222448A0 (it) 1982-07-19
NL8202908A (nl) 1983-02-16
PL237566A1 (en) 1984-03-12
PH18502A (en) 1985-08-02
DK319982A (da) 1983-01-21

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