WO2009008391A1 - 生体摂取物微粒子の製造方法、生体摂取物微粒子及びこれを含有する分散体、医薬組成物 - Google Patents

生体摂取物微粒子の製造方法、生体摂取物微粒子及びこれを含有する分散体、医薬組成物 Download PDF

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Publication number
WO2009008391A1
WO2009008391A1 PCT/JP2008/062234 JP2008062234W WO2009008391A1 WO 2009008391 A1 WO2009008391 A1 WO 2009008391A1 JP 2008062234 W JP2008062234 W JP 2008062234W WO 2009008391 A1 WO2009008391 A1 WO 2009008391A1
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microparticles
ingested
solvent
thin film
approachable
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PCT/JP2008/062234
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English (en)
French (fr)
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Masakazu Enomura
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M.Technique Co., Ltd.
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Application filed by M.Technique Co., Ltd. filed Critical M.Technique Co., Ltd.
Priority to JP2009503347A priority Critical patent/JP4419157B2/ja
Priority to US12/668,021 priority patent/US8623415B2/en
Priority to CN200880104295XA priority patent/CN101784258B/zh
Priority to EP08790914.9A priority patent/EP2177210B1/en
Publication of WO2009008391A1 publication Critical patent/WO2009008391A1/ja

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Transplantation (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

微粒子化する対象物質を溶解している第１溶媒を含む溶液と、その微粒子に対して第１溶媒よりも溶解度の低い第２溶媒となりうる溶媒を、対向して配設された近接・離反可能な処理用面をもつ、少なくとも一方が他方に対して回転する処理用面の間にできる薄膜流体中で、生体摂取物微粒子を析出させる方法を用いて得る。 　生体摂取物微粒子原料を流体中において中和反応により析出させて生体摂取物微粒子を製造するに際して、上記の流体を、近接・離反可能に互いに対向して配設され、少なくとも一方が他方に対して回転する処理用面の間にできる薄膜流体とするものであり、当該薄膜流体中において中和反応により生体摂取物微粒子を析出させる。 点眼薬主成分である薬物を溶解している第１溶媒を含む溶液と、その薬物に対して第１溶媒よりも溶解度の低い第２溶媒となりうる溶媒を、対向して配設された近接・離反可能な処理用面をもつ、少なくとも一方が他方に対して回転する処理用面の間にできる薄膜流体中で、混合させることにより析出した薬物粒子を主成分とする懸濁点眼液を提供する。
PCT/JP2008/062234 2007-07-06 2008-07-04 生体摂取物微粒子の製造方法、生体摂取物微粒子及びこれを含有する分散体、医薬組成物 WO2009008391A1 (ja)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2009503347A JP4419157B2 (ja) 2007-07-06 2008-07-04 生体摂取物微粒子の製造方法
US12/668,021 US8623415B2 (en) 2007-07-06 2008-07-04 Method for producing biologically ingestible microparticles, biologically ingestible microparticles, and dispersion and pharmaceutical composition containing the same
CN200880104295XA CN101784258B (zh) 2007-07-06 2008-07-04 生物摄取物微粒子及其制造方法、分散体、医药组成物
EP08790914.9A EP2177210B1 (en) 2007-07-06 2008-07-04 Method of producing microparticles to be ingested into the body, microparticles to be ingested into the body and dispersion and medicinal composition containing the same

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
JP2007-179098 2007-07-06
JP2007179098 2007-07-06
JP2007179102 2007-07-06
JP2007179104 2007-07-06
JP2007-179102 2007-07-06
JP2007-179104 2007-07-06
JP2007180349 2007-07-09
JP2007-180349 2007-07-09
JP2007203850 2007-08-06
JP2007-203850 2007-08-06
JP2007-214821 2007-08-21
JP2007214821 2007-08-21

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WO2009008391A1 true WO2009008391A1 (ja) 2009-01-15

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PCT/JP2008/062234 WO2009008391A1 (ja) 2007-07-06 2008-07-04 生体摂取物微粒子の製造方法、生体摂取物微粒子及びこれを含有する分散体、医薬組成物

Country Status (5)

Country Link
US (1) US8623415B2 (ja)
EP (1) EP2177210B1 (ja)
JP (1) JP4419157B2 (ja)
CN (1) CN101784258B (ja)
WO (1) WO2009008391A1 (ja)

Cited By (8)

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JPWO2012165000A1 (ja) * 2011-05-28 2015-02-23 エム・テクニック株式会社 強制薄膜式流体処理装置を用いた処理物の付着防止方法
KR20170031082A (ko) 2014-07-14 2017-03-20 엠. 테크닉 가부시키가이샤 단결정 산화아연 나노 입자의 제조 방법
WO2017221314A1 (ja) * 2016-06-20 2017-12-28 エム・テクニック株式会社 有機物微粒子の製造方法
WO2018038267A1 (ja) * 2016-08-26 2018-03-01 株式会社 先端医療開発 ポリラクチドグリコライド共重合体ナノ粒子及びポリラクチドグリコライド共重合体ナノ粒子の製造方法
US10003393B2 (en) 2014-12-16 2018-06-19 Blackberry Limited Method and apparatus for antenna selection
CN109091390A (zh) * 2018-08-28 2018-12-28 陈科 便于泄放药液的电式煎药壶
JP2022136376A (ja) * 2021-03-08 2022-09-21 ユーシービージャパン株式会社 レベチラセタムを有効成分とする注射用製剤
US11633359B2 (en) 2014-12-15 2023-04-25 M. Technique Co., Ltd. Method for producing organic material microparticles, and method for modifying organic material microparticles

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US8609035B2 (en) * 2008-11-25 2013-12-17 M. Technique Co., Ltd. Fluid processing apparatus and processing method
EP2532715B1 (en) * 2010-02-03 2018-12-26 M Technique Co., Ltd. Method for producing nanoparticles
US8978702B2 (en) * 2010-02-26 2015-03-17 M. Technique Co., Ltd. Fluid processing apparatus and processing method
KR20140038467A (ko) * 2011-07-13 2014-03-28 엠. 테크닉 가부시키가이샤 결정자 지름이 제어된 미립자의 제조 방법
JPWO2013164886A1 (ja) * 2012-05-01 2015-12-24 エム・テクニック株式会社 微粒子の製造方法
CN104411428B (zh) * 2012-09-12 2017-05-03 M技术株式会社 镍微粒的制造方法
CN108469465B (zh) * 2018-03-19 2020-11-03 西北大学 一种用于激光剥蚀的载样装置
JP2019200291A (ja) * 2018-05-16 2019-11-21 京セラドキュメントソリューションズ株式会社 画像処理装置
CN113102032A (zh) * 2021-04-14 2021-07-13 皇甫现超 一种应用于颗粒物药材研磨设备

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Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPWO2012165000A1 (ja) * 2011-05-28 2015-02-23 エム・テクニック株式会社 強制薄膜式流体処理装置を用いた処理物の付着防止方法
KR20170031082A (ko) 2014-07-14 2017-03-20 엠. 테크닉 가부시키가이샤 단결정 산화아연 나노 입자의 제조 방법
US10364508B2 (en) 2014-07-14 2019-07-30 M. Technique Co., Ltd. Method for producing single crystalline zinc oxide nanoparticles
US11633359B2 (en) 2014-12-15 2023-04-25 M. Technique Co., Ltd. Method for producing organic material microparticles, and method for modifying organic material microparticles
US10003393B2 (en) 2014-12-16 2018-06-19 Blackberry Limited Method and apparatus for antenna selection
WO2017221314A1 (ja) * 2016-06-20 2017-12-28 エム・テクニック株式会社 有機物微粒子の製造方法
WO2018038267A1 (ja) * 2016-08-26 2018-03-01 株式会社 先端医療開発 ポリラクチドグリコライド共重合体ナノ粒子及びポリラクチドグリコライド共重合体ナノ粒子の製造方法
CN109091390A (zh) * 2018-08-28 2018-12-28 陈科 便于泄放药液的电式煎药壶
JP2022136376A (ja) * 2021-03-08 2022-09-21 ユーシービージャパン株式会社 レベチラセタムを有効成分とする注射用製剤

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EP2177210A4 (en) 2013-01-23
CN101784258A (zh) 2010-07-21
CN101784258B (zh) 2013-07-17
EP2177210B1 (en) 2018-08-22
US8623415B2 (en) 2014-01-07
EP2177210A1 (en) 2010-04-21
JPWO2009008391A1 (ja) 2010-09-09
US20100322997A1 (en) 2010-12-23
JP4419157B2 (ja) 2010-02-24

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