UA97834C2 - Производные сульфониламида для лечения анормального роста клеток - Google Patents

Производные сульфониламида для лечения анормального роста клеток

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Publication number
UA97834C2
UA97834C2 UAA200910461A UAA200910461A UA97834C2 UA 97834 C2 UA97834 C2 UA 97834C2 UA A200910461 A UAA200910461 A UA A200910461A UA A200910461 A UAA200910461 A UA A200910461A UA 97834 C2 UA97834 C2 UA 97834C2
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Ukraine
Prior art keywords
treatment
cell growth
abnormal cell
amide derivatives
sulfonyl amide
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UAA200910461A
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English (en)
Ukrainian (uk)
Inventor
Майкл Джозэф Луццио
Кристофэр Лоуэлл Отри
Самит Кумар Бхаттачаря
Кэвин Дэниэл Фриман-Кук
Мэттью Мэррилл Хэйворд
Кэтрин Энджил Халфорд
Кэндра Луиз Нэльсон
Джун Ксяо
Ксюмяо Жао
Original Assignee
Пфайзер Продактс Инк.
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Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of UA97834C2 publication Critical patent/UA97834C2/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
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    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D475/00—Heterocyclic compounds containing pteridine ring systems

Abstract

Представленное изобретение касается соединения формулы I, Iв котором R- R, А, В, n и m имеют значения, как определено в данной заявке.Такие производные сульфониламида являются пригодными для применения в лечении ненормального роста клеток, такого как рак, у млекопитающих.Данное изобретение также касается применения таких соединений в лечении ненормального роста клеток у млекопитающих, особенно людей, и фармацевтических композиций, которые содержат такие соединения.
UAA200910461A 2007-04-18 2008-04-07 Производные сульфониламида для лечения анормального роста клеток UA97834C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91259707P 2007-04-18 2007-04-18
PCT/IB2008/000845 WO2008129380A1 (en) 2007-04-18 2008-04-07 Sulfonyl amide derivatives for the treatment of abnormal cell growth

Publications (1)

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UA97834C2 true UA97834C2 (ru) 2012-03-26

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US (12) US7928109B2 (ru)
EP (1) EP2146779B1 (ru)
JP (1) JP4782239B2 (ru)
KR (1) KR101132880B1 (ru)
CN (2) CN101678215B (ru)
AP (1) AP2009005010A0 (ru)
AR (1) AR066125A1 (ru)
AU (1) AU2008240359B2 (ru)
BR (1) BRPI0810411B8 (ru)
CA (1) CA2684447C (ru)
CL (1) CL2008001076A1 (ru)
CO (1) CO6260093A2 (ru)
CU (1) CU23813A3 (ru)
DK (1) DK2146779T3 (ru)
DO (1) DOP2009000248A (ru)
EA (1) EA016679B1 (ru)
EC (1) ECSP099694A (ru)
ES (1) ES2593486T3 (ru)
GE (1) GEP20125581B (ru)
GT (1) GT200900272A (ru)
HK (2) HK1136985A1 (ru)
IL (3) IL201468A (ru)
MA (1) MA31319B1 (ru)
MX (1) MX2009011090A (ru)
NI (1) NI200900190A (ru)
NZ (1) NZ580372A (ru)
PA (1) PA8777101A1 (ru)
PE (1) PE20090434A1 (ru)
TN (1) TN2009000428A1 (ru)
TW (1) TWI369205B (ru)
UA (1) UA97834C2 (ru)
UY (1) UY31026A1 (ru)
WO (1) WO2008129380A1 (ru)

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