UY23787A1 - Procedimiento para la preparacion de compuestos que contienen un anillo biciclico fusionado - Google Patents
Procedimiento para la preparacion de compuestos que contienen un anillo biciclico fusionadoInfo
- Publication number
- UY23787A1 UY23787A1 UY23787A UY23787A UY23787A1 UY 23787 A1 UY23787 A1 UY 23787A1 UY 23787 A UY23787 A UY 23787A UY 23787 A UY23787 A UY 23787A UY 23787 A1 UY23787 A1 UY 23787A1
- Authority
- UY
- Uruguay
- Prior art keywords
- preparation
- procedure
- compounds containing
- fused bicycle
- bicycle ring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
- C07C327/34—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups with amino groups bound to the same hydrocarbon radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Reduction Or Emphasis Of Bandwidth Of Signals (AREA)
- Dram (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Peptides Or Proteins (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Steroid Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Treatments Of Macromolecular Shaped Articles (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procedimiento para preparar los compuestos de la fórmula (I), representados en la figura 1, que comprende: A - acoplar la cadena lateral de acilmercapto de fórmula general representada en la figura 2, o una forma activada de la misma con la amina de fórmula general representada en la figura 3, en presencia de un reactivo de acoplamiento para dar el compuesto representado en la figura 4, donde: X es O o S-(O)t, donde t es 0, 1 o 2; m es cero o uno; Y es CH2, S-(O)t u O con la condición de que Y es S-(O)t u O, solamente cuando m es 1; R1 y R12 se seleccionan independientemente del grupo que consiste en hidrógeno, alquilo, alquenilo, cicloalquilo, alquilo sustituido, alquenilo sustituido, arilo, arilo sustituido, heteroarilo, cicloalquil-alquenilo, aril-alquenilo, aril-alquenilo sustituido, y heteroaril-alquenilo o R1 y R12 tomados conjuntamente con el átomo de carbonoal están unidos completan un anillo cicloalquílico o un anillo cicloalquílico benzofusionado; R3 es hidríogeno, alquilo, alquilo sustituido, aril-(CH2)p-, aril sustituido-(CH2)p-, o heteroariul-(CH2)p-, p es 0 o un entero de 1 a 6; r es 0 o 1; B- tratar el producto de la etapa A- para separar el grupo acilo, y cuando R3 es otro que no sea hidrógeno, separar el grupo protector de ácido carboxílico R3 para dar el producto deseado de la fórmula (I). Ejemplo no limitante: Ácido [4S-[4alfa(R*),7alfa,10a beta]]-octahidro-4-[(2-mercapto-1-oxo-3fenilpropil)amino]-5-oxo-78H-pirido[2,1-b][1,3]-oxazepin-carboxílico. Estos compuestos son inhibidores duales de endopeptidasa neutra (NEP) y enzima de conversión de angiotensina (ACE); por tanto son útiles para tratar enfermedades vasculares como la hipertensión, la insuficiencia cardíaca congestiva, edema, y la insuficiencia renal.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US7797893A | 1993-06-15 | 1993-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
UY23787A1 true UY23787A1 (es) | 1994-12-06 |
Family
ID=22141128
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UY23787A UY23787A1 (es) | 1993-06-15 | 1994-06-15 | Procedimiento para la preparacion de compuestos que contienen un anillo biciclico fusionado |
Country Status (38)
Country | Link |
---|---|
US (5) | US5508272A (es) |
EP (1) | EP0629627B1 (es) |
JP (1) | JP3569550B2 (es) |
KR (1) | KR100395604B1 (es) |
CN (1) | CN1046525C (es) |
AT (1) | ATE266032T1 (es) |
AU (1) | AU672899B2 (es) |
BG (1) | BG62139B1 (es) |
BR (1) | BR1100970A (es) |
CA (1) | CA2124375C (es) |
CY (1) | CY2492B1 (es) |
CZ (1) | CZ289488B6 (es) |
DE (1) | DE69433752T2 (es) |
DK (1) | DK0629627T3 (es) |
EE (1) | EE03178B1 (es) |
EG (1) | EG20537A (es) |
ES (1) | ES2219644T3 (es) |
FI (3) | FI106464B (es) |
GE (1) | GEP19981301B (es) |
HK (1) | HK1001814A1 (es) |
HU (1) | HU216791B (es) |
IL (2) | IL109924A (es) |
LT (1) | LT3626B (es) |
LV (1) | LV10622B (es) |
MY (1) | MY123673A (es) |
NO (1) | NO306405B1 (es) |
NZ (1) | NZ260736A (es) |
PH (1) | PH30830A (es) |
PL (1) | PL178469B1 (es) |
PT (1) | PT629627E (es) |
RO (1) | RO112870B1 (es) |
RU (1) | RU2125056C1 (es) |
SG (1) | SG46510A1 (es) |
SK (1) | SK282529B6 (es) |
TW (1) | TW329423B (es) |
UA (1) | UA39924C2 (es) |
UY (1) | UY23787A1 (es) |
ZA (1) | ZA944163B (es) |
Families Citing this family (121)
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