WO2011083999A3 - 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 - Google Patents

바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 Download PDF

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WO2011083999A3
WO2011083999A3 PCT/KR2011/000098 KR2011000098W WO2011083999A3 WO 2011083999 A3 WO2011083999 A3 WO 2011083999A3 KR 2011000098 W KR2011000098 W KR 2011000098W WO 2011083999 A3 WO2011083999 A3 WO 2011083999A3
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biguanide derivative
preparation
pharmaceutical composition
active ingredient
composition containing
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PCT/KR2011/000098
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French (fr)
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WO2011083999A2 (ko
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김성욱
전성수
민창희
박세환
김용은
김덕
이지선
오주훈
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한올바이오파마주식회사
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Priority to EP11731937A priority Critical patent/EP2522654A2/en
Priority to US13/520,905 priority patent/US9133110B2/en
Priority to CN201180005604.XA priority patent/CN102725264B/zh
Publication of WO2011083999A2 publication Critical patent/WO2011083999A2/ko
Publication of WO2011083999A3 publication Critical patent/WO2011083999A3/ko
Priority to US14/847,692 priority patent/US9464042B2/en

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Abstract

본 발명은 N4-N5-치환된 화학식 1로 표시되는 바이구아나이드 유도체 또는 그의 약학적으로 허용 가능한 염, 이의 제조방법 및 이를 유효성분으로 약학 조성물을 제공한다. 본 발명의 바이구아나이드　유도체는 기존 약물에 비해 적은 양으로도 우수한 AMPKα 활성화 효과 및 암세포 증식 억제 효과를 나타내어 당뇨, 비만, 고지혈증, 고콜레스테롤혈증, 지방간, 관상동맥질환, 골다공증, 다낭성 난소증후군, 대사성 증후군, 암 등의 치료를 위해 유용하게 이용될 수 있다.
PCT/KR2011/000098 2010-01-06 2011-01-06 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물 WO2011083999A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP11731937A EP2522654A2 (en) 2010-01-06 2011-01-06 Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient
US13/520,905 US9133110B2 (en) 2010-01-06 2011-01-06 Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient
CN201180005604.XA CN102725264B (zh) 2010-01-06 2011-01-06 双胍衍生物、其制备方法以及包含其作为活性成分的药物组合物
US14/847,692 US9464042B2 (en) 2010-01-06 2015-09-08 Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
KR10-2010-0001021 2010-01-06
KR20100001021 2010-01-06
KR1020110001442A KR101285719B1 (ko) 2010-01-06 2011-01-06 바이구아나이드 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 약학 조성물
KR10-2011-0001442 2011-01-06

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/520,905 A-371-Of-International US9133110B2 (en) 2010-01-06 2011-01-06 Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient
US14/847,692 Division US9464042B2 (en) 2010-01-06 2015-09-08 Biguanide derivative, preparation method thereof, and pharmaceutical composition containing same as an active ingredient

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