UA8324A1 - Process for the preparation of derivatives of 4-amino-2-(piperazin-1-yl) quinazoline or pharmaceutically acceptable salts thereof with acids - Google Patents

Process for the preparation of derivatives of 4-amino-2-(piperazin-1-yl) quinazoline or pharmaceutically acceptable salts thereof with acids

Info

Publication number
UA8324A1
UA8324A1 UA2679598A UA2679598A UA8324A1 UA 8324 A1 UA8324 A1 UA 8324A1 UA 2679598 A UA2679598 A UA 2679598A UA 2679598 A UA2679598 A UA 2679598A UA 8324 A1 UA8324 A1 UA 8324A1
Authority
UA
Ukraine
Prior art keywords
quinazoline
piperazin
derivatives
amino
preparation
Prior art date
Application number
UA2679598A
Other languages
Russian (ru)
Ukrainian (uk)
Inventor
Фрейзер Кемпбелл Саймон
Original Assignee
Пфайзер Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Корпорейшн filed Critical Пфайзер Корпорейшн
Publication of UA8324A1 publication Critical patent/UA8324A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

A process for the preparation of derivatives of 4-amino-2-(piperazin-1-yl) or homopiperazin-1-yl)quinazoline involves interaction of quinazoline with piperazin or homopiperazin. The end product is formed free state or as pharmaceutically acceptable salt with acid.
UA2679598A 1977-11-05 1978-10-31 Process for the preparation of derivatives of 4-amino-2-(piperazin-1-yl) quinazoline or pharmaceutically acceptable salts thereof with acids UA8324A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4612877 1977-11-05

Publications (1)

Publication Number Publication Date
UA8324A1 true UA8324A1 (en) 1996-03-29

Family

ID=10439957

Family Applications (1)

Application Number Title Priority Date Filing Date
UA2679598A UA8324A1 (en) 1977-11-05 1978-10-31 Process for the preparation of derivatives of 4-amino-2-(piperazin-1-yl) quinazoline or pharmaceutically acceptable salts thereof with acids

Country Status (36)

Country Link
JP (1) JPS5498792A (en)
AR (2) AR219562A1 (en)
AT (1) AT365186B (en)
AU (1) AU509329B2 (en)
BE (1) BE871771A (en)
CA (1) CA1088059A (en)
CH (1) CH643255A5 (en)
CS (2) CS207671B2 (en)
DD (1) DD139850A5 (en)
DE (1) DE2847623C2 (en)
DK (1) DK154082C (en)
EG (1) EG13594A (en)
ES (2) ES474805A1 (en)
FI (1) FI64366C (en)
FR (1) FR2407929A1 (en)
GR (1) GR81514B (en)
HK (1) HK94284A (en)
HU (1) HU176306B (en)
IE (1) IE47888B1 (en)
IL (1) IL55857A (en)
IN (1) IN148828B (en)
IT (1) IT1100919B (en)
KE (1) KE3350A (en)
LU (2) LU80470A1 (en)
MY (1) MY8500286A (en)
NL (2) NL174549C (en)
NO (1) NO150158C (en)
NZ (1) NZ188813A (en)
PH (1) PH13966A (en)
PL (2) PL119586B1 (en)
PT (1) PT68735A (en)
SE (1) SE437518B (en)
SU (1) SU816403A3 (en)
UA (1) UA8324A1 (en)
YU (2) YU40204B (en)
ZA (1) ZA786184B (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1985004658A1 (en) * 1984-04-04 1985-10-24 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepine derivatives and their preparation
WO1985002617A1 (en) * 1983-12-14 1985-06-20 Takeda Chemical Industries. Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
WO1986002644A1 (en) * 1984-11-01 1986-05-09 Takeda Chemical Industries, Ltd. 1,5-benzoxathiepin derivatives and process for their preparation
EP0849264A1 (en) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Novel polymorphic form of doxazosin mesylate (form I)
EP0849266B8 (en) * 1996-12-20 2007-10-03 Heumann PCS GmbH Novel polymorphic form of doxazosin mesylate (form III)
EP0849265A1 (en) * 1996-12-20 1998-06-24 HEUMANN PHARMA GmbH Novel polymorphic form of doxazosin mesylate (form II)
TW448155B (en) * 1999-03-29 2001-08-01 Dev Center Biotechnology Method for producing amide compounds and quinazolin derivatives
EP1403263B1 (en) * 2002-09-27 2005-06-22 Council of Scientific and Industrial Research Process for the preparation of N-(2,3-dihydrobenzo 1,4 dioxin-2-carbonyl) piperazine

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3663706A (en) * 1969-09-29 1972-05-16 Pfizer Use of 2,4-diaminoquinazolines as hypotensive agents
US3669968A (en) * 1970-05-21 1972-06-13 Pfizer Trialkoxy quinazolines

Also Published As

Publication number Publication date
HU176306B (en) 1981-01-28
LU80470A1 (en) 1980-06-05
PL210681A1 (en) 1979-11-05
IL55857A0 (en) 1979-01-31
SU816403A3 (en) 1981-03-23
AT365186B (en) 1981-12-28
IT1100919B (en) 1985-09-28
NL174549B (en) 1984-02-01
AU509329B2 (en) 1980-05-08
DK154082C (en) 1989-02-27
NL7810909A (en) 1979-05-08
ES480121A0 (en) 1980-07-16
PH13966A (en) 1980-11-12
SE437518B (en) 1985-03-04
YU40204B (en) 1985-08-31
DK154082B (en) 1988-10-10
FI783347A (en) 1979-05-06
NZ188813A (en) 1980-10-08
CH643255A5 (en) 1984-05-30
LU88331I2 (en) 1994-05-04
SE7811382L (en) 1979-05-06
NO783705L (en) 1979-05-08
IE47888B1 (en) 1984-07-11
DE2847623A1 (en) 1979-05-23
FI64366B (en) 1983-07-29
EG13594A (en) 1982-03-31
ZA786184B (en) 1979-10-31
CS354491A3 (en) 1992-06-17
ES474805A1 (en) 1980-01-16
NL930062I1 (en) 1993-09-01
FR2407929A1 (en) 1979-06-01
FR2407929B1 (en) 1981-02-27
YU38683A (en) 1983-06-30
GR81514B (en) 1984-12-11
ES8308559A1 (en) 1980-07-16
PL119586B1 (en) 1982-01-30
JPS5625233B2 (en) 1981-06-11
BE871771A (en) 1979-05-03
IL55857A (en) 1982-07-30
ATA784378A (en) 1981-05-15
IE782179L (en) 1979-05-05
NL930062I2 (en) 1993-11-16
AU4132278A (en) 1979-05-17
FI64366C (en) 1983-11-10
PL119419B1 (en) 1981-12-31
NL174549C (en) 1984-07-02
YU255378A (en) 1983-06-30
DE2847623C2 (en) 1983-06-01
CS207671B2 (en) 1981-08-31
NO150158C (en) 1984-08-29
AR223015A1 (en) 1981-07-15
CA1088059A (en) 1980-10-21
MY8500286A (en) 1985-12-31
NO150158B (en) 1984-05-21
JPS5498792A (en) 1979-08-03
DK428678A (en) 1979-05-06
IT7829434A0 (en) 1978-11-03
PT68735A (en) 1978-12-01
IN148828B (en) 1981-06-27
AR219562A1 (en) 1980-08-29
DD139850A5 (en) 1980-01-23
KE3350A (en) 1983-12-16
HK94284A (en) 1984-12-07
YU40419B (en) 1985-12-31

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