WO2022044781A1 - Composition de gel - Google Patents

Composition de gel Download PDF

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Publication number
WO2022044781A1
WO2022044781A1 PCT/JP2021/029367 JP2021029367W WO2022044781A1 WO 2022044781 A1 WO2022044781 A1 WO 2022044781A1 JP 2021029367 W JP2021029367 W JP 2021029367W WO 2022044781 A1 WO2022044781 A1 WO 2022044781A1
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WIPO (PCT)
Prior art keywords
hyaluronic acid
gel
mass
thickener
composition
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PCT/JP2021/029367
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English (en)
Japanese (ja)
Inventor
俊輔 徳永
陽子 橋爪
友紀奈 倉田
慶子 平野
Original Assignee
日本コルマー株式会社
キユーピー株式会社
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Publication of WO2022044781A1 publication Critical patent/WO2022044781A1/fr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin

Definitions

  • the present invention relates to a gel-like composition.
  • Hyaluronic acid is a linear high molecular weight polysaccharide with a molecular weight of tens of thousands to millions, in which N-acetylglucosamine and D-glucuronic acid are alternately bound, which was isolated and identified from bovine vitreous by Meyer et al. In 1934. It is widely distributed in the living body and is present in connective tissues and organs such as skin, joint fluid, blood vessels, brain and cartilage. Hyaluronic acid has high water retention, is viscous due to its water retention capacity, exerts a cell retention function, and functions to maintain the flexibility of tissues. Utilizing this property, hyaluronic acid and hyaluronic acid derivatives are widely used as raw materials for pharmaceuticals, cosmetics, and foods. For example, cosmetics containing hyaluronic acid form a film containing water on the surface of the skin, have the effect of preventing the evaporation of water from the skin, and are useful for maintaining the moisturized state of the skin.
  • a highly viscous gel-like composition containing hyaluronic acid or the like having a high concentration of 0.2% by mass or more which can be used as an all-in-one cosmetic and more positively utilizes the characteristics of hyaluronic acid.
  • the high-viscosity gel-like composition containing a high concentration of hyaluronic acid and the like has a problem that the stability over time is poor, the gel becomes non-uniform over time, and it is easy to be fooled.
  • Patent Document 1 contains 0.01% by mass or more and 5% by mass or less of a thickener, and 0.1 parts or more and 5 parts or more of modified hyaluronic acid containing a carboxymethyl group and / or a salt thereof with respect to 1 part of the thickener.
  • the gel-like cosmetics containing less than a portion are described. However, since this gel-like cosmetic contains a high concentration of hyaluronic acid and the like, its stability over time is not sufficient, and there is the above problem.
  • Patent Documents 2 and 3 describe gel-like compositions containing hyaluronic acid and the like, using an associative thickener.
  • Patent Documents 1 to 3 do not describe the use of an anionic polymer compound thickener and an associative thickener in combination as a thickener, and there are examples in which these are used in combination. do not do.
  • the subject of the present invention is hyaluronic acid having a high concentration of 0.2% by mass or more, which has stability over time, does not have gel inhomogeneity over time, is less likely to be fooled, and has an excellent usability. It is an object of the present invention to provide a highly viscous gel-like composition containing.
  • the present inventors have made a case where only (B) anionic polymer compound thickener is used as the thickener. And (C) When only the associative thickener was used, the obtained gel-like composition containing a high concentration of hyaluronic acid and the like was not stable over time, but (B) was highly anionic.
  • the molecular compound thickener and the (C) associative thickener are combined in a mass ratio of 5: 1 to 0.15: 1, a high concentration of 0.2% by mass or more of hyaluronic acid or the like is contained.
  • the present invention has been completed by finding that the gel-like composition having a viscosity unexpectedly has stability over time, does not cause non-uniformity of the gel over time, and is less likely to be fooled.
  • the present invention is as follows. [1] (A) A gel-like composition containing 0.2% by mass or more of hyaluronic acid and / or a hyaluronic acid derivative or a salt thereof and having a viscosity of 15,000 to 60,000 mPa ⁇ s.
  • the gel-like composition contains (B) anionic polymer compound thickener in an amount of 0.1% by mass or more and (C) an associative thickener in an amount of 0.05% by mass or more.
  • the (B) anionic polymer compound thickener is an anionic polymer compound thickener other than (A) hyaluronic acid and / or a hyaluronic acid derivative or a salt thereof.
  • a gel-like composition in which the mass ratio of the (B) anionic polymer compound thickener to the (C) associative thickener is 5: 1 to 0.15: 1.
  • the gel-like composition of the present invention has stability over time, does not have gel non-uniformity over time, is less likely to be fooled, spreads well on the skin, is not sticky, and is excellent in usability. There is.
  • the present invention is a gel-like composition containing (A) hyaluronic acid and / or a hyaluronic acid derivative or a salt thereof in an amount of 0.2% by mass or more and having a viscosity of 15,000 to 60,000 mPa ⁇ s.
  • the gel-like composition contains (B) an anionic polymer compound thickener in an amount of 0.1% by mass or more, (C) an associative thickener in an amount of 0.05% by mass or more, and (B) an anionic polymer.
  • the present invention relates to a gel-like composition in which the mass ratio of the compound thickener to the (C) associative thickener is 5: 1 to 0.15: 1.
  • hyaluronic acid those extracted from animal tissues, those produced by a fermentation method by culturing microorganisms, and the like are known, and commercially available hyaluronic acid may be appropriately used.
  • the average molecular weight is 500,000 to 3,000,000.
  • those having a high molecular weight, those having a high molecular weight, those having an average molecular weight of 10,000 or less, and the like can be used.
  • Low-molecular-weight hyaluronic acid is produced, for example, by dissolving high-molecular-weight hyaluronic acid in a buffer solution, adding hyaluronidase, incubating for several days, inactivating the enzyme, and then producing (Japanese Patent Laid-Open No. 10-195107). It is produced by using a method of hydrolyzing hyaluronic acid with an acid or the like.
  • the average molecular weight of hyaluronic acid and / or hyaluronic acid derivatives or salts thereof specified in the present invention can be measured by the following method.
  • a calibration curve is prepared from the retention time of a plurality of hyaluronic acids (reference substances) having known molecular weights by liquid chromatography analysis using a gel filtration column.
  • hyaluronic acid and / or hyaluronic acid derivatives or salts thereof to be measured are analyzed by liquid chromatography and the molecular weight is determined using the above calibration curve to obtain hyaluronic acid and / or hyaluronic acid derivatives or salts thereof.
  • the molecular weight of can be determined.
  • Examples of the liquid chromatography analyzer that can be used for liquid chromatography analysis include Waters Alliance 2690 HPLC Separations Module (Waters), Waters Alliance 2695 HPLC Separations Module (Waters), 1200 Agilents. ).
  • Examples of the column that can be used for liquid chromatography analysis include a column for ligand exchange chromatography manufactured by shodex (ligand exchange mode + size exclusion mode), model name "SUGAR KS-801", and the like. "SUGAR KS-802”, “SUGAR KS-803”, “SUGAR KS-804", “SUGAR KS-805", “SUGAR KS-806”, “SUGAR KS-807", and TOSOH size exclusion chromatography columns, The model name "TSKgel GMPW” can be mentioned.
  • hyaluronic acid derivative examples include derivatives obtained by etherifying, esterifying, acetylating, amidating, acetalizing, and ketalizing the hydroxyl group and carboxyl group of hyaluronic acid.
  • a cationized hyaluronic acid having a quaternary ammonium group-containing group WO2008 / 133267
  • a modified hyaluronic acid containing a glycerin skeleton-containing group WO2011 / 102462
  • WO2016 carboxymethyl group-containing modified hyaluronic acid
  • hyaluronic acid and the hyaluronic acid derivative may be salts such as sodium salt, potassium salt, calcium salt, magnesium salt, ammonium salt, basic amino acid salt and zinc salt.
  • the hyaluronic acid and / or the hyaluronic acid derivative a commercially available hyaluronic acid and / or the hyaluronic acid derivative may be appropriately used. Since a gel-like composition containing a high concentration of hyaluronic acid or the like can be stabilized over time, the hyaluronic acid and / or the hyaluronic acid derivative has an average molecular weight of 500,000 or more and 2 million or less.
  • the hyaluronic acid and / or the hyaluronic acid derivative includes two or more hyaluronic acid and / or hyaluronic acid derivatives having an average molecular weight of 500,000 or more and 2 million or less, and hyaluronic acid and / or hyaluronic acid derivatives having an average molecular weight of 10,000 or less.
  • the hyaluronic acid and / or hyaluronic acid derivative contains a medium-high molecular weight hyaluronic acid having an average molecular weight of 500,000 or more and 2 million or less, a low-molecular-weight hyaluronic acid having an average molecular weight of 10,000 or less, and / or a hyaluronic acid derivative, and a quaternary ammonium group.
  • a combination thereof is also preferable (Japanese Patent Laid-Open No. 2016-166133).
  • Hyaluronic acid and / or hyaluronic acid derivatives having an average molecular weight of 500,000 or more and 2 million or less have a property of staying on the skin surface and preventing water from evaporating from the skin surface, and thus exhibit a continuous skin moisturizing effect.
  • Examples of the low molecular weight hyaluronic acid and / or hyaluronic acid derivative having an average molecular weight of 10,000 or less include those having an average molecular weight of 800 or more and 10,000 or less and 1,000 or more and 10,000 or less.
  • This low-molecular-weight hyaluronic acid and / or hyaluronic acid derivative has a high permeability to the skin and has a property of improving the moisturization of the stratum corneum, and thus exhibits a continuous skin moisturizing effect.
  • the cationized hyaluronic acid derivative having a quaternary ammonium group-containing group more preferably has a cationization degree of 0.15 to 0.6, and more preferably has a cationization degree of 0.15 to 0.4. Things can be mentioned.
  • the degree of cationization refers to the number of quaternary ammonium group-containing groups per disaccharide, which is a constituent unit of hyaluronic acid, and is determined by a conventional method or a semi-micro Kjeldahl method. This cationized hyaluronic acid exerts a long-lasting moisturizing effect on the skin.
  • the "carboxymethyl group" of the modified hyaluronic acid derivative containing a carboxymethyl group means a group represented by "-CH 2 - CO 2 H" or "-CH 2 -CO 2- ", and at least one. Hyaluronic acid in which a carboxymethyl group is introduced.
  • the modified hyaluronic acid derivative containing a carboxymethyl group more preferably has a carboxymethylation rate of 5% or more and 200% or less with respect to the disaccharide unit constituting hyaluronic acid, and more preferably with respect to the disaccharide unit constituting hyaluronic acid. Examples thereof include those having a carboxymethylation rate of 60% or more and 200% or less.
  • the disaccharide unit constituting hyaluronic acid refers to one unit composed of adjacently bonded disaccharides (glucuronic acid and N-acetylglucosamine) constituting hyaluronic acid, and is a disaccharide unit constituting hyaluronic acid.
  • the carboxymethylation rate with respect to 1 unit is the number of carboxymethyl groups contained in the 1 unit, and more specifically, when the 1 unit is 100%, the 1 unit is related to the 1 unit. The ratio (%) of the number of carboxymethyl groups contained in the unit.
  • This modified hyaluronic acid derivative containing a carboxymethyl group exerts a long-lasting moisturizing effect on the skin.
  • the modified hyaluronic acid containing a glycerin skeleton-containing group is preferably of the formula: -O-CH 2 -CHOH-CH 2 -OR 1 (where R 1 represents a linear or branched alkyl or alkenyl). It is a modified hyaluronic acid containing a glycerin skeleton-containing group represented.
  • This modified hyaluronic acid has the property of repairing the lamellar structure composed of the aqueous layer and the lipid layer and improving the barrier function repairing effect of the skin, and thus exerts a continuous skin moisturizing effect.
  • Zinc hyaluronic acid is a complex formed by the interaction of zinc ions with carboxyl ions derived from the carboxyl groups constituting hyaluronic acid.
  • Preferred zinc hyaluronates have a zinc content of 55 to 100 mg per gram, more preferably 60 to 80 mg.
  • Zinc hyaluronate exerts a long-lasting moisturizing effect on the skin.
  • the gel-like composition of the present invention contains 0.2% by mass or more of hyaluronic acid and / or a hyaluronic acid derivative. Preferred contents include 0.2 to 5% by mass, more preferably 0.25 to 3% by mass, and further preferably 0.3 to 2% by mass.
  • 5% by mass or more of hyaluronic acid and / or a hyaluronic acid derivative is contained in the gel-like composition of the present invention, the viscosity of the gel-like composition becomes high, the stability over time becomes insufficient, and over time. Gel non-uniformity may occur.
  • hyaluronic acid and / or hyaluronic acid derivatives or salts thereof those having an average molecular weight of 500,000 to 2,000,000 are preferably contained in an amount of 0.1% by mass or more. .. When it is contained in an amount of 0.1% by mass or more, it stays on the skin surface and has a property of preventing water from evaporating from the skin surface, so that a continuous skin moisturizing effect is exhibited.
  • the more preferable content is 0.1 to 3% by mass, more preferably 0.1 to 1% by mass, and even more preferably 0.1 to 0.2% by mass.
  • aluronic acid and / or hyaluronic acid derivatives or salts thereof those having an average molecular weight of 10,000 or less are preferably contained in an amount of 0.1% by mass or more.
  • it When it is contained in an amount of 0.1% by mass or more, it has a high permeability to the skin and has a property of improving the moisturization of the stratum corneum, so that a continuous skin moisturizing effect is exhibited.
  • More preferable content is 0.1 to 3% by mass or more, further preferably 0.1 to 1% by mass, and even more preferably 0.1 to 0.25% by mass. ..
  • the anionic polymer compound thickener is an anionic polymer compound thickener other than (A) hyaluronic acid and / or a hyaluronic acid derivative or a salt thereof, and is, for example, from a carboxy group, a sulfo group, a phospho group, or the like. It is a polymer compound having a selected anionic group in the molecule, and may be a synthetic polymer or a natural polymer. Preferably, the anionic polymer compound thickener has a carboxy group in the molecule.
  • anionic synthetic polymer compound thickener examples include unsaturated monocarboxylic acid-based monomers (acrylic acid, methacrylic acid, clonic acid, neutralized products of these acids, partially neutralized products, etc.) and unsaturated dicarboxylic acids.
  • Acid-based monomers maleic acid, fumaric acid, itaconic acid, citraconic acid, neutralized products of these acids, partially neutralized products, etc.
  • unsaturated sulfonic acid-based monomers vinyl sulfonic acid, allyl sulfonic acid, methacrylic sulfone, etc.
  • Anionic natural polymer compound thickeners include pectic acid, alginic acid, agar, carrageenan, fucoidan, heparin, gellan gum, native gellan gum, xanthan gum, dextran gum, arabic rubber, carboxymethyl cellulose, carboxymethyl hydroxyethyl cellulose, carboxymethyl starch, Examples thereof include carboxymethyl dextran, polyglutamic acid, succinylated collagen, carboxymethyl chitin, succinylated chitosan, sodium cellulose sulfate, gelatin, mucin, dextran and the like.
  • Preferred anionic polymer compound thickeners include anionic synthetic polymer compound thickeners. More preferably, an acrylic acid-based anionic polymer compound thickener such as a (meth) acrylic acid / alkyl (meth) acrylic acid copolymer is mentioned, and more preferably, an acrylic acid / alkyl methacrylate copolymer is mentioned. And even more preferably (Acrylate / alkyl acrylate (10 to 30 carbon atoms)) crosspolymers.
  • the gel-like composition contains 0.1% by mass or more of an anionic polymer compound thickener. Preferred contents include 0.1 to 2% by mass, more preferably 0.15 to 1% by mass, and further preferably 0.2 to 0.5% by mass.
  • Associative thickeners are thickeners that contain both hydrophilic and hydrophobic areas.
  • a thickener having a hydrophobic region containing at least one C8-36 fat chain and a hydrophilic region and at least one hydrophilic region can be mentioned.
  • Associative thickeners include, for example, those defined in the Encyclopedia of Polymer Science and Engineering, 2nd Edition, 17, 772-779. Hydrophobic regions can bind to hydrophobic moieties and hydrophilic regions can bind to hydrophilic moieties.
  • the associative thickener forms a network (network structure) by these bonds, that is, by associating the hydrophobic regions with each other, and further by associating the hydrophobic regions with other hydrophobic substances. , Thickening action is exhibited.
  • Examples of the associative thickener include those described in Special Table 2015-514788, Special Table 2017-310649, Special Table 2016-591159, Special Table 2005-500397, WO2011 / 162421, WO2018 / 088312 and the like.
  • Examples of associative thickeners include: (A) Nonionic amphipathic polymer containing at least one C8-36 fatty chain and at least one hydrophilic unit; (B) An anionic amphipathic polymer containing at least one hydrophilic unit and at least one unit having a C8-36 fatty chain; (C) A cationic amphipathic polymer containing at least one hydrophilic unit and at least one unit having a C8-36 fatty chain; (D) An amphoteric amphoteric polymer containing at least one hydrophilic unit and at least one unit having a C8-36 fatty chain.
  • nonionic amphipathic polymers are preferred.
  • examples of the (a) nonionic amphipathic polymer include the following. (1) Cellulose modified with a group having at least one C8-36 fatty chain (hydrophobic modified alkyl cellulose); (2) Urethane polyether (hydrophobic modified polyether urethane) containing at least one type of C8-36 fat chain; (3) Hydroxypropyl guar compound modified with a group having at least one C8-36 fatty chain; (4) Copolymer of vinylpyrrolidone and a hydrophobic monomer having a C8-36 fatty chain; (5) Copolymer of amphipathic monomer containing C 1-6 alkyl methacrylate or C 1-6 alkyl acrylate and at least one C 8-36 fatty chain; (6) A copolymer of a hydrophobic monomer containing hydrophilic methacrylate or acrylate and at least one C8-36 fatty chain.
  • hydrophobized modified alkyl cellulose examples include those described in WO2011 / 162421, formula (1) :.
  • R 1 , R 2 and R 3 are the same or different, hydrogen atom, alkyl,-[CH 2 CH 2-k (CH 3 ) k O] m -H, or -CH 2 CH (OH). ) CH 2 OC j H 2j + 1 . However, -CH 2 CH (OH) CH 2 OC j H 2j + 1 is always included.
  • n is an integer of 100 to 10000.
  • k is 0 or 1.
  • m is an integer from 1 to 10.
  • j is an integer of 6 to 26.
  • the hydrophobized modified alkyl cellulose is preferably Alkyl is 10 to 50% by mass, -[CH 2 CH 2-k (CH 3 ) k O] m -H is contained in an amount of 3 to 20% by mass, and -CH 2 CH (OH) CH 2 OC j H 2j + 1 is contained in an amount of 0.1 to 10% by mass. ..
  • the hydrophobized modified alkyl cellulose is more preferably one in which j is 18.
  • hydroxypropylmethyl cellulose stearoxy ether for example, Sangelose (registered trademark) (manufactured by Daido Kasei Kogyo Co., Ltd.)
  • Sangelose registered trademark
  • hydrophobically modified polyether urethane examples include those described in WO2018 / 088312, and the formula (2): R 1 - ⁇ (OR 2 ) k -OCONH-R 3 [-NHCOO- (R 4 -O) n -R 5 ] h ⁇ m
  • R 1 , R 2 and R 4 are each independently a hydrocarbon group having 2 to 4 carbon atoms.
  • R 3 is a hydrocarbon group having 1 to 10 carbon atoms which may have a urethane bond.
  • R5 is a hydrocarbon group having 8 to 36 carbon atoms.
  • m is a number of 2 or more.
  • h is a number of 1 or more.
  • k is a number from 1 to 500.
  • n is a number from 1 to 200.
  • hydrophobically modified polyether urethane a (PEG-240 / decyltetradeceth-20 / hexamethyldiisocyanate) copolymer (for example, Adecanol (registered trademark) GT-700 (manufactured by ADEKA)) or the like can be used.
  • a (PEG-240 / decyltetradeceth-20 / hexamethyldiisocyanate) copolymer for example, Adecanol (registered trademark) GT-700 (manufactured by ADEKA)
  • Adecanol registered trademark
  • GT-700 manufactured by ADEKA
  • the associative thickener examples include (a) a nonionic amphoteric polymer, more preferably a hydrophobic modified alkyl cellulose, a hydrophobic modified polyether urethane, and the like, and further preferably hydroxypropylmethyl cellulose steer.
  • a nonionic amphoteric polymer more preferably a hydrophobic modified alkyl cellulose, a hydrophobic modified polyether urethane, and the like, and further preferably hydroxypropylmethyl cellulose steer.
  • examples thereof include rhoxyethers, (PEG-240 / decyltetradeceth-20 / hexamethyldiisocyanate) polymers, and even more preferably hydroxypropylmethylcellulose stearoxy ethers.
  • the mass ratio of (B) anionic polymer compound thickener to (C) associative thickener is It is 5: 1 to 0.15: 1.
  • the mass ratio is preferably 4: 1 to 1: 1 and more preferably 3.5: 1 to 1.2: 1.
  • the gel-like composition of the present invention can contain 5% by mass or more and 20% by mass or less of oil in terms of enhancing the effect of improving skin compatibility.
  • the oil content used in the gel-like composition of the present invention is not particularly limited as long as it is an oil-soluble raw material that can be used in cosmetics and the like.
  • the gel-like composition of the present invention contains water as a solvent. Further, the gel-like composition of the present invention can contain, as other components, components generally blended in cosmetics and the like in an amount suitable for the purpose. Other components include, for example, surfactants (anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants), moisturizers, functional ingredients, natural product extracts, protein hydrolysis.
  • Substances amino acids, cationized polysaccharides, higher alcohols, polyhydric alcohols, amphoteric polymer resin compounds, cationic polymer resin compounds, preservatives, antioxidants, metal sequestering agents, UV absorbers, UV reflectors, pH adjustment Examples include agents, fragrances and pigments.
  • anionic surfactant examples include alkylbenzene sulfonates, polyoxyalkylene alkyl ether sulfate esters, alkyl sulfate ester salts, olefin sulfonates, dialkyl sulfosuccinates and the like.
  • nonionic surfactant examples include polyoxyethylene fatty acid ester, polyoxyethylene hydrogenated castor oil derivative and the like.
  • the cationic surfactant examples include alkyltrimethylammonium salt, dialkyldimethylammonium salt, alkylpyridinium salt, stearyltrimethylammonium chloride and the like.
  • amphoteric tenside examples include alkyl betaine, alkylamide propyl betaine, imidazolinium betaine, egg yolk lecithin, soybean lecithin and the like.
  • moisturizer examples include diphytosteryl octyldodecyl lauroyl glutamate, phytoglycogen, hydrolyzed eggshell membrane, trehalose, atelocollagen, sorbitol, maltitol and the like.
  • Examples of the functional component include albutin, polyquaternium 51, elastin, platinum nanocolloid, allantin, sodium dilauroyl glutamate lysine, ascorbic magnesium phosphate, L-ascorbic acid 2-glucoside, ellagic acid, niacin, vitamin A oil, and the like.
  • Natural product extracts include, for example, Kujin extract, Kazil extract, Seaweed extract, Eucalyptus extract, Royal jelly extract, Rosemary extract, Beech tree extract, Asenyaku extract, Bunanome extract, Ukon extract, Dokudami extract, Oubaku extract, Merilot extract, Odorikosou extract.
  • Kanzo extract, Shakuyaku extract, Sabonsou extract, Hechima extract, Kina extract, Yukinoshita extract, Clara extract, Kohone extract, Uikyo extract, Sakurasou extract, Rose extract, Dio extract, Lemon extract, Shikon extract, Aloe extract, Shobu root extract, Eucalyptus extract, Sugina extract, sage extract, thyme extract, tea extract, cucumber extract, butterfly extract, strawberry extract, melissa extract, carrot extract, carrot extract, marronnier extract, peach extract, peach leaf extract, kuwa extract, yagurumagiku extract, hamamelis extract, placenta extract, Chest line extract, silk extract and the like can be mentioned.
  • Examples of the protein hydrolyzate include keratin peptide, collagen peptide, soybean peptide, wheat peptide, milk peptide, silk peptide, egg white peptide, hydrolyzed eggshell membrane and the like.
  • Examples of amino acids include arginine, glutamic acid, glycine, alanine, hydroxyproline, cysteine, serine, L-theanine and the like.
  • Examples of the cationized polysaccharide include cationized hydroxyethyl cellulose, cationized guar gum, cationized starch, cationized locust bean gum, cationized dextran, cationized chitosan, cationized honey and the like.
  • Examples of the higher alcohol include cetyl alcohol, behenyl alcohol, isostearyl alcohol, bacillic alcohol and the like.
  • Examples of the polyhydric alcohol include propylene glycol, polyethylene glycol, pentylene glycol, caprylyl glycol, hexanediol, ethylhexyl gluserine, 1,3-butylene glycol, 1,3-propanediol, diglycerin, glycerin and the like. Be done.
  • amphoteric polymer resin compound examples include betaineized dialkylaminoalkyl acrylate copolymers.
  • examples of the cationic polymer resin compound include vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer cationized products, polydimethyldiallyl ammonium halide-type cationic polymers, and the like.
  • examples of the preservative include methylparaben, ethylparaben, butylparaben, propylparaben, phenoxyethanol and the like.
  • examples of the antioxidant include tocopherol, BHT and the like.
  • Examples of the metal sequestering agent include EDTA-2Na, EDTA-4Na, edetate, etidronate and the like.
  • Examples of the ultraviolet absorber include a benzophenone derivative, a para-aminobenzoic acid derivative, a methoxycinnamic acid derivative and the like.
  • Examples of the ultraviolet reflector include titanium oxide, zinc oxide and the like.
  • pH adjuster examples include alkaline hydroxides such as sodium hydroxide and acids such as hydrochloric acid, sulfuric acid, phosphoric acid and methanesulfonic acid.
  • the pH of the gelled composition of the present invention can be adjusted to preferably pH 5 to 7.5, more preferably pH 6 to 7, using a pH adjuster.
  • the gel-like composition of the present invention can be produced according to a conventional method. For example, it can be produced by mixing each of the above components with a thickener and gelling. The produced gel-like composition is filled and sealed in a container or the like according to the intended use.
  • the gel-like composition of the present invention can be suitably used as a high-viscosity cosmetic such as an all-in-one cosmetic and a hair cosmetic.
  • Examples 1 to 16 and Comparative Examples 1 to 4 ⁇ Preparation of gel-like composition> Each component (mass%) shown in Tables 1 to 4 is added to ion-exchanged water (residual) and mixed, and if necessary, an aqueous sodium hydroxide solution is added to adjust the pH to 6 to 7.5. By doing so, the gel-like compositions of Examples 1 to 16 and Comparative Examples 1 to 4 were prepared.
  • Table 5 shows the results of evaluation of the gelled compositions of Examples 1 to 16 and Comparative Examples 1 to 4.
  • the anionic synthetic polymer compound thickener is more preferable in the (B) anionic polymer compound thickener. Further, for example, by comparing Examples 1 to 4, it can be seen that the viscosity increases as the content of the component (B) increases.
  • the gelled compositions of Examples 1 to 6 using the (Acrylate / alkyl acrylate (C10-30)) crosspolymer as the component (B) gave favorable results in the comprehensive evaluation of the feeling of use. .. Therefore, it can be seen that in the (B) anionic polymer compound thickener, an acrylic acid-based anionic polymer compound thickener such as (Acrylate / alkyl acrylate (C10-30)) crosspolymer is more suitable. ..
  • the present invention is in the form of a highly viscous gel containing hyaluronic acid or the like having a high concentration of 0.2% by mass or more, which has stability over time, does not cause non-uniformity of the gel over time, and is less likely to be fooled.
  • the composition is provided.

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Abstract

La présente invention concerne une composition de gel qui contient au moins 0,2 % en masse d'acide hyaluronique et/ou d'un dérivé d'acide hyaluronique ou d'un sel correspondant (A) et qui présente une viscosité de 15 000 à 60 000 mPa•s, ladite composition de gel contenant au moins 0,1 % en masse d'un épaississant à base de composé polymère anionique (B) et au moins 0,05 % en masse d'un épaississant associatif (C), l'épaississant à base de composé polymère anionique (B) étant un épaississant à base de composé polymère anionique autre que l'acide hyaluronique et/ou un dérivé d'acide hyaluronique ou un sel correspondant (A) ; et le rapport en masse de l'épaississant à base de composé polymère anionique (B) à l'épaississant associatif (C) étant de 5:1 à 0,15:1.
PCT/JP2021/029367 2020-08-28 2021-08-06 Composition de gel WO2022044781A1 (fr)

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Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06287107A (ja) * 1993-03-31 1994-10-11 Sunstar Inc ゲル状乳化化粧料
JP2011513481A (ja) * 2008-03-13 2011-04-28 バイオランド エルティディ 低分子及び高分子ヒアルロン酸と楡根皮とから抽出した多糖類を含有する老化防止用組成物
WO2013125634A1 (fr) * 2012-02-22 2013-08-29 株式会社ヒアルロン酸研究所 Agent tlr4, agent d'homéostasie tissulaire, activateur du facteur de croissance des hépatocytes, agent de réparation tissulaire, et activateur de sirtuine ayant des fragments d'acide hyaluronique en tant que principes actifs associés
JP2013170149A (ja) * 2012-02-22 2013-09-02 Hyaluronan Kenkyusho:Kk ヒアルロン酸オリゴ糖を有効成分とする細胞外基質形成促進剤
JP2013249259A (ja) * 2012-05-30 2013-12-12 Kao Corp ゲル状フレグランス組成物
JP2019044086A (ja) * 2017-09-04 2019-03-22 大日精化工業株式会社 医療用・美容材料の製造方法及び医療用・美容材料
JP2019214537A (ja) * 2018-06-14 2019-12-19 日本精化株式会社 ホスファチジルイノシトール含有化粧料又は皮膚外用剤

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06287107A (ja) * 1993-03-31 1994-10-11 Sunstar Inc ゲル状乳化化粧料
JP2011513481A (ja) * 2008-03-13 2011-04-28 バイオランド エルティディ 低分子及び高分子ヒアルロン酸と楡根皮とから抽出した多糖類を含有する老化防止用組成物
WO2013125634A1 (fr) * 2012-02-22 2013-08-29 株式会社ヒアルロン酸研究所 Agent tlr4, agent d'homéostasie tissulaire, activateur du facteur de croissance des hépatocytes, agent de réparation tissulaire, et activateur de sirtuine ayant des fragments d'acide hyaluronique en tant que principes actifs associés
JP2013170149A (ja) * 2012-02-22 2013-09-02 Hyaluronan Kenkyusho:Kk ヒアルロン酸オリゴ糖を有効成分とする細胞外基質形成促進剤
JP2013249259A (ja) * 2012-05-30 2013-12-12 Kao Corp ゲル状フレグランス組成物
JP2019044086A (ja) * 2017-09-04 2019-03-22 大日精化工業株式会社 医療用・美容材料の製造方法及び医療用・美容材料
JP2019214537A (ja) * 2018-06-14 2019-12-19 日本精化株式会社 ホスファチジルイノシトール含有化粧料又は皮膚外用剤

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