WO2008148074A3 - Inhibitors of mtor and methods of treatment using same - Google Patents

Inhibitors of mtor and methods of treatment using same Download PDF

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Publication number
WO2008148074A3
WO2008148074A3 PCT/US2008/064809 US2008064809W WO2008148074A3 WO 2008148074 A3 WO2008148074 A3 WO 2008148074A3 US 2008064809 W US2008064809 W US 2008064809W WO 2008148074 A3 WO2008148074 A3 WO 2008148074A3
Authority
WO
WIPO (PCT)
Prior art keywords
treatment
methods
mtor
inhibitors
present
Prior art date
Application number
PCT/US2008/064809
Other languages
French (fr)
Other versions
WO2008148074A2 (en
Inventor
Richard Lin
Dale Drueckhammer
Jun Yong Choi
Lisa Ballou
Original Assignee
Univ New York State Res Found
Richard Lin
Dale Drueckhammer
Jun Yong Choi
Lisa Ballou
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ New York State Res Found, Richard Lin, Dale Drueckhammer, Jun Yong Choi, Lisa Ballou filed Critical Univ New York State Res Found
Publication of WO2008148074A2 publication Critical patent/WO2008148074A2/en
Publication of WO2008148074A3 publication Critical patent/WO2008148074A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Abstract

The present invention provides novel compounds that inhibit mTOR activity. Compositions, including pharmaceutical compositions, comprising compounds of the present invention are also provided. The present invention also provides methods of treatment comprising administering compositions of the present invention to a subject in need thereof.
PCT/US2008/064809 2007-05-24 2008-05-24 Inhibitors of mtor and methods of treatment using same WO2008148074A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US93185807P 2007-05-24 2007-05-24
US60/931,858 2007-05-24

Publications (2)

Publication Number Publication Date
WO2008148074A2 WO2008148074A2 (en) 2008-12-04
WO2008148074A3 true WO2008148074A3 (en) 2009-03-19

Family

ID=40075755

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2008/064809 WO2008148074A2 (en) 2007-05-24 2008-05-24 Inhibitors of mtor and methods of treatment using same

Country Status (1)

Country Link
WO (1) WO2008148074A2 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2710039C (en) 2007-12-26 2018-07-03 Critical Outcome Technologies, Inc. Semicarbazones, thiosemicarbazones and related compounds and methods for treatment of cancer
CA2730890C (en) 2008-07-17 2018-05-15 Critical Outcome Technologies Inc. Thiosemicarbazone inhibitor compounds and cancer treatment methods
AU2010267814B2 (en) * 2009-07-02 2015-07-16 Sanofi Novel 2,3-dihydro-1H-imidazo(1,2-a)pyrimidin-5-one derivatives, preparation thereof, and pharmaceutical use thereof
FR2951173B1 (en) * 2009-10-09 2011-12-02 Sanofi Aventis NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
FR2951174B1 (en) * 2009-10-09 2011-12-02 Sanofi Aventis NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
FR2947550B1 (en) * 2009-07-02 2012-05-18 Sanofi Aventis NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
US8846670B2 (en) * 2009-07-02 2014-09-30 Sanofi 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
FR2947551B1 (en) * 2009-07-02 2012-05-18 Sanofi Aventis NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A) PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
RS53317B (en) 2009-07-02 2014-10-31 Sanofi Novel (6-oxo-1,6-dihydro-pyrimidin-2-yl)amide derivatives, prepration thereof, and pharmaceutical use thereof as akt phosphorylation inhibitors
AR077628A1 (en) 2009-07-02 2011-09-14 Sanofi Aventis DERIVATIVES OF 6- (MORFOLIN-4-IL) -PIRIMIDIN-4 (3H) -ONA, ITS PREPARATION AND ITS PHARMACEUTICAL USE AS INHIBITORS OF THE AKT PHOSPHORILATION (PKB)
JP2013521002A (en) 2010-03-05 2013-06-10 プレジデント アンド フェロウズ オブ ハーバード カレッジ Induced dendritic cell composition and use thereof
US9248110B2 (en) * 2010-03-18 2016-02-02 Steven Lehrer Compositions and methods of treating and preventing lung cancer and lymphangioleiomyomatosis
US8987272B2 (en) 2010-04-01 2015-03-24 Critical Outcome Technologies Inc. Compounds and method for treatment of HIV
FR2969613B1 (en) * 2010-12-23 2013-02-08 Sanofi Aventis NOVEL 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
SI2655375T1 (en) 2010-12-23 2015-03-31 Sanofi Pyrimidinone derivatives, preparation thereof and pharmaceutical use thereof
FR2969612B1 (en) * 2010-12-23 2013-02-08 Sanofi Aventis NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
LT2658844T (en) 2010-12-28 2017-02-10 Sanofi Novel pyrimidine derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
FR2969608B1 (en) * 2010-12-28 2013-02-08 Sanofi Aventis NOVEL (5-HALO-6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
FR2969614A1 (en) * 2010-12-28 2012-06-29 Sanofi Aventis New pyrimidinone compounds are akt phosphorylation inhibitors useful for treating e.g. gastric cancer, glioblastomas, thyroid cancer, bladder cancer, breast cancer, melanoma, lymphoid or myeloid hematopoietic tumors, and sarcomas
FR2969607B1 (en) * 2010-12-28 2013-02-08 Sanofi Aventis NOVEL THIOPYRIMIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS PHOSPHORYLATION INHIBITORS OF AKT (PKB)
FR2969610B1 (en) * 2010-12-28 2013-04-05 Sanofi Aventis NOVEL (6-OXO-1,6-DIHYDRO-PYRIMIDIN-2-YL) -INDOLINAMIDE DERIVATIVES, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE AS AKT PHOSPHORYLATION INHIBITORS (PKB)
FR2992316A1 (en) 2012-06-22 2013-12-27 Sanofi Sa PYRIMIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION
FR2992314B1 (en) 2012-06-22 2015-10-16 Sanofi Sa NOVEL 2,3-DIHYDRO-1H-IMIDAZO {1,2-A} PYRIMIDIN-5-ONE AND 1,2,3,4-TETRAHYDRO-PYRIMIDO {1,2-A} PYRIMIDIN-6-ONE DERIVATIVES COMPRISING A SUBSTITUTED MORPHOLINE, THEIR PREPARATION AND THEIR PHARMACEUTICAL USE

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
US20070112005A1 (en) * 2005-11-17 2007-05-17 Xin Chen Fused bicyclic mTOR inhibitors

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4661592A (en) * 1984-06-27 1987-04-28 G. D. Searle & Co. 4H-pyrimido[2,1-a]isoquinolin-4-one derivatives
US20070112005A1 (en) * 2005-11-17 2007-05-17 Xin Chen Fused bicyclic mTOR inhibitors

Also Published As

Publication number Publication date
WO2008148074A2 (en) 2008-12-04

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