MX2009012891A - Proteinas de union a antigeno dirigidas a staphylococcus aureus orf0657n. - Google Patents

Proteinas de union a antigeno dirigidas a staphylococcus aureus orf0657n.

Info

Publication number
MX2009012891A
MX2009012891A MX2009012891A MX2009012891A MX2009012891A MX 2009012891 A MX2009012891 A MX 2009012891A MX 2009012891 A MX2009012891 A MX 2009012891A MX 2009012891 A MX2009012891 A MX 2009012891A MX 2009012891 A MX2009012891 A MX 2009012891A
Authority
MX
Mexico
Prior art keywords
binding proteins
antigen
aureus
orf0657n
proteins targeting
Prior art date
Application number
MX2009012891A
Other languages
English (en)
Inventor
Annaliesa S Anderson
Desmond J Clark
Zhiqiang An
Fubao Wang
Susan L Secore
Eberhard Durr
Leslie D Cope
Tessie Mcneely
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of MX2009012891A publication Critical patent/MX2009012891A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/32—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bacillus (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77—Internalization into the cell
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a proteínas de unión a antígeno que se unen a una región que se ha encontrado que tiene un epítope que puede ser dirigido para proveer protección contra infección por S. aureus; la región se designa aquí como la región objetivo "CS-D7"; la región objetivo CS-D7 provee un epítope de S. aureus ORF0657n que puede ser dirigido para reducir la probabilidad o severidad de una infección por S. aureus.
MX2009012891A 2007-05-31 2008-05-29 Proteinas de union a antigeno dirigidas a staphylococcus aureus orf0657n. MX2009012891A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US93278807P 2007-05-31 2007-05-31
US799807P 2007-12-17 2007-12-17
PCT/US2008/006791 WO2009029132A2 (en) 2007-05-31 2008-05-29 Antigen-binding proteins targeting s. aureus orf0657n

Publications (1)

Publication Number Publication Date
MX2009012891A true MX2009012891A (es) 2009-12-10

Family

ID=40380548

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009012891A MX2009012891A (es) 2007-05-31 2008-05-29 Proteinas de union a antigeno dirigidas a staphylococcus aureus orf0657n.

Country Status (12)

Country Link
US (1) US20100166772A1 (es)
EP (1) EP2164869A2 (es)
JP (1) JP2010528607A (es)
KR (1) KR20100021577A (es)
CN (1) CN101679516B (es)
AU (1) AU2008294038A1 (es)
BR (1) BRPI0811193A2 (es)
CA (1) CA2687681A1 (es)
IL (1) IL201906A0 (es)
MX (1) MX2009012891A (es)
RU (1) RU2009149294A (es)
WO (1) WO2009029132A2 (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101375161A (zh) * 2006-01-27 2009-02-25 默克公司 靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白
US9181329B2 (en) 2007-08-31 2015-11-10 The University Of Chicago Methods and compositions related to immunizing against Staphylococcal lung diseases and conditions
JP5658564B2 (ja) 2007-08-31 2015-01-28 ザ・ユニバーシティ・オブ・シカゴＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ Ｏｆ Ｃｈｉｃａｇｏ ブドウ球菌肺疾患および状態に対する免疫に関連した方法および組成物
US8758765B2 (en) 2008-07-29 2014-06-24 The University Of Chicago Compositions and methods related to Staphylococcal bacterium proteins
BRPI1010307B1 (pt) 2009-04-03 2021-07-27 University Of Chicago Polipeptídeos variantes de proteína a (spa), composição imunogênica compreendendo os mesmos, vacina, método de produção da referida vacina, bem como uso dos referidos polipeptídeos
NZ612315A (en) 2009-04-14 2014-10-31 Novartis Ag Compositions for immunising against staphylococcus aureus
CA2779798C (en) 2009-09-30 2019-03-19 Novartis Ag Conjugation of staphylococcus aureus type 5 and type 8 capsular polysaccharides
US20120208986A1 (en) * 2009-10-20 2012-08-16 Wenger Marc D Use of mixed mode chromatography for the capture and purification of basic antibody products
CN102971009A (zh) 2009-10-30 2013-03-13 诺华有限公司 金黄色葡萄球菌5型和8型荚膜多糖的纯化
GB0919690D0 (en) 2009-11-10 2009-12-23 Guy S And St Thomas S Nhs Foun compositions for immunising against staphylococcus aureus
ES2655701T3 (es) 2010-07-02 2018-02-21 The University Of Chicago Composiciones y métodos relacionados con variantes de la proteína A (SpA)
CA2826566C (en) * 2011-02-08 2022-09-13 Medimmune, Llc Antibodies that specifically bind staphylococcus aureus alpha toxin and methods of use
CN102649817A (zh) * 2011-02-24 2012-08-29 复旦大学 一种抑制细菌生物膜形成的单克隆抗体
US8945588B2 (en) 2011-05-06 2015-02-03 The University Of Chicago Methods and compositions involving protective staphylococcal antigens, such as EBH polypeptides
US9988439B2 (en) 2011-12-23 2018-06-05 Nicholas B. Lydon Immunoglobulins and variants directed against pathogenic microbes
WO2013096948A1 (en) 2011-12-23 2013-06-27 Lydon Nicholas B Immunoglobulins and variants directed against pathogenic microbes
KR102100009B1 (ko) 2016-05-04 2020-04-10 이길봉 3축 트레일러의 조향장치
KR20170003596U (ko) 2017-06-16 2017-10-17 배경률 자동차용 스노우 체인
CA3076632A1 (en) 2017-09-29 2019-04-04 Regeneron Pharmaceuticals, Inc. Bispecific antigen-binding molecules that bind a staphylococcus target antigen and a complement component and uses thereof

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6916605B1 (en) * 1990-07-10 2005-07-12 Medical Research Council Methods for producing members of specific binding pairs
US6610293B1 (en) 1997-06-16 2003-08-26 The Henry M. Jackson Foundation For The Advancement Of Military Medicine Opsonic and protective monoclonal and chimeric antibodies specific for lipoteichoic acid of gram positive bacteria
US7250494B2 (en) 1998-06-15 2007-07-31 Biosynexus Incorporated Opsonic monoclonal and chimeric antibodies specific for lipoteichoic acid of Gram positive bacteria
PT2281843T (pt) * 2000-06-16 2017-01-02 Human Genome Sciences Inc Anticorpos que se ligam imunoespecificamente a blys
US7138496B2 (en) * 2002-02-08 2006-11-21 Genetastix Corporation Human monoclonal antibodies against human CXCR4
EP1377314B1 (en) * 2001-01-26 2011-09-14 Inhibitex, Inc. Monoclonal antibodies to the clfa protein and method of use in treating or preventing infections
CN1615315A (zh) * 2001-11-19 2005-05-11 应用分子发展公司 肿瘤特异性单克隆抗体
US20040132101A1 (en) 2002-09-27 2004-07-08 Xencor Optimized Fc variants and methods for their generation
NZ570750A (en) * 2003-07-24 2009-12-24 Merck & Co Inc Polypeptides for inducing a protective immune response against staphylococcus aureus
US20070134263A1 (en) 2004-02-18 2007-06-14 Anderson Annaliesa S Polypeptides for inducing a protective immune response against staphyloococcus aureus
WO2005086663A2 (en) 2004-02-27 2005-09-22 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphlococcus aureus
US20070243205A1 (en) 2004-05-25 2007-10-18 Anderson Annaliesa S Polypeptides for Inducing a Protective Immune Response Against Staphylococcus Aureus
WO2006033918A2 (en) 2004-09-17 2006-03-30 Merck & Co., Inc. Polypeptides for inducing a protective immune response against staphylococcus aureus
AU2006206577B2 (en) 2005-01-21 2012-03-08 Merck Sharp & Dohme Corp. Polypeptides for inducing a protective immune response against Staphylococcus aureus
CN1320125C (zh) * 2005-09-28 2007-06-06 兰州生物制品研究所 一种单克隆抗体的制备方法及其应用
CN101375161A (zh) * 2006-01-27 2009-02-25 默克公司 靶定金黄色葡萄球菌ORF0657n的抗原结合蛋白
EP2027155B1 (en) * 2006-06-06 2016-01-27 Crucell Holland B.V. Human binding molecules having killing activity against staphylococci and uses thereof
WO2007141278A2 (en) * 2006-06-06 2007-12-13 Crucell Holland B.V. Human binding molecules having killing activity against enterococci and staphylococcus aureus and uses thereof

Also Published As

Publication number Publication date
EP2164869A2 (en) 2010-03-24
IL201906A0 (en) 2010-06-16
RU2009149294A (ru) 2011-07-10
CN101679516A (zh) 2010-03-24
WO2009029132A2 (en) 2009-03-05
JP2010528607A (ja) 2010-08-26
KR20100021577A (ko) 2010-02-25
CN101679516B (zh) 2013-11-13
BRPI0811193A2 (pt) 2014-11-11
US20100166772A1 (en) 2010-07-01
AU2008294038A1 (en) 2009-03-05
CA2687681A1 (en) 2009-03-05
WO2009029132A3 (en) 2009-05-14

Similar Documents

Publication Publication Date Title
MX2009012891A (es) Proteinas de union a antigeno dirigidas a staphylococcus aureus orf0657n.
MX2009004532A (es) Composiciones y metodos para unir esfingosina-1-fosfato.
UA111818C2 (uk) Антитіло проти csf-1r
UA117901C2 (uk) Спосіб посилення ефекторної функції вихідного поліпептиду, його варіанти та їх застосування
PH12015500248A1 (en) Humanized anti-cxcr5 antibodies, derivatives thereof and their uses
MY166776A (en) Humanised anti-ctla4 antibodies
EA201101593A1 (ru) КОМПОЗИЦИИ И СПОСОБЫ, ПРЕДНАЗНАЧЕННЫЕ ДЛЯ НАПРАВЛЕННОГО ВОЗДЕЙСТВИЯ АНТИТЕЛ НА БЕЛОК С3b СИСТЕМЫ КОМПЛЕМЕНТА
JO3118B1 (ar) تراكيب وطرق لبروتين c5 المتمم يستهدف الأجسام المضادة
WO2010017103A3 (en) Fully human anti-human nkg2d monoclonal antibodies
BR112013020086A2 (pt) anticorpos que se ligam especificamente à alfa-toxina de staphylococcus aureus e métodos de utilização
WO2011119979A3 (en) Antibodies to muc16 and methods of use thereof
EA201000903A1 (ru) Антитела к pcrv-антигену pseudomonas aeruginosa
WO2009112245A9 (en) Antibody against the csf-1 r
BR112014002758A2 (pt) composições para cuidados pessoais contendo zinco piritiona submetido à secagem
WO2008097439A3 (en) Anti-autoimmune antibodies for treatment of pemphigus
WO2011004028A3 (en) Tlr3 binding agents
JO3437B1 (ar) أجسام مضادة محسنة مضادة للفراكتالكين البشري واستخداماتها
NZ607615A (en) Antibodies directed against il-17
WO2009114560A3 (en) Compositions and methods for the therapy and diagnosis of cytomegalovirus infections
BRPI1010911A2 (pt) "anticorpos ou fragmentos destes direcionados contra um epitopo de staphylococcus aureus"
EA201070826A1 (ru) Антитела против pcrv
MX2011009100A (es) Anticuerpo humanizado pcrv que tiene actividad anti-pseudomonal.
NZ702282A (en) Compositions and methods related to antibodies that neutralize coagulase activity during staphylococcus aureus disease
WO2012031260A3 (en) Staphylococcus aureus specific human recombinant polyclonal antibodies and uses thereof
WO2011123819A3 (en) Epha3 antibodies for the treatment of multiple myeloma

Legal Events

Date Code Title Description
HH Correction or change in general
HC Change of company name or juridical status
FG Grant or registration
GB Transfer or rights
HC Change of company name or juridical status