ATE423122T1 - Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) - Google Patents

Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Info

Publication number
ATE423122T1
ATE423122T1 AT04743692T AT04743692T ATE423122T1 AT E423122 T1 ATE423122 T1 AT E423122T1 AT 04743692 T AT04743692 T AT 04743692T AT 04743692 T AT04743692 T AT 04743692T AT E423122 T1 ATE423122 T1 AT E423122T1
Authority
AT
Austria
Prior art keywords
glutamatracemase
muri
inhibitors
condensed heterocycles
heterocycles
Prior art date
Application number
AT04743692T
Other languages
English (en)
Inventor
Gregory Basarab
Charles Eyermann
Madhusudhan Gowravaram
Oluyinka Green
Andrew Kiely
Lawrence Macpherson
Marshall Morningstar
Nguyen Thanh
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE423122T1 publication Critical patent/ATE423122T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
AT04743692T 2003-08-15 2004-08-12 Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri) ATE423122T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US49561503P 2003-08-15 2003-08-15

Publications (1)

Publication Number Publication Date
ATE423122T1 true ATE423122T1 (de) 2009-03-15

Family

ID=34193331

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04743692T ATE423122T1 (de) 2003-08-15 2004-08-12 Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Country Status (6)

Country Link
US (1) US7371757B2 (de)
EP (1) EP1664052B1 (de)
JP (1) JP2007502307A (de)
AT (1) ATE423122T1 (de)
DE (1) DE602004019548D1 (de)
WO (1) WO2005016929A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1664052B1 (de) 2003-08-15 2009-02-18 AstraZeneca AB Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)
EP2285783B1 (de) 2008-04-29 2014-05-21 Boehringer Ingelheim International GmbH Indazolverbindungen als ccr1-rezeptorantagonisten
JP5411927B2 (ja) * 2008-05-06 2014-02-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１アンタゴニストとしてのピラゾール化合物
PE20110854A1 (es) 2008-09-26 2011-12-23 Boehringer Ingelheim Int DERIVADOS DE 1-FENIL-1H-PIRAZOLO[3,4-c]PIRIDINA-4-CARBONILAMINA COMO ANTAGONISTAS DE LOS RECEPTORES CCR1
US9040528B2 (en) 2008-10-14 2015-05-26 Astrazeneca Ab Chemical compounds 542
AU2009305203B2 (en) * 2008-10-14 2013-03-07 Entasis Therapeutics Limited Fused, spirocyclic heteroaromatic compounds for the treatment of bacterial infections
SI2491028T1 (sl) 2009-10-21 2014-03-31 Boehringer Ingelheim International Gmbh Indazolne in pirazolopiridinske spojine kot antagonisti receptorja CCR1
JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
IN2012DN05081A (de) * 2009-12-08 2015-10-09 Boehringer Ingelheim Int
US8871786B2 (en) 2010-04-30 2014-10-28 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as CCR1 receptor antagonists
WO2012087782A1 (en) 2010-12-23 2012-06-28 Boehringer Ingelheim International Gmbh Pyrazolopiperidine compounds as ccr1 receptor antagonists
EP2855440A1 (de) 2012-05-31 2015-04-08 Phenex Pharmaceuticals AG Carboxamid- oder sulfonamidsubstituierte thiazole und zugehörige derivate als modulatoren für orphan-nuklearrezeptor ror?
JO3215B1 (ar) 2012-08-09 2018-03-08 Phenex Pharmaceuticals Ag حلقات غير متجانسة بها 5 ذرات تحتوي على النيتروجين بها استبدال بكربوكساميد أو سلفوناميد كمعدلات لمستقبل نووي غير محمي RORy
US8889671B2 (en) 2013-01-23 2014-11-18 Astrazeneca Ab Compounds and methods for treating bacterial infections
WO2014160405A1 (en) * 2013-03-13 2014-10-02 University Of Iowa Research Foundation Compounds, compositions comprising same, and methods related thereto
EP3148546A1 (de) 2014-05-29 2017-04-05 Entasis Therapeutics Limited Kondensierte spirocyclische heteroaromatische verbindungen zur behandlung von bakteriellen infektionen
HUE050317T2 (hu) 2015-05-20 2020-11-30 Amgen Inc APJ receptor triazol agonistái
DK3386500T3 (da) 2015-12-09 2022-12-12 Univ Illinois Benzothiophen-baserede selektive østrogenreceptor ned-regulatorer
EP3452466B1 (de) 2016-05-03 2020-08-12 Amgen Inc. Heterocyclische triazolverbindungen als agonisten des apj-rezeptors
WO2018081168A2 (en) 2016-10-24 2018-05-03 The Board Of Trustees Of The University Of Illinois Benzothiophene-based selective mixed estrogen receptor downregulators
MA46827A (fr) 2016-11-16 2019-09-25 Amgen Inc Composés de triazole à substitution cycloalkyle en tant qu'agonistes du récepteur apj
WO2018093576A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Alkyl substituted triazole compounds as agonists of the apj receptor
WO2018097944A1 (en) 2016-11-16 2018-05-31 Amgen Inc. Triazole furan compounds as agonists of the apj receptor
WO2018093579A1 (en) 2016-11-16 2018-05-24 Amgen Inc. Triazole phenyl compounds as agonists of the apj receptor
EP3541805B1 (de) 2016-11-16 2020-10-14 Amgen Inc. Heteroaryl-substituierte triazole als apj-rezeptoragonisten
US10689367B2 (en) 2016-11-16 2020-06-23 Amgen Inc. Triazole pyridyl compounds as agonists of the APJ receptor
CN110177554B (zh) 2017-01-06 2023-06-02 G1治疗公司 用于治疗癌症的组合疗法
KR20190117582A (ko) 2017-02-10 2019-10-16 쥐원 쎄라퓨틱스, 인크. 벤조티오펜 에스트로겐 수용체 조정제
US11149040B2 (en) 2017-11-03 2021-10-19 Amgen Inc. Fused triazole agonists of the APJ receptor
US11807624B2 (en) 2018-05-01 2023-11-07 Amgen Inc. Substituted pyrimidinones as agonists of the APJ receptor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0102315D0 (sv) * 2001-06-28 2001-06-28 Astrazeneca Ab Compounds
EP1664052B1 (de) 2003-08-15 2009-02-18 AstraZeneca AB Kondensierte heterocyclen als inhibitoren von glutamatracemase (muri)

Also Published As

Publication number Publication date
US7371757B2 (en) 2008-05-13
EP1664052B1 (de) 2009-02-18
JP2007502307A (ja) 2007-02-08
WO2005016929A1 (en) 2005-02-24
DE602004019548D1 (de) 2009-04-02
EP1664052A1 (de) 2006-06-07
US20060252781A1 (en) 2006-11-09

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