DK1501804T3 - Isoquinolinderivat MAO-B-inhibitorer - Google Patents

Isoquinolinderivat MAO-B-inhibitorer

Info

Publication number
DK1501804T3
DK1501804T3 DK03725018T DK03725018T DK1501804T3 DK 1501804 T3 DK1501804 T3 DK 1501804T3 DK 03725018 T DK03725018 T DK 03725018T DK 03725018 T DK03725018 T DK 03725018T DK 1501804 T3 DK1501804 T3 DK 1501804T3
Authority
DK
Denmark
Prior art keywords
mao
inhibitors
isoquinoline derivative
isoquinoline
derivative
Prior art date
Application number
DK03725018T
Other languages
English (en)
Inventor
Sarmiento Rosa Maria Rodriguez
Andrea Cesura
Michelangelo Scalone
Andrew William Thomas
Rene Wyler
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1501804T3 publication Critical patent/DK1501804T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
DK03725018T 2002-04-26 2003-04-14 Isoquinolinderivat MAO-B-inhibitorer DK1501804T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02009253 2002-04-26
PCT/EP2003/003845 WO2003091219A1 (en) 2002-04-26 2003-04-14 Isoquinoline derivatives

Publications (1)

Publication Number Publication Date
DK1501804T3 true DK1501804T3 (da) 2009-10-12

Family

ID=29265896

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03725018T DK1501804T3 (da) 2002-04-26 2003-04-14 Isoquinolinderivat MAO-B-inhibitorer

Country Status (31)

Country Link
US (1) US6818774B2 (da)
EP (1) EP1501804B1 (da)
JP (1) JP4322685B2 (da)
KR (1) KR100681585B1 (da)
CN (1) CN1310890C (da)
AR (1) AR039651A1 (da)
AT (1) ATE440821T1 (da)
AU (1) AU2003227614B2 (da)
BR (1) BR0309562A (da)
CA (1) CA2483461C (da)
DE (1) DE60328978D1 (da)
DK (1) DK1501804T3 (da)
ES (1) ES2329354T3 (da)
GT (1) GT200300095A (da)
HK (1) HK1080836A1 (da)
HR (1) HRP20040952A2 (da)
IL (1) IL164677A0 (da)
MX (1) MXPA04010537A (da)
MY (1) MY133527A (da)
NO (1) NO20044571L (da)
NZ (1) NZ535885A (da)
PA (1) PA8572001A1 (da)
PE (1) PE20040594A1 (da)
PL (1) PL373697A1 (da)
PT (1) PT1501804E (da)
RU (1) RU2318812C2 (da)
SI (1) SI1501804T1 (da)
TW (1) TWI278451B (da)
UY (1) UY27786A1 (da)
WO (1) WO2003091219A1 (da)
ZA (1) ZA200408281B (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004103309A2 (en) * 2003-05-19 2004-12-02 Irm Llc Immunosuppressant compounds and compositions
MY150088A (en) 2003-05-19 2013-11-29 Irm Llc Immunosuppressant compounds and compositions
WO2004113330A1 (en) * 2003-05-19 2004-12-29 Irm Llc Immunosuppressant compounds and compositions
ES2527117T3 (es) 2003-08-29 2015-01-20 Ono Pharmaceutical Co., Ltd. Compuesto capaz de unirse a receptor SIP y uso farmacéutico del mismo
US7825109B2 (en) 2003-08-29 2010-11-02 Ono Pharmaceutical Co., Ltd. Compound capable of binding S1P receptor and pharmaceutical use thereof
BRPI0415842A (pt) * 2003-10-23 2007-01-02 Hoffmann La Roche derivativos de benzapepina como inibidores de mao-b
PT1751111E (pt) 2004-03-01 2015-04-01 Actelion Pharmaceuticals Ltd Derivados de 1,2,3,4-tetrahidroisoquinolina substituída
EP2371811B1 (en) 2004-12-13 2014-10-08 Ono Pharmaceutical Co., Ltd. Azetidinecarboxylic acid derivative and medicinal use thereof
JP4934055B2 (ja) * 2005-01-28 2012-05-16 ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト イソクロマンおよびその誘導体の製造方法
KR20070094666A (ko) 2005-02-25 2007-09-20 에프. 호프만-라 로슈 아게 약제 물질 분산성이 향상된 정제
PT1963280E (pt) 2005-12-22 2016-02-02 Newron Pharm Spa Derivados de 2-feniletilamino como cálcio e/ou moduladores do canal de sódio
WO2007105177A1 (en) * 2006-03-15 2007-09-20 Actelion Pharmaceuticals Ltd Tetrahydroisoquinoline derivatives to enhance memory function
EP2013209B1 (en) 2006-04-26 2011-01-19 Actelion Pharmaceuticals Ltd. Pyrazolo-tetrahydropyridine derivatives as orexin receptor antagonists
KR101220182B1 (ko) * 2009-02-25 2013-01-11 에스케이바이오팜 주식회사 치환된 아졸 유도체 화합물, 이를 포함하는 약제학적 조성물 및 이를 이용한 파킨슨씨 병 치료방법
CN105315204B (zh) * 2014-07-04 2018-02-09 中南大学 7‑氨基‑1,4‑二氢异喹啉‑3(2h)‑酮衍生物及其合成方法和用途
CN105585527B (zh) * 2015-12-17 2018-06-26 浙江工业大学 2-(3,4-二氢异喹啉-1(2h)-亚基)乙腈类化合物及其应用
CN105461626B (zh) * 2015-12-17 2018-05-08 浙江工业大学 芳环或稠杂环联3,4-二氢异喹啉类共轭结构化合物及其应用
WO2018183171A1 (en) * 2017-03-27 2018-10-04 Bristol-Myers Squibb Company Substituted isoquionline derivatives as immunomudulators
CN114591238B (zh) * 2022-03-25 2022-11-15 邦恩泰(山东)生物医药科技集团股份有限公司 一种异喹啉类药物中间体的合成方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL110172A (en) * 1993-07-22 2001-10-31 Lilly Co Eli Bicycle compounds and pharmaceuticals containing them
US6137002A (en) * 1993-07-22 2000-10-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US6448269B1 (en) * 1993-07-22 2002-09-10 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US5731324A (en) * 1993-07-22 1998-03-24 Eli Lilly And Company Glycoprotein IIb/IIIa antagonists
US5679715A (en) 1995-06-07 1997-10-21 Harris; Richard Y. Method for treating multiple sclerosis
CN1116870C (zh) 1996-03-15 2003-08-06 萨默塞特药品有限公司 司立吉林在制备用于预防或治疗外周神经病的药物中的应用
WO2001034172A2 (en) 1999-11-05 2001-05-17 Vela Pharmaceuticals Inc. Methods and compositions for treating reward deficiency syndrome

Also Published As

Publication number Publication date
AU2003227614B2 (en) 2008-06-26
HRP20040952A2 (en) 2005-06-30
KR20040104628A (ko) 2004-12-10
EP1501804A1 (en) 2005-02-02
MXPA04010537A (es) 2005-01-25
TW200307670A (en) 2003-12-16
KR100681585B1 (ko) 2007-02-09
AR039651A1 (es) 2005-03-02
PA8572001A1 (es) 2003-12-10
IL164677A0 (en) 2005-12-18
TWI278451B (en) 2007-04-11
US20030225122A1 (en) 2003-12-04
DE60328978D1 (de) 2009-10-08
PT1501804E (pt) 2009-10-29
EP1501804B1 (en) 2009-08-26
CN1310890C (zh) 2007-04-18
CA2483461A1 (en) 2003-11-06
NO20044571L (no) 2004-10-22
ATE440821T1 (de) 2009-09-15
RU2318812C2 (ru) 2008-03-10
NZ535885A (en) 2007-05-31
RU2004134575A (ru) 2005-07-20
US6818774B2 (en) 2004-11-16
JP2005533761A (ja) 2005-11-10
BR0309562A (pt) 2005-02-15
SI1501804T1 (sl) 2009-12-31
PE20040594A1 (es) 2004-08-30
WO2003091219A1 (en) 2003-11-06
UY27786A1 (es) 2003-10-31
GT200300095A (es) 2004-01-15
JP4322685B2 (ja) 2009-09-02
CN1649844A (zh) 2005-08-03
ES2329354T3 (es) 2009-11-25
PL373697A1 (en) 2005-09-05
HK1080836A1 (en) 2006-05-04
MY133527A (en) 2007-11-30
CA2483461C (en) 2010-12-21
AU2003227614A1 (en) 2003-11-10
ZA200408281B (en) 2005-10-14

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