WO2005046630A1 - Compositions de regeneration capillaire et agent antiprurigineux - Google Patents

Compositions de regeneration capillaire et agent antiprurigineux Download PDF

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Publication number
WO2005046630A1
WO2005046630A1 PCT/JP2004/016719 JP2004016719W WO2005046630A1 WO 2005046630 A1 WO2005046630 A1 WO 2005046630A1 JP 2004016719 W JP2004016719 W JP 2004016719W WO 2005046630 A1 WO2005046630 A1 WO 2005046630A1
Authority
WO
WIPO (PCT)
Prior art keywords
extract
shogaol
hair restorer
hair
derivative
Prior art date
Application number
PCT/JP2004/016719
Other languages
English (en)
Japanese (ja)
Inventor
Hirotoshi Kanatani
Masufumi Morita
Takuji Yamaguchi
Miki Tanaka
Original Assignee
Tsumura & Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tsumura & Co. filed Critical Tsumura & Co.
Publication of WO2005046630A1 publication Critical patent/WO2005046630A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/75—Anti-irritant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair

Definitions

  • the present invention relates to a hair restorer composition and an itching inhibitor.
  • Patent Document 1 describes a hair restorer containing ginger solution.
  • Patent Document 1 discloses that the main component of ginger is camphene, ferrandrene, gingiberene, gingiberol, cineol, linalool, borneol, methylheptenone, zingerone, and shogaol. It has been mentioned whether the hair growth effect is exerted by the synergistic action of these components.
  • Patent Document 2 describes that essential oils such as camphene, cineol, and linalool are used for prevention and treatment of hair loss. .
  • Patent Document 3 describes that an external preparation for skin containing Shogaol has an effect of preventing hot flashes, rough skin, power razors, inflammation, etc. after sunburn. There is no report on the effect of hair growth. Also, the content of shogaol in ginger varies greatly depending on the type of ginger, and for example, it has been reported that the content of shogaol in ginger produced in Japan is very small (Non-Patent Document 1). Therefore, it has been difficult for ginger to develop a hair restorer that can contain Shogaol quantitatively.
  • Patent Document 1 JP-A-58-103310 (Claim 1, page 1, right column, line 18, line 1 page 2, upper left column, line 7)
  • Patent Document 2 Japanese Patent Publication No. 2001-520178 (abstract, claims 1, 7 and 11)
  • Patent Document 3 JP-A-61-263909 (Claim 1, Industrial application field)
  • Non-Patent Document 1 Pharmaceutical Journal, 113 (4), 307-315 (1993) (p. 310, FIGS. 1 and 31)
  • An object of the present invention is to provide a hair restorer composition containing shogaol, which has not been conventionally used as a hair restorer, and an itching inhibitor.
  • the present invention includes the following inventions.
  • a hair restorer composition containing shogaol (1) A hair restorer composition containing shogaol.
  • the itching inhibitor according to (1) The itching inhibitor according to (1).
  • the itching inhibitor according to the above (5) which comprises:
  • a hair restorer composition containing Shogaol which has been conventionally used as a hair restorer.
  • the stability of the active ingredient, shogaol can be improved by blending specific components together or forming an aerosol preparation.
  • a conventionally unknown itch suppressant containing shogaol there is provided.
  • the Shogaol used in the present invention has the following formula:
  • n represents an integer, usually 118, preferably 418.
  • the Shogaol used in the present invention is not particularly limited, but preferably [6], [8], [10] Shogaol, and more preferably [6] Shogaol.
  • Shogaol can be produced by a known synthesis method or extraction method. Synthesis method For example, a method described in Japanese Patent No. 2780316 (Example 1 and Reference Example) can be mentioned. As an extraction method, for example, Biol. Pharm. Bull., 25 (9), 1183-1187 (2002) ) (P. 1184, section of Extraction, Fractionation and Isolation).
  • the amount of the hair restorer composition of the present invention is not particularly limited, but is usually 0 based on the total amount of the hair restorer composition of the present invention. 0.0001-0.1% by weight, and preferably 0.0001-0.01% by weight in terms of hair growth effect, economy and irritation.
  • the hair restorer composition of the present invention includes a Kanzo I extract, a Kinseiso II extract, a Kuddin extract, a Senpuri extract, a Capsicum extract, and a Toucia extract from the viewpoint of improving the stability of Shogaol as an active ingredient.
  • Extract carrot extract, hocoway extract, button extract, mican extract, isopropylmethylphenol, glycyrrhizic acid or its derivative, glycyrrhetinic acid or its derivative, cepharanthin, tocopherols or its derivative, hinokitiol, pentadecanoic acid Or a derivative thereof, and minoxidilka at least one selected from the group consisting of, for example, quinceiso extract, kujin extract, sempuri extract, toucia extract, carrot extract, hokoway extract, button extract and mandarin extract.
  • Group strength At least one selected It is preferred,.
  • the amount (total) of these components is usually 0.0001 to 50% by weight, preferably 0.0001 to 5% by weight, based on the total amount of the hair restorer composition.
  • the weight ratio with respect to the blending amount (total) is usually 10000: 1 to 1: 500,000, preferably ⁇ 100: 1 to 1: 50,000, and more preferably ⁇ 10: 1 to 1: 10000.
  • Kanzo is a legume
  • y zo (ulvcvrrhiza uralensis ischer, Glvcvrrhiza glabra Linne or other congeners), and it is particularly preferable to use roots and strons or leaves.
  • Kinsiso Venus grass
  • Lepisorusfe plants such as Noxinobu (Lepisorus thunbergianus (Kaulr. It is preferable to use whole plants. Aiton), and it is particularly preferable to use the root site.
  • the term “simpuri” (drug) refers to a plant of the family Lindian (Gentianaceae) (Swertia iaponica Makino), and it is particularly preferable to use whole plants.
  • Capsicum is the capsicum of the Solanaceae family.
  • Tota refers to AmpeloDsis grossedentata (Hand-Mazz) W. T. Wang of the grape family (Vitaceae), and it is particularly preferable to use the branch and leaf sites.
  • Carrot is a Panax ginseng C.A. Mever of Araliaceae, and it is particularly preferable to use a root site. Examples of the hocoway include plants of the genus lam S1 such as Mokotanhopo (Taraxacum mongolicum Hand.—Mazz. J) of the family Asteraceae (Compositae), and it is particularly preferable to use the root site.
  • examples of oranges include Citrus unshiu Markovich (AH MS) and the like. Citrus genuine foods are preferred, and it is particularly preferable to use the pericarp region.
  • These extraction solvents include water, organic solvents and mixtures thereof, from the viewpoints of safety and compatibility in the formulation. It is preferable to select one or more of water, ethanol, 1,3-butylene glycol and glycerin.
  • the derivative in the present invention refers to salts such as alkali metals and amines, and esters.
  • any base commonly used in cosmetic compositions can be used, for example, water, monohydric alcohols such as ethanol, glycerin, ethylene and the like.
  • Monohydric alcohols such as ethanol, glycerin, ethylene and the like.
  • Polyhydric alcohols such as glycols, oils and fats, and surfactants can be used.
  • the hair restorer composition of the present invention can contain other components having a hair restorer effect and components that can be used in a hair restorer or a hair styling agent, as long as the effects are not impaired.
  • Ingredients include, for example, hormones, vitamins, amino acids, herbal extracts, pigments, resorcin, cooling agents, humectants, flavors and the like.
  • Examples of the dosage form of the hair restorer composition of the present invention include a liquid preparation, an aerosol preparation, an ointment, a cream, a jewel, an oil, a knock, a shampoo, a rinse, and a treatment.
  • Aerosol preparations are preferred in terms of improving the stability of Shogaol, the active ingredient!
  • Examples of the pruritus suppressant of the present invention include: drinking foods and drinks, health foods, functional health foods (foods for specified health use, nutritional foods), etc., drinking by pharmaceuticals, administration by injection, etc., quasi-drugs
  • an external application that can be applied directly to a site where itching occurs selectively is preferable.
  • External preparations include liquids, aerosols, ointments, creams, jewels, oils, knocks, shampoos, and rinses.
  • aerosol preparations are preferred in terms of improving the stability of Shogaol.
  • the hair restorer composition and the itch suppressant of the present invention when applied to the human scalp or animal skin, exhibit a strong hair restorer effect and an itching inhibitory effect.
  • [6] -Shogaol obtained in Production Example 1 was dissolved in 50 vol% ethanol so that the concentrations became 0.0001 vol%, 0.001 vol%, and 0.01 vol%, respectively.
  • a Shogaol solution having the composition shown in Table 2 was prepared, sealed in a glass bottle, and stored for one month in an environment at 50 ° C.
  • the amount of [6] -shogaol before and after the test was quantified by HPLC analysis, and the residual ratio of [6] -shogaol was calculated. Table 2 shows the results.
  • a liquid obtained by mixing the following components was used as a stock solution.
  • the stock solution was sealed in a glass bottle to serve as a control.
  • An aerosol formulation was prepared by caulking 33.3% of dimethyl ether with respect to 66.7% of the stock solution, and this was filled in an aerosol can to prepare an example.
  • the concentration of [6] -shogaol obtained in Production Example 1 in 50 vol% ethanol was 0.1% each.
  • ICR mice were intradermally administered with 50 ⁇ g of each formaldehyde condensate of N-methyl-p-methoxyphenethylamine (compound 48/80) on the back of the neck to induce itching, and immediately after the administration,
  • the itch-suppressing effect was evaluated by applying 100 L of a Shogaol solution and measuring the number of times of drawing to the back (average value) for 30 minutes after administration. Table 3 shows the results.
  • a heartonic was produced by a conventional method.
  • a heartonic was produced by a conventional method.
  • An aerosol formulation was prepared by adding 33.3% of dimethyl ether to 66.7% of the base material (viscosity: 12,450 cp) obtained by mixing the above components, and then filling into an aerosol can having a jet diameter of 0.5 mm to grow hair. Aerosol products (internal pressure: 4.3 kg / cm 2 , at 25 ° C)
  • N-coconut oil fatty triethanolamine solution 10.0 coconut fatty acid amide propylbetaine solution 10.0 coconut fatty acid ethanolamide 4.0 0 ethylene glycol stearate 2.0 0 Cationized senorelose 1.0 0 Cationized guar gum 0-20
  • EDT A 2 Na 0.30 Paraoxybenzoic acid ester 0.40 Cunic acid 0.20 Fragrance 0.30 Purified water
  • Hair shaving was produced by a conventional method.
  • a hair treatment was produced by a conventional method.
  • the present invention is used in the fields of hair restorer and itch suppressant.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Birds (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention concerne des compositions de régénération capillaire, et un agent antiprurigineux, contenant tous deux du shogaol, un composant qui n'a pas encore été utilisé comme ingrédient de régénération capillaire à ce jour. Les compositions de régénération capillaire décrites contiennent du shogaol. Dans une des formes de réalisation décrites, ces compositions contiennent en outre un ingrédient spécifique qui confère une stabilité améliorée au shogaol. Ces compositions de régénération capillaire peuvent être conditionnées sous forme d'aérosol.
PCT/JP2004/016719 2003-11-17 2004-11-11 Compositions de regeneration capillaire et agent antiprurigineux WO2005046630A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003-386834 2003-11-17
JP2003386834A JP2005145900A (ja) 2003-11-17 2003-11-17 育毛剤組成物及び痒み抑制剤

Publications (1)

Publication Number Publication Date
WO2005046630A1 true WO2005046630A1 (fr) 2005-05-26

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WO (1) WO2005046630A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010070496A (ja) * 2008-09-18 2010-04-02 Tsumura Lifescience Co Ltd 毛髪および／または毛包強化因子産生促進剤
US9827188B2 (en) 2015-08-14 2017-11-28 Johnson & Johnson Consumer Inc. Compositions comprising ampelopsis grossedentata and albizia julibrissin extracts

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7072346B2 (ja) * 2015-03-27 2022-05-20 大正製薬株式会社 ローション剤
WO2020013179A1 (fr) * 2018-07-09 2020-01-16 国立大学法人九州大学 Composition d'absorption percutanée à libération contrôlée de minoxidil
CN109998974B (zh) * 2019-05-23 2022-03-11 佛山市百分之秀化妆品有限公司 一种包含生姜提取物的促进毛发生长、防脱发以及去屑的洗发水
WO2021132529A1 (fr) * 2019-12-27 2021-07-01 国立大学法人九州大学 Composition à absorption transdermique contenant de l'eau

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61263909A (ja) * 1985-05-20 1986-11-21 Shiseido Co Ltd 皮膚外用剤
WO2000051576A2 (fr) * 1999-03-03 2000-09-08 Ida Royalty Aps Nouveaux produits pharmaceutiques, supplements alimentaires et compositions cosmetiques, et utilisation de certains melanges pour preparer un medicament ou un supplement alimentaire afin de traiter ou de prevenir une inflammation, des reactions d'hypersensibilite ou une douleur
JP2000319135A (ja) * 1999-04-30 2000-11-21 Hideo Yamada 育毛・発毛剤
JP2004002517A (ja) * 2002-05-31 2004-01-08 Dae Sil Kim 生姜成分を含む石鹸の組成物及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4033981B2 (ja) * 1998-09-24 2008-01-16 ツムラ ライフサイエンス株式会社 テストステロン ５α−リダクターゼ阻害剤
JP2002316917A (ja) * 2001-04-19 2002-10-31 Naris Cosmetics Co Ltd 養毛・育毛，白髪改善化粧料
JP3590797B2 (ja) * 2002-04-22 2004-11-17 株式会社ノエビア 育毛剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61263909A (ja) * 1985-05-20 1986-11-21 Shiseido Co Ltd 皮膚外用剤
WO2000051576A2 (fr) * 1999-03-03 2000-09-08 Ida Royalty Aps Nouveaux produits pharmaceutiques, supplements alimentaires et compositions cosmetiques, et utilisation de certains melanges pour preparer un medicament ou un supplement alimentaire afin de traiter ou de prevenir une inflammation, des reactions d'hypersensibilite ou une douleur
JP2000319135A (ja) * 1999-04-30 2000-11-21 Hideo Yamada 育毛・発毛剤
JP2004002517A (ja) * 2002-05-31 2004-01-08 Dae Sil Kim 生姜成分を含む石鹸の組成物及びその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAMAHARA ET AL: "Pharmacological study on ginger processing I., Antiallergic activity and cardiotonic action of gingerols and shogaols", NATURAL MEDICINES, vol. 49, no. 1, 1995, pages 76 - 83, XP002986955 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010070496A (ja) * 2008-09-18 2010-04-02 Tsumura Lifescience Co Ltd 毛髪および／または毛包強化因子産生促進剤
US9827188B2 (en) 2015-08-14 2017-11-28 Johnson & Johnson Consumer Inc. Compositions comprising ampelopsis grossedentata and albizia julibrissin extracts
US9925136B2 (en) 2015-08-14 2018-03-27 Johnson & Johnson Consumer Inc. Methods of reducing signs of skin aging using compositions comprising ampelopsis grossedentata and albizia julibrissin extracts
US10004677B2 (en) 2015-08-14 2018-06-26 Johnson & Johnson Consumer Inc. Methods of reducing skin inflammation using compositions comprising Ampelopsis grossedentata and Albizia julibrissin extracts

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