WO2007079999A3 - Pyridopyrazin-derivate und deren verwendung als modulatoren der signaltransduktionswege - Google Patents

Pyridopyrazin-derivate und deren verwendung als modulatoren der signaltransduktionswege Download PDF

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Publication number
WO2007079999A3
WO2007079999A3 PCT/EP2006/068323 EP2006068323W WO2007079999A3 WO 2007079999 A3 WO2007079999 A3 WO 2007079999A3 EP 2006068323 W EP2006068323 W EP 2006068323W WO 2007079999 A3 WO2007079999 A3 WO 2007079999A3
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WIPO (PCT)
Prior art keywords
signal transduction
modulators
transduction paths
pyridopyrazine derivatives
pyridopyrazine
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PCT/EP2006/068323
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English (en)
French (fr)
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WO2007079999A2 (de
Inventor
Irene Seipelt
Eckhard Claus
Eckhard Guenther
Tilmann Schuster
Michael Czech
Emmanuel Polymeropoulos
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Aeterna Zentaris Gmbh
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Publication date
Priority to JP2008539444A priority Critical patent/JP5448450B2/ja
Priority to CA002628186A priority patent/CA2628186A1/en
Priority to EP06849272.7A priority patent/EP1962854B1/de
Priority to PL06849272T priority patent/PL1962854T3/pl
Priority to ES06849272.7T priority patent/ES2543962T3/es
Priority to CN200680047112.6A priority patent/CN101330918B/zh
Priority to BRPI0618451-0A priority patent/BRPI0618451A2/pt
Priority to AU2006334721A priority patent/AU2006334721B2/en
Application filed by Aeterna Zentaris Gmbh filed Critical Aeterna Zentaris Gmbh
Priority to RU2008123219/15A priority patent/RU2487713C2/ru
Publication of WO2007079999A2 publication Critical patent/WO2007079999A2/de
Publication of WO2007079999A3 publication Critical patent/WO2007079999A3/de
Priority to IL191160A priority patent/IL191160A/en
Priority to NO20082509A priority patent/NO20082509L/no
Priority to HK09102357.4A priority patent/HK1125823A1/zh

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Abstract

Die vorliegende Erfindung stellt neue Pyridopyrazin-Verbindungen bereit, die geeignet sind zur Behandlung oder Prophylaxe von durch Signaltransduktionswege und/oder Enzyme vermittelte und/oder modulierte physiologische und/oder pathophysiologische Zustände in Säugetieren, insbesondere im Menschen.
PCT/EP2006/068323 2005-11-11 2006-11-10 Pyridopyrazin-derivate und deren verwendung als modulatoren der signaltransduktionswege WO2007079999A2 (de)

Priority Applications (12)

Application Number Priority Date Filing Date Title
BRPI0618451-0A BRPI0618451A2 (pt) 2005-11-11 2006-11-10 derivados de piridopirazina, seu uso, composição farmacêutica e estojo
EP06849272.7A EP1962854B1 (de) 2005-11-11 2006-11-10 Pyridopyrazin-derivate und deren verwendung als modulatoren der signaltransduktionswege
PL06849272T PL1962854T3 (pl) 2005-11-11 2006-11-10 Pochodne pirydopirazyny i ich zastosowanie jako modulatorów szlaków transdukcji sygnału
ES06849272.7T ES2543962T3 (es) 2005-11-11 2006-11-10 Derivados de piridopirazina y su uso como moduladores de las vías de transducción de señales
CN200680047112.6A CN101330918B (zh) 2005-11-11 2006-11-10 吡啶并吡嗪衍生物及其作为信号转导途径调节剂的应用
JP2008539444A JP5448450B2 (ja) 2005-11-11 2006-11-10 ピリドピラジン誘導体及びその使用
AU2006334721A AU2006334721B2 (en) 2005-11-11 2006-11-10 Pyridopyrazine derivatives and use thereof as modulators of the signal transduction paths
CA002628186A CA2628186A1 (en) 2005-11-11 2006-11-10 Pyridopyrazine derivatives and the use thereof as medicaments in pi3k related diseases
RU2008123219/15A RU2487713C2 (ru) 2005-11-11 2006-11-10 Фармацевтическая композиция и способ лечения или профилактики физиологических и/или патофизиологических состояний, ассоциированных с ингибированием киназ pi3k, у млекопитающих
IL191160A IL191160A (en) 2005-11-11 2008-04-30 Use of pyrido [3,2- b] pyrazine-6-yl urine urine for the preparation of drugs to treat diseases caused by the enzyme pi3k inhibition.
NO20082509A NO20082509L (no) 2005-11-11 2008-06-03 Pyridopyrazinderivater og deres anvendelse
HK09102357.4A HK1125823A1 (zh) 2005-11-11 2009-03-12 吡啶並吡嗪衍生物及其作為信號轉導途徑調節劑的應用

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US73570705P 2005-11-11 2005-11-11
EP05024692.5 2005-11-11
EP05024692A EP1790342A1 (de) 2005-11-11 2005-11-11 Pyridopyrazin-Derivate und deren Verwendung als Modulatoren der Signaltransduktionswege
US60/735,707 2005-11-11

Publications (2)

Publication Number Publication Date
WO2007079999A2 WO2007079999A2 (de) 2007-07-19
WO2007079999A3 true WO2007079999A3 (de) 2007-10-04

Family

ID=36424666

Family Applications (1)

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PCT/EP2006/068323 WO2007079999A2 (de) 2005-11-11 2006-11-10 Pyridopyrazin-derivate und deren verwendung als modulatoren der signaltransduktionswege

Country Status (21)

Country Link
US (1) US8937068B2 (de)
EP (2) EP1790342A1 (de)
JP (1) JP5448450B2 (de)
KR (1) KR101473662B1 (de)
CN (1) CN101330918B (de)
AR (1) AR056216A1 (de)
AU (1) AU2006334721B2 (de)
BR (1) BRPI0618451A2 (de)
CA (1) CA2628186A1 (de)
ES (1) ES2543962T3 (de)
HK (1) HK1125823A1 (de)
IL (1) IL191160A (de)
NO (1) NO20082509L (de)
NZ (1) NZ595879A (de)
PL (1) PL1962854T3 (de)
RU (1) RU2487713C2 (de)
SG (1) SG10201401061XA (de)
TW (1) TWI423973B (de)
UA (1) UA95464C2 (de)
WO (1) WO2007079999A2 (de)
ZA (1) ZA200803867B (de)

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WO2007054556A1 (de) * 2005-11-11 2007-05-18 Æterna Zentaris Gmbh Neue pyridopyrazine und deren verwendung als modulatoren von kinasen
US9139630B2 (en) 2006-07-11 2015-09-22 Rutgers, The State University Of New Jersey Compositions and methods for preparing recombinant MG53 and methods for optimizing same
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WO2009073808A2 (en) * 2007-12-04 2009-06-11 University Of Medicine And Dentistry Of New Jersey Compositions and methods to modulate cell membrane resealing
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WO2010045374A1 (en) * 2008-10-15 2010-04-22 Gilead Palo Alto, Inc. 3-hydroquinazolin-4-one derivatives for use as stearoyl coa desaturase inhibitors
WO2010052448A2 (en) * 2008-11-05 2010-05-14 Ucb Pharma S.A. Fused pyrazine derivatives as kinase inhibitors
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
WO2011142744A1 (en) * 2010-05-11 2011-11-17 University Of Medicine And Dentistry Of New Jersey Compositions and methods for the treatment and prevention of cardiac ischemic injury
WO2012061793A1 (en) 2010-11-05 2012-05-10 Trimedicine, Inc. Serum mg53 as a diagnostic marker for tissue injury
GB201020179D0 (en) 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
EP2508184A1 (de) * 2011-04-06 2012-10-10 Æterna Zentaris GmbH Pyridopyrazinderivate und ihre Verwendungen
JP5792128B2 (ja) * 2011-07-29 2015-10-07 富士フイルム株式会社 １，５−ナフチリジン誘導体又はその塩
GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201118675D0 (en) 2011-10-28 2011-12-14 Astex Therapeutics Ltd New compounds
GB201118656D0 (en) * 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
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WO2014109414A1 (ja) 2013-01-11 2014-07-17 富士フイルム株式会社 含窒素複素環化合物またはその塩
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
MX2016012368A (es) 2014-03-26 2017-02-23 Astex Therapeutics Ltd Combinaciones de un inhibidor del factor de crecimiento de fibroblasto (fgfr) y un inhibidor del receptor del factor de crecimiento 1 similar a insulina (igf1r).
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
KR102479693B1 (ko) 2014-03-26 2022-12-22 아스텍스 테라퓨틱스 리미티드 조합물
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
WO2016203335A1 (en) * 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
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SI3353177T1 (sl) 2015-09-23 2020-08-31 Janssen Pharmaceutica Nv Triciklični heterocikli za zdravljenje raka
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CN111892597B (zh) * 2020-09-01 2023-07-25 山西天宏达安医药科技有限公司 一种喹喔啉基吡啶并吡嗪类化合物及其制备方法与应用

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