UY27786A1 - Derivados de isoquinolina. - Google Patents

Derivados de isoquinolina.

Info

Publication number
UY27786A1
UY27786A1 UY27786A UY27786A UY27786A1 UY 27786 A1 UY27786 A1 UY 27786A1 UY 27786 A UY27786 A UY 27786A UY 27786 A UY27786 A UY 27786A UY 27786 A1 UY27786 A1 UY 27786A1
Authority
UY
Uruguay
Prior art keywords
isoquinoline derivatives
preparation
well
relates
medicaments
Prior art date
Application number
UY27786A
Other languages
English (en)
Inventor
Andrea Cesura
Andrew W Thomas
Michelangelo Scalone
Rene Wyler
Rosa M Rodriguez
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY27786A1 publication Critical patent/UY27786A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring

Abstract

Esta invención se refiere a derivados de isoquinolina de fórmula general en donde Y es >C=O o -CH2-, Z es >C=H2-, y R1, R2 y m son tal como se han definido en la especificación, así como sus sales farmacéuticamente aceptables. La invención además se refiere a medicamentos que contienen estos compuestos, un proceso para su preparación así como su uso para la preparación de medicamentos para el tratamiento o prevención de enfermedades en que los inhibidores de la MAO-B puedan ser beneficiosos.
UY27786A 2002-04-26 2003-04-28 Derivados de isoquinolina. UY27786A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP02009253 2002-04-26

Publications (1)

Publication Number Publication Date
UY27786A1 true UY27786A1 (es) 2003-10-31

Family

ID=29265896

Family Applications (1)

Application Number Title Priority Date Filing Date
UY27786A UY27786A1 (es) 2002-04-26 2003-04-28 Derivados de isoquinolina.

Country Status (31)

Country Link
US (1) US6818774B2 (es)
EP (1) EP1501804B1 (es)
JP (1) JP4322685B2 (es)
KR (1) KR100681585B1 (es)
CN (1) CN1310890C (es)
AR (1) AR039651A1 (es)
AT (1) ATE440821T1 (es)
AU (1) AU2003227614B2 (es)
BR (1) BR0309562A (es)
CA (1) CA2483461C (es)
DE (1) DE60328978D1 (es)
DK (1) DK1501804T3 (es)
ES (1) ES2329354T3 (es)
GT (1) GT200300095A (es)
HK (1) HK1080836A1 (es)
HR (1) HRP20040952A2 (es)
IL (1) IL164677A0 (es)
MX (1) MXPA04010537A (es)
MY (1) MY133527A (es)
NO (1) NO20044571L (es)
NZ (1) NZ535885A (es)
PA (1) PA8572001A1 (es)
PE (1) PE20040594A1 (es)
PL (1) PL373697A1 (es)
PT (1) PT1501804E (es)
RU (1) RU2318812C2 (es)
SI (1) SI1501804T1 (es)
TW (1) TWI278451B (es)
UY (1) UY27786A1 (es)
WO (1) WO2003091219A1 (es)
ZA (1) ZA200408281B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2558761T3 (es) * 2003-05-19 2016-02-08 Novartis Ag Compuestos y composiciones inmunosupresores
JP4575920B2 (ja) * 2003-05-19 2010-11-04 アイアールエム・リミテッド・ライアビリティ・カンパニー 免疫抑制化合物および組成物
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
KR101186386B1 (ko) 2003-08-29 2012-09-26 오노 야꾸힝 고교 가부시키가이샤 Ｓ１ｐ 수용체 결합능을 갖는 화합물 및 그 의약 용도
CN1874991A (zh) 2003-08-29 2006-12-06 小野药品工业株式会社 能够结合s1p受体的化合物及其药物用途
ATE411027T1 (de) * 2003-10-23 2008-10-15 Hoffmann La Roche Benzazepin-derivate als mao-b-hemmer
AU2005250077B2 (en) 2004-03-01 2011-06-09 Idorsia Pharmaceuticals Ltd Substituted 1,2,3,4-tetrahydroisoquinoline derivatives
KR101262400B1 (ko) 2004-12-13 2013-05-08 오노 야꾸힝 고교 가부시키가이샤 아미노카르복실산 유도체 및 그 의약 용도
EP1844033B1 (de) * 2005-01-28 2011-07-27 Boehringer Ingelheim Pharma GmbH & Co. KG Verfahren zur herstellung von isochroman und derivaten davon
BRPI0606187A2 (pt) 2005-02-25 2009-06-09 Hoffmann La Roche comprimidos com capacidade de dispersão da substáncia do fármaco melhorada
AU2006329040C1 (en) * 2005-12-22 2011-12-08 Newron Pharmaceuticals S.P.A. 2 -Phenylethylamino derivatives as calcium and/or sodium channel modulators
CN101400348A (zh) * 2006-03-15 2009-04-01 埃科特莱茵药品有限公司 用于提高记忆功能的四氢异喹啉衍生物
EP2013209B1 (en) 2006-04-26 2011-01-19 Actelion Pharmaceuticals Ltd. Pyrazolo-tetrahydropyridine derivatives as orexin receptor antagonists
KR101220182B1 (ko) * 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CN105315204B (zh) * 2014-07-04 2018-02-09 中南大学 7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途
CN105585527B (zh) * 2015-12-17 2018-06-26 浙江工业大学 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用
CN105461626B (zh) * 2015-12-17 2018-05-08 浙江工业大学 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用
ES2961550T3 (es) * 2017-03-27 2024-03-12 Bristol Myers Squibb Co Derivados de isoquinolina sustituidos como inmunomoduladores
CN114591238B (zh) * 2022-03-25 2022-11-15 邦恩泰(山东)生物医药科技集团股份有限公司 一种异喹啉类药物中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448269B1 (en) * 1993-07-22 2002-09-10 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
US6137002A (en) * 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
JP3258027B2 (ja) 1996-03-15 2002-02-18 サマーセット・ファーマシューティカルズ・インコーポレイテッド セレジリン投与による末梢ニューロパシーの予防および治療方法
AU1359801A (en) 1999-11-05 2001-06-06 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
RU2004134575A (ru) 2005-07-20
RU2318812C2 (ru) 2008-03-10
ATE440821T1 (de) 2009-09-15
JP4322685B2 (ja) 2009-09-02
PT1501804E (pt) 2009-10-29
HRP20040952A2 (en) 2005-06-30
ES2329354T3 (es) 2009-11-25
AU2003227614A1 (en) 2003-11-10
AU2003227614B2 (en) 2008-06-26
WO2003091219A1 (en) 2003-11-06
JP2005533761A (ja) 2005-11-10
NO20044571L (no) 2004-10-22
KR100681585B1 (ko) 2007-02-09
US6818774B2 (en) 2004-11-16
IL164677A0 (en) 2005-12-18
AR039651A1 (es) 2005-03-02
GT200300095A (es) 2004-01-15
SI1501804T1 (sl) 2009-12-31
DE60328978D1 (de) 2009-10-08
HK1080836A1 (en) 2006-05-04
BR0309562A (pt) 2005-02-15
MXPA04010537A (es) 2005-01-25
PE20040594A1 (es) 2004-08-30
TW200307670A (en) 2003-12-16
DK1501804T3 (da) 2009-10-12
KR20040104628A (ko) 2004-12-10
CA2483461A1 (en) 2003-11-06
MY133527A (en) 2007-11-30
CN1310890C (zh) 2007-04-18
ZA200408281B (en) 2005-10-14
PL373697A1 (en) 2005-09-05
PA8572001A1 (es) 2003-12-10
CA2483461C (en) 2010-12-21
EP1501804A1 (en) 2005-02-02
NZ535885A (en) 2007-05-31
EP1501804B1 (en) 2009-08-26
US20030225122A1 (en) 2003-12-04
TWI278451B (en) 2007-04-11
CN1649844A (zh) 2005-08-03

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Effective date: 20150126