IN2014DN09348A - - Google Patents
Info
- Publication number
- IN2014DN09348A IN2014DN09348A IN9348DEN2014A IN2014DN09348A IN 2014DN09348 A IN2014DN09348 A IN 2014DN09348A IN 9348DEN2014 A IN9348DEN2014 A IN 9348DEN2014A IN 2014DN09348 A IN2014DN09348 A IN 2014DN09348A
- Authority
- IN
- India
- Prior art keywords
- compounds
- disorders
- substituents
- useful
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
Abstract
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof wherein the substituents are as those disclosed in the specification. These compounds and the pharmaceutical compositions containing them are useful for the treatment of inflammatory diseases and disorders such as for example pulmonary fibrosis...
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661961P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062461 WO2013189864A1 (en) | 2012-06-20 | 2013-06-17 | N-alkyltriazole compounds as lpar antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
IN2014DN09348A true IN2014DN09348A (en) | 2015-07-17 |
Family
ID=48628667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IN9348DEN2014 IN2014DN09348A (en) | 2012-06-20 | 2013-06-17 |
Country Status (22)
Country | Link |
---|---|
US (1) | US9321738B2 (en) |
EP (1) | EP2864300A1 (en) |
JP (1) | JP2015520202A (en) |
KR (1) | KR20150021057A (en) |
CN (1) | CN104411692A (en) |
AU (1) | AU2013279512A1 (en) |
BR (1) | BR112014030685A2 (en) |
CA (1) | CA2869541A1 (en) |
CL (1) | CL2014003243A1 (en) |
CO (1) | CO7131358A2 (en) |
CR (1) | CR20140525A (en) |
EA (1) | EA201492285A1 (en) |
HK (1) | HK1206342A1 (en) |
IL (1) | IL236088A0 (en) |
IN (1) | IN2014DN09348A (en) |
MA (1) | MA37764A1 (en) |
MX (1) | MX2014014710A (en) |
PE (1) | PE20142448A1 (en) |
PH (1) | PH12014502789A1 (en) |
SG (1) | SG11201407220YA (en) |
UA (1) | UA109868C2 (en) |
WO (1) | WO2013189864A1 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2014001732A (en) | 2011-08-15 | 2014-07-09 | Intermune Inc | Lysophosphatidic acid receptor antagonists. |
SG11201407228PA (en) * | 2012-06-20 | 2014-12-30 | Hoffmann La Roche | N-aryltriazole compounds as lpar antagonists |
AU2014232383B2 (en) | 2013-03-15 | 2019-01-17 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
MX370408B (en) | 2014-06-27 | 2019-12-11 | Ube Industries | Salt of halogen-substituted heterocyclic compound. |
AR108838A1 (en) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | CARBAMOYLOXIMETHYL ACID TRIAZOL CYCLOHEXILO AS LPA ANTAGONISTS |
ES2944304T3 (en) | 2017-12-19 | 2023-06-20 | Bristol Myers Squibb Co | Pyrazole cyclohexylic acid azines as LPA antagonists |
EP3728240B1 (en) * | 2017-12-19 | 2022-06-29 | Bristol-Myers Squibb Company | Isoxazole o-linked carbamoyl cyclohexyl acids as lpa antagonists |
MX2020005818A (en) * | 2017-12-19 | 2020-08-20 | Bristol Myers Squibb Co | Cyclohexyl acid triazole azoles as lpa antagonists. |
US11384067B2 (en) | 2017-12-19 | 2022-07-12 | Bristol-Myers Squibb Company | Pyrazole n-linked carbamoyl cyclohexyl acids as LPA antagonists |
CN112041302A (en) | 2017-12-19 | 2020-12-04 | 百时美施贵宝公司 | Pyrazole O-linked carbamoylcyclohexanoic acids as LPA antagonists |
PE20210655A1 (en) * | 2017-12-19 | 2021-03-31 | Bristol Myers Squibb Co | CARBAMOIL CYCLOHEXIL N-LINKED ACIDS OF TRIAZOLE AS ANTAGONISTS OF LPA |
KR20200100754A (en) * | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Cyclohexyl acid isoxazole azole as an LPA antagonist |
JP7208240B2 (en) * | 2017-12-19 | 2023-01-18 | ブリストル-マイヤーズ スクイブ カンパニー | Cyclohexylate triazole azines as LPA antagonists |
WO2019126103A1 (en) | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid pyrazole azoles as lpa antagonists |
US11447475B2 (en) | 2017-12-19 | 2022-09-20 | Bristol-Myers Squibb Company | Isoxazole N-linked carbamoyl cyclohexyl acids as LPA antagonists |
JP2021506878A (en) * | 2017-12-19 | 2021-02-22 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | Isoxazoleazine cyclohexyl as an LPA antagonist |
AR114070A1 (en) * | 2017-12-29 | 2020-07-15 | Biomarin Pharm Inc | GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF A DISEASE |
CN113473985A (en) * | 2018-09-18 | 2021-10-01 | 百时美施贵宝公司 | Cyclopentanoic acid as LPA antagonist |
CN112702998A (en) * | 2018-09-18 | 2021-04-23 | 百时美施贵宝公司 | Cycloheptanoic acids as LPA antagonists |
US20210317131A1 (en) * | 2018-09-18 | 2021-10-14 | Bristol-Myers Squibb Company | Oxabicyclo acids as lpa antagonists |
CN114728168B (en) * | 2019-11-15 | 2024-04-09 | 吉利德科学公司 | Triazole carbamate pyridylsulfonamides as LPA receptor antagonists and their use |
TW202344504A (en) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa receptor antagonists and uses thereof |
KR20230019880A (en) | 2020-06-03 | 2023-02-09 | 길리애드 사이언시즈, 인코포레이티드 | LPA receptor antagonists and uses thereof |
WO2023107938A1 (en) | 2021-12-08 | 2023-06-15 | Gilead Sciences, Inc. | Lpa receptor antagonists and uses thereof |
TW202342017A (en) | 2022-02-25 | 2023-11-01 | 美商洛子峰生物有限公司 | Compounds and compositions for treating conditions associated with lpa receptor activity |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
US20110065695A1 (en) | 2009-09-11 | 2011-03-17 | Jeremy Beauchamp | Use of aminodihydrothiazines for the treatment or prevention of diabetes |
GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
WO2011159550A2 (en) * | 2010-06-14 | 2011-12-22 | Amidra Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonist and uses thereof |
WO2011159633A1 (en) * | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Inhalable formulations of lysophosphatdic acid receptor antagonists |
EP2648714B1 (en) * | 2010-12-07 | 2015-11-18 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonists and uses thereof |
WO2012138648A1 (en) | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
MX2014001732A (en) * | 2011-08-15 | 2014-07-09 | Intermune Inc | Lysophosphatidic acid receptor antagonists. |
-
2013
- 2013-06-17 KR KR1020147035768A patent/KR20150021057A/en not_active Application Discontinuation
- 2013-06-17 WO PCT/EP2013/062461 patent/WO2013189864A1/en active Application Filing
- 2013-06-17 MA MA37764A patent/MA37764A1/en unknown
- 2013-06-17 AU AU2013279512A patent/AU2013279512A1/en not_active Abandoned
- 2013-06-17 SG SG11201407220YA patent/SG11201407220YA/en unknown
- 2013-06-17 BR BR112014030685A patent/BR112014030685A2/en not_active Application Discontinuation
- 2013-06-17 CA CA2869541A patent/CA2869541A1/en not_active Abandoned
- 2013-06-17 EP EP13729330.4A patent/EP2864300A1/en not_active Withdrawn
- 2013-06-17 JP JP2015517704A patent/JP2015520202A/en not_active Ceased
- 2013-06-17 PE PE2014002232A patent/PE20142448A1/en not_active Application Discontinuation
- 2013-06-17 IN IN9348DEN2014 patent/IN2014DN09348A/en unknown
- 2013-06-17 UA UAA201500428A patent/UA109868C2/en unknown
- 2013-06-17 US US14/401,009 patent/US9321738B2/en not_active Expired - Fee Related
- 2013-06-17 CN CN201380032285.0A patent/CN104411692A/en active Pending
- 2013-06-17 MX MX2014014710A patent/MX2014014710A/en unknown
- 2013-06-17 EA EA201492285A patent/EA201492285A1/en unknown
-
2014
- 2014-11-17 CR CR20140525A patent/CR20140525A/en unknown
- 2014-11-21 CO CO14256136A patent/CO7131358A2/en unknown
- 2014-11-28 CL CL2014003243A patent/CL2014003243A1/en unknown
- 2014-12-04 IL IL236088A patent/IL236088A0/en unknown
- 2014-12-15 PH PH12014502789A patent/PH12014502789A1/en unknown
-
2015
- 2015-07-21 HK HK15106927.8A patent/HK1206342A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112014030685A2 (en) | 2017-06-27 |
UA109868C2 (en) | 2015-10-12 |
PH12014502789A1 (en) | 2015-02-09 |
WO2013189864A1 (en) | 2013-12-27 |
US20150133511A1 (en) | 2015-05-14 |
PE20142448A1 (en) | 2015-01-28 |
EP2864300A1 (en) | 2015-04-29 |
MA37764A1 (en) | 2016-01-29 |
MX2014014710A (en) | 2015-03-04 |
SG11201407220YA (en) | 2014-12-30 |
CO7131358A2 (en) | 2014-12-01 |
KR20150021057A (en) | 2015-02-27 |
EA201492285A1 (en) | 2015-04-30 |
US9321738B2 (en) | 2016-04-26 |
JP2015520202A (en) | 2015-07-16 |
IL236088A0 (en) | 2015-02-01 |
CA2869541A1 (en) | 2013-12-27 |
CL2014003243A1 (en) | 2015-03-20 |
CN104411692A (en) | 2015-03-11 |
CR20140525A (en) | 2015-01-12 |
HK1206342A1 (en) | 2016-01-08 |
AU2013279512A1 (en) | 2014-10-16 |
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