MXPA04001977A - Antagonistas v de receptor ccr-3. - Google Patents

Antagonistas v de receptor ccr-3.

Info

Publication number
MXPA04001977A
MXPA04001977A MXPA04001977A MXPA04001977A MXPA04001977A MX PA04001977 A MXPA04001977 A MX PA04001977A MX PA04001977 A MXPA04001977 A MX PA04001977A MX PA04001977 A MXPA04001977 A MX PA04001977A MX PA04001977 A MXPA04001977 A MX PA04001977A
Authority
MX
Mexico
Prior art keywords
ccr
receptor antagonists
diaminocyclopentane
derivatives
compounds
Prior art date
Application number
MXPA04001977A
Other languages
English (en)
Inventor
Joe Du Bois Daisy
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MXPA04001977A publication Critical patent/MXPA04001977A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
    • C07C233/41—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/38—One sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Abstract

La presente invencion se refiere a derivados de 1,2-diaminociclopentano de Formula (I): (ver formula) en donde R1-R4 son como se definieron en la descripcion de la invencion. Los compuestos son utiles como antagonistas de los receptores CCR-3 y por lo tanto pueden ser usados para el tratamiento de enfermedades mediadas por CCR-3.
MXPA04001977A 2001-09-13 2002-09-05 Antagonistas v de receptor ccr-3. MXPA04001977A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31899201P 2001-09-13 2001-09-13
PCT/EP2002/009934 WO2003022799A1 (en) 2001-09-13 2002-09-05 Ccr-3 receptor antagonists v

Publications (1)

Publication Number Publication Date
MXPA04001977A true MXPA04001977A (es) 2004-06-07

Family

ID=23240431

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04001977A MXPA04001977A (es) 2001-09-13 2002-09-05 Antagonistas v de receptor ccr-3.

Country Status (12)

Country Link
US (2) US7049317B2 (es)
EP (1) EP1427696A1 (es)
JP (1) JP2005502700A (es)
KR (1) KR100652451B1 (es)
CN (1) CN1267412C (es)
AR (1) AR036508A1 (es)
BR (1) BR0212451A (es)
CA (1) CA2459364A1 (es)
MX (1) MXPA04001977A (es)
PL (1) PL370367A1 (es)
RU (1) RU2286339C2 (es)
WO (1) WO2003022799A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7291615B2 (en) * 2003-05-01 2007-11-06 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
CN1839116B (zh) 2003-06-30 2010-05-26 住友化学株式会社 不对称脲化合物和通过用其作催化剂的不对称共轭加成反应制备不对称化合物的方法
US7378409B2 (en) * 2003-08-21 2008-05-27 Bristol-Myers Squibb Company Substituted cycloalkylamine derivatives as modulators of chemokine receptor activity
RU2008115499A (ru) * 2005-09-22 2009-10-27 Санофи-Авентис (Fr) Новые производные аминокиламидов в качестве антагонистов лигандов рецепторов ccr3
HUP0500879A2 (en) 2005-09-22 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use and intermediates
HUP0500886A2 (en) * 2005-09-23 2007-05-29 Sanofi Aventis Amide derivatives as ccr3 receptor ligands, process for producing them, pharmaceutical compositions containing them and their use

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098904A (en) * 1976-11-12 1978-07-04 The Upjohn Company Analgesic n-(2-aminocycloaliphatic)benzamides
US4204003A (en) * 1976-11-30 1980-05-20 The Upjohn Company N-(2-Aminocyclopentyl)-N-alkanoylanilides as CNS anti-depressants
US5420164A (en) * 1991-04-04 1995-05-30 Yoshitomi Pharmaceutical Industries, Ltd. Cycloalkylurea compounds
JPH09503994A (ja) 1993-03-03 1997-04-22 イーライ・リリー・アンド・カンパニー バラノイド
DE4326344A1 (de) 1993-08-05 1995-02-09 Thomae Gmbh Dr K Carbonamide, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
FR2729140A1 (fr) 1995-01-06 1996-07-12 Smithkline Beecham Lab Nouveaux derives d'amine, leur procede de preparation et leur utilisation en tant que medicaments et notamment en tant qu'agents anti-arythmiques
IL139913A0 (en) 1998-06-08 2002-02-10 Schering Corp Neuropeptide y5 receptor antagonists
ID29067A (id) * 1998-11-20 2001-07-26 Hoffmann La Roche Turunan pirolidina-antagonis reseptor ccr-3
US6462076B2 (en) * 2000-06-14 2002-10-08 Hoffmann-La Roche Inc. Beta-amino acid nitrile derivatives as cathepsin K inhibitors
US6706712B2 (en) * 2000-12-20 2004-03-16 Bristol-Myers Squibb Pharma Company Cyclic derivatives as modulators of chemokine receptor activity
US6576792B2 (en) * 2001-05-04 2003-06-10 Eastman Kodak Company 2-halo-1-cycloalkenecarboxamides and their preparation
US7291744B2 (en) * 2003-11-13 2007-11-06 Bristol-Myers Squibb Company N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity

Also Published As

Publication number Publication date
US20030119885A1 (en) 2003-06-26
PL370367A1 (en) 2005-05-16
KR20040044915A (ko) 2004-05-31
US7049317B2 (en) 2006-05-23
CA2459364A1 (en) 2003-03-20
BR0212451A (pt) 2004-10-19
US20060167105A1 (en) 2006-07-27
CN1555358A (zh) 2004-12-15
CN1267412C (zh) 2006-08-02
KR100652451B1 (ko) 2006-12-01
EP1427696A1 (en) 2004-06-16
WO2003022799A1 (en) 2003-03-20
AR036508A1 (es) 2004-09-15
JP2005502700A (ja) 2005-01-27
RU2286339C2 (ru) 2006-10-27
RU2004111535A (ru) 2005-10-20

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MXPA04001977A (es) Antagonistas v de receptor ccr-3.

Legal Events

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FA Abandonment or withdrawal