WO1990014427A3 - Represseur polyvalent de fonctions geniques - Google Patents

Represseur polyvalent de fonctions geniques Download PDF

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Publication number
WO1990014427A3
WO1990014427A3 PCT/EP1990/000831 EP9000831W WO9014427A3 WO 1990014427 A3 WO1990014427 A3 WO 1990014427A3 EP 9000831 W EP9000831 W EP 9000831W WO 9014427 A3 WO9014427 A3 WO 9014427A3
Authority
WO
WIPO (PCT)
Prior art keywords
viral
htlv
hiv
rev
transdominant
Prior art date
Application number
PCT/EP1990/000831
Other languages
English (en)
Other versions
WO1990014427A2 (fr
Inventor
Helmut Bachmayer
Ernst Boehnlein
Bryan R Cullen
Warner C Greene
Joachim Hauber
Original Assignee
Sandoz Ltd
Univ Duke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898915602A external-priority patent/GB8915602D0/en
Priority claimed from GB898924396A external-priority patent/GB8924396D0/en
Application filed by Sandoz Ltd, Univ Duke filed Critical Sandoz Ltd
Priority to AU57388/90A priority Critical patent/AU648256B2/en
Priority to KR1019910700090A priority patent/KR100215949B1/ko
Priority to CA002032158A priority patent/CA2032158C/fr
Publication of WO1990014427A2 publication Critical patent/WO1990014427A2/fr
Publication of WO1990014427A3 publication Critical patent/WO1990014427A3/fr
Priority to FI910371A priority patent/FI110437B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
    • C07K16/1036—Retroviridae, e.g. leukemia viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
    • C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
    • C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Répresseurs transdominants de l'expression phénotypique de gènes viraux, dérivés du produit génique rev du HIV-1 ou du produit génique rex du HTLV-I, et gènes porteurs des mutations correspondantes, qui sont capables de réprimer la fonction Rev dans le HIV-1 et/ou la fonction Rex dans le HTLV-I et le HTLV-II. On a analysé à cet effet l'expressivité transitoire d'une série de mutants à sens faussé ou à délétion. Certains des mutants répriment à la fois la fonction Rev et la fonction Rex et sont donc actifs dans plus d'une espèce virale. Les mutants viraux transdominants représentent une nouvelle catégorie d'agents antiviraux à vaste potentiel. L'expression cellulaire de ces inhibiteurs transdominants peut être utilisée dans des méthodes thérapeutiques telles que l'immunisation intracellulaire, pour protéger les cellules contre les effets nocifs des infections virales, par exemple par le HIV-1.
PCT/EP1990/000831 1989-05-25 1990-05-23 Represseur polyvalent de fonctions geniques WO1990014427A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU57388/90A AU648256B2 (en) 1989-05-25 1990-05-23 Multivalent repressor of gene function
KR1019910700090A KR100215949B1 (ko) 1989-05-25 1990-05-23 유전자기능의다가억제제
CA002032158A CA2032158C (fr) 1989-05-25 1990-05-23 Represseur multivalent de la fonction d'un gene
FI910371A FI110437B (fi) 1989-05-25 1991-01-24 Menetelmä mutanttia virusproteiinia koodaavan DNA-molekyylin valmistamiseksi

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US35687889A 1989-05-25 1989-05-25
GB898915602A GB8915602D0 (en) 1989-07-07 1989-07-07 Multivalent repressor of gene function
GB8915602.0 1989-07-07
GB8924396.8 1989-10-30
GB898924396A GB8924396D0 (en) 1989-10-30 1989-10-30 Multivalent repressor of gene function
US44267089A 1989-11-29 1989-11-29
US356,878 1989-11-29
US442,670 1989-11-29

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
US44267089A Continuation-In-Part 1989-05-25 1989-11-29

Related Child Applications (3)

Application Number Title Priority Date Filing Date
US4237993A Continuation 1989-05-25 1993-04-02
US4237993A Continuation-In-Part 1989-05-25 1993-04-02
US08/042,370 Continuation US5434041A (en) 1989-05-25 1993-04-02 Photographic elements containing particular color couplers in combination with hydroquinone type stabilizers

Publications (2)

Publication Number Publication Date
WO1990014427A2 WO1990014427A2 (fr) 1990-11-29
WO1990014427A3 true WO1990014427A3 (fr) 1991-01-10

Family

ID=27450368

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1990/000831 WO1990014427A2 (fr) 1989-05-25 1990-05-23 Represseur polyvalent de fonctions geniques

Country Status (13)

Country Link
EP (1) EP0406557B1 (fr)
JP (2) JP3126378B2 (fr)
KR (1) KR100215949B1 (fr)
AT (1) ATE207122T1 (fr)
AU (2) AU648256B2 (fr)
CA (1) CA2032158C (fr)
DE (1) DE69033829T2 (fr)
DK (1) DK0406557T3 (fr)
ES (1) ES2166748T3 (fr)
FI (1) FI110437B (fr)
HU (2) HU217091B (fr)
IL (1) IL94482A (fr)
WO (1) WO1990014427A2 (fr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0554389T4 (da) * 1990-10-17 2002-11-11 Us Health Molekylære kloner af HIV-1 og anvendelse deraf
US5534408A (en) * 1993-09-24 1996-07-09 University Of Massachusetts Medical Center 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
US5650306A (en) * 1993-06-07 1997-07-22 University Of Michigan Recombinant nucleic acids for inhibiting HIV gene expression
WO1995004546A1 (fr) * 1993-08-06 1995-02-16 Kai Juhani Ernst Krohn Nouveaux virus de l'immunodeficience humaine et simienne a mutation et vaccins contenant lesdits virus
US6228369B1 (en) 1993-12-13 2001-05-08 Transgene S.A. Composition of trans-dominant variants of viral proteins for obtaining an anti-viral effect
US5981258A (en) * 1993-12-13 1999-11-09 Transgene S.A. Composition of trans-dominant variants of viral proteins for obtaining an antiviral effect
FR2713651B1 (fr) * 1993-12-13 1996-04-19 Transgene Sa Nouvelle composition pour un effet antiviral.
CN1991365A (zh) 1996-01-26 2007-07-04 沃尔科股份有限公司 根据人类hiv病毒株的表型药物敏感性控制hiv阳性病人化疗的方法
US6776986B1 (en) 1996-06-06 2004-08-17 Novartis Ag Inhibition of HIV-1 replication by antisense RNA expression
EP0914423A2 (fr) * 1996-06-06 1999-05-12 Novartis AG Inhibition de la replication du vih-1 au moyen de l'expression d'arn antisens
WO1997046687A1 (fr) * 1996-06-06 1997-12-11 Novartis Ag Vecteurs comprenant des elements sar
EP1144621A2 (fr) * 1998-12-22 2001-10-17 Subsidiary N0. 3, INC. Elements de suppresseur genetiques agissant contre le virus de l'immunodeficience humaine
WO2000040606A2 (fr) * 1999-01-06 2000-07-13 The Regents Of The University Of California Modulation de la replication du vih par l'utilisation de sam68
WO2004064501A2 (fr) 2003-01-23 2004-08-05 Gala Design Inc. Animaux transgeniques exprimant des acides nucleiques retroviraux negatifs transdominants et des proteines
JP5653549B1 (ja) 2014-05-30 2015-01-14 株式会社松風 イオン徐放性歯科用レジン系仮封材組成物

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246882A2 (fr) * 1986-05-20 1987-11-25 Dana Farber Cancer Institute Segments nucléotidiques ART, vecteurs, lignées cellulaire, méthodes de préparation et d'utilisation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0246882A2 (fr) * 1986-05-20 1987-11-25 Dana Farber Cancer Institute Segments nucléotidiques ART, vecteurs, lignées cellulaire, méthodes de préparation et d'utilisation

Also Published As

Publication number Publication date
JPH10165188A (ja) 1998-06-23
EP0406557B1 (fr) 2001-10-17
AU6757394A (en) 1994-11-17
IL94482A (en) 2003-09-17
KR920701440A (ko) 1992-08-11
JPH04500009A (ja) 1992-01-09
WO1990014427A2 (fr) 1990-11-29
HU211530A9 (en) 1995-11-28
IL94482A0 (en) 1991-03-10
CA2032158A1 (fr) 1990-11-26
HU904245D0 (en) 1991-06-28
AU648256B2 (en) 1994-04-21
FI110437B (fi) 2003-01-31
ATE207122T1 (de) 2001-11-15
DE69033829D1 (de) 2001-11-22
DK0406557T3 (da) 2002-02-11
AU5738890A (en) 1990-12-18
KR100215949B1 (ko) 1999-08-16
JP3159671B2 (ja) 2001-04-23
FI910371A0 (fi) 1991-01-24
DE69033829T2 (de) 2002-04-04
CA2032158C (fr) 2009-09-15
HUT56135A (en) 1991-07-29
EP0406557A3 (en) 1991-05-02
HU217091B (hu) 1999-11-29
JP3126378B2 (ja) 2001-01-22
ES2166748T3 (es) 2002-05-01
EP0406557A2 (fr) 1991-01-09
AU678478B2 (en) 1997-05-29

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