UA109868C2 - Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar) - Google Patents

Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar)

Info

Publication number
UA109868C2
UA109868C2 UAA201500428A UAA201500428A UA109868C2 UA 109868 C2 UA109868 C2 UA 109868C2 UA A201500428 A UAA201500428 A UA A201500428A UA A201500428 A UAA201500428 A UA A201500428A UA 109868 C2 UA109868 C2 UA 109868C2
Authority
UA
Ukraine
Prior art keywords
compounds
alkyltriazole
asr
disorders
substituents
Prior art date
Application number
UAA201500428A
Other languages
English (en)
Ukrainian (uk)
Inventor
Стівен Дімс Гебріель
Метью Майкл Гамільтон
Метью С. Лукас
Імінь Цянь
Ачютарао Сіддурі
Original Assignee
Ф. Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48628667&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA109868(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Ф. Хоффманн-Ля Рош Аг filed Critical Ф. Хоффманн-Ля Рош Аг
Publication of UA109868C2 publication Critical patent/UA109868C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms

Abstract

В данном изобретении предложены соединения формулы (I): EMBED ISISServer , а также их фармацевтически приемлемые соли, где заместители являются такими, как раскрыто в описании. Данные соединения и фармацевтические композиции, которые их содержат, полезны для лечения воспалительных заболеваний и расстройств, таких как, например, фиброз легких.
UAA201500428A 2012-06-20 2013-06-17 Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar) UA109868C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261661961P 2012-06-20 2012-06-20
PCT/EP2013/062461 WO2013189864A1 (en) 2012-06-20 2013-06-17 N-alkyltriazole compounds as lpar antagonists

Publications (1)

Publication Number Publication Date
UA109868C2 true UA109868C2 (ru) 2015-10-12

Family

ID=48628667

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA201500428A UA109868C2 (ru) 2012-06-20 2013-06-17 Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar)

Country Status (22)

Country Link
US (1) US9321738B2 (ru)
EP (1) EP2864300A1 (ru)
JP (1) JP2015520202A (ru)
KR (1) KR20150021057A (ru)
CN (1) CN104411692A (ru)
AU (1) AU2013279512A1 (ru)
BR (1) BR112014030685A2 (ru)
CA (1) CA2869541A1 (ru)
CL (1) CL2014003243A1 (ru)
CO (1) CO7131358A2 (ru)
CR (1) CR20140525A (ru)
EA (1) EA201492285A1 (ru)
HK (1) HK1206342A1 (ru)
IL (1) IL236088A0 (ru)
IN (1) IN2014DN09348A (ru)
MA (1) MA37764A1 (ru)
MX (1) MX2014014710A (ru)
PE (1) PE20142448A1 (ru)
PH (1) PH12014502789A1 (ru)
SG (1) SG11201407220YA (ru)
UA (1) UA109868C2 (ru)
WO (1) WO2013189864A1 (ru)

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SG2014011555A (en) 2011-08-15 2014-08-28 Intermune Inc Lysophosphatidic acid receptor antagonists
EP2864301A1 (en) * 2012-06-20 2015-04-29 F. Hoffmann-La Roche AG N-aryltriazole compounds as lpar antagonists
SG10201803833WA (en) 2013-03-15 2018-06-28 Epigen Biosciences Inc Heterocyclic compounds useful in the treatment of disease
MX370408B (es) 2014-06-27 2019-12-11 Ube Industries Sal de compuesto heterociclico sustituido con halogeno.
AR108838A1 (es) 2016-06-21 2018-10-03 Bristol Myers Squibb Co Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa
KR20200100753A (ko) 2017-12-19 2020-08-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헥실 산 피라졸 아졸
JP7256807B2 (ja) * 2017-12-19 2023-04-12 ブリストル－マイヤーズ スクイブ カンパニー Ｌｐａアンタゴニストとしてのシクロヘキシル酸イソキサゾールアゾール
BR112020011965A2 (pt) * 2017-12-19 2020-11-17 Bristol-Myers Squibb Company triazol azinas de ácido ciclo-hexílico como antagonistas de lpa
EP3728240B1 (en) * 2017-12-19 2022-06-29 Bristol-Myers Squibb Company Isoxazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
US11447475B2 (en) 2017-12-19 2022-09-20 Bristol-Myers Squibb Company Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
EP3728222B1 (en) 2017-12-19 2023-03-29 Bristol-Myers Squibb Company Cyclohexyl acid pyrazole azines as lpa antagonists
AU2018388482A1 (en) 2017-12-19 2020-07-30 Bristol-Myers Squibb Company Pyrazole N-linked carbamoyl cyclohexyl acids as LPA antagonists
EP3728209A1 (en) * 2017-12-19 2020-10-28 Bristol-Myers Squibb Company Cyclohexyl acid isoxazole azines as lpa antagonists
AR113965A1 (es) * 2017-12-19 2020-07-01 Bristol Myers Squibb Co Triazol azoles ciclohexil ácidos como antagonistas de lpa
CN112189010A (zh) * 2017-12-19 2021-01-05 百时美施贵宝公司 作为lpa拮抗剂的***n-连接的氨基甲酰基环己基酸
WO2019126098A1 (en) 2017-12-19 2019-06-27 Bristol-Myers Squibb Company Pyrazole o-linked carbamoyl cyclohexyl acids as lpa antagonists
TW202340155A (zh) * 2017-12-29 2023-10-16 美商拜奧馬林製藥公司 用於疾病治療之乙醇酸酯氧化酶抑制劑
EP3853232B1 (en) * 2018-09-18 2023-03-01 Bristol-Myers Squibb Company Oxabicyclo acids as lpa antagonists
KR20210060547A (ko) * 2018-09-18 2021-05-26 브리스톨-마이어스 스큅 컴퍼니 Lpa 길항제로서의 시클로헵틸 산
WO2020060915A1 (en) * 2018-09-18 2020-03-26 Bristol-Myers Squibb Company Cyclopentyl acids as lpa antagonists
KR20220101137A (ko) * 2019-11-15 2022-07-19 길리애드 사이언시즈, 인코포레이티드 Lpa 수용체 길항제로서의 트라이아졸 카르바메이트 피리딜 설폰아미드 및 이의 용도
TW202344504A (zh) 2020-06-03 2023-11-16 美商基利科學股份有限公司 Lpa受體拮抗劑及其用途
AU2021282986B2 (en) 2020-06-03 2024-03-07 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
US11939318B2 (en) 2021-12-08 2024-03-26 Gilead Sciences, Inc. LPA receptor antagonists and uses thereof
TW202342017A (zh) 2022-02-25 2023-11-01 美商洛子峰生物有限公司 用於治療與ｌｐａ受體活性相關的病狀的化合物及組合物

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TW200827346A (en) 2006-11-03 2008-07-01 Astrazeneca Ab Chemical compounds
GB2466121B (en) * 2008-12-15 2010-12-08 Amira Pharmaceuticals Inc Antagonists of lysophosphatidic acid receptors
GB2470833B (en) * 2009-06-03 2011-06-01 Amira Pharmaceuticals Inc Polycyclic antagonists of lysophosphatidic acid receptors
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GB2474748B (en) 2009-10-01 2011-10-12 Amira Pharmaceuticals Inc Polycyclic compounds as lysophosphatidic acid receptor antagonists
WO2011159550A2 (en) * 2010-06-14 2011-12-22 Amidra Pharmaceuticals, Inc. Lysophosphatidic acid receptor antagonist and uses thereof
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SG2014011555A (en) * 2011-08-15 2014-08-28 Intermune Inc Lysophosphatidic acid receptor antagonists

Also Published As

Publication number Publication date
CO7131358A2 (es) 2014-12-01
IL236088A0 (en) 2015-02-01
MA37764A1 (fr) 2016-01-29
SG11201407220YA (en) 2014-12-30
US9321738B2 (en) 2016-04-26
IN2014DN09348A (ru) 2015-07-17
JP2015520202A (ja) 2015-07-16
EP2864300A1 (en) 2015-04-29
PE20142448A1 (es) 2015-01-28
CL2014003243A1 (es) 2015-03-20
US20150133511A1 (en) 2015-05-14
CA2869541A1 (en) 2013-12-27
MX2014014710A (es) 2015-03-04
CR20140525A (es) 2015-01-12
KR20150021057A (ko) 2015-02-27
WO2013189864A1 (en) 2013-12-27
BR112014030685A2 (pt) 2017-06-27
CN104411692A (zh) 2015-03-11
EA201492285A1 (ru) 2015-04-30
PH12014502789A1 (en) 2015-02-09
HK1206342A1 (en) 2016-01-08
AU2013279512A1 (en) 2014-10-16

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