TW202304908A - 四氫吡啶并嘧啶化合物 - Google Patents

四氫吡啶并嘧啶化合物 Download PDF

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Publication number
TW202304908A
TW202304908A TW111113796A TW111113796A TW202304908A TW 202304908 A TW202304908 A TW 202304908A TW 111113796 A TW111113796 A TW 111113796A TW 111113796 A TW111113796 A TW 111113796A TW 202304908 A TW202304908 A TW 202304908A
Authority
TW
Taiwan
Prior art keywords
oxy
fluorophenyl
tetrahydropyrimidine
pyrimidin
tetrahydropyrido
Prior art date
Application number
TW111113796A
Other languages
English (en)
Chinese (zh)
Inventor
井上諭
村井則夫
山根義伸
東宏
永尾聰
塚本俊太郎
Original Assignee
日商衛材R&D企管股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商衛材R&D企管股份有限公司 filed Critical 日商衛材R&D企管股份有限公司
Publication of TW202304908A publication Critical patent/TW202304908A/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
TW111113796A 2021-04-14 2022-04-12 四氫吡啶并嘧啶化合物 TW202304908A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2021068414 2021-04-14
JP2021-068414 2021-04-14

Publications (1)

Publication Number Publication Date
TW202304908A true TW202304908A (zh) 2023-02-01

Family

ID=83640095

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111113796A TW202304908A (zh) 2021-04-14 2022-04-12 四氫吡啶并嘧啶化合物

Country Status (3)

Country Link
JP (1) JPWO2022220227A1 (fr)
TW (1) TW202304908A (fr)
WO (1) WO2022220227A1 (fr)

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2078010T3 (da) * 2006-12-29 2014-04-28 Rigel Pharmaceuticals Inc Polycyklisk heteroaryl-substituerede triazoler, der er anvendelige som axl-hæmmere
WO2010005876A2 (fr) * 2008-07-09 2010-01-14 Rigel Pharmaceuticals, Inc. Triazoles à substitution hétéroaryle polycycliques utiles en tant qu’inhibiteurs d’axl
JP5858789B2 (ja) * 2009-01-16 2016-02-10 ライジェル ファーマシューティカルズ， インコーポレイテッド 転移性癌の予防、治療、または管理のための併用療法に用いるためのａｘｌ阻害薬
WO2012135800A1 (fr) * 2011-04-01 2012-10-04 University Of Utah Research Foundation Analogues de n-phénylpyrimidine-2-amine substitués en tant qu'inhibiteurs de l'axl kinase
HUE033032T2 (hu) * 2011-11-14 2017-11-28 Ignyta Inc Uracil-származékok mint AXL és c-MET kináz inhibitorok
PT2810937T (pt) * 2012-01-31 2017-03-03 Daiichi Sankyo Co Ltd Derivado de piridona
TWI649308B (zh) * 2013-07-24 2019-02-01 小野藥品工業股份有限公司 喹啉衍生物
EP3103453B1 (fr) * 2014-02-04 2020-04-01 Astellas Pharma Inc. Composition médicinale comprenant un composé de carboxamide hétérocyclique diamino en tant qu'agent actif
TWI723572B (zh) * 2014-07-07 2021-04-01 日商第一三共股份有限公司 具有四氫吡喃基甲基之吡啶酮衍生物及其用途
ES2746839T3 (es) * 2014-12-18 2020-03-09 Pfizer Derivados de pirimidina y triazina y su uso como inhibidores de AXL

Also Published As

Publication number Publication date
JPWO2022220227A1 (fr) 2022-10-20
WO2022220227A1 (fr) 2022-10-20

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