MX2013003202A - Inhibidores de oxadiazol de la produccion de leucotrienos. - Google Patents

Inhibidores de oxadiazol de la produccion de leucotrienos.

Info

Publication number
MX2013003202A
MX2013003202A MX2013003202A MX2013003202A MX2013003202A MX 2013003202 A MX2013003202 A MX 2013003202A MX 2013003202 A MX2013003202 A MX 2013003202A MX 2013003202 A MX2013003202 A MX 2013003202A MX 2013003202 A MX2013003202 A MX 2013003202A
Authority
MX
Mexico
Prior art keywords
compounds
leukotriene production
oxadiazole
inhibitors
oxadiazole inhibitors
Prior art date
Application number
MX2013003202A
Other languages
English (en)
Inventor
Doris Riether
Zhidong Chen
Weimin Liu
Lifen Wu
Todd Bosanac
Alessandra Bartolozzi
Alan Olague
d huber John
Heather Tye
M Zindell Renee
Stephane De Lombaert
Alan Dines Jonathon
Leng Loke Pui
Marie Morwick Tina
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44720163&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013003202(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2013003202A publication Critical patent/MX2013003202A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

La presente invención se refiere a compuestos de la fórmula (I) y (IA): (ver Fórmula) y sus sales farmacéuticamente aceptables, en donde R1-R5 son tal como se definen en la presente. La invención también se refiere a composiciones farmacéuticas que comprenden estos compuestos, métodos de uso de estos compuestos en el tratamiento de diversas enfermedades y trastornos, procesos para preparar estos compuestos e intermediarios, de utilidad en estos procesos.
MX2013003202A 2010-09-23 2011-09-20 Inhibidores de oxadiazol de la produccion de leucotrienos. MX2013003202A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38573310P 2010-09-23 2010-09-23
US201161533349P 2011-09-12 2011-09-12
PCT/US2011/052254 WO2012040139A1 (en) 2010-09-23 2011-09-20 Oxadiazole inhibitors of leukotriene production

Publications (1)

Publication Number Publication Date
MX2013003202A true MX2013003202A (es) 2013-04-24

Family

ID=44720163

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013003202A MX2013003202A (es) 2010-09-23 2011-09-20 Inhibidores de oxadiazol de la produccion de leucotrienos.

Country Status (18)

Country Link
US (1) US8575201B2 (es)
EP (1) EP2619197B1 (es)
JP (1) JP5713511B2 (es)
KR (1) KR20130109122A (es)
CN (1) CN103261193A (es)
AU (1) AU2011305667A1 (es)
BR (1) BR112013008638A2 (es)
CA (1) CA2812449A1 (es)
CL (1) CL2013000788A1 (es)
CO (1) CO6710902A2 (es)
EA (1) EA201300389A1 (es)
EC (1) ECSP13012548A (es)
IN (1) IN2013DN02555A (es)
MX (1) MX2013003202A (es)
PE (1) PE20131398A1 (es)
SG (1) SG188604A1 (es)
WO (1) WO2012040139A1 (es)
ZA (1) ZA201301747B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2609092B1 (en) * 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
JP5828188B2 (ja) * 2010-09-23 2015-12-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
US9079866B2 (en) * 2013-02-04 2015-07-14 Janssen Pharmaceutica Nv Flap modulators
ES2596248T3 (es) 2013-11-26 2017-01-05 Citrage N-Carbamoilputrescina para mejorar la síntesis de proteínas musculares

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100795484B1 (ko) 1999-08-06 2008-01-16 얀센 파마슈티카 엔.브이. 인터루킨-5를 저해하는 6-아자우라실 유도체
MXPA05013637A (es) * 2003-08-13 2006-02-24 Chiron Corp Inhibidores gsk-3 y usos de los mismos.
US7319108B2 (en) 2004-01-25 2008-01-15 Sanofi-Aventis Deutschland Gmbh Aryl-substituted heterocycles, process for their preparation and their use as medicaments
CN101039938A (zh) 2004-10-18 2007-09-19 默克公司 作为flap抑制剂的二苯基取代的烷烃
US8399666B2 (en) * 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US7977359B2 (en) * 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
JP2009533435A (ja) * 2006-04-11 2009-09-17 メルク エンド カムパニー インコーポレーテッド ジアリール置換アルカン
ES2376396T3 (es) 2006-06-26 2012-03-13 Amgen Inc. Método para tratar aterosclerosis.
CA2666686A1 (en) * 2006-09-01 2008-03-13 Merck & Co., Inc. Inhibitors of 5-lipoxygenase activating protein (flap)
JP2010524861A (ja) 2007-04-20 2010-07-22 メルク フロスト カナダ リミテツド ステアロイル−補酵素ａデルタ−９デサチュラーゼの阻害剤としての新規な複素環式芳香族化合物
EP2170065A4 (en) 2007-06-20 2011-11-23 Merck Sharp & Dohme DIPHENYL SUBSTITUTED ALKANES
WO2009048547A1 (en) 2007-10-10 2009-04-16 Merck & Co., Inc. Diphenyl substituted cycloalkanes
DE102008037790A1 (de) * 2008-08-14 2010-02-18 Merck Patent Gmbh Bicyclische Triazolderivate
EP2358371B1 (en) * 2008-10-31 2015-02-11 Merck Sharp & Dohme Corp. P2x3, receptor antagonists for treatment of pain
JP2012516885A (ja) 2009-02-04 2012-07-26 ファイザー・インク ４−アミノ−７，８−ジヒドロピリド［４，３−ｄ］ピリミジン−５（６Ｈ）−オン誘導体
JP2013526544A (ja) 2010-05-12 2013-06-24 ヴァンダービルト ユニバーシティー 複素環スルホンｍＧｌｕＲ４アロステリック増強剤、組成物、および神経機能不全を治療する方法
KR20130100105A (ko) * 2010-08-16 2013-09-09 베링거 인겔하임 인터내셔날 게엠베하 류코트리엔 생성 억제제인 옥사디아졸
EP2609092B1 (en) * 2010-08-26 2015-04-01 Boehringer Ingelheim International GmbH Oxadiazole inhibitors of leukotriene production
JP5828188B2 (ja) * 2010-09-23 2015-12-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
EA201300389A1 (ru) 2010-09-23 2013-09-30 Бёрингер Ингельхайм Интернациональ Гмбх Оксадиазольные ингибиторы продуцирования лейкотриена

Also Published As

Publication number Publication date
KR20130109122A (ko) 2013-10-07
EP2619197A1 (en) 2013-07-31
CO6710902A2 (es) 2013-07-15
CN103261193A (zh) 2013-08-21
CL2013000788A1 (es) 2013-06-28
AU2011305667A1 (en) 2013-03-21
EA201300389A1 (ru) 2013-09-30
PE20131398A1 (es) 2013-12-19
US8575201B2 (en) 2013-11-05
CA2812449A1 (en) 2012-03-29
JP2013537909A (ja) 2013-10-07
WO2012040139A1 (en) 2012-03-29
BR112013008638A2 (pt) 2016-06-21
EP2619197B1 (en) 2015-08-05
JP5713511B2 (ja) 2015-05-07
IN2013DN02555A (es) 2015-08-07
ECSP13012548A (es) 2013-06-28
SG188604A1 (en) 2013-04-30
ZA201301747B (en) 2014-08-27
US20120295896A1 (en) 2012-11-22

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