US20040122222A1 - Instrument and method for collecting nucleic acids - Google Patents

Instrument and method for collecting nucleic acids Download PDF

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Publication number
US20040122222A1
US20040122222A1 US10/468,598 US46859804A US2004122222A1 US 20040122222 A1 US20040122222 A1 US 20040122222A1 US 46859804 A US46859804 A US 46859804A US 2004122222 A1 US2004122222 A1 US 2004122222A1
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US
United States
Prior art keywords
nucleic acid
reagent
solid phases
tips
acid capturing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
US10/468,598
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English (en)
Inventor
Toshinari Sakurai
Toshiaki Yokobayashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hitachi Ltd
Original Assignee
Hitachi Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hitachi Ltd filed Critical Hitachi Ltd
Assigned to HITACHI, LTD. reassignment HITACHI, LTD. ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: YOKOBAYASHI, TOSHIAKI, SAKURAI, TOSHINARI
Publication of US20040122222A1 publication Critical patent/US20040122222A1/en
Priority to US12/869,519 priority Critical patent/US8183054B2/en
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00—Apparatus for enzymology or microbiology
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
    • G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0275—Interchangeable or disposable dispensing tips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0631—Purification arrangements, e.g. solid phase extraction [SPE]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00178—Special arrangements of analysers
    • G01N2035/00237—Handling microquantities of analyte, e.g. microvalves, capillary networks
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/103—General features of the devices using disposable tips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1048—General features of the devices using the transfer device for another function
    • G01N2035/1058—General features of the devices using the transfer device for another function for mixing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0099—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor comprising robots or similar manipulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
    • G01N35/028—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations having reaction cells in the form of microtitration plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1004—Cleaning sample transfer devices
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction

Definitions

  • NAT nucleic-acid amplification testing
  • PCR technique the polymerase chain reaction technique
  • PCR technique allows nucleic acids in a solution to be amplified sequence-specifically, for example, the existence of virus, only a trace amount of which is contained in serum, may be indirectly proved by amplifying and detecting the nucleic acids, which are genes of the virus.
  • JP-A No. 250681/1995 the method for purifying a DNA extraction liquid using a cartridge vessel having a quadruple-structured filtering member, wherein a glass powder layer is inserted between two glass fiber filters and membrane filters, is disclosed.
  • the sample to be purified is extracted in such a manner that a prepared DNA-containing culture is pre-processed and pipetted on a trap filter, and then an elution reagent is added on it to elute plasmid DNA from a cell.
  • any of substances, which can have action of dissolving the nucleic acids from the solid phase may be used, and the method, which uses a low concentration of salt solution or deionized water, is known.
  • 10 mmol/L bicine (pH8.5) and 0.1 mmol/L EDTA are used.
  • a third reagent bottle 19 used in Step 3a, a fifth reagent bottle 20 used in Step 5, a first reagent bottle 21 used in Step 1, a fourth reagent bottle 102 used in Step 4, a second reagent bottle 22 used in Steps 2a and 2b, and others are set.
  • the arm 16 and the nozzle holders 17 automatically removed the used dispensing tips 15 by taking advantage of the action of the tip detaching device 27 .
  • the arm 16 and the nozzle holders 17 attached new dispensing tips 15 , 100 ⁇ L of second reagent was aspirated from the second reagent bottle 22 , discharged into the processing vessel 24 with the mixture of the sample and the first reagent filled, the liquid was repeatedly aspirated and discharged five times, and then the whole amount of liquid was discharged into the processing vessel 24 .

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
US10/468,598 2001-03-28 2001-12-20 Instrument and method for collecting nucleic acids Abandoned US20040122222A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/869,519 US8183054B2 (en) 2001-03-28 2010-08-26 Instrument and method for collecting nucleic acids

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/JP2001/002577 WO2002078847A1 (fr) 2001-03-28 2001-03-28 Instrument et procede permettant de recuperer de l'acide nucleique
WOPCT/JP01/02577 2001-03-28
PCT/JP2001/011212 WO2002078846A1 (fr) 2001-03-28 2001-12-20 Instrument et procede de recolte d'acides nucleiques

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/869,519 Division US8183054B2 (en) 2001-03-28 2010-08-26 Instrument and method for collecting nucleic acids

Publications (1)

Publication Number Publication Date
US20040122222A1 true US20040122222A1 (en) 2004-06-24

Family

ID=11737173

Family Applications (2)

Application Number Title Priority Date Filing Date
US10/468,598 Abandoned US20040122222A1 (en) 2001-03-28 2001-12-20 Instrument and method for collecting nucleic acids
US12/869,519 Expired - Fee Related US8183054B2 (en) 2001-03-28 2010-08-26 Instrument and method for collecting nucleic acids

Family Applications After (1)

Application Number Title Priority Date Filing Date
US12/869,519 Expired - Fee Related US8183054B2 (en) 2001-03-28 2010-08-26 Instrument and method for collecting nucleic acids

Country Status (6)

Country Link
US (2) US20040122222A1 (de)
EP (1) EP1374997B1 (de)
JP (3) JP3619514B2 (de)
KR (1) KR100505380B1 (de)
DE (1) DE60121477T2 (de)
WO (2) WO2002078847A1 (de)

Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127705A1 (en) * 2000-05-31 2002-09-12 Volker Lehmann Method and arrangement for taking up a first medium, which is present in a first phase, into a capillary device
US20050042138A1 (en) * 2003-08-20 2005-02-24 Sysmex Corporation Sample analyzer, nucleic acid detector and nucleic acid detection method
US20050175499A1 (en) * 2004-02-06 2005-08-11 Quest Diagnostics Investments Incorporated Method of reducing cross sample contamination during filter sampling
US20060019407A1 (en) * 2004-07-23 2006-01-26 Fulton Scott P Immunoassay assembly and methods of use
US20060252142A1 (en) * 2005-05-06 2006-11-09 Hitachi High-Technologies Corporation Method for nucleic acid isolation and an instrument for nucleic acid isolation
US20080038740A1 (en) * 2006-06-26 2008-02-14 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US20090029867A1 (en) * 2005-01-26 2009-01-29 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US20090111193A1 (en) * 2007-10-31 2009-04-30 Cooney Christopher G Sample preparation device
WO2009058432A1 (en) * 2007-10-31 2009-05-07 Akonni Biosystems Sample preparation device
US20090215125A1 (en) * 2006-06-26 2009-08-27 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US20110203688A1 (en) * 2008-11-04 2011-08-25 Blood Cell Storage, Inc. Nucleic acid extraction on curved glass surfaces
US8012349B2 (en) 2006-11-20 2011-09-06 Orbital Biosciences, Llc Small volume unitary molded filters and supports for adsorbent beds
US8629264B2 (en) 2011-05-19 2014-01-14 Blood Cell Storage, Inc. Gravity flow fluidic device for nucleic acid extraction
US20150105300A1 (en) * 2003-02-05 2015-04-16 Iquum, Inc. Sample Processing Methods
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
US10125388B2 (en) 2007-10-31 2018-11-13 Akonni Biosystems, Inc. Integrated sample processing system
CN109073513A (zh) * 2016-04-07 2018-12-21 田边工业株式会社 粉体采集器、粉体采集装置及自动粉体采集***
US10429403B2 (en) 2014-06-17 2019-10-01 Yamaha Hatsudoki Kabushiki Kaisha Head device for mounting dispensing tip thereon, and movement device using same
US20210025910A1 (en) * 2017-12-29 2021-01-28 Beckman Coulter, Inc. Probe Washing Arrangement With Multiple Configurations For Sample Analyzer And Method Of Using

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CN1694966A (zh) * 2002-11-13 2005-11-09 株式会社日立高新技术 核酸的扩增方法及其装置
JP2004337108A (ja) * 2003-05-16 2004-12-02 Hitachi High-Technologies Corp 核酸精製装置、核酸捕捉用チップ、及び核酸精製方法
JP4090443B2 (ja) * 2004-02-24 2008-05-28 株式会社日立ハイテクノロジーズ 核酸回収器具、その部品、及び核酸回収器具の生産方法
JP4699868B2 (ja) * 2005-11-04 2011-06-15 株式会社日立ハイテクノロジーズ 核酸精製方法及び核酸精製器具
GB201010237D0 (en) * 2010-06-18 2010-07-21 Lgc Ltd Methods and apparatuses
CN102947449A (zh) * 2010-06-18 2013-02-27 东洋纺株式会社 同时进行抗酸菌的溶菌和抗酸菌的核酸的分离的方法
EP2455764A1 (de) * 2010-11-18 2012-05-23 BTP TECNO S.r.l. Diagnosevorrichtung zur Analyse von organischen Proben
KR20140066567A (ko) 2012-11-23 2014-06-02 주식회사 엘지화학 리튬 이차전지용 전해액 및 이를 포함하는 리튬 이차전지

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US5188730A (en) * 1990-05-07 1993-02-23 Kronwald Separationstechnik Gmbh Multipart chromatography column connection
US5910246A (en) * 1995-04-01 1999-06-08 Boehringer Mannheim Gmbh Device for isolating nucleic acids
US6168922B1 (en) * 1997-04-09 2001-01-02 Schleicher & Schuell, Inc. Methods and devices for collecting and storing clinical samples for genetic analysis
US6162356A (en) * 1998-03-19 2000-12-19 Hitachi, Ltd. Chip for use in nucleic acid separation, structural element and process for forming the structural element
US6326189B1 (en) * 1999-03-04 2001-12-04 Hitachi, Ltd. Nucleic acid separating vessel, a method of manufacturing the nucleic acid separating vessel, and a method for separating the nucleic acid

Cited By (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020127705A1 (en) * 2000-05-31 2002-09-12 Volker Lehmann Method and arrangement for taking up a first medium, which is present in a first phase, into a capillary device
US7470546B2 (en) * 2000-05-31 2008-12-30 Infineon Technologies Ag Method and arrangement for taking up a first medium, which is present in a first phase, into a capillary device
US9708599B2 (en) * 2003-02-05 2017-07-18 Roche Molecular Systems, Inc. Sample processing methods
US20150105300A1 (en) * 2003-02-05 2015-04-16 Iquum, Inc. Sample Processing Methods
US20050042138A1 (en) * 2003-08-20 2005-02-24 Sysmex Corporation Sample analyzer, nucleic acid detector and nucleic acid detection method
US20050175499A1 (en) * 2004-02-06 2005-08-11 Quest Diagnostics Investments Incorporated Method of reducing cross sample contamination during filter sampling
US20060019407A1 (en) * 2004-07-23 2006-01-26 Fulton Scott P Immunoassay assembly and methods of use
US8158064B2 (en) 2004-07-23 2012-04-17 Agilent Technologies, Inc. Immunoassay assembly and methods of use
US20100323372A1 (en) * 2004-07-23 2010-12-23 Fulton Scott P Immunoassay assembly and methods of use
US7799279B2 (en) 2004-07-23 2010-09-21 Biosystem Development, Llc Immunoassay assembly and methods of use
US8802026B2 (en) 2004-07-23 2014-08-12 Agilent Technologies, Inc. Immunoassay assembly and methods of use
US20100173330A1 (en) * 2004-07-23 2010-07-08 Fulton Scott P Immunoassay assembly and methods of use
US20090029867A1 (en) * 2005-01-26 2009-01-29 Reed Michael W DNA purification and analysis on nanoengineered surfaces
US20060252142A1 (en) * 2005-05-06 2006-11-09 Hitachi High-Technologies Corporation Method for nucleic acid isolation and an instrument for nucleic acid isolation
US20080038740A1 (en) * 2006-06-26 2008-02-14 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US20100047808A1 (en) * 2006-06-26 2010-02-25 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US7608399B2 (en) 2006-06-26 2009-10-27 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US20090215125A1 (en) * 2006-06-26 2009-08-27 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US8771955B2 (en) 2006-06-26 2014-07-08 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US8148115B2 (en) 2006-06-26 2012-04-03 Blood Cell Storage, Inc. Device and method for extraction and analysis of nucleic acids from biological samples
US8163535B2 (en) 2006-06-26 2012-04-24 Blood Cell Storage, Inc. Devices and processes for nucleic acid extraction
US8012349B2 (en) 2006-11-20 2011-09-06 Orbital Biosciences, Llc Small volume unitary molded filters and supports for adsorbent beds
WO2009058432A1 (en) * 2007-10-31 2009-05-07 Akonni Biosystems Sample preparation device
US10093919B2 (en) 2007-10-31 2018-10-09 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
US8236553B2 (en) 2007-10-31 2012-08-07 Akonni Biosystems, Inc. Apparatus, system and method for purifying nucleic acids
US8574923B2 (en) 2007-10-31 2013-11-05 Akonni Biosystems, Inc. Sample preparation device
US10125388B2 (en) 2007-10-31 2018-11-13 Akonni Biosystems, Inc. Integrated sample processing system
US8236501B2 (en) 2007-10-31 2012-08-07 Akonni Biosystems, Inc. Apparatus, system and method for purifying nucleic acids
US20100240882A1 (en) * 2007-10-31 2010-09-23 Akonni Biosystems Apparatus, System and Method for Purifying Nucleic Acids
US20100240123A1 (en) * 2007-10-31 2010-09-23 Akonni Biosystems Apparatus, System and Method for Purifying Nucleic Acids
US9428746B2 (en) 2007-10-31 2016-08-30 Akonni Biosystems, Inc. Method and kit for purifying nucleic acids
US20090111193A1 (en) * 2007-10-31 2009-04-30 Cooney Christopher G Sample preparation device
US20110203688A1 (en) * 2008-11-04 2011-08-25 Blood Cell Storage, Inc. Nucleic acid extraction on curved glass surfaces
US8629264B2 (en) 2011-05-19 2014-01-14 Blood Cell Storage, Inc. Gravity flow fluidic device for nucleic acid extraction
US10429403B2 (en) 2014-06-17 2019-10-01 Yamaha Hatsudoki Kabushiki Kaisha Head device for mounting dispensing tip thereon, and movement device using same
CN109073513A (zh) * 2016-04-07 2018-12-21 田边工业株式会社 粉体采集器、粉体采集装置及自动粉体采集***
US10942093B2 (en) * 2016-04-07 2021-03-09 Tanabe Engineering Corporation Powder collector, powder collection device, and automatic powder collecting system
US20210025910A1 (en) * 2017-12-29 2021-01-28 Beckman Coulter, Inc. Probe Washing Arrangement With Multiple Configurations For Sample Analyzer And Method Of Using

Also Published As

Publication number Publication date
US8183054B2 (en) 2012-05-22
JP4081468B2 (ja) 2008-04-23
EP1374997B1 (de) 2006-07-12
KR20030078897A (ko) 2003-10-08
JP3663207B2 (ja) 2005-06-22
EP1374997A4 (de) 2004-05-12
US20110015381A1 (en) 2011-01-20
JP3619514B2 (ja) 2005-02-09
DE60121477D1 (de) 2006-08-24
JP2004290211A (ja) 2004-10-21
DE60121477T2 (de) 2007-02-15
EP1374997A1 (de) 2004-01-02
JP2005110687A (ja) 2005-04-28
WO2002078847A1 (fr) 2002-10-10
KR100505380B1 (ko) 2005-07-29
JPWO2002078846A1 (ja) 2004-07-22
WO2002078846A1 (fr) 2002-10-10

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