WO2019047654A1 - 一种取代苯乙酸衍生物的制备方法 - Google Patents
一种取代苯乙酸衍生物的制备方法 Download PDFInfo
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- WO2019047654A1 WO2019047654A1 PCT/CN2018/099121 CN2018099121W WO2019047654A1 WO 2019047654 A1 WO2019047654 A1 WO 2019047654A1 CN 2018099121 W CN2018099121 W CN 2018099121W WO 2019047654 A1 WO2019047654 A1 WO 2019047654A1
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- YMBXTVYHTMGZDW-UHFFFAOYSA-N CC(C(O)=O)c1ccc(CC(CCC2)C2=O)cc1 Chemical compound CC(C(O)=O)c1ccc(CC(CCC2)C2=O)cc1 YMBXTVYHTMGZDW-UHFFFAOYSA-N 0.000 description 1
- YBADSZVDWMSDGJ-UHFFFAOYSA-N CC(c1ccc(CC(CCC2)(C(OC)=O)C2=O)cc1)C#N Chemical compound CC(c1ccc(CC(CCC2)(C(OC)=O)C2=O)cc1)C#N YBADSZVDWMSDGJ-UHFFFAOYSA-N 0.000 description 1
- PYKRPRJLEJBNOC-UHFFFAOYSA-N COC(C(CCC1)C11OCCO1)=O Chemical compound COC(C(CCC1)C11OCCO1)=O PYKRPRJLEJBNOC-UHFFFAOYSA-N 0.000 description 1
- BWVAOONFBYYRHY-UHFFFAOYSA-N OCc1ccc(CO)cc1 Chemical compound OCc1ccc(CO)cc1 BWVAOONFBYYRHY-UHFFFAOYSA-N 0.000 description 1
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- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
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- C07C255/32—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring
- C07C255/40—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by doubly-bound oxygen atoms
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- C07C255/41—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms having cyano groups bound to acyclic carbon atoms of a carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by carboxyl groups, other than cyano groups
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- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
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- C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
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Definitions
- the invention belongs to the field of pharmaceutical synthesis, and relates to a preparation method of a substituted phenylacetic acid derivative, in particular to a preparation method of preparing 2-[4-(2-oxopentyl)phenylpropionic acid].
- Loxoprofen is a class of non-steroidal anti-inflammatory propionic acid derivatives. This class of propionic acid derivatives also includes ibuprofen and naproxen. Loxoprofen is marketed in the form of sodium salt by Sankyo Corporation in Brazil, Mexico and Japan, Loxoprofen sodium, Japanese trade name Loxonin, Argentina under the trade name Oxeno, and India under the trade name Loxomac. It is suitable for oral administration in these countries, and its injectable preparation is approved for sale in Japan in January 2006.
- the present invention provides a synthetic process for replacing a phenylacetic acid compound such as loxoprofen.
- the synthesis process of the present invention enables the preparation of substituted phenylacetic acid compounds at low cost and in high yield.
- the present invention provides novel compounds of formula G 1 G and the intermediate compound of formula the following structural formula:
- R 1 is hydrogen or a low-substituted alkyl group
- Z is a cyclopentanone group and a precursor thereof, the precursor form being Deion or metal reagent, or R 3 is a low substituted alkyl group
- L 2 has the same definition as R 2 .
- a second aspect of the present invention provides a method of preparing compounds of formula G and G type. 1, the disubstituted benzyl group cyclopentanone compound with a precursor form of a compound of formula or dihalo benzyl compounds prepared by reaction of the reaction equation below:
- X is a halogen
- L 1 is a halogen
- OH, OMs, OTs, OTf, L 2 have the same definition as R 2 and are the same as defined above
- Z is a cyclopentanone group and a precursor thereof, the precursor In the form Deion or metal reagent, or
- the above disubstituted benzyl compound is prepared from a dihalobenzyl compound or a dibenzyl alcohol compound, and the reaction formula is as follows:
- X is a halogen
- R 3 is a low-substituted alkyl group
- L 1 and L 2 are the same or different and are OMs, OTs, OTf, nitromethane, CN or carbon-carbon oxime bonds or
- X is a halogen and R 3 is a low-substituted alkyl group.
- a compound of Formula G Formula G. 1 and comprises a decarboxylation step in the preparation of compounds loxoprofen.
- the order of the decarboxylation steps involved may be the first step, the second step or the third step, i.e., the order is variable. More preferably, the decarboxylation step precedes the cyanation reaction.
- a compound of Formula G. 1 and comprises a step of cyclopentanone precursor form convert groups of cyclopentanone in the preparation of compounds loxoprofen.
- the step sequence of converting the cyclopentanone group in the form of the precursor to cyclopentanone may be the first step, the second step or the third step.
- R 1 is hydrogen or a low substituted alkyl group
- R 3 is the same as described above.
- the compound of the above formula III-1 is prepared by reacting 1,4-p-dihalobenzyl with an alkyl 2-oxocyclopentanecarboxylate, and the reaction formula is as follows:
- X is a halogen, and in the formula, R 1 is hydrogen, and R 3 has the same meaning as defined above.
- the above compound of the formula III-1' is prepared by reacting 1,4-p-dibenzyl alcohol with an alkyl 2-oxocyclopentanecarboxylate, and the reaction formula is as follows:
- R 3 is the same as described above.
- R 2 is another substituent which can be obtained by converting a compound of the formula III-1 and a compound of the formula III-1'.
- 1,4-p-dibenzyl alcohol and 1,4-p-dihalobenzyl firstly prepared by a sulfonic acid esterification reaction, an amination reaction, a coupling reaction, etc., which are common in the art, or by a substitution reaction, or with a Grignard reagent After the reaction, it is further prepared by reacting with carbon dioxide.
- the sulfonation reaction can be expressed as follows:
- R 3 is the same as described above.
- the compound of the above formula III-2 is prepared by cyanation of a compound of the formula III-1, and the reaction formula is as follows:
- R 3 is the same as described above.
- R 3 is the same as described above.
- the compound of the above formula III-3 is prepared by alkylation of a compound of the formula III-2, and the reaction formula is as follows:
- R 1 and R 3 are the same as described above.
- the above three-step reaction such as the substitution reaction of 1 with an alkyl 2-oxocyclopentanecarboxylate, the 2 cyanation reaction, and the 3 alkylation reaction may be in any order in the reaction sequence.
- 123 may be used as the above reaction equation, and the reaction sequence may also be 132, 321, or 213, and the reaction sequence may also be 231.
- reaction formula is as follows:
- R 1 and R 3 have the same meanings as defined above.
- reaction sequence that is, the cyanation reaction is carried out first, then the alkylation reaction is carried out, and then reacted with the alkyl 2-oxocyclopentanecarboxylate, the reaction formula is expressed as follows:
- R 1 and R 3 have the same meanings as defined above.
- substitution reaction with the alkyl 2-oxocyclopentanecarboxylate of the present invention is carried out in the presence of a base such as potassium carbonate, sodium carbonate, sodium alkoxide or the like.
- the cyanation reaction of the present invention uses a common cyanating agent such as sodium cyanide, potassium cyanide, cyanide or the like.
- the alkylation reaction of the present invention uses a common alkylating agent such as dimethyl carbonate, dimethyl sulfate, trimethyl orthoformate or halomethane.
- a common alkylating agent such as dimethyl carbonate, dimethyl sulfate, trimethyl orthoformate or halomethane.
- the above reaction of the present invention can be carried out under the action of an organic solvent.
- the organic solvent may be an organic solvent commonly used by those skilled in the art for substitution reaction, alkylation reaction, cyanation reaction, etc., such as DMF DMSO, NMP, 1,4-dioxane, methanol, ethanol, acetic acid. Ethyl ester, tetrahydrofuran, methyl tert-butyl ether or acetonitrile.
- the intermediate compounds of the invention are useful in the preparation of loxoprofen. More preferably, the compound of formula III-3 is prepared by hydrolysis, and the reaction formula is as follows:
- R 1 and R 3 have the same meanings as defined above, and when R 1 is a methyl group, it is loxoprofen.
- the hydrolysis reagent used in the hydrolysis reaction is an acid commonly used in the art, and may be an organic acid or an inorganic acid such as sulfuric acid, hydrochloric acid or trifluoroacetic acid.
- the invention uses a dihalobenzyl compound as a starting material, and obtains an intermediate compound of the formula III by a substitution reaction in any order, a cyanation reaction and an alkylation reaction.
- R 1 is hydrogen or a low-substituted alkyl group
- R 2 is a halogen or a cyano group
- R 3 is a low-substituted alkyl group.
- R 1 is a methyl group
- R 2 is a cyano group
- R 3 is a low-substituted alkyl group
- a process for the preparation of a loxoprofen-type compound of the invention comprises the step of converting a cyclopentanone group to a cyclopentanone in the form of a precursor.
- a cyclization reaction or the like well known in the art is employed.
- the loxoprofen precursor form compound of the present invention is useful for the preparation of loxoprofen-like compounds.
- the present invention also provides a preparation method of a loxoprofen compound by a substitution reaction, a decarboxylation reaction, a cyanation reaction and an alkylation reaction of a dihalobenzyl compound, and the specific reaction formula is as follows:
- R 1 and R 3 have the same meanings as defined above.
- the preparation method provided by the present invention has the following beneficial effects.
- Second, the preparation process of the present invention is not taught by the prior art and is completely different from the use of the compound of U.S. Patent No. 568,1979.
- the preparation method provided by the invention is suitable for industrial scale production and has certain economic benefits.
- 1,4-p-Dichlorobenzyl (30 g, 0.17 mol), DMF (150 g, 4.74 vol) and sodium carbonate (19.8 g, 0.19 mol) were added to a 250 ml reaction flask, stirred uniformly, heated at 60 ° C, and added dropwise 2- Methyl oxocyclopentanecarboxylate (22.1 g, 0.16 mol) was added dropwise in about 1 hour. After the addition of the incubation reaction for 30 minutes, the temperature was lowered to 25 ° C, and the mother liquor was added with an appropriate amount of water to stir, and a solid precipitated.
- a compound of formula III-1 (corresponding to R 1 is hydrogen, R 2 is chlorine, R 3 is methyl) (10 g, 0.036 mol), acetonitrile (50 g, 49.1 vol), sodium cyanide (1.9 g) is added to a 100 ml reaction flask. After the raw material disappeared, the mixture was cooled to room temperature (25 ° C), filtered, and concentrated under reduced pressure.
- the compound of the formula III-2 (corresponding to R 1 being hydrogen, R 2 being a cyano group and R 3 being a methyl group) was obtained in an amount of 9.8 g, the content was 93.7%, and the yield was 94.7%.
- a compound of formula III-2 (corresponding to R 1 being hydrogen, R 2 being cyano, R 3 being methyl) (30 g, 0.11 mol), dimethyl carbonate (24.8 g, 0.28 mol), was added to a 100 ml autoclave. Potassium carbonate (1.5 g, 0.011 mol), tetrabutylammonium bromide (1.8 g, 0.006 mol). The temperature was raised at 130-140 ° C, the autoclave pressure was about 0.3 MPa, and after continuous reaction for 10 hours, the temperature was lowered to 28 ° C, and a small amount of benzaldehyde was added dropwise to terminate the reaction.
- a compound of formula III-3 (corresponding to R 1 is methyl, R 2 is cyano, R 3 is methyl) (18.5 g, 0.065 mol) and 80% sulfuric acid solution (16 g, 0.13 mol) is added to a 100 ml reaction flask. Start heating at 80-90 ° C, keep the reaction for 5 hours, start sampling and monitoring. When the raw materials disappear, start to cool to room temperature (25 ° C), extract with ethyl acetate, wash the organic layer with water, and concentrate to dryness under reduced pressure; Loxoprofen 16.4g, content 93.7%, yield 96.2%.
- Insulation reaction 2.5-3.5 hours, start sampling and monitoring, when the raw materials disappear, start to cool down to 15-25 ° C, add tap water and ethyl acetate extraction, the organic layer is washed with 5% NaHCO 3 water, then washed with saturated NaCl, Finally, it was washed with tap water; the organic layer was concentrated to dryness under reduced pressure; 20.5 g of loxoprofen was obtained, the content was 93.7%, and the yield was 96.2%.
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Abstract
Description
Claims (14)
- 权利要求1中的式G和式G 1化合物,其特征在于,在制备洛索洛芬类化合物上包括了脱羧步骤。
- 根据权利要求6所述的制备方法,其特征在于,所述包括的脱羧步骤的顺序为第一步,第二步或第三步。
- 权利要求1中式G和式G 1化合物的用途,其特征在于,进一步包括将前体形式的环戊酮基转换为环戊酮的步骤制备洛索洛芬类化合物。
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EP18853433.3A EP3680227A4 (en) | 2017-09-07 | 2018-08-07 | PROCESS FOR THE PREPARATION OF A SUBSTITUTED PHENYLACETIC ACID DERIVATIVE |
JP2020535284A JP7068467B2 (ja) | 2017-09-07 | 2018-08-07 | 置換フェニル酢酸誘導体の製造方法 |
KR1020207006285A KR102393122B1 (ko) | 2017-09-07 | 2018-08-07 | 치환된 페닐아세트산 유도체의 제조방법 |
US16/644,205 US20210078941A1 (en) | 2017-09-07 | 2018-08-07 | Method For Preparing Substituted Phenylacetic Acid Derivative |
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CN201710800788.8A CN109467506B (zh) | 2017-09-07 | 2017-09-07 | 一种取代苯乙酸衍生物的制备方法 |
CN201710800788.8 | 2017-09-07 |
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CN117203189A (zh) * | 2021-04-14 | 2023-12-08 | 株式会社Lg化学 | 制备用于合成鞘氨醇-1-磷酸酯受体激动剂的中间体的方法 |
Citations (7)
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US4161538A (en) | 1977-04-05 | 1979-07-17 | Sankyo Company Limited | Substituted phenylacetic acid derivatives and process for the preparation thereof |
US5681979A (en) | 1995-03-10 | 1997-10-28 | Kureha Kagaku Kogyo Kabushiki Kaisha | Process for the producing of alkylcyclopentanone derivatives |
JP2000327603A (ja) * | 1999-05-20 | 2000-11-28 | Ohara Yakuhin Kogyo Kk | プロピオン酸誘導体の製造方法 |
CN101412670A (zh) * | 2007-10-19 | 2009-04-22 | 浙江普洛医药科技有限公司 | 洛索洛芬钠的合成方法 |
CN104326903A (zh) * | 2014-10-14 | 2015-02-04 | 合肥远志医药科技开发有限公司 | 一种高纯度洛索洛芬钠二水合物的工业化生产方法 |
CN104710309A (zh) * | 2015-02-05 | 2015-06-17 | 浙江普洛医药科技有限公司 | 洛索洛芬钠及其中间体的合成方法 |
CN105017009A (zh) * | 2015-06-29 | 2015-11-04 | 千辉药业(安徽)有限责任公司 | 一种洛索洛芬钠的合成方法 |
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- 2017-09-07 CN CN201710800788.8A patent/CN109467506B/zh active Active
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- 2018-08-07 WO PCT/CN2018/099121 patent/WO2019047654A1/zh unknown
- 2018-08-07 US US16/644,205 patent/US20210078941A1/en not_active Abandoned
- 2018-08-07 EP EP18853433.3A patent/EP3680227A4/en not_active Withdrawn
- 2018-08-07 JP JP2020535284A patent/JP7068467B2/ja active Active
- 2018-08-07 KR KR1020207006285A patent/KR102393122B1/ko active IP Right Grant
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Also Published As
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KR102393122B1 (ko) | 2022-05-02 |
JP7068467B2 (ja) | 2022-05-16 |
EP3680227A1 (en) | 2020-07-15 |
US20210078941A1 (en) | 2021-03-18 |
CN109467506B (zh) | 2021-12-07 |
EP3680227A4 (en) | 2021-06-02 |
KR20200035109A (ko) | 2020-04-01 |
JP2020532593A (ja) | 2020-11-12 |
CN109467506A (zh) | 2019-03-15 |
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