UY25811A1 - Derivados de pirrolidina que son antagonistas del receptor ccr-3 - Google Patents

Derivados de pirrolidina que son antagonistas del receptor ccr-3

Info

Publication number
UY25811A1
UY25811A1 UY25811A UY25811A UY25811A1 UY 25811 A1 UY25811 A1 UY 25811A1 UY 25811 A UY25811 A UY 25811A UY 25811 A UY25811 A UY 25811A UY 25811 A1 UY25811 A1 UY 25811A1
Authority
UY
Uruguay
Prior art keywords
alkyl
haloalkyl
heteroalkyl
acyl
alkylene
Prior art date
Application number
UY25811A
Other languages
English (en)
Inventor
John Patrick Williams
John Saunders
Daniel Harry Rogers
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY25811A1 publication Critical patent/UY25811A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)

Abstract

Esta invención se refiere a determinados derivados de 3-aminometilpirrolidina de fórmula (1), en la que: Z es -N- o -(N+ER)-X-, en donde R es alquilo, haloalquilo, aralquilo, hidroxialquilo, carboxialquilo, alcoxicarbonilalquilo o cianoalquilo, y X- es un contraión farmacéuticamente aceptable; Ar1 y Ar2 son, independientemente uno de otro, arilo o heteroarilo; Q es un alquileno; R1 es H o alquilo; A es: I) -N(R2)C(O)- cuando B es: i) un alquileno, -NR5C(O)- y -N(R6)SO2; o ii) una cadena alquinileno; en la que: R2 es H, alquilo, acilo, haloalquilo, heteroalquilo; y R5 y R6 son, independientemente uno de otro, H, alquilo, acilo, haloalquilo, heteroalquilo; o II) un grupo seleccionado de -N(R2)C(S)-, -N(R2)C(O)N(R3), -N(R2)SO2-, -OC(O)N(R3)-, en el que B es: i) un enlace; ii) una cadena alquileno; iii) una cadena alquenileno; o iv) una cadena alquinileno; en la que: R3 es H, alquilo, acilo, haloalquilo, heteroalquilo; y profármacos, isómeros individuales y sales farmacéuticamente aceptables de los mismos. Asimismo, la invención se refiere a composiciones farmacéuticas que los contienen, a métodos para su uso y a métodos para la preparación de estos compuestos. Dichos compuestos son antagonistas del receptor CCR-3 y por tanto, son útiles en el tratamiento del asma. Ej. no limitante: N-[1-(2,3-diclorobencil)pirrolidin-3-(RS)-ilmetil]-2-[5-(4-metoxifenil)pirimidin-2-ilsulfanil]acetamida
UY25811A 1998-11-20 1999-11-19 Derivados de pirrolidina que son antagonistas del receptor ccr-3 UY25811A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10929798P 1998-11-20 1998-11-20

Publications (1)

Publication Number Publication Date
UY25811A1 true UY25811A1 (es) 2001-07-31

Family

ID=22326918

Family Applications (1)

Application Number Title Priority Date Filing Date
UY25811A UY25811A1 (es) 1998-11-20 1999-11-19 Derivados de pirrolidina que son antagonistas del receptor ccr-3

Country Status (27)

Country Link
US (1) US6166015A (es)
EP (1) EP1131288A1 (es)
JP (1) JP3593037B2 (es)
KR (1) KR20010086045A (es)
CN (1) CN1158256C (es)
AR (1) AR023707A1 (es)
AU (1) AU763960B2 (es)
BR (1) BR9915520A (es)
CA (1) CA2350903A1 (es)
CO (1) CO5140119A1 (es)
CZ (1) CZ20011760A3 (es)
DE (1) DE19955794A1 (es)
ES (1) ES2158814B1 (es)
FR (1) FR2786185A1 (es)
GB (1) GB2343893B (es)
HU (1) HUP0104364A2 (es)
ID (1) ID29067A (es)
IL (1) IL143226A0 (es)
IT (1) IT1307900B1 (es)
MA (1) MA26762A1 (es)
NO (1) NO20012411D0 (es)
PE (1) PE20001403A1 (es)
PL (1) PL348375A1 (es)
TR (1) TR200101398T2 (es)
UY (1) UY25811A1 (es)
WO (1) WO2000031032A1 (es)
ZA (1) ZA200103942B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL125658A0 (en) 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
US6339087B1 (en) 1997-08-18 2002-01-15 Syntex (U.S.A.) Llc Cyclic amine derivatives-CCR-3 receptor antagonists
US6316623B1 (en) * 1998-08-21 2001-11-13 Isis Pharmaceuticals, Inc. Ethylenediamine compound libraries
DE69938193D1 (de) 1998-11-20 2008-04-03 Hoffmann La Roche Piperidin ccr-3 rezeptor-hemmer
CN1240699C (zh) 1999-05-18 2006-02-08 帝人株式会社 与趋化因子有关的疾病的治疗或预防药物
US7576117B1 (en) 1999-08-04 2009-08-18 Teijin Limited Cyclic amine CCR3 antagonist
EP1238970B9 (en) * 1999-12-08 2007-05-09 Teijin Limited Cycloamine ccr5 receptor antagonists
BR0114321A (pt) * 2000-09-29 2003-07-01 Glaxo Group Ltd Composto, composição farmacêutica, uso de um composto, método de tratamento ou profilaxia de doenças inflamatórias, e, processo para preparar um composto
HUP0302302A2 (hu) 2000-09-29 2003-12-29 Glaxo Group Limited Morfolin-acetamid-származékok gyulladásos betegségek kezelésére, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények
AU2002216107A1 (en) * 2000-12-19 2002-07-01 F. Hoffmann-La Roche Ag Substituted pyrrolidines as CCR-3 receptor antagonists
FR2821356A1 (fr) * 2001-02-23 2002-08-30 Cerep Nouveaux derives d'arylcarbamates et d'arylurees, preparations et utilisations
GB0117387D0 (en) * 2001-07-17 2001-09-05 Novartis Ag Organic compounds
MXPA04001977A (es) * 2001-09-13 2004-06-07 Hoffmann La Roche Antagonistas v de receptor ccr-3.
US7067549B2 (en) * 2001-12-31 2006-06-27 Actelion Pharmaceuticals Ag Pyrrolidone carboxamides
GB0207443D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207436D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207439D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207432D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0212355D0 (en) * 2002-05-29 2002-07-10 Glaxo Group Ltd Novel compounds
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
DE60328690D1 (de) 2002-06-12 2009-09-17 Chemocentryx Inc 1-aryl-4-substituierte piperazin-derivate zur verwendung als ccr1-antagonisten zur behandlung von entzündungen und immunerkrankungen
BR0312358A (pt) 2002-07-02 2005-04-05 Hoffmann La Roche Derivados de pirimidina 2,5-substituìda como antagonistas ix de receptor de ccr-3
WO2004028530A1 (en) * 2002-09-26 2004-04-08 Bristol-Myers Squibb Company N-substituted heterocyclic amines as modulators of chemokine receptor activity
ES2330107T3 (es) 2003-03-06 2009-12-04 Glaxo Group Limited Derivados de urea heterociclicos para el tratamiento del dolor.
WO2004078744A2 (en) 2003-03-07 2004-09-16 Glaxo Group Limited Urea derivatives and their use as vanilloid receptor antagonists in the treatment of pain
GB0305426D0 (en) 2003-03-08 2003-04-16 Glaxo Group Ltd Novel compounds
TWI344955B (en) 2003-03-14 2011-07-11 Ono Pharmaceutical Co Heterocyclic rinf having nitrogen atom derivatives and medicament containing the derivatives as active ingredient
EP2364982A1 (en) 2003-04-18 2011-09-14 ONO Pharmaceutical Co., Ltd. Spiro-piperidine compounds as chemokine receptor antagonists and medicinal use thereof
KR20060061393A (ko) * 2003-10-24 2006-06-07 에프. 호프만-라 로슈 아게 Ｃｃｒ3 수용체 길항제
CN1950082B (zh) 2004-03-03 2013-02-06 凯莫森特里克斯股份有限公司 双环和桥连的含氮杂环化物
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
AU2005244904B2 (en) * 2004-05-14 2011-10-13 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
JP4894518B2 (ja) 2004-09-13 2012-03-14 小野薬品工業株式会社 含窒素複素環誘導体およびそれらを有効成分とする薬剤
WO2006088541A2 (en) 2005-02-17 2006-08-24 State Of Oregon Acting By & Through The State Board Of Higher Edu. On Behalf Of Portland State Unv. Quinoline derivatives and uses thereof
US20110052612A1 (en) 2005-05-31 2011-03-03 Ono Pharmaceutical Co., Ltd. Spiropiperidine compound and medicinal use thereof
WO2007011292A1 (en) * 2005-07-21 2007-01-25 Astrazeneca Ab N-benzyl-morpholine derivatives as modulators of the chemokine receptor
KR100743617B1 (ko) * 2005-08-25 2007-07-27 주식회사 알에스텍 고광학순도를 갖는 키랄 3-히드록시 피롤리딘 및 그유도체를 제조하는 방법
HUP0500877A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500879A2 (en) * 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
JP2009508929A (ja) * 2005-09-22 2009-03-05 サノフイ−アベンテイス Ｃｃｒ３受容体リガンドとしてのアミノ−アルキル−アミド誘導体
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use
PT1942108E (pt) 2005-10-28 2013-10-24 Ono Pharmaceutical Co Composto com um grupo básico e a sua utilização
US8168783B2 (en) 2005-11-18 2012-05-01 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonists and use thereof
RU2008140144A (ru) 2006-03-10 2010-04-20 Оно Фармасьютикал Ко., Лтд. (Jp) Азотосодержащее гетероциклическое производное и фармацевтическое средство, включающее такое производное в качестве активного ингредиента
US8618122B2 (en) 2006-05-16 2013-12-31 Ono Pharmaceutical Co., Ltd. Compound having acidic group which may be protected, and use thereof
WO2008016006A1 (en) 2006-07-31 2008-02-07 Ono Pharmaceutical Co., Ltd. Compound having cyclic group bound thereto through spiro binding and use thereof
WO2010129351A1 (en) 2009-04-28 2010-11-11 Schepens Eye Research Institute Method to identify and treat age-related macular degeneration
CN101906060B (zh) * 2010-05-06 2012-07-04 爱斯医药科技(南京)有限公司 N-取代的3-氨甲基吡咯烷的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459757A (en) * 1965-10-22 1969-08-05 American Cyanamid Co Imidazolidines
NZ186175A (en) * 1977-01-27 1980-03-05 Shionogi & Co Meta-sulphonamidobenzamide derivatives
JPS59186969A (ja) * 1983-04-08 1984-10-23 Yoshitomi Pharmaceut Ind Ltd ベンゾフラン−およびベンゾピランカルボキサミド誘導体
FI95572C (fi) * 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JPH01117860A (ja) * 1987-10-30 1989-05-10 Dainippon Pharmaceut Co Ltd 安息香酸アミド誘導体
JPH02104572A (ja) * 1988-10-13 1990-04-17 Dainippon Pharmaceut Co Ltd 安息香酸アミド誘導体
FR2662162B1 (fr) * 1990-05-18 1995-01-20 Adir Nouveaux derives de l'amino piperidine, de l'amino pyrrolidine et de l'amino perhydroazepine, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
US5214055A (en) * 1990-05-18 1993-05-25 Adir Et Compagnie Aminopiperidine 4-oxo-4H-chromen-2-yl compounds
US5254569A (en) * 1991-01-14 1993-10-19 The Du Pont Merck Pharmaceutical Company (Amidomethyl)nitrogen heterocyclic analgesics
GB9113031D0 (en) * 1991-06-17 1991-08-07 Smithkline Beecham Plc Compounds
FR2679906B1 (fr) * 1991-07-31 1995-01-20 Adir Nouvelles (isoquinolein-5 yl) sulfonamides, leur procede de preparation et les compositions pharmaceutiques qui les contiennent.
EP0600955A1 (en) * 1991-08-20 1994-06-15 Smithkline Beecham Plc 5-ht4 receptor antagonists
JPH06212757A (ja) * 1993-01-19 1994-08-02 Ribaa Kentetsu Kk ソリ型運搬治具による折板屋根葺き工法
EP0742208A1 (en) * 1995-05-05 1996-11-13 Grelan Pharmaceutical Co., Ltd. 2-Ureido-benzamide derivatives
US5827875A (en) * 1996-05-10 1998-10-27 Bristol-Myers Squibb Company Inhibitors of microsomal triglyceride transfer protein and method
EP0916668A4 (en) * 1996-07-29 2000-08-16 Banyu Pharma Co Ltd CHEMOKINE RECEPTOR ANTAGONISTS
IL125658A0 (en) * 1997-08-18 1999-04-11 Hoffmann La Roche Ccr-3 receptor antagonists
JPH11140276A (ja) * 1997-11-11 1999-05-25 Sumitomo Chem Co Ltd 多官能シアン酸エステル樹脂組成物および樹脂封止型半導体装置
UA67757C2 (uk) * 1997-11-18 2004-07-15 Тейджин Лімітед Похідні циклічних амінів та спосіб інгібування зв'язування хемокіну

Also Published As

Publication number Publication date
ITTO991009A0 (it) 1999-11-19
EP1131288A1 (en) 2001-09-12
MA26762A1 (fr) 2004-12-20
FR2786185A1 (fr) 2000-05-26
NO20012411L (no) 2001-05-16
ES2158814B1 (es) 2002-03-16
ID29067A (id) 2001-07-26
CZ20011760A3 (cs) 2001-12-12
ES2158814A1 (es) 2001-09-01
CO5140119A1 (es) 2002-03-22
HUP0104364A2 (hu) 2002-04-29
BR9915520A (pt) 2001-07-17
NO20012411D0 (no) 2001-05-16
IT1307900B1 (it) 2001-11-19
CN1331677A (zh) 2002-01-16
ZA200103942B (en) 2002-08-15
ITTO991009A1 (it) 2001-05-19
GB2343893A (en) 2000-05-24
IL143226A0 (en) 2002-04-21
US6166015A (en) 2000-12-26
JP3593037B2 (ja) 2004-11-24
TR200101398T2 (tr) 2001-09-21
JP2002530374A (ja) 2002-09-17
PL348375A1 (en) 2002-05-20
CN1158256C (zh) 2004-07-21
AU1382500A (en) 2000-06-13
AU763960B2 (en) 2003-08-07
WO2000031032A1 (en) 2000-06-02
DE19955794A1 (de) 2000-05-31
KR20010086045A (ko) 2001-09-07
CA2350903A1 (en) 2000-06-02
GB2343893B (en) 2002-01-09
GB9927227D0 (en) 2000-01-12
PE20001403A1 (es) 2000-12-15
AR023707A1 (es) 2002-09-04

Similar Documents

Publication Publication Date Title
UY25811A1 (es) Derivados de pirrolidina que son antagonistas del receptor ccr-3
RU2327701C2 (ru) Нуклеозидные производные и фармацевтическая композиция, обладающая антивирусной активностью в отношении hcv
AR023659A1 (es) Un compuesto inhibidor de p38, una composicion farmaceutica que lo comprende y el uso de dicha composicion en el tratamiento y prevencion de estados patologicos
UY25804A1 (es) Derivados de 4-aroilpiperidina que son antagonistas de los receptores ccr-3
ES2161418T3 (es) Compuestos de piridilfurano y de piridiltiofeno y uso farmaceutico de los mismos.
AR065937A2 (es) Compuesto derivado indazol, composicion farmaceutica que lo comprende y su uso en la fabricacion de medicamentos para modular la actividad de proteina quinasa
ES2095960T3 (es) Compuestos que tienen propiedades antihipertensivas y antiisquemicas.
MX9400206A (es) Derivados de vinil-azaindol, proceso para su preparacion y composiciones farmaceuticas que los contienen.
ITMI981902A0 (it) Derivati ammine cicliche che sono antagonisti di recettori ccr-3 composizioni farmaceutiche che li contengono metodi per il loro
EA200101203A1 (ru) Производные пурина
AR003453A1 (es) Inhibidores de agregado de plaquetas, su uso en la fabricacion de medicamentos, composicion farmaceutica que los contiene y procedimiento para la preparacion de dichos inhibidores
DK0889877T3 (da) Meta-substituerede phenylenderivater og deres anvendelse som alfav-beta3-integrin-antagonister eller -inhibitorer
AR019153A1 (es) Compuestos de beta-carbolina, composicion farmaceutica que los contiene, su uso para la manufactura de un medicamento y compuesto intermediario
AR007827A1 (es) 3-ureido-piridofuranos y -piridotiofenos, procedimiento para su preparacion, composicion que los comprende y uso de dichos compuestos para lapreparacion de medicamentos.
FI970317A0 (fi) Antiproliferatiivisina aineina ja Garft-inhibiittoreina käyttökelpoisia yhdisteitä
YU21803A (sh) Farmaceutski aktivni derivati sulfonamida koji imaju i lipofilne i jonizujuće osobine kao inhibitori protein-junkinaza
AR044825A1 (es) Derivados de 5,6-diaril-pirazinas-2-carboxamida y -2-sulfonamidas -3-sustituidas como moduladores de cb1
DE69127690T2 (de) Antiatherosklerotische und antithrombotische 1-benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on-derivate
ES2137998T3 (es) Nuevos derivados de aminoacidos, procedimiento para su preparacion y composiciones farmaceuticas que contienen estos compuestos.
AR024969A1 (es) Derivados de 8-fenil-6,9-dihidro-[1,2,4]triazol[3,4-i]purin-5-ona
ES2136037B1 (es) Inhibidores de sulfamida-metaloproteasa
AR016440A1 (es) Analogos tetraciclicos de camptotecina sus procedimientos de preparacion, productos intermediarios utilizados en dichos procedimientos, preparacion dedichos productos intermedios, uso de dichos analogos tetraciclicos para la preparacion de medicamentos y medicamentos y composiciones farmaceuticas qu
AR012489A1 (es) Tiofenopiridinas antagonistas del factor de liberacion de corticotropina. procedimiento para su preparacion, el uso de las mismas en la preparacionde un medicamento, composicion farmaceutica que las comprende, procedimiento para la preparacion de dicha composicion, un compuesto intermediario y
MEP56908A (en) Reconstitutable parenteral composition containing a cox-2 inhibitor
ES2134801T3 (es) Monohidrato de hidrocloruro de tiagabina cristalina, su preparacion y su uso.

Legal Events

Date Code Title Description
ABAN Application deemed to be withdrawn (no publication fee paid)

Effective date: 20090416