UA97369C2 - Противоопухолевые соединения дигидропиран-2-она и фармацевтическая композиция на их основе - Google Patents

Противоопухолевые соединения дигидропиран-2-она и фармацевтическая композиция на их основе

Info

Publication number
UA97369C2
UA97369C2 UAA200900292A UAA200900292A UA97369C2 UA 97369 C2 UA97369 C2 UA 97369C2 UA A200900292 A UAA200900292 A UA A200900292A UA A200900292 A UAA200900292 A UA A200900292A UA 97369 C2 UA97369 C2 UA 97369C2
Authority
UA
Ukraine
Prior art keywords
compounds
pharmaceutical composition
composition based
antitumoral
dihydropyran
Prior art date
Application number
UAA200900292A
Other languages
English (en)
Ukrainian (uk)
Inventor
Лопес Ма Хесус Мартин
МОЛИНЕРО Лаура КОЭЛЬО
БЕНИТЕС Хосе Фернандо РЕЙЕС
ВИСЕНТЕ Альберто РОДРИГЕС
ГАРСИА-ИБАРРОЛА Мария ГАРРАНСО
ПЕРЕС Кармен МУРСИЯ
Сольосо Франсиско Франсесч
САНЧО Франсиско САНЧЕС
Марчанте Мария дель Кармен Куэвас
РОДРИГЕС Рохелио ФЕРНАНДЕС
Original Assignee
Фарма Мар, С.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фарма Мар, С.А. filed Critical Фарма Мар, С.А.
Publication of UA97369C2 publication Critical patent/UA97369C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/32—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Противоопухолевые соединения общей формулы (I), (I)полученные из губки семейства Raspailiidae, род Lithoplocamia, вид lithistoides, и их производные.
UAA200900292A 2006-06-16 2007-06-15 Противоопухолевые соединения дигидропиран-2-она и фармацевтическая композиция на их основе UA97369C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06380173 2006-06-16
PCT/EP2007/055959 WO2007144423A1 (en) 2006-06-16 2007-06-15 Antitumoral dihydropyran-2-one compounds

Publications (1)

Publication Number Publication Date
UA97369C2 true UA97369C2 (ru) 2012-02-10

Family

ID=38508885

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200900292A UA97369C2 (ru) 2006-06-16 2007-06-15 Противоопухолевые соединения дигидропиран-2-она и фармацевтическая композиция на их основе

Country Status (30)

Country Link
US (2) US8324406B2 (ru)
EP (3) EP2032551B9 (ru)
JP (2) JP5117491B2 (ru)
KR (1) KR101474031B1 (ru)
CN (2) CN101679340B (ru)
AR (1) AR061506A1 (ru)
AT (1) ATE522514T1 (ru)
AU (1) AU2007259257B8 (ru)
BR (2) BRPI0713031B8 (ru)
CA (1) CA2654334C (ru)
CY (1) CY1112103T1 (ru)
DK (1) DK2032551T3 (ru)
ES (1) ES2371942T3 (ru)
HK (1) HK1130052A1 (ru)
HR (1) HRP20110845T1 (ru)
IL (1) IL195676A (ru)
MX (1) MX2008015754A (ru)
MY (1) MY145788A (ru)
NO (2) NO341508B1 (ru)
NZ (1) NZ573706A (ru)
PL (1) PL2032551T3 (ru)
PT (1) PT2032551E (ru)
RS (1) RS52034B (ru)
RU (2) RU2444519C2 (ru)
SG (1) SG174830A1 (ru)
SI (1) SI2032551T1 (ru)
TW (2) TW201213316A (ru)
UA (1) UA97369C2 (ru)
WO (1) WO2007144423A1 (ru)
ZA (1) ZA200810315B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2231590T3 (da) 2007-12-20 2012-07-09 Pharma Mar Sa Antitumorforbindelser
MX2010008922A (es) 2008-02-20 2010-09-07 Actelion Pharmaceuticals Ltd Compuestos antibioticos azatriciclicos.
ES2398939T3 (es) 2008-02-22 2013-03-22 Actelion Pharmaceuticals Ltd. Derivados de oxazolidinona
BRPI0920895A8 (pt) 2008-10-07 2017-12-26 Actelion Pharmaceuticals Ltd Compostos antibióticos de oxazolidinona tricíclica
AU2009302007B2 (en) 2008-10-10 2015-01-15 Actelion Pharmaceuticals Ltd Oxazolidinyl antibiotics
WO2010149688A2 (en) 2009-06-24 2010-12-29 Pharma Mar, S.A. Antitumoral compounds
GB201309807D0 (en) * 2013-05-31 2013-07-17 Pharma Mar Sau Antibody drug conjugates
CN108467378A (zh) * 2017-02-23 2018-08-31 复旦大学 一种二氢吡喃酮类化合物及其制备方法和用途
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
CN110790737B (zh) * 2019-11-07 2022-07-22 河南中烟工业有限责任公司 一种2,3-二氢-3,5-二羟基-6-乙基-4h-吡喃-4-酮的制备方法
WO2023067132A1 (en) 2021-10-22 2023-04-27 Pharma Mar, S.A. Antitumoral compounds

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA938019B (en) * 1992-11-13 1995-04-28 Upjohn Co Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating HIV and other retroviruses
CA2176043A1 (en) * 1993-11-19 1995-05-26 Warner-Lambert Company 5,6-dihydropyrone derivatives as protease inhibitors and antiviral agents
US7446196B2 (en) * 2004-06-03 2008-11-04 Kosan Biosciences, Incorporated Leptomycin compounds

Also Published As

Publication number Publication date
JP5117491B2 (ja) 2013-01-16
KR20090024261A (ko) 2009-03-06
RU2444519C2 (ru) 2012-03-10
KR101474031B1 (ko) 2014-12-17
ES2371942T3 (es) 2012-01-11
HK1130052A1 (en) 2009-12-18
CN101679340B (zh) 2013-06-05
WO2007144423A1 (en) 2007-12-21
AU2007259257B8 (en) 2012-04-05
TW201213316A (en) 2012-04-01
ATE522514T1 (de) 2011-09-15
NO341508B1 (no) 2017-11-27
EP2404913A2 (en) 2012-01-11
CN102336730A (zh) 2012-02-01
JP2012021023A (ja) 2012-02-02
DK2032551T3 (da) 2012-01-02
EP2404913A3 (en) 2012-06-06
EP2404912A3 (en) 2012-07-25
EP2032551B9 (en) 2012-02-29
BRPI0713031B8 (pt) 2021-05-25
EP2404912A2 (en) 2012-01-11
JP2009539943A (ja) 2009-11-19
NO20090054L (no) 2009-01-06
HRP20110845T1 (hr) 2011-12-31
NZ573706A (en) 2011-09-30
SG174830A1 (en) 2011-10-28
TW200811128A (en) 2008-03-01
RU2009101150A (ru) 2010-07-27
CN101679340A (zh) 2010-03-24
US8324406B2 (en) 2012-12-04
AU2007259257A1 (en) 2007-12-21
CY1112103T1 (el) 2015-11-04
US20090186938A1 (en) 2009-07-23
CA2654334A1 (en) 2007-12-21
SI2032551T1 (sl) 2012-01-31
EP2032551B1 (en) 2011-08-31
BRPI0722429A2 (pt) 2013-11-26
AU2007259257A8 (en) 2012-04-05
RS52034B (en) 2012-04-30
US20120190870A1 (en) 2012-07-26
US20100048690A2 (en) 2010-02-25
IL195676A (en) 2012-06-28
ZA200810315B (en) 2010-02-24
BRPI0713031B1 (pt) 2020-10-06
NO20111248L (no) 2008-12-16
TWI373469B (en) 2012-10-01
CA2654334C (en) 2014-06-10
US8501968B2 (en) 2013-08-06
PT2032551E (pt) 2011-12-06
RU2011133128A (ru) 2013-02-10
BRPI0713031A2 (pt) 2013-03-12
MX2008015754A (es) 2009-01-12
IL195676A0 (en) 2009-09-01
AU2007259257B2 (en) 2011-12-08
MY145788A (en) 2012-04-30
EP2032551A1 (en) 2009-03-11
PL2032551T3 (pl) 2012-01-31
AR061506A1 (es) 2008-09-03

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