UA116871C2 - СПОСІБ ЛІКУВАННЯ МІЄЛОДИСПЛАСТИЧНОГО СИНДРОМУ, ТАЛАСЕМІЇ ТА СЕРПОПОДІБНО-КЛІТИННОЇ АНЕМІЇ ЗА ДОПОМОГОЮ ЗАСТОСУВАННЯ АНТАГОНІСТА АКТИВІНУ ПОЛІПЕПТИДУ ActRII - Google Patents
СПОСІБ ЛІКУВАННЯ МІЄЛОДИСПЛАСТИЧНОГО СИНДРОМУ, ТАЛАСЕМІЇ ТА СЕРПОПОДІБНО-КЛІТИННОЇ АНЕМІЇ ЗА ДОПОМОГОЮ ЗАСТОСУВАННЯ АНТАГОНІСТА АКТИВІНУ ПОЛІПЕПТИДУ ActRIIInfo
- Publication number
- UA116871C2 UA116871C2 UAA201214689A UAA201214689A UA116871C2 UA 116871 C2 UA116871 C2 UA 116871C2 UA A201214689 A UAA201214689 A UA A201214689A UA A201214689 A UAA201214689 A UA A201214689A UA 116871 C2 UA116871 C2 UA 116871C2
- Authority
- UA
- Ukraine
- Prior art keywords
- treatment
- syndrome
- cell anemia
- myelodylasplastic
- antagonistu
- Prior art date
Links
- 208000007502 anemia Diseases 0.000 title 1
- 239000005557 antagonist Substances 0.000 title 1
- 208000011580 syndromic disease Diseases 0.000 title 1
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 2
- 201000003793 Myelodysplastic syndrome Diseases 0.000 abstract 1
- 208000002903 Thalassemia Diseases 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 208000007056 sickle cell anemia Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1796—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/38—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5082—Supracellular entities, e.g. tissue, organisms
- G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/80—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood groups or blood types or red blood cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Neurology (AREA)
- Tropical Medicine & Parasitology (AREA)
Abstract
Винахід належить до способу лікування захворювання, вибраного з групи, яка складається з мієлодиспластичного синдрому, таласемії та серпоподібно-клітинної анемії, шляхом введення пацієнту-людині, який цього потребує, ефективної кількості поліпептиду ActRII, та застосування пептиду ActRII для лікування вказаних захворювань.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87568206P | 2006-12-18 | 2006-12-18 | |
UAA200906746A UA101309C2 (uk) | 2006-12-18 | 2007-12-18 | Антагоністи активіну-actrii та їх застосування для підвищення рівня еритроцитів |
Publications (1)
Publication Number | Publication Date |
---|---|
UA116871C2 true UA116871C2 (uk) | 2018-05-25 |
Family
ID=39183159
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200906746A UA101309C2 (uk) | 2006-12-18 | 2007-12-18 | Антагоністи активіну-actrii та їх застосування для підвищення рівня еритроцитів |
UAA201214689A UA116871C2 (uk) | 2006-12-18 | 2007-12-18 | СПОСІБ ЛІКУВАННЯ МІЄЛОДИСПЛАСТИЧНОГО СИНДРОМУ, ТАЛАСЕМІЇ ТА СЕРПОПОДІБНО-КЛІТИННОЇ АНЕМІЇ ЗА ДОПОМОГОЮ ЗАСТОСУВАННЯ АНТАГОНІСТА АКТИВІНУ ПОЛІПЕПТИДУ ActRII |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UAA200906746A UA101309C2 (uk) | 2006-12-18 | 2007-12-18 | Антагоністи активіну-actrii та їх застосування для підвищення рівня еритроцитів |
Country Status (29)
Country | Link |
---|---|
US (7) | US7988973B2 (uk) |
EP (6) | EP2468290B1 (uk) |
JP (8) | JP5415279B2 (uk) |
KR (6) | KR101803620B1 (uk) |
CN (4) | CN104524548A (uk) |
AU (1) | AU2007334333B2 (uk) |
BR (1) | BRPI0720476B1 (uk) |
CA (1) | CA2672758C (uk) |
CO (1) | CO6230995A2 (uk) |
CR (1) | CR10889A (uk) |
DK (2) | DK2124999T3 (uk) |
EA (3) | EA035911B1 (uk) |
EC (1) | ECSP099514A (uk) |
ES (1) | ES2396734T3 (uk) |
HK (3) | HK1137368A1 (uk) |
HR (1) | HRP20121035T1 (uk) |
IL (5) | IL199451A (uk) |
ME (1) | ME02335B (uk) |
MX (1) | MX2009006651A (uk) |
MY (3) | MY162136A (uk) |
NZ (4) | NZ720955A (uk) |
PL (2) | PL2468290T3 (uk) |
PT (1) | PT2124999E (uk) |
RS (1) | RS52537B (uk) |
SG (1) | SG10201702157QA (uk) |
SI (1) | SI2124999T1 (uk) |
UA (2) | UA101309C2 (uk) |
WO (1) | WO2008076437A2 (uk) |
ZA (2) | ZA200904454B (uk) |
Families Citing this family (82)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
USRE46351E1 (en) | 2001-05-10 | 2017-03-28 | Battelle Energy Alliance, Llc | Antibody profiling sensitivity through increased reporter antibody layering |
US6989276B2 (en) | 2001-05-10 | 2006-01-24 | Battelle Energy Alliance, Llc | Rapid classification of biological components |
EP3059245B1 (en) * | 2004-07-23 | 2018-11-07 | Acceleron Pharma Inc. | Actrii receptor antagonistic antibodies |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
PL1973559T3 (pl) | 2005-11-23 | 2013-06-28 | Acceleron Pharma Inc | Antagoniści aktywiny-ActRIIa i zastosowanie do pobudzania wzrostu kości |
EA035911B1 (ru) | 2006-12-18 | 2020-08-31 | Акселерон Фарма Инк. | Применение полипептида, который ингибирует опосредованный активином сигнальный путь, в качестве лекарственного средства |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
US20100028332A1 (en) * | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
JP5237970B2 (ja) * | 2007-02-01 | 2013-07-17 | アクセルロン ファーマ, インコーポレイテッド | 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用 |
TWI548647B (zh) | 2007-02-02 | 2016-09-11 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
TR200906329T1 (tr) | 2007-02-09 | 2010-01-21 | Acceleron Pharma Inc. | Kanser Hastalarında Kemik Gelişimini Desteklemek için A |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
US20080286881A1 (en) * | 2007-05-14 | 2008-11-20 | Apel William A | Compositions and methods for combining report antibodies |
EP3243524A1 (en) | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
JP5778576B2 (ja) * | 2008-06-26 | 2015-09-16 | アクセルロン ファーマ, インコーポレイテッド | アクチビン−ActRIIaアンタゴニストを投薬する方法および処置される患者をモニターする方法 |
WO2009158033A2 (en) * | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
AU2015202035B2 (en) * | 2008-08-14 | 2017-03-23 | Acceleron Pharma Inc. | Use of GDF traps to increase red blood cell levels |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
TWI617316B (zh) | 2008-08-14 | 2018-03-11 | 艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
US20110262466A1 (en) * | 2008-10-16 | 2011-10-27 | The Trustees Of The University Of Pennsylvania | Compositions containing thrombomodulin domains and uses thereof |
KR101778134B1 (ko) | 2008-11-26 | 2017-09-13 | 암젠 인크 | 액티빈 iib 수용체 폴리펩타이드의 변이체 및 이의 용도 |
WO2010083034A1 (en) | 2009-01-13 | 2010-07-22 | Acceleron Pharma Inc. | Methods for increasing adiponectin |
WO2010144452A1 (en) | 2009-06-08 | 2010-12-16 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
MX351286B (es) * | 2009-06-12 | 2017-10-09 | Acceleron Pharma Inc | Proteinas de fusion actriib-fc truncadas. |
BR112012003232B1 (pt) * | 2009-08-13 | 2022-02-22 | Acceleron Pharma Inc | Uso de um polipeptídeo em conjunto com um ativador do receptor de eritropoetina para aumentar os níveis de célula vermelha no sangue ou tratar anemia |
CA2773494A1 (en) * | 2009-09-09 | 2011-03-17 | Acceleron Pharma Inc. | Actriib antagonists and dosing and uses thereof |
US9410965B2 (en) * | 2009-09-17 | 2016-08-09 | Battelle Energy Alliance, Llc | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual |
US8969009B2 (en) * | 2009-09-17 | 2015-03-03 | Vicki S. Thompson | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual |
US20110129469A1 (en) * | 2009-11-03 | 2011-06-02 | Acceleron Pharma Inc. | Methods for treating fatty liver disease |
US8710016B2 (en) * | 2009-11-17 | 2014-04-29 | Acceleron Pharma, Inc. | ActRIIB proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
WO2012027065A2 (en) * | 2010-08-27 | 2012-03-01 | Celgene Corporation | Combination therapy for treatment of disease |
SG190679A1 (en) | 2010-10-01 | 2013-07-31 | Jason Schrum | Engineered nucleic acids and methods of use thereof |
CA2817008A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
SG11201401196WA (en) | 2011-10-03 | 2014-05-29 | Moderna Therapeutics Inc | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
AU2012352180A1 (en) | 2011-12-16 | 2014-07-31 | Moderna Therapeutics, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9192651B2 (en) | 2012-04-02 | 2015-11-24 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of secreted proteins |
US9303079B2 (en) | 2012-04-02 | 2016-04-05 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
US9809636B2 (en) * | 2012-04-06 | 2017-11-07 | Acceleron Pharma Inc. | Methods for increasing red blood cell levels comprising administering BMP9 |
GB201206559D0 (en) | 2012-04-13 | 2012-05-30 | Ucl Business Plc | Polypeptide |
JP6214537B2 (ja) * | 2012-08-21 | 2017-10-25 | 国立大学法人九州大学 | 貧血患者の貧血の要因を検出するためのバイオマーカー |
CN112957462A (zh) * | 2012-10-24 | 2021-06-15 | 细胞基因公司 | 用于治疗贫血的方法 |
CN104968801B (zh) * | 2012-10-24 | 2021-06-15 | 细胞基因公司 | 用于治疗贫血症的生物标志物 |
EP2914277B1 (en) * | 2012-11-02 | 2017-09-13 | Celgene Corporation | Activin-actrii antagonists and uses for treating bone and other disorders |
US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
MX2015009901A (es) | 2013-02-01 | 2016-04-06 | Santa Maria Biotherapeutics Inc | Administración de un compuesto de antiactivina a a un sujeto. |
US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
MX2016004249A (es) | 2013-10-03 | 2016-11-08 | Moderna Therapeutics Inc | Polinulcleotidos que codifican el receptor de lipoproteina de baja densidad. |
MA39722A (fr) * | 2014-03-21 | 2021-06-02 | Acceleron Pharma Inc | Composition pour son utilisation dans une methode de traitement ou de prevention de l'anemie par l'inhibition de l'activine b et du gdf11 |
JP6568110B2 (ja) | 2014-06-04 | 2019-08-28 | アクセルロン ファーマ, インコーポレイテッド | フォリスタチンポリペプチドによる障害の処置のための方法および組成物 |
US10010498B2 (en) | 2014-06-04 | 2018-07-03 | Acceleron Pharma Inc. | Methods for treatment of amyotrophic lateral sclerosis with follistatin fusion proteins |
EP3154566B1 (en) * | 2014-06-13 | 2022-08-03 | Acceleron Pharma Inc. | Actrii antagonist for the treatment or prevention of a cutaneous ulcer in a subject that has anemia |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
CA2964808C (en) | 2014-10-30 | 2023-06-27 | Acceleron Pharma Inc. | Methods and compositions using gdf15 polypeptides for increasing red blood cells |
MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
PT3227675T (pt) * | 2014-12-03 | 2023-05-30 | Celgene Corp | Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica |
EP3250588A1 (en) * | 2015-01-29 | 2017-12-06 | Board of Trustees of Michigan State University | Cryptic polypeptides and uses thereof |
WO2016128523A1 (en) | 2015-02-12 | 2016-08-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
CN107636154A (zh) | 2015-03-26 | 2018-01-26 | 阿塞勒隆制药公司 | 促滤泡素抑制素相关的融合蛋白及其用途 |
WO2016164089A2 (en) * | 2015-04-06 | 2016-10-13 | Acceleron Pharma Inc. | Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof |
CA2983440C (en) | 2015-04-22 | 2024-03-12 | Alivegen Usa Inc. | Novel hybrid actriib ligand trap proteins for treating muscle wasting diseases |
KR102640198B1 (ko) * | 2015-05-13 | 2024-02-23 | 셀진 코포레이션 | Actrii 리간드 트랩을 사용한 베타-탈라세미아의 치료 |
MA42160A (fr) | 2015-05-20 | 2018-03-28 | Maria Cappellini | Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii |
KR102605758B1 (ko) * | 2015-07-06 | 2023-11-23 | 미츠비시 가스 가가쿠 가부시키가이샤 | 수지 조성물, 프리프레그, 레진 시트, 적층판, 및 프린트 배선판 |
EP3370754A4 (en) | 2015-11-04 | 2019-10-23 | Acceleron Pharma Inc. | METHODS FOR INCREASING ERYTHROCYTE RATES AND TREATING INEFFECTIVE ERYTHROPOISIS |
CN108697793B (zh) | 2015-11-23 | 2023-08-01 | 阿塞勒隆制药公司 | 治疗眼睛疾病的方法 |
US20170306027A1 (en) | 2016-04-06 | 2017-10-26 | Acceleron Pharma Inc. | Alk7 antagonists and uses thereof |
DK3496739T3 (da) | 2016-07-15 | 2021-05-10 | Acceleron Pharma Inc | Sammensætninger omfattende actriia-polypeptider til brug i behandlingen af pulmonal hypertension |
JP6944768B2 (ja) | 2016-08-29 | 2021-10-06 | エア・ウォーター株式会社 | ペリクルの製造方法 |
KR102595559B1 (ko) | 2016-10-05 | 2023-10-30 | 악셀레론 파마 인코포레이티드 | 변이체 actriib 단백질 및 이의 용도 |
CN110461349A (zh) | 2016-11-10 | 2019-11-15 | 科乐斯疗法公司 | 激活素受体iia型变体及其使用方法 |
US10982000B2 (en) | 2017-03-24 | 2021-04-20 | Novartis Ag | Methods for treating and/or reducing the likelihood of heart failure by administering anti-activin receptor type II (anti-ActRII) antibody |
JP7258021B2 (ja) | 2017-11-09 | 2023-04-14 | ケロス セラピューティクス インコーポレイテッド | アクチビンIIa型受容体変異体を含む医薬組成物 |
AU2019206634B2 (en) | 2018-01-12 | 2024-06-27 | Keros Therapeutics, Inc. | Activin receptor type IIB variants and methods of use thereof |
CA3098679A1 (en) * | 2018-05-09 | 2019-11-14 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
EP4065607A1 (en) | 2019-11-29 | 2022-10-05 | Kymab Limited | Treatment for physiological iron overload |
CA3226249A1 (en) * | 2021-08-16 | 2023-02-23 | Thermolife International, Llc | Iron supplement compositions and methods of use thereof |
WO2023141724A1 (en) | 2022-01-28 | 2023-08-03 | 35Pharma Inc. | Activin receptor type iib variants and uses thereof |
Family Cites Families (81)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US71927A (en) * | 1867-12-10 | Improvement in apparatus fob turning on gas | ||
JPH0637520B2 (ja) | 1985-07-03 | 1994-05-18 | 味の素株式会社 | ポリペプチド |
US4973577A (en) | 1986-04-04 | 1990-11-27 | The Salk Institute For Biological Studies | FSH-releasing peptides |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
AU8761391A (en) * | 1990-09-13 | 1992-04-15 | Children's Hospital Medical Center Of Northern California | Method for increasing red blood cell production by treatment with activin or activin-related peptides |
US5118667A (en) | 1991-05-03 | 1992-06-02 | Celtrix Pharmaceuticals, Inc. | Bone growth factors and inhibitors of bone resorption for promoting bone formation |
US5885794A (en) | 1991-05-10 | 1999-03-23 | The Salk Institute For Biological Studies | Recombinant production of vertebrate activin receptor polypeptides and identification of receptor DNAs in the activin/TGF-β superfamily |
US6162896A (en) | 1991-05-10 | 2000-12-19 | The Salk Institute For Biological Studies | Recombinant vertebrate activin receptors |
WO1992020793A1 (en) | 1991-05-10 | 1992-11-26 | The Salk Institute For Biological Studies | CLONING AND RECOMBINANT PRODUCTION OF RECEPTOR(S) OF THE ACTIVIN/TGF-β SUPERFAMILY |
US6692925B1 (en) | 1992-11-17 | 2004-02-17 | Ludwig Institute For Cancer Research | Proteins having serine/threonine kinase domains, corresponding nucleic acid molecules, and their use |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
US5831050A (en) | 1993-06-07 | 1998-11-03 | Creative Biomolecules, Inc. | Morphogen cell surface receptor |
JPH09503673A (ja) | 1993-10-14 | 1997-04-15 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | ニューロン細胞の誘導および維持法 |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5658876A (en) | 1994-04-28 | 1997-08-19 | The General Hospital Corporation | Activin antagonists as novel contraceptives |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
AU716893B2 (en) | 1995-04-11 | 2000-03-09 | General Hospital Corporation, The | Reverse two-hybrid systems |
US6132988A (en) | 1995-10-27 | 2000-10-17 | Takeda Chemical Industries, Ltd. | DNA encoding a neuronal cell-specific receptor protein |
US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
AU8666398A (en) | 1997-08-01 | 1999-02-22 | Johns Hopkins University School Of Medicine, The | Methods to identify growth differentiation factor (gdf) receptors |
US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
US6656475B1 (en) | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
US6696260B1 (en) | 1997-08-01 | 2004-02-24 | The Johns Hopkins University School Of Medicine | Methods to identify growth differentiation factor (GDF) binding proteins |
US6953662B2 (en) | 1997-08-29 | 2005-10-11 | Human Genome Sciences, Inc. | Follistatin-3 |
AU772694B2 (en) | 1999-01-21 | 2004-05-06 | Metamorphix International, Inc. | Growth differentiation factor inhibitors and uses therefor |
CA2365449A1 (en) | 1999-04-19 | 2000-10-26 | Kyowa Hakko Kogyo Co., Ltd. | Inhibitor of the growth of androgen-independent tumor |
US6468543B1 (en) | 1999-05-03 | 2002-10-22 | Zymogenetics, Inc. | Methods for promoting growth of bone using ZVEGF4 |
CN1250288C (zh) * | 1999-12-15 | 2006-04-12 | 研究发展基金会 | 作为抑制素受体的β聚糖及其用途 |
JP4487376B2 (ja) | 2000-03-31 | 2010-06-23 | 味の素株式会社 | 腎疾患治療剤 |
WO2002032925A2 (en) | 2000-10-16 | 2002-04-25 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
AU2002236558A1 (en) | 2000-12-01 | 2002-06-11 | Regents Of The University Of California | Method and composition for modulating bone growth |
TW200526779A (en) | 2001-02-08 | 2005-08-16 | Wyeth Corp | Modified and stabilized GDF propeptides and uses thereof |
AU2002256371B2 (en) | 2001-04-26 | 2008-01-10 | Amgen Mountain View Inc. | Combinatorial libraries of monomer domains |
CA2448253A1 (en) | 2001-05-25 | 2002-11-28 | Genset S.A. | Human cdnas and proteins and uses thereof |
AUPR638101A0 (en) | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
US6855344B2 (en) | 2001-07-17 | 2005-02-15 | Integrated Chinese Medicine Holdings, Ltd. | Compositions and methods for prostate and kidney health and disorders, an herbal preparation |
US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
US6784154B2 (en) | 2001-11-01 | 2004-08-31 | University Of Utah Research Foundation | Method of use of erythropoietin to treat ischemic acute renal failure |
US20030144203A1 (en) | 2001-12-19 | 2003-07-31 | Voyager Pharmaceutical Corporation | Methods for slowing senescence and treating and preventing diseases associated with senescence |
BR0307907A2 (pt) | 2002-02-21 | 2011-07-05 | Wyeth Corp | gasp1: proteìna contendo domìnio de folistatina |
US20030219846A1 (en) * | 2002-02-28 | 2003-11-27 | Pfizer Inc. | Assay for activity of the ActRIIB kinase |
JP2004121008A (ja) * | 2002-09-30 | 2004-04-22 | Toray Ind Inc | ネコアクチビンaおよびそのサブユニット並びにその製造法 |
US7261893B2 (en) | 2002-10-22 | 2007-08-28 | Wyeth | Neutralizing antibodies against GDF-8 and uses therefor |
US20040223966A1 (en) | 2002-10-25 | 2004-11-11 | Wolfman Neil M. | ActRIIB fusion polypeptides and uses therefor |
US20040197828A1 (en) | 2003-03-26 | 2004-10-07 | Gaddy Dana P. | Method for diagnosis and treatment of bone turnover |
WO2005028517A2 (en) | 2003-05-09 | 2005-03-31 | The General Hospital Corporation | SOLUBLE TGF-β TYPE III RECEPTOR FUSION PROTEINS |
JP5110877B2 (ja) | 2003-06-02 | 2012-12-26 | ワイス・エルエルシー | 神経筋障害を処置するための、コルチコステロイドと組み合わせたミオスタチン(gdf8)インヒビターの使用 |
WO2005009460A2 (en) * | 2003-07-25 | 2005-02-03 | Medexis, S.A. | Pharmaceutical composition comprising activin a, alk-4 or derivatives thereof for the treatment of ophthalmic disorders or cancer |
EP1732589A2 (en) | 2004-03-26 | 2006-12-20 | Acceleron Pharma Inc. | Bmp-3 propeptides and related methods |
EP1730186A2 (en) | 2004-03-31 | 2006-12-13 | Xencor, Inc. | Bmp-7 variants with improved properties |
US7465706B2 (en) | 2004-06-24 | 2008-12-16 | Acceleron Pharma Inc. | GDF3 propeptides and related methods |
EP3059245B1 (en) | 2004-07-23 | 2018-11-07 | Acceleron Pharma Inc. | Actrii receptor antagonistic antibodies |
CA2581896C (en) | 2004-09-29 | 2015-11-10 | Mount Sinai School Of Medicine Of New York University | Fsh and fsh receptor modulator compositions and methods for inhibiting osteoclastic bone resorption and bone loss in osteoporosis |
JP2008520207A (ja) | 2004-11-16 | 2008-06-19 | アヴィディア リサーチ インスティテュート | タンパク質骨格およびその使用 |
NZ538097A (en) | 2005-02-07 | 2006-07-28 | Ovita Ltd | Method and compositions for improving wound healing |
EP1858541B1 (en) | 2005-02-16 | 2012-07-25 | The General Hospital Corporation | Use of bmp antagonists to regulate hepcidin-mediated iron metabolism and treat iron deficiency |
CN101198321A (zh) * | 2005-04-26 | 2008-06-11 | 味之素株式会社 | 骨髓祖红细胞分化诱导剂 |
US8067562B2 (en) | 2005-11-01 | 2011-11-29 | Amgen Inc. | Isolated nucleic acid molecule comprising the amino acid sequence of SEQ ID NO:1 |
PL1973559T3 (pl) | 2005-11-23 | 2013-06-28 | Acceleron Pharma Inc | Antagoniści aktywiny-ActRIIa i zastosowanie do pobudzania wzrostu kości |
AU2006321906C1 (en) | 2005-12-06 | 2014-01-16 | Amgen Inc. | Uses of myostatin antagonists |
WO2007084977A2 (en) | 2006-01-20 | 2007-07-26 | Beckman Coulter, Inc. | Low hemoglobin concentration cell percentage and method of use in detection of iron deficiency |
US20080075692A1 (en) | 2006-05-09 | 2008-03-27 | Perrine Susan P | Methods for treating blood disorders |
PL2048948T3 (pl) | 2006-07-21 | 2012-07-31 | Lyne Laboratories Inc | Płynne kompozycje octanu wapnia |
CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
US7547781B2 (en) | 2006-09-11 | 2009-06-16 | Curis, Inc. | Quinazoline based EGFR inhibitors containing a zinc binding moiety |
WO2008060139A1 (en) | 2006-11-17 | 2008-05-22 | Erasmus University Medical Center Rotterdam | Methods for controlling mineralization of extracellular matrix, therapeutic methods based thereon and medicaments for use therein |
US8895016B2 (en) * | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
EA035911B1 (ru) | 2006-12-18 | 2020-08-31 | Акселерон Фарма Инк. | Применение полипептида, который ингибирует опосредованный активином сигнальный путь, в качестве лекарственного средства |
JP5237970B2 (ja) | 2007-02-01 | 2013-07-17 | アクセルロン ファーマ, インコーポレイテッド | 乳癌を治療または予防するためのアクチビンActRIIaアンタゴニストおよび使用 |
TWI548647B (zh) | 2007-02-02 | 2016-09-11 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
TR200906329T1 (tr) | 2007-02-09 | 2010-01-21 | Acceleron Pharma Inc. | Kanser Hastalarında Kemik Gelişimini Desteklemek için A |
TWI573802B (zh) | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
EP2150560A1 (en) | 2007-06-01 | 2010-02-10 | Wyeth | Methods and compositions for modulating bmp-10 activity |
GB0715087D0 (en) | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
WO2009019504A1 (en) | 2007-08-03 | 2009-02-12 | Summit Corporation Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
EP3243524A1 (en) | 2007-09-18 | 2017-11-15 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
PE20091163A1 (es) | 2007-11-01 | 2009-08-09 | Wyeth Corp | Anticuerpos para gdf8 |
US20110104133A1 (en) | 2008-05-06 | 2011-05-05 | Joslin Diabetes Center, Inc. | Methods and compositions for inducing brown adipogenesis |
-
2007
- 2007-12-18 EA EA201201199A patent/EA035911B1/ru not_active IP Right Cessation
- 2007-12-18 US US12/002,872 patent/US7988973B2/en active Active
- 2007-12-18 BR BRPI0720476-0A patent/BRPI0720476B1/pt active IP Right Grant
- 2007-12-18 RS RS20120548A patent/RS52537B/en unknown
- 2007-12-18 KR KR1020157013795A patent/KR101803620B1/ko active IP Right Grant
- 2007-12-18 DK DK07863068.8T patent/DK2124999T3/da active
- 2007-12-18 MY MYPI20092540A patent/MY162136A/en unknown
- 2007-12-18 SG SG10201702157QA patent/SG10201702157QA/en unknown
- 2007-12-18 KR KR1020167001731A patent/KR101831534B1/ko active IP Right Grant
- 2007-12-18 KR KR1020187004410A patent/KR20180019768A/ko active Search and Examination
- 2007-12-18 WO PCT/US2007/025868 patent/WO2008076437A2/en active Application Filing
- 2007-12-18 CA CA2672758A patent/CA2672758C/en active Active
- 2007-12-18 JP JP2009542880A patent/JP5415279B2/ja active Active
- 2007-12-18 EP EP11195130.7A patent/EP2468290B1/en active Active
- 2007-12-18 PL PL11195130T patent/PL2468290T3/pl unknown
- 2007-12-18 NZ NZ720955A patent/NZ720955A/en unknown
- 2007-12-18 NZ NZ577847A patent/NZ577847A/en unknown
- 2007-12-18 CN CN201410670950.5A patent/CN104524548A/zh active Pending
- 2007-12-18 EP EP17182870.0A patent/EP3320911B1/en active Active
- 2007-12-18 ME MEP-2016-200A patent/ME02335B/me unknown
- 2007-12-18 UA UAA200906746A patent/UA101309C2/uk unknown
- 2007-12-18 PL PL07863068T patent/PL2124999T3/pl unknown
- 2007-12-18 KR KR1020207006948A patent/KR102223231B1/ko active IP Right Grant
- 2007-12-18 DK DK11195130.7T patent/DK2468290T3/en active
- 2007-12-18 EA EA202091230A patent/EA202091230A3/ru unknown
- 2007-12-18 ES ES07863068T patent/ES2396734T3/es active Active
- 2007-12-18 MY MYPI2013002844A patent/MY170509A/en unknown
- 2007-12-18 PT PT78630688T patent/PT2124999E/pt unknown
- 2007-12-18 NZ NZ617196A patent/NZ617196A/en unknown
- 2007-12-18 UA UAA201214689A patent/UA116871C2/uk unknown
- 2007-12-18 EA EA200970603A patent/EA018037B1/ru unknown
- 2007-12-18 KR KR1020097014226A patent/KR101688228B1/ko active IP Right Grant
- 2007-12-18 CN CN201610145040.4A patent/CN105582521A/zh active Pending
- 2007-12-18 SI SI200731110T patent/SI2124999T1/sl unknown
- 2007-12-18 NZ NZ707292A patent/NZ707292A/en unknown
- 2007-12-18 EP EP11195282A patent/EP2446896A1/en not_active Withdrawn
- 2007-12-18 MX MX2009006651A patent/MX2009006651A/es active IP Right Grant
- 2007-12-18 EP EP21205033.0A patent/EP4026553A1/en not_active Withdrawn
- 2007-12-18 AU AU2007334333A patent/AU2007334333B2/en active Active
- 2007-12-18 MY MYPI2016001928A patent/MY188973A/en unknown
- 2007-12-18 CN CN201610144786.3A patent/CN105797135A/zh active Pending
- 2007-12-18 EP EP07863068A patent/EP2124999B1/en active Active
- 2007-12-18 KR KR1020217005960A patent/KR20210027508A/ko not_active Application Discontinuation
- 2007-12-18 EP EP11195140.6A patent/EP2468291B1/en active Active
- 2007-12-19 CN CN200780051416.4A patent/CN101687015B/zh active Active
-
2008
- 2008-09-29 US US12/286,333 patent/US8007809B2/en active Active
- 2008-09-29 US US12/286,381 patent/US20100204092A1/en not_active Abandoned
-
2009
- 2009-06-18 IL IL199451A patent/IL199451A/en active IP Right Grant
- 2009-06-24 CR CR10889A patent/CR10889A/es unknown
- 2009-06-25 ZA ZA2009/04454A patent/ZA200904454B/en unknown
- 2009-07-09 CO CO09071017A patent/CO6230995A2/es not_active Application Discontinuation
- 2009-07-14 EC EC2009009514A patent/ECSP099514A/es unknown
-
2010
- 2010-06-01 HK HK10105399.4A patent/HK1137368A1/xx unknown
-
2011
- 2011-07-22 US US13/189,353 patent/US20120052067A1/en not_active Abandoned
-
2012
- 2012-03-19 ZA ZA2012/02027A patent/ZA201202027B/en unknown
- 2012-12-14 HR HRP20121035TT patent/HRP20121035T1/hr unknown
-
2013
- 2013-03-18 JP JP2013055102A patent/JP5865281B2/ja active Active
- 2013-11-26 JP JP2013243668A patent/JP2014040483A/ja active Pending
-
2015
- 2015-08-12 IL IL240523A patent/IL240523A/en active IP Right Grant
- 2015-08-12 IL IL240524A patent/IL240524A/en active IP Right Grant
- 2015-10-22 HK HK15110382.8A patent/HK1209624A1/xx unknown
- 2015-10-27 JP JP2015211115A patent/JP2016020391A/ja active Pending
-
2017
- 2017-02-03 JP JP2017018409A patent/JP2017075187A/ja active Pending
- 2017-06-19 JP JP2017119494A patent/JP2017155064A/ja not_active Withdrawn
- 2017-12-11 IL IL256247A patent/IL256247B/en unknown
-
2018
- 2018-10-31 HK HK18113934.2A patent/HK1254840A1/zh unknown
-
2019
- 2019-01-04 US US16/240,276 patent/US20200031903A1/en not_active Abandoned
- 2019-03-12 JP JP2019044553A patent/JP2019089850A/ja not_active Withdrawn
-
2020
- 2020-12-23 US US17/132,024 patent/US20210355191A1/en not_active Abandoned
-
2021
- 2021-03-01 JP JP2021032007A patent/JP2021080290A/ja active Pending
- 2021-07-07 IL IL284693A patent/IL284693A/en unknown
- 2021-08-05 US US17/395,365 patent/US20220204588A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UA116871C2 (uk) | СПОСІБ ЛІКУВАННЯ МІЄЛОДИСПЛАСТИЧНОГО СИНДРОМУ, ТАЛАСЕМІЇ ТА СЕРПОПОДІБНО-КЛІТИННОЇ АНЕМІЇ ЗА ДОПОМОГОЮ ЗАСТОСУВАННЯ АНТАГОНІСТА АКТИВІНУ ПОЛІПЕПТИДУ ActRII | |
EA201270221A1 (ru) | Лечение болезни крона с применением лаквинимода | |
EA201290964A1 (ru) | Пептидные конъюгаты агонистов рецептора glp-1 и их применение | |
NO20074999L (no) | Metode og preparat for behandling av perifere vaskulaere sykdommer | |
CY1117603T1 (el) | Η λιξισενατιδη ως προσθετο στη μετφορμινη στην θεραπευτικη αγωγη του διαβητη τυπου 2 | |
LTC1781298I2 (lt) | Farmacinės kompozicijos, turinčios benzoksazino, skirtos respiracinių ligų gydymui | |
EA200801842A1 (ru) | Антитела против бета-амилоидного пептида | |
WO2008050329A3 (en) | Novel sirnas and methods of use thereof | |
EA201391581A1 (ru) | Способы лечения болезни альцгеймера, болезни хантингтона, аутизма и других расстройств | |
EA201290078A1 (ru) | Гетероциклические соединения для ингибирования pask | |
WO2007011606A3 (en) | USE OF HMGBl ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY SKIN CONDITIONS | |
UA109633C2 (uk) | Антитіло людини проти тканинного фактора | |
UA107578C2 (uk) | Комбінована терапія при лікуванні діабету | |
BRPI0912411B8 (pt) | uso de uma muteína de interleucina humana-2 (muteína de hil-2) e composição farmacêutica para o tratamento e/ou profilaxia de uma doença autoimune | |
UA112434C2 (uk) | Антигензв'язувальний білок, який специфічно зв'язується з всма | |
WO2011127333A3 (en) | Compounds for treating disease, for administering, and for pharmaceutical compositions | |
UA116194C2 (uk) | Антитіло, яке специфічно зв'язується з людським альфа-синуклеїном | |
EA200971053A1 (ru) | Способы лечения кожных язв | |
CL2007000161A1 (es) | Compuestos derivados de 2,4-dioxoimidazolidina sustituida, inhibidores de proteinas cinasas; composicion farmaceutica; y uso en el tratamiento de enfermedades tales como cancer. | |
WO2008148074A3 (en) | Inhibitors of mtor and methods of treatment using same | |
EA200801997A1 (ru) | Новые соединения | |
EA201170753A1 (ru) | Налмефена гидрохлорид дигидрат | |
BRPI0710682B8 (pt) | combinação farmacêutica compreendendo 3-(3-dimetilamino-1-etil-2-metil-propil)-fenol e paracetamol | |
EA200970532A1 (ru) | Фумаратная соль (альфа s, бета r)-6-бром-альфа-[2-(диметиламино)этил]-2-метокси-альфа-1-нафталенил-бета-фенил-3-хинолинэтанола | |
MX2011000255A (es) | Combinacion de un antagonista a c-met y un compuesto aminoheteroarilo, para el tratamiento de cancer. |