MA42160A - Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii - Google Patents
Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type iiInfo
- Publication number
- MA42160A MA42160A MA042160A MA42160A MA42160A MA 42160 A MA42160 A MA 42160A MA 042160 A MA042160 A MA 042160A MA 42160 A MA42160 A MA 42160A MA 42160 A MA42160 A MA 42160A
- Authority
- MA
- Morocco
- Prior art keywords
- thalassemia
- cell culture
- beta
- receptor ligand
- vitro cell
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0641—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/4833—Physical analysis of biological material of solid biological material, e.g. tissue samples, cell cultures
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Mycology (AREA)
- Analytical Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Developmental Biology & Embryology (AREA)
- Endocrinology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
Abstract
La présente invention concerne des procédés de traitement de la bêta-thalassémie chez un sujet comprenant l'administration d'un inhibiteur de signalisation du récepteur d'actine ii (actrii) (par exemple, un piège à ligand activine) et l'utilisation d'une ou plusieurs méthodes de culture cellulaire in vitro. ) sélection du sujet à traiter selon les méthodes fournies ici; et / ou (ii) la surveillance du sujet traité selon les méthodes fournies ici.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562164367P | 2015-05-20 | 2015-05-20 | |
US201662320032P | 2016-04-08 | 2016-04-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA42160A true MA42160A (fr) | 2018-03-28 |
Family
ID=57320751
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA042160A MA42160A (fr) | 2015-05-20 | 2016-05-19 | Procédés de culture de cellules in vitro pour la beta-thalassemie a l'aide de pieges a ligands du recepteur de l'activine de type ii |
Country Status (8)
Country | Link |
---|---|
US (2) | US10548976B2 (fr) |
EP (2) | EP4190805A3 (fr) |
JP (2) | JP2018522579A (fr) |
CN (1) | CN108350057A (fr) |
CA (1) | CA2986432A1 (fr) |
HK (1) | HK1252174A1 (fr) |
MA (1) | MA42160A (fr) |
WO (1) | WO2016187378A1 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20210091358A (ko) | 2012-11-02 | 2021-07-21 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
PT3227675T (pt) | 2014-12-03 | 2023-05-30 | Celgene Corp | Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica |
JP2018522579A (ja) | 2015-05-20 | 2018-08-16 | セルジーン コーポレイション | アクチビンII型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 |
WO2017079591A2 (fr) * | 2015-11-04 | 2017-05-11 | Acceleron Pharma Inc. | Méthodes pour augmenter les taux d'érythrocytes et traiter l'érythropoïèse inefficace |
US11013785B2 (en) | 2016-11-10 | 2021-05-25 | Keros Therapeutics, Inc. | Activin receptor type IIA variants and methods of use thereof |
CN110099995A (zh) * | 2017-01-06 | 2019-08-06 | 奥林巴斯株式会社 | 细胞观察*** |
EP3706777B1 (fr) | 2017-11-09 | 2024-05-22 | Keros Therapeutics, Inc. | Variants de type iia du récepteur de l'activine et leurs méthodes d'utilisation |
CA3087008A1 (fr) | 2018-01-12 | 2019-07-18 | Keros Therapeutics, Inc. | Variants de type iib du recepteur de l'activine et leurs methodes d'utilisation |
AU2019266314A1 (en) * | 2018-05-09 | 2020-11-19 | Keros Therapeutics, Inc. | Activin receptor type iia variants and methods of use thereof |
JP7388679B2 (ja) * | 2019-05-28 | 2023-11-29 | 学校法人 東洋大学 | 熱中症マーカー及びその利用 |
WO2021189019A1 (fr) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Chimères de type ii du récepteur d'activine et leurs méthodes d'utilisation |
PE20231442A1 (es) * | 2020-04-28 | 2023-09-14 | Acceleron Pharma Inc | Proteinas actrii y sus usos |
WO2022098877A1 (fr) * | 2020-11-06 | 2022-05-12 | Acceleron Pharma Inc. | Formulations comprenant des variants polypeptidiques actrii |
Family Cites Families (41)
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BR0009403A (pt) * | 1999-02-04 | 2001-11-27 | Technion Res & Dev Foundation | Método de expansão/conservação das células detronco hemopoiéticas indiferenciadas ou dascélulas progenitoras, método de preparação deum meio condicionado de célula estomacal útil naexpansão/conservação das células de troncohemopoiéticas indiferenciadas ou das célulasprogenitoras, método de transplante de célulasde tronco hemopoiéticas indiferenciadas ou decélulas progenitoras em um recipiente, tampão debiorreator e biorreator |
EP1356075A4 (fr) | 2000-10-16 | 2005-04-13 | Compound Therapeutics Inc | Echafaudages proteiniques internes pour analogues d'anticorps et autres proteines de liaison |
US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
JP4369662B2 (ja) | 2001-04-26 | 2009-11-25 | アビディア インコーポレイテッド | 単量体ドメインのコンビナトリアルライブラリー |
EP2314617B1 (fr) | 2004-07-23 | 2015-06-24 | Acceleron Pharma Inc. | Polypeptides du récepteur ActRII |
AU2005307789A1 (en) | 2004-11-16 | 2006-05-26 | Avidia Research Institute | Protein scaffolds and uses thereof |
EP1973559B1 (fr) | 2005-11-23 | 2013-01-09 | Acceleron Pharma Inc. | Antagonistes de l'activine-actriia et utilisations pour activer la croissance osseuse |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
US20100028332A1 (en) | 2006-12-18 | 2010-02-04 | Acceleron Pharma Inc. | Antagonists of actriib and uses for increasing red blood cell levels |
SI2124999T1 (sl) * | 2006-12-18 | 2013-02-28 | Acceleron Pharma, Inc. | Activin-actrii antagonisti in uporaba za zdravljenje anemije |
CA2677007A1 (fr) | 2007-02-01 | 2008-08-07 | Acceleron Pharma Inc. | Antagonistes de l'activine-actriia et leurs utilisations dans le traitement ou la prevention du cancer du sein |
TW201803890A (zh) | 2007-02-02 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
CA3039330C (fr) | 2007-02-09 | 2021-11-09 | Acceleron Pharma Inc. | Antagonistes de l'activine-actriia et utilisations pour la promotion de la croissance osseuse chez les patients cancereux |
CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
AU2009262970A1 (en) | 2008-06-26 | 2009-12-30 | Acceleron Pharma Inc. | Methods for dosing an activin-ActRIIa antagonist and monitoring of treated patients |
DK2340031T3 (da) * | 2008-08-14 | 2019-07-15 | Acceleron Pharma Inc | Gdf-fanger til anvendelse ved behandling af anæmi |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
EP2387412A4 (fr) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | Procédés permettant d'augmenter l'adiponectine |
MX2011013172A (es) | 2009-06-08 | 2012-04-02 | Acceleron Pharma Inc | Metodos para aumentar adipocitos termogenicos. |
KR20120028358A (ko) | 2009-06-12 | 2012-03-22 | 악셀레론 파마 인코포레이티드 | 절두된 ActRIIB-FC 융합 단백질 |
IL287990B (en) | 2009-08-13 | 2022-07-01 | Acceleron Pharma Inc | Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels |
BR112012005225B8 (pt) | 2009-09-09 | 2023-01-10 | Acceleron Pharma Inc | Uso de uma proteína de fusão actriib-fc para o tratamento de um transtorno relacionado ao osso ou associado à perda de músculo por crescimento muscular insuficiente |
CA2779472C (fr) | 2009-11-03 | 2021-03-16 | Acceleron Pharma Inc. | L'utilisation d'une composition renfermant un polypeptide recepteur d'activine de type iib pour le traitement de steatose hepatique |
EP3332796A1 (fr) | 2009-11-17 | 2018-06-13 | Acceleron Pharma Inc. | Protéines actriib et variants et leurs utilisations se rapportant à l'induction de l'utrophine pour une thérapie de la dystrophie musculaire |
EA202090053A3 (ru) * | 2011-10-17 | 2020-06-30 | Акселерон Фарма, Инк. | Способы и композиции для лечения неэффективного эритропоэза |
WO2014066487A2 (fr) | 2012-10-24 | 2014-05-01 | Celgene Corporation | Méthodes de traitement de l'anémie |
ES2753811T3 (es) | 2012-10-24 | 2020-04-14 | Celgene Corp | Biomarcador para uso en el tratamiento de anemia |
KR20210091358A (ko) | 2012-11-02 | 2021-07-21 | 셀진 코포레이션 | 골 및 다른 장애를 치료하기 위한 액티빈-actrii 길항제 및 용도 |
MX2016013635A (es) | 2014-04-18 | 2017-02-02 | Acceleron Pharma Inc | Métodos para aumentar los niveles de eritrocitos y tratar de la enfermedad de células falciformes. |
WO2015192111A1 (fr) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Méthodes et compositions de traitement d'ulcères |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
PT3227675T (pt) | 2014-12-03 | 2023-05-30 | Celgene Corp | Antagonistas da ativina-actrii e utilizações para tratamento da síndrome mielodisplásica |
MA41119A (fr) | 2014-12-03 | 2017-10-10 | Acceleron Pharma Inc | Méthodes de traitement de syndromes myélodysplasiques et d'anémie sidéroblastique |
CN107847562A (zh) | 2015-05-13 | 2018-03-27 | 细胞基因公司 | 使用 ACTRII 配体陷阱治疗 β‑地中海贫血 |
JP2018522579A (ja) | 2015-05-20 | 2018-08-16 | セルジーン コーポレイション | アクチビンII型受容体リガンドトラップを使用するβ−サラセミアのインビトロ細胞培養法 |
WO2017079591A2 (fr) | 2015-11-04 | 2017-05-11 | Acceleron Pharma Inc. | Méthodes pour augmenter les taux d'érythrocytes et traiter l'érythropoïèse inefficace |
AU2016359695A1 (en) | 2015-11-23 | 2018-06-14 | Acceleron Pharma Inc. | Methods for treating eye disorders |
WO2018013936A1 (fr) | 2016-07-15 | 2018-01-18 | Acceleron Pharma Inc. | Compositions et procédés de traitement de l'hypertension pulmonaire |
FI3490582T3 (fi) | 2016-07-27 | 2024-08-01 | Acceleron Pharma Inc | Koostumuksia käytettäväksi myelofibroosin hoitamisessa |
EP3638243B1 (fr) | 2017-06-14 | 2024-08-07 | Celgene Corporation | Méthodes de traitement de la myélofibrose associée à un néoplasme myéloprolifératif et de l'anémie |
-
2016
- 2016-05-19 JP JP2018512825A patent/JP2018522579A/ja active Pending
- 2016-05-19 US US15/574,897 patent/US10548976B2/en not_active Expired - Fee Related
- 2016-05-19 EP EP22201847.5A patent/EP4190805A3/fr not_active Withdrawn
- 2016-05-19 CA CA2986432A patent/CA2986432A1/fr active Pending
- 2016-05-19 WO PCT/US2016/033187 patent/WO2016187378A1/fr active Application Filing
- 2016-05-19 CN CN201680042691.9A patent/CN108350057A/zh active Pending
- 2016-05-19 MA MA042160A patent/MA42160A/fr unknown
- 2016-05-19 EP EP16797267.8A patent/EP3298034A4/fr not_active Withdrawn
-
2018
- 2018-09-07 HK HK18111575.0A patent/HK1252174A1/zh unknown
-
2019
- 2019-12-11 US US16/711,039 patent/US20200101157A1/en not_active Abandoned
-
2021
- 2021-09-29 JP JP2021158571A patent/JP2022023072A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
HK1252174A1 (zh) | 2019-05-17 |
JP2018522579A (ja) | 2018-08-16 |
EP3298034A1 (fr) | 2018-03-28 |
EP4190805A3 (fr) | 2023-08-16 |
EP4190805A2 (fr) | 2023-06-07 |
CN108350057A (zh) | 2018-07-31 |
CA2986432A1 (fr) | 2016-11-24 |
US20180161426A1 (en) | 2018-06-14 |
US20200101157A1 (en) | 2020-04-02 |
WO2016187378A1 (fr) | 2016-11-24 |
JP2022023072A (ja) | 2022-02-07 |
US10548976B2 (en) | 2020-02-04 |
EP3298034A4 (fr) | 2019-02-13 |
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