BR112014030685A2 - compostos de n-alquiltriazol como antagonistas de lpar - Google Patents
compostos de n-alquiltriazol como antagonistas de lparInfo
- Publication number
- BR112014030685A2 BR112014030685A2 BR112014030685A BR112014030685A BR112014030685A2 BR 112014030685 A2 BR112014030685 A2 BR 112014030685A2 BR 112014030685 A BR112014030685 A BR 112014030685A BR 112014030685 A BR112014030685 A BR 112014030685A BR 112014030685 A2 BR112014030685 A2 BR 112014030685A2
- Authority
- BR
- Brazil
- Prior art keywords
- compounds
- alkyltriazole
- context
- formula
- lpar antagonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
- C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4192—1,2,3-Triazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
1/1 resumo compostos de n-alquiltriazol como antagonistas de lpar proporcionam-se neste contexto compostos da fórmula (i): r3 o n o n r4 r2 nn r1 (i), bem como os seus sais farmaceuticamente aceitáveis, em que os substituintes são tais como aqueles expostos no relatório. estes compostos, e as composições farmacêuticas que os contêm, são de utilidade para o tratamento de enfermidades e distúrbios inflamatórios, tais como, por exemplo, fibrose pulmonar.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261661961P | 2012-06-20 | 2012-06-20 | |
PCT/EP2013/062461 WO2013189864A1 (en) | 2012-06-20 | 2013-06-17 | N-alkyltriazole compounds as lpar antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112014030685A2 true BR112014030685A2 (pt) | 2017-06-27 |
Family
ID=48628667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014030685A BR112014030685A2 (pt) | 2012-06-20 | 2013-06-17 | compostos de n-alquiltriazol como antagonistas de lpar |
Country Status (22)
Country | Link |
---|---|
US (1) | US9321738B2 (pt) |
EP (1) | EP2864300A1 (pt) |
JP (1) | JP2015520202A (pt) |
KR (1) | KR20150021057A (pt) |
CN (1) | CN104411692A (pt) |
AU (1) | AU2013279512A1 (pt) |
BR (1) | BR112014030685A2 (pt) |
CA (1) | CA2869541A1 (pt) |
CL (1) | CL2014003243A1 (pt) |
CO (1) | CO7131358A2 (pt) |
CR (1) | CR20140525A (pt) |
EA (1) | EA201492285A1 (pt) |
HK (1) | HK1206342A1 (pt) |
IL (1) | IL236088A0 (pt) |
IN (1) | IN2014DN09348A (pt) |
MA (1) | MA37764A1 (pt) |
MX (1) | MX2014014710A (pt) |
PE (1) | PE20142448A1 (pt) |
PH (1) | PH12014502789A1 (pt) |
SG (1) | SG11201407220YA (pt) |
UA (1) | UA109868C2 (pt) |
WO (1) | WO2013189864A1 (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104066729A (zh) | 2011-08-15 | 2014-09-24 | 英特穆恩公司 | 溶血磷脂酸受体拮抗剂 |
SG11201407228PA (en) * | 2012-06-20 | 2014-12-30 | Hoffmann La Roche | N-aryltriazole compounds as lpar antagonists |
WO2014145873A2 (en) | 2013-03-15 | 2014-09-18 | Epigen Biosciences, Inc. | Heterocyclic compounds useful in the treatment of disease |
CN106458964B (zh) | 2014-06-27 | 2019-11-22 | 宇部兴产株式会社 | 卤素取代杂环化合物的盐 |
AR108838A1 (es) | 2016-06-21 | 2018-10-03 | Bristol Myers Squibb Co | Ácidos de carbamoiloximetil triazol ciclohexilo como antagonistas de lpa |
JP7208240B2 (ja) * | 2017-12-19 | 2023-01-18 | ブリストル-マイヤーズ スクイブ カンパニー | Lpaアンタゴニストとしてのシクロヘキシル酸トリアゾールアジン |
CN112189010A (zh) * | 2017-12-19 | 2021-01-05 | 百时美施贵宝公司 | 作为lpa拮抗剂的***n-连接的氨基甲酰基环己基酸 |
CN112055710A (zh) | 2017-12-19 | 2020-12-08 | 百时美施贵宝公司 | 作为lpa拮抗剂的环己基酸吡唑吖嗪 |
KR20200101957A (ko) | 2017-12-19 | 2020-08-28 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 이속사졸 o-연결된 카르바모일 시클로헥실 산 |
WO2019126087A1 (en) * | 2017-12-19 | 2019-06-27 | Bristol-Myers Squibb Company | Cyclohexyl acid isoxazole azoles as lpa antagonists |
EA202091500A1 (ru) | 2017-12-19 | 2020-09-14 | Бристол-Маерс Сквибб Компани | Пиразол n-связанные карбамоилциклогексильные кислоты в качестве антагонистов lpa |
KR20200100722A (ko) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 이속사졸 아진 |
KR20200100753A (ko) | 2017-12-19 | 2020-08-26 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헥실 산 피라졸 아졸 |
US11261174B2 (en) | 2017-12-19 | 2022-03-01 | Bristol-Myers Squibb Company | Pyrazole O-linked carbamoyl cyclohexyl acids as LPA antagonists |
CN112041304A (zh) | 2017-12-19 | 2020-12-04 | 百时美施贵宝公司 | 作为lpa拮抗剂的异噁唑n-连接的氨基甲酰基环己基酸 |
US11319315B2 (en) * | 2017-12-19 | 2022-05-03 | Bristol-Myers Squibb Company | Cyclohexyl acid triazole azoles as LPA antagonists |
AR114070A1 (es) * | 2017-12-29 | 2020-07-15 | Biomarin Pharm Inc | Inhibidores de glicolato oxidasa para el tratamiento de una enfermedad |
CN113473985A (zh) * | 2018-09-18 | 2021-10-01 | 百时美施贵宝公司 | 作为lpa拮抗剂的环戊酸 |
CN113366000A (zh) * | 2018-09-18 | 2021-09-07 | 百时美施贵宝公司 | 作为lpa拮抗剂的氧杂双环酸 |
KR20210060547A (ko) * | 2018-09-18 | 2021-05-26 | 브리스톨-마이어스 스큅 컴퍼니 | Lpa 길항제로서의 시클로헵틸 산 |
CA3158743A1 (en) * | 2019-11-15 | 2021-05-20 | Gilead Sciences, Inc. | Triazole carbamate pyridyl sulfonamides as lpa receptor antagonists and uses thereof |
US11702407B2 (en) | 2020-06-03 | 2023-07-18 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
TW202344504A (zh) | 2020-06-03 | 2023-11-16 | 美商基利科學股份有限公司 | Lpa受體拮抗劑及其用途 |
US11939318B2 (en) | 2021-12-08 | 2024-03-26 | Gilead Sciences, Inc. | LPA receptor antagonists and uses thereof |
TW202342017A (zh) | 2022-02-25 | 2023-11-01 | 美商洛子峰生物有限公司 | 用於治療與lpa受體活性相關的病狀的化合物及組合物 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TW200827346A (en) | 2006-11-03 | 2008-07-01 | Astrazeneca Ab | Chemical compounds |
GB2466121B (en) * | 2008-12-15 | 2010-12-08 | Amira Pharmaceuticals Inc | Antagonists of lysophosphatidic acid receptors |
GB2470833B (en) * | 2009-06-03 | 2011-06-01 | Amira Pharmaceuticals Inc | Polycyclic antagonists of lysophosphatidic acid receptors |
US20110065695A1 (en) | 2009-09-11 | 2011-03-17 | Jeremy Beauchamp | Use of aminodihydrothiazines for the treatment or prevention of diabetes |
GB2474748B (en) * | 2009-10-01 | 2011-10-12 | Amira Pharmaceuticals Inc | Polycyclic compounds as lysophosphatidic acid receptor antagonists |
WO2011159550A2 (en) * | 2010-06-14 | 2011-12-22 | Amidra Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonist and uses thereof |
WO2011159633A1 (en) | 2010-06-15 | 2011-12-22 | Amira Pharmaceuticals, Inc. | Inhalable formulations of lysophosphatdic acid receptor antagonists |
AU2011338561A1 (en) * | 2010-12-07 | 2013-07-25 | Amira Pharmaceuticals, Inc. | Lysophosphatidic acid receptor antagonists and their use in the treatment of fibrosis |
WO2012138648A1 (en) | 2011-04-06 | 2012-10-11 | Irm Llc | Compositions and methods for modulating lpa receptors |
CN104066729A (zh) * | 2011-08-15 | 2014-09-24 | 英特穆恩公司 | 溶血磷脂酸受体拮抗剂 |
-
2013
- 2013-06-17 JP JP2015517704A patent/JP2015520202A/ja not_active Ceased
- 2013-06-17 IN IN9348DEN2014 patent/IN2014DN09348A/en unknown
- 2013-06-17 EA EA201492285A patent/EA201492285A1/ru unknown
- 2013-06-17 UA UAA201500428A patent/UA109868C2/ru unknown
- 2013-06-17 CA CA2869541A patent/CA2869541A1/en not_active Abandoned
- 2013-06-17 EP EP13729330.4A patent/EP2864300A1/en not_active Withdrawn
- 2013-06-17 KR KR1020147035768A patent/KR20150021057A/ko not_active Application Discontinuation
- 2013-06-17 BR BR112014030685A patent/BR112014030685A2/pt not_active Application Discontinuation
- 2013-06-17 PE PE2014002232A patent/PE20142448A1/es not_active Application Discontinuation
- 2013-06-17 MX MX2014014710A patent/MX2014014710A/es unknown
- 2013-06-17 CN CN201380032285.0A patent/CN104411692A/zh active Pending
- 2013-06-17 SG SG11201407220YA patent/SG11201407220YA/en unknown
- 2013-06-17 US US14/401,009 patent/US9321738B2/en not_active Expired - Fee Related
- 2013-06-17 MA MA37764A patent/MA37764A1/fr unknown
- 2013-06-17 AU AU2013279512A patent/AU2013279512A1/en not_active Abandoned
- 2013-06-17 WO PCT/EP2013/062461 patent/WO2013189864A1/en active Application Filing
-
2014
- 2014-11-17 CR CR20140525A patent/CR20140525A/es unknown
- 2014-11-21 CO CO14256136A patent/CO7131358A2/es unknown
- 2014-11-28 CL CL2014003243A patent/CL2014003243A1/es unknown
- 2014-12-04 IL IL236088A patent/IL236088A0/en unknown
- 2014-12-15 PH PH12014502789A patent/PH12014502789A1/en unknown
-
2015
- 2015-07-21 HK HK15106927.8A patent/HK1206342A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CO7131358A2 (es) | 2014-12-01 |
PE20142448A1 (es) | 2015-01-28 |
EP2864300A1 (en) | 2015-04-29 |
CA2869541A1 (en) | 2013-12-27 |
UA109868C2 (ru) | 2015-10-12 |
MX2014014710A (es) | 2015-03-04 |
MA37764A1 (fr) | 2016-01-29 |
CL2014003243A1 (es) | 2015-03-20 |
HK1206342A1 (en) | 2016-01-08 |
CN104411692A (zh) | 2015-03-11 |
WO2013189864A1 (en) | 2013-12-27 |
IN2014DN09348A (pt) | 2015-07-17 |
CR20140525A (es) | 2015-01-12 |
SG11201407220YA (en) | 2014-12-30 |
JP2015520202A (ja) | 2015-07-16 |
US9321738B2 (en) | 2016-04-26 |
KR20150021057A (ko) | 2015-02-27 |
US20150133511A1 (en) | 2015-05-14 |
PH12014502789A1 (en) | 2015-02-09 |
AU2013279512A1 (en) | 2014-10-16 |
EA201492285A1 (ru) | 2015-04-30 |
IL236088A0 (en) | 2015-02-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |