AR028624A1 - Heterociclilalquilaminas como antagonistas de receptores muscarinicos - Google Patents
Heterociclilalquilaminas como antagonistas de receptores muscarinicosInfo
- Publication number
- AR028624A1 AR028624A1 ARP010102491A ARP010102491A AR028624A1 AR 028624 A1 AR028624 A1 AR 028624A1 AR P010102491 A ARP010102491 A AR P010102491A AR P010102491 A ARP010102491 A AR P010102491A AR 028624 A1 AR028624 A1 AR 028624A1
- Authority
- AR
- Argentina
- Prior art keywords
- antagonists
- muscarinic receptors
- heterociclilalquilaminas
- compounds
- isomers
- Prior art date
Links
- 102000014415 Muscarinic acetylcholine receptor Human genes 0.000 title abstract 2
- 108050003473 Muscarinic acetylcholine receptor Proteins 0.000 title abstract 2
- 239000005557 antagonist Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000005856 abnormality Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 210000002460 smooth muscle Anatomy 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
- C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
- C07D207/27—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with substituted hydrocarbon radicals directly attached to the ring nitrogen atom
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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Abstract
Compuestos que son generalmente antagonistas de los receptores muscarínicos M2/M3 y que están representados por la formula 1 en donde X, Y, y Z son -O-, -S- o >N-R5, y los otros sustituyentes son tal como se definen en la descripcion o profármacos, isomeros individuales, mezclas racémicas o no racémicas de isomeros, y sales o solvatos farmacéuticamente aceptables de los mismos. Composiciones farmacéuticas que contienen dichos compuestos. Los procesos para su preparacion y su utilidad para el tratamiento de enfermedades asociadas con anomalías en el musculo liso.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US20748300P | 2000-05-25 | 2000-05-25 | |
US26757901P | 2001-02-09 | 2001-02-09 |
Publications (1)
Publication Number | Publication Date |
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AR028624A1 true AR028624A1 (es) | 2003-05-14 |
Family
ID=26902273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP010102491A AR028624A1 (es) | 2000-05-25 | 2001-05-24 | Heterociclilalquilaminas como antagonistas de receptores muscarinicos |
Country Status (28)
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US (3) | US6667301B2 (es) |
EP (1) | EP1289965B1 (es) |
JP (1) | JP4071000B2 (es) |
KR (1) | KR100544000B1 (es) |
CN (1) | CN1178922C (es) |
AR (1) | AR028624A1 (es) |
AT (1) | ATE307806T1 (es) |
AU (1) | AU782191B2 (es) |
BR (1) | BR0111061A (es) |
CA (1) | CA2409841C (es) |
CZ (1) | CZ302807B6 (es) |
DE (1) | DE60114413T2 (es) |
ES (1) | ES2251517T3 (es) |
HR (1) | HRP20020904A2 (es) |
HU (1) | HUP0302010A2 (es) |
IL (1) | IL152701A0 (es) |
MA (1) | MA26906A1 (es) |
MX (1) | MXPA02011418A (es) |
MY (1) | MY140835A (es) |
NO (1) | NO20025640L (es) |
NZ (1) | NZ522411A (es) |
PE (1) | PE20011325A1 (es) |
PL (1) | PL204753B1 (es) |
RU (1) | RU2241702C2 (es) |
TW (1) | TWI306095B (es) |
UY (1) | UY26729A1 (es) |
WO (1) | WO2001090081A1 (es) |
YU (1) | YU88902A (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4071000B2 (ja) * | 2000-05-25 | 2008-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | 置換1−アミノアルキルラクタム及びムスカリン受容体アンタゴニストとしてのそれらの使用 |
HUP0400167A3 (en) * | 2001-06-11 | 2012-09-28 | Xenoport Inc | Prodrugs of gaba analogs, compositions and uses thereof |
US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
JP4322675B2 (ja) | 2001-12-03 | 2009-09-02 | エフ.ホフマン−ラ ロシュ アーゲー | ムスカリン受容体アンタゴニストとしてのアミノテトラリン誘導体 |
EP1453805B1 (en) | 2001-12-03 | 2010-12-22 | F. Hoffmann-La Roche AG | 4-piperidinyl alkylamine derivatives as muscarinic receptor antagonists |
BR0215801A (pt) | 2002-07-08 | 2005-05-10 | Ranbaxy Lab Ltd | Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos |
WO2004089898A1 (en) | 2003-04-09 | 2004-10-21 | Ranbaxy Laboratories Limited | Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists |
CN100436414C (zh) | 2003-04-11 | 2008-11-26 | 兰贝克赛实验室有限公司 | 作为毒蕈碱受体拮抗剂的氮杂双环衍生物 |
US8795725B2 (en) | 2004-11-04 | 2014-08-05 | Xenoport, Inc. | GABA analog prodrug sustained release oral dosage forms |
CN101262867A (zh) | 2005-07-01 | 2008-09-10 | 叶林发现公司 | 用于治疗肥胖的mao-b抑制剂 |
WO2007045979A1 (en) | 2005-10-19 | 2007-04-26 | Ranbaxy Laboratories Limited | Pharmaceutical compositions of muscarinic receptor antagonists |
TWI423967B (zh) * | 2008-02-21 | 2014-01-21 | Dainippon Sumitomo Pharma Co | 醯胺衍生物及含有其之醫藥組合物 |
BRPI0907898B8 (pt) * | 2008-02-29 | 2021-05-25 | Mimetica Pty Ltd | antagonistas do receptor da melanocortina-5 3-substituído-1, 4-diazepan-2-ona |
US8008291B2 (en) * | 2008-02-29 | 2011-08-30 | Mimetica Pty Ltd | 3-aminoalkyl-1,4-diazepan-2-one melanocortin-5 receptor antagonists |
BRPI0911764A2 (pt) * | 2008-05-01 | 2015-10-06 | Boehringer Ingelheim Int | inibidores cíclicos de 11beta-hidroxiesteroide desigrogenase 1 |
CN102119160B (zh) * | 2008-07-25 | 2014-11-05 | 贝林格尔·英格海姆国际有限公司 | 11β-羟基类固醇脱氢酶1的环状抑制剂 |
WO2010012619A1 (en) * | 2008-07-28 | 2010-02-04 | F. Hoffmann-La Roche Ag | Diazepan and piperazine derivatives modulators of chemokine receptors |
US8757092B2 (en) | 2011-03-22 | 2014-06-24 | Eco-Composites Llc | Animal bedding and associated method for preparing the same |
US9737047B2 (en) | 2011-03-22 | 2017-08-22 | Ccd Holdings Llc | Method for the treatment, control, minimization, and prevention of bovine mastitis |
USRE49111E1 (en) * | 2014-06-06 | 2022-06-21 | Astellas Pharma Inc. | 2-acylaminothiazole derivative or salt thereof |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3054794A (en) | 1958-01-17 | 1962-09-18 | Us Vitamin Pharm Corp | Process for preparing 3-(aminoalkyl)-oxazolidine-2, 4-diones |
US4065471A (en) | 1965-04-09 | 1977-12-27 | Sterling Drug Inc. | N-(4-Amino-2-butynyl)imides |
US3354178A (en) | 1965-04-09 | 1967-11-21 | Sterling Drug Inc | Nu-(4-amino-2-butynyl)-nu-alkylcarboxamides |
US4087541A (en) | 1975-03-06 | 1978-05-02 | Boehringer Ingelheim Gmbh | 2-(Aralkylaminoalkyl)phthalimidines |
DD123741A5 (es) | 1975-03-06 | 1977-01-12 | ||
AT345806B (de) | 1975-03-06 | 1978-10-10 | Thomae Gmbh Dr K | Verfahren zur herstellung neuer substituierter arylalkylamine und deren salze |
US4083407A (en) * | 1977-02-07 | 1978-04-11 | The Dow Chemical Company | Spacer composition and method of use |
US4490369A (en) | 1981-05-19 | 1984-12-25 | Dr. Karl Thomae Gesellschaft Mit Beschrankter Haftung | Benzazepine derivatives, their pharmaceutical compositions and method of use |
US4729994A (en) | 1986-08-20 | 1988-03-08 | Mcneilab, Inc. | Benzothiazepine vasodilators having aralkyl substitution |
DE3631013A1 (de) | 1986-09-12 | 1988-03-24 | Thomae Gmbh Dr K | Neue naphthylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
US5177089A (en) | 1988-06-01 | 1993-01-05 | Eisai Co., Ltd. | Butenoic or propenoic acid derivative |
FI892362A (fi) | 1988-06-01 | 1989-12-02 | Eisai Co Ltd | Buten- eller propensyraderivat. |
US5998452A (en) | 1993-06-23 | 1999-12-07 | Chugai Seiyaku Kabushiki Kaisha | Benzene derivatives, compositions and methods for treating ischemic diseases |
SE9303274D0 (sv) | 1993-10-07 | 1993-10-07 | Astra Ab | Novel phenylethyl and phenylproplamines |
US6319920B1 (en) * | 1998-02-27 | 2001-11-20 | Syntex (U.S.A.) Llc | 2-arylethyl-(piperidin-4-ylmethyl)amine derivatives |
JP4071000B2 (ja) * | 2000-05-25 | 2008-04-02 | エフ.ホフマン−ラ ロシュ アーゲー | 置換1−アミノアルキルラクタム及びムスカリン受容体アンタゴニストとしてのそれらの使用 |
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2001
- 2001-05-16 JP JP2001586270A patent/JP4071000B2/ja not_active Expired - Fee Related
- 2001-05-16 YU YU88902A patent/YU88902A/sh unknown
- 2001-05-16 CA CA002409841A patent/CA2409841C/en not_active Expired - Fee Related
- 2001-05-16 DE DE60114413T patent/DE60114413T2/de not_active Expired - Lifetime
- 2001-05-16 ES ES01980030T patent/ES2251517T3/es not_active Expired - Lifetime
- 2001-05-16 CZ CZ20024200A patent/CZ302807B6/cs not_active IP Right Cessation
- 2001-05-16 KR KR1020027015885A patent/KR100544000B1/ko not_active IP Right Cessation
- 2001-05-16 AT AT01980030T patent/ATE307806T1/de active
- 2001-05-16 NZ NZ522411A patent/NZ522411A/en unknown
- 2001-05-16 IL IL15270101A patent/IL152701A0/xx unknown
- 2001-05-16 EP EP01980030A patent/EP1289965B1/en not_active Expired - Lifetime
- 2001-05-16 AU AU10122/02A patent/AU782191B2/en not_active Ceased
- 2001-05-16 BR BR0111061-6A patent/BR0111061A/pt active Search and Examination
- 2001-05-16 RU RU2002133208/04A patent/RU2241702C2/ru not_active IP Right Cessation
- 2001-05-16 HU HU0302010A patent/HUP0302010A2/hu unknown
- 2001-05-16 CN CNB018100430A patent/CN1178922C/zh not_active Expired - Fee Related
- 2001-05-16 WO PCT/EP2001/005584 patent/WO2001090081A1/en active IP Right Grant
- 2001-05-16 PL PL361282A patent/PL204753B1/pl unknown
- 2001-05-16 MX MXPA02011418A patent/MXPA02011418A/es active IP Right Grant
- 2001-05-21 PE PE2001000457A patent/PE20011325A1/es not_active Application Discontinuation
- 2001-05-22 US US09/862,286 patent/US6667301B2/en not_active Expired - Lifetime
- 2001-05-23 MY MYPI20012428A patent/MY140835A/en unknown
- 2001-05-24 AR ARP010102491A patent/AR028624A1/es not_active Application Discontinuation
- 2001-05-24 UY UY26729A patent/UY26729A1/es not_active Application Discontinuation
- 2001-05-25 TW TW090112671A patent/TWI306095B/zh not_active IP Right Cessation
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2002
- 2002-11-14 HR HRP20020904 patent/HRP20020904A2/hr not_active Application Discontinuation
- 2002-11-22 MA MA26922A patent/MA26906A1/fr unknown
- 2002-11-22 NO NO20025640A patent/NO20025640L/no not_active Application Discontinuation
-
2003
- 2003-10-14 US US10/685,124 patent/US7094778B2/en not_active Expired - Fee Related
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