FI910371A0 - Flervaerd repressor av genfunktion. - Google Patents

Flervaerd repressor av genfunktion.

Info

Publication number: FI910371A0
Authority: FI; Finland
Prior art keywords: viral; htlv; hiv; rev; transdominant
Prior art date: 1989-05-25

Application number

FI910371A

Other languages

English (en)

Other versions

FI110437B (fi

Inventor

Helmut Bachmayer

Ernst Boehnlein

Bryan R Cullen

Warner C Greene

Joachim Hauber

Original Assignee

Sandoz Ltd

Duke University Office Of Tech

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-05-25

Filing date

1991-01-24

Publication date

1991-01-24

1989-07-07 Priority claimed from GB898915602A external-priority patent/GB8915602D0/en

1989-10-30 Priority claimed from GB898924396A external-priority patent/GB8924396D0/en

1991-01-24 Application filed by Sandoz Ltd, Duke University Office Of Tech filed Critical Sandoz Ltd

1991-01-24 Publication of FI910371A0 publication Critical patent/FI910371A0/fi

2003-01-31 Application granted granted Critical

2003-01-31 Publication of FI110437B publication Critical patent/FI110437B/fi

Links

101710150336 Protein Rex Proteins 0.000 abstract 3
230000014509 gene expression Effects 0.000 abstract 3
230000003612 virological effect Effects 0.000 abstract 3
241000714260 Human T-lymphotropic virus 1 Species 0.000 abstract 2
241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
208000031886 HIV Infections Diseases 0.000 abstract 1
206010020460 Human T-cell lymphotropic virus type I infection Diseases 0.000 abstract 1
241000714259 Human T-lymphotropic virus 2 Species 0.000 abstract 1
101710150344 Protein Rev Proteins 0.000 abstract 1
108700005077 Viral Genes Proteins 0.000 abstract 1
239000003443 antiviral agent Substances 0.000 abstract 1
238000013459 approach Methods 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
230000002939 deleterious effect Effects 0.000 abstract 1
238000012217 deletion Methods 0.000 abstract 1
230000037430 deletion Effects 0.000 abstract 1
238000010195 expression analysis Methods 0.000 abstract 1
230000003053 immunization Effects 0.000 abstract 1
238000002649 immunization Methods 0.000 abstract 1
239000003112 inhibitor Substances 0.000 abstract 1
230000003834 intracellular effect Effects 0.000 abstract 1
108090000623 proteins and genes Proteins 0.000 abstract 1
230000000754 repressing effect Effects 0.000 abstract 1
241000894007 species Species 0.000 abstract 1
230000001225 therapeutic effect Effects 0.000 abstract 1
230000001052 transient effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/14011—Deltaretrovirus, e.g. bovine leukeamia virus
- C12N2740/14022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16311—Human Immunodeficiency Virus, HIV concerning HIV regulatory proteins
- C12N2740/16322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Virology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Biomedical Technology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Physics & Mathematics (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Plant Pathology (AREA)
Microbiology (AREA)
Hematology (AREA)
Gastroenterology & Hepatology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)

FI910371A 1989-05-25 1991-01-24 Menetelmä mutanttia virusproteiinia koodaavan DNA-molekyylin valmistamiseksi FI110437B (fi)

Applications Claiming Priority (10)

Application Number	Priority Date	Filing Date	Title
US35687889A	1989-05-25	1989-05-25
US35687889		1989-05-25
GB8915602		1989-07-07
GB898915602A GB8915602D0 (en)	1989-07-07	1989-07-07	Multivalent repressor of gene function
GB898924396A GB8924396D0 (en)	1989-10-30	1989-10-30	Multivalent repressor of gene function
GB8924396		1989-10-30
US44267089A	1989-11-29	1989-11-29
US44267089		1989-11-29
EP9000831		1990-05-23
PCT/EP1990/000831 WO1990014427A2 (en)	1989-05-25	1990-05-23	Multivalent repressor of gene function

Publications (2)

Publication Number	Publication Date
FI910371A0 true FI910371A0 (fi)	1991-01-24
FI110437B FI110437B (fi)	2003-01-31

Family

ID=27450368

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI910371A FI110437B (fi)	1989-05-25	1991-01-24	Menetelmä mutanttia virusproteiinia koodaavan DNA-molekyylin valmistamiseksi

Country Status (13)

Country	Link
EP (1)	EP0406557B1 (fi)
JP (2)	JP3126378B2 (fi)
KR (1)	KR100215949B1 (fi)
AT (1)	ATE207122T1 (fi)
AU (2)	AU648256B2 (fi)
CA (1)	CA2032158C (fi)
DE (1)	DE69033829T2 (fi)
DK (1)	DK0406557T3 (fi)
ES (1)	ES2166748T3 (fi)
FI (1)	FI110437B (fi)
HU (2)	HU217091B (fi)
IL (1)	IL94482A (fi)
WO (1)	WO1990014427A2 (fi)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK0554389T4 (da) *	1990-10-17	2002-11-11	Us Health	Molekylære kloner af HIV-1 og anvendelse deraf
US5534408A (en) *	1993-09-24	1996-07-09	University Of Massachusetts Medical Center	2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
US5650306A (en) *	1993-06-07	1997-07-22	University Of Michigan	Recombinant nucleic acids for inhibiting HIV gene expression
WO1995004546A1 (en) *	1993-08-06	1995-02-16	Kai Juhani Ernst Krohn	Novel mutated human and simian immunodeficiency viruses and vaccines containing said viruses
US6228369B1 (en)	1993-12-13	2001-05-08	Transgene S.A.	Composition of trans-dominant variants of viral proteins for obtaining an anti-viral effect
US5981258A (en) *	1993-12-13	1999-11-09	Transgene S.A.	Composition of trans-dominant variants of viral proteins for obtaining an antiviral effect
FR2713651B1 (fr) *	1993-12-13	1996-04-19	Transgene Sa	Nouvelle composition pour un effet antiviral.
CN1991365A (zh)	1996-01-26	2007-07-04	沃尔科股份有限公司	根据人类hiv病毒株的表型药物敏感性控制hiv阳性病人化疗的方法
US6776986B1 (en)	1996-06-06	2004-08-17	Novartis Ag	Inhibition of HIV-1 replication by antisense RNA expression
EP0914423A2 (en) *	1996-06-06	1999-05-12	Novartis AG	Inhibition of hiv-1 replication by antisense rna expression
WO1997046687A1 (en) *	1996-06-06	1997-12-11	Novartis Ag	Vectors comprising sar elements
EP1144621A2 (en) *	1998-12-22	2001-10-17	Subsidiary N0. 3, INC.	Genetic suppressor elements against human immunodeficiency virus
WO2000040606A2 (en) *	1999-01-06	2000-07-13	The Regents Of The University Of California	Modulation of hiv replication using sam68
WO2004064501A2 (en)	2003-01-23	2004-08-05	Gala Design Inc.	Transgenic animals expressing transdominant negative retroviral nucleic acids and proteins
JP5653549B1 (ja)	2014-05-30	2015-01-14	株式会社松風	イオン徐放性歯科用レジン系仮封材組成物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4935372A (en) *	1986-05-20	1990-06-19	Dana Farber Cancer Institute	Art nucleotide segments, vectors, cell lines methods of preparation and use

1990
- 1990-05-23 WO PCT/EP1990/000831 patent/WO1990014427A2/en active IP Right Grant
- 1990-05-23 KR KR1019910700090A patent/KR100215949B1/ko not_active IP Right Cessation
- 1990-05-23 ES ES90109892T patent/ES2166748T3/es not_active Expired - Lifetime
- 1990-05-23 IL IL9448290A patent/IL94482A/xx not_active IP Right Cessation
- 1990-05-23 EP EP90109892A patent/EP0406557B1/en not_active Expired - Lifetime
- 1990-05-23 AU AU57388/90A patent/AU648256B2/en not_active Expired
- 1990-05-23 CA CA002032158A patent/CA2032158C/en not_active Expired - Lifetime
- 1990-05-23 DE DE69033829T patent/DE69033829T2/de not_active Expired - Lifetime
- 1990-05-23 HU HU904245A patent/HU217091B/hu unknown
- 1990-05-23 AT AT90109892T patent/ATE207122T1/de not_active IP Right Cessation
- 1990-05-23 JP JP02507933A patent/JP3126378B2/ja not_active Expired - Lifetime
- 1990-05-23 DK DK90109892T patent/DK0406557T3/da active
1991
- 1991-01-24 FI FI910371A patent/FI110437B/fi active
1994
- 1994-07-20 AU AU67573/94A patent/AU678478B2/en not_active Expired
1995
- 1995-06-19 HU HU95P/P00249P patent/HU211530A9/hu unknown
1997
- 1997-11-19 JP JP31805597A patent/JP3159671B2/ja not_active Expired - Lifetime

Also Published As

Publication number	Publication date
JPH10165188A (ja)	1998-06-23
EP0406557B1 (en)	2001-10-17
AU6757394A (en)	1994-11-17
IL94482A (en)	2003-09-17
KR920701440A (ko)	1992-08-11
JPH04500009A (ja)	1992-01-09
WO1990014427A2 (en)	1990-11-29
HU211530A9 (en)	1995-11-28
IL94482A0 (en)	1991-03-10
CA2032158A1 (en)	1990-11-26
HU904245D0 (en)	1991-06-28
AU648256B2 (en)	1994-04-21
FI110437B (fi)	2003-01-31
ATE207122T1 (de)	2001-11-15
DE69033829D1 (de)	2001-11-22
DK0406557T3 (da)	2002-02-11
AU5738890A (en)	1990-12-18
KR100215949B1 (ko)	1999-08-16
JP3159671B2 (ja)	2001-04-23
DE69033829T2 (de)	2002-04-04
CA2032158C (en)	2009-09-15
WO1990014427A3 (en)	1991-01-10
HUT56135A (en)	1991-07-29
EP0406557A3 (en)	1991-05-02
HU217091B (hu)	1999-11-29
JP3126378B2 (ja)	2001-01-22
ES2166748T3 (es)	2002-05-01
EP0406557A2 (en)	1991-01-09
AU678478B2 (en)	1997-05-29

Legal Events

Date	Code	Title	Description
1997-08-27	GB	Transfer or assigment of application	Owner name: NOVARTIS AG

Publication	Publication Date	Title
FI910371A0 (fi)	1991-01-24	Flervaerd repressor av genfunktion.
ES2123065T3 (es)	1999-01-01	Hidroxietilamino-sulfonamidas utiles como inhibidores de proteasas retroviricas.
CA2051562A1 (en)	1992-04-13	Bacillus thuringiensis isolates active against dipteran pests
BG102048A (en)	1998-08-31	Tetrahydrofuran-containing sulphonamides as aspartylprotease inhibitors
HUP0203075A2 (hu)	2003-01-28	Aromás diamidszármazékok és sóik, ezeket tartalmazó, a mezőgazdaságban és a kertészetben alkalmazható készítmények és ezek alkalmazása
TR199900848T2 (xx)	1999-06-21	Oksadiazoller, elde edilmeleri ve ila� olarak kullan�mlar�.
ATE131472T1 (de)	1995-12-15	Von perhalogenierten sultonen abgeleiteten monomere,sowie aus diesen monomeren hergestellte polymere
NO991742L (no)	1999-04-13	Lentivirale vektorer
CA2051288A1 (en)	1992-03-15	Viral targeted destruction of neoplastic cells
FI853648A0 (fi)	1985-09-23	Foerfarande foer framstaellning av farmaceutiskt aktiva 4,5-dihydro-4-okso-2-/(2-trans-fenylcyklopropyl) amino/-3-furankarboxylsyror och derivat daerav.
DK0789764T3 (da)	2002-04-22	Ny familie af proteaseinhibitorer og andre biologisk aktive substanser
IT7967979A0 (it)	1979-05-09	Macchina polivalente per lavori di sterro e movimentazione di carichi
AU2253288A (en)	1989-03-09	Expression vectors for the synthesis of proteins and plasmid replicons and sequence cassettes for use in constructing such vectors
EP0474797A4 (en)	1992-08-05	Protein having a transactivating property, vectors expressing this protein, cell lines, and uses thereof
ATE95815T1 (de)	1993-10-15	Mittel zum schutz von pflanzen gegen krankheiten.
SU872166A1 (ru)	1981-10-15	Способ восстановлени изношенной поверхности изделий
Michailova	2001	Polytene chromosomes of different subfamilies of family Chironomidae, Diptera
TR23745A (tr)	1990-08-01	1-dimetilkarbomoil-3-suebstituee 1h-1.2.4-triazoller
ATE277186T1 (de)	2004-10-15	Zusammensetzung von transdominanten varianten von virus- proteinen zur antiviralen wirkung
FR2643368B1 (fr)	1991-06-07	Nouveaux derives du glycerol, leur procede de preparation, compositions reticulantes en contenant, et leur utilisation dans l'industrie textile
IT1234895B (it)	1992-06-02	Rete di polarizzazione per coppie di amplificatori integrati commutabili da una configurazione asimmetrica ad una configurazione a ponte e viceversa.
SU852578A1 (ru)	1981-08-07	Способ воздействи на процессуСАдКи глиНиСТыХ гРуНТОВ
FR2632310B1 (fr)	1992-04-10	Peptides ayant des proprietes protectrices d'un virus pathogene du type hiv dans des cellules sensibles
NO912099D0 (no)	1991-05-31	Ekspresjon av hiv-proteiner i drosophilia-celler.
SU834585A1 (ru)	1981-05-30	Цифровой анализатор