UY36684A - Agonistas de triazol del receptor apj - Google Patents

Agonistas de triazol del receptor apj

Info

Publication number
UY36684A
UY36684A UY0001036684A UY36684A UY36684A UY 36684 A UY36684 A UY 36684A UY 0001036684 A UY0001036684 A UY 0001036684A UY 36684 A UY36684 A UY 36684A UY 36684 A UY36684 A UY 36684A
Authority
UY
Uruguay
Prior art keywords
agonists
apj
triazol
receiver
formula
Prior art date
Application number
UY0001036684A
Other languages
English (en)
Inventor
Steven H Olson
Chen Xiaoqi
Chen Yinhong
Alan C Cheng
Richard V Connors
Mikkel V Debenedetto
Deignan Jeffrey
Dransfield Paul John
Du Xiaohui
Robert P Farrell
Fu Zice
Simon J Hedley
Heath Julie Anne
Daniel B Horne
Houze Jonathan
Ted C Judd
Matthew R Kaller
Kayser Frank
Khakoo Aarif Yusuf
Kopecky David John
Lai Su-Jen
Ma Zhihua
Lawrence R Mcgee
Julio C Medina
Jeffrey T Mihalic
Pattaropong Vatee
Swaminath Gayathri
Wang Xiaodong
Yang Kevin
Yeh Wen-Chen
Nishimura Nobuko
Chen Ning
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of UY36684A publication Critical patent/UY36684A/es

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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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Abstract

Se describen compuestos de la Fórmula I y Fórmula II, sal farmacéuticamente aceptable del mismo, estereoisómeros de cualquiera de los anteriores, o mezclas de los mismos que son agonistas del receptor APJ y tienen uso en tratar afecciones cardiovasculares y otras. Los compuestos de la Fórmula I y Fórmula II tienen las siguientes estructuras donde las definiciones de las variables se proporcionan en la presente.
UY0001036684A 2015-05-20 2016-05-20 Agonistas de triazol del receptor apj UY36684A (es)

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