UA86798C2 - 9-substituted 8-oxoadenine compound - Google Patents

9-substituted 8-oxoadenine compound

Info

Publication number
UA86798C2
UA86798C2 UAA200611260A UAA200611260A UA86798C2 UA 86798 C2 UA86798 C2 UA 86798C2 UA A200611260 A UAA200611260 A UA A200611260A UA A200611260 A UAA200611260 A UA A200611260A UA 86798 C2 UA86798 C2 UA 86798C2
Authority
UA
Ukraine
Prior art keywords
alkyl
rrepresents
xrepresents
alkylene
sulfur
Prior art date
Application number
UAA200611260A
Other languages
English (en)
Ukrainian (uk)
Inventor
Аюму Куримото
Казуки Хасимото
Йосиаки Исобе
Стивен Броу
Ян Милличип
Хироки ВАДА
Роджер Боннерт
Томас МакИналли
Original Assignee
ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД.
Астразенека Актиэболаг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД., Астразенека Актиэболаг filed Critical ДАЙНИППОН СУМИТОМО ФАРМА Ко., ЛТД.
Publication of UA86798C2 publication Critical patent/UA86798C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/18—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one oxygen and one nitrogen atom, e.g. guanine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Данное изобретение описывает 8-производное оксоаденина, который имеет иммуномодулирующую активность, такую как интерферониндуцирующая активность, и является полезным как противовирусное средство и противоаллергическое средство, представленное формулой (1):, (1)где кольцо представляет собой 6-10-членное ароматическое карбоциклическое кольцо и подобное ему,R представляет собой атом галогена, алкильную группу и подобную ей,n представляет собой целое число 0-2,Zпредставляет собой алкилен,Xпредставляет собой атом кислорода, атом серы, SO, NR, CO, CONR, NRCO и им подобные, Y, Yи Yнезависимо представляют собой простую связь или алкиленовую группу,Xпредставляет собой атом кислорода, атом серы, NR(Rпредставляет собой атом водорода или алкильную группу) или простую связь,Rпредставляет собой замещенную или незаме
UAA200611260A 2004-03-26 2005-03-24 9-substituted 8-oxoadenine compound UA86798C2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2004093672 2004-03-26

Publications (1)

Publication Number Publication Date
UA86798C2 true UA86798C2 (en) 2009-05-25

Family

ID=35056129

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200611260A UA86798C2 (en) 2004-03-26 2005-03-24 9-substituted 8-oxoadenine compound

Country Status (20)

Country Link
US (3) US8012964B2 (ru)
EP (1) EP1728793B1 (ru)
JP (2) JP4472693B2 (ru)
KR (1) KR101217303B1 (ru)
CN (1) CN1938307B (ru)
AU (1) AU2005226359B2 (ru)
BR (1) BRPI0509258A8 (ru)
CA (1) CA2559036C (ru)
ES (1) ES2563952T3 (ru)
HK (1) HK1098140A1 (ru)
IL (1) IL177518A (ru)
MX (1) MXPA06011080A (ru)
MY (1) MY148686A (ru)
NO (1) NO20064857L (ru)
NZ (1) NZ549903A (ru)
RU (1) RU2397171C2 (ru)
TW (2) TWI392678B (ru)
UA (1) UA86798C2 (ru)
WO (1) WO2005092893A1 (ru)
ZA (1) ZA200607574B (ru)

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AU2005226359B2 (en) 2011-02-03
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