TW200745088A - Benzimidazoles useful as inhibitors of protein kinases - Google Patents

Benzimidazoles useful as inhibitors of protein kinases

Info

Publication number
TW200745088A
TW200745088A TW095127328A TW95127328A TW200745088A TW 200745088 A TW200745088 A TW 200745088A TW 095127328 A TW095127328 A TW 095127328A TW 95127328 A TW95127328 A TW 95127328A TW 200745088 A TW200745088 A TW 200745088A
Authority
TW
Taiwan
Prior art keywords
inhibitors
protein kinases
compounds
useful
benzimidazoles useful
Prior art date
Application number
TW095127328A
Other languages
English (en)
Chinese (zh)
Inventor
Binch Hayley
Simon Everitt
Michael Mortimore
Daniel Robinson
Dean Stamos
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of TW200745088A publication Critical patent/TW200745088A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
TW095127328A 2005-07-26 2006-07-26 Benzimidazoles useful as inhibitors of protein kinases TW200745088A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70239905P 2005-07-26 2005-07-26

Publications (1)

Publication Number Publication Date
TW200745088A true TW200745088A (en) 2007-12-16

Family

ID=37680602

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095127328A TW200745088A (en) 2005-07-26 2006-07-26 Benzimidazoles useful as inhibitors of protein kinases

Country Status (17)

Country Link
US (1) US8076343B2 (fr)
EP (2) EP2336122B1 (fr)
JP (2) JP5255438B2 (fr)
KR (1) KR20080034483A (fr)
CN (1) CN101291927A (fr)
AT (1) ATE484501T1 (fr)
AU (1) AU2006276088A1 (fr)
CA (1) CA2616159A1 (fr)
DE (1) DE602006017574D1 (fr)
ES (1) ES2351357T3 (fr)
IL (1) IL188942A0 (fr)
NO (1) NO20080967L (fr)
NZ (1) NZ566021A (fr)
RU (1) RU2415853C2 (fr)
TW (1) TW200745088A (fr)
WO (1) WO2007015923A2 (fr)
ZA (1) ZA200800992B (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2214486A4 (fr) 2007-10-19 2011-03-09 Avila Therapeutics Inc Composés hétéroaryles et leurs utilisations
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
CA2723961C (fr) 2008-05-21 2017-03-21 Ariad Pharmaceuticals, Inc. Derives phosphores servant d'inhibiteurs de kinase
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
CN103501612B (zh) 2011-05-04 2017-03-29 阿里亚德医药股份有限公司 抑制表皮生长因子受体导致的癌症中细胞增殖的化合物
WO2013169401A1 (fr) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Composés pour inhiber la prolifération cellulaire dans les cancers induits par l'egfr
US9336046B2 (en) 2012-06-15 2016-05-10 International Business Machines Corporation Transaction abort processing
US9512136B2 (en) * 2012-11-26 2016-12-06 Universal Display Corporation Organic electroluminescent materials and devices
EP2976336A1 (fr) * 2013-03-21 2016-01-27 Bayer Pharma Aktiengesellschaft Indazoles 3-hétéroaryle substituées
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
WO2014170421A1 (fr) * 2013-04-19 2014-10-23 F. Hoffmann-La Roche Ag Inhibiteurs de sérine/thréonine kinases
CA3079607A1 (fr) 2017-10-19 2019-04-25 Effector Therapeutics, Inc. Inhibiteurs de benzimidazole-indole de mnk1 et mnk2
CN112552287B (zh) * 2020-12-16 2021-11-30 北京华氏精恒医药科技有限公司 一种吲哚类衍生物药物制剂及其制备方法
WO2023116888A1 (fr) * 2021-12-23 2023-06-29 杭州多域生物技术有限公司 Composé à cinq et six chaînons, procédé de préparation, composition pharmaceutique et utilisation

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69927516T2 (de) * 1998-11-17 2006-03-16 Kumiai Chemical Industry Co., Ltd. Pyrimidinylbenzimidazol- und triazinylbenzimidazol-derivate und fungizide für landwirtschaft/gartenbau
JP4535350B2 (ja) * 1998-11-17 2010-09-01 クミアイ化学工業株式会社 ピリミジニルベンズイミダゾール誘導体及び農園芸用殺菌剤
JP2003511378A (ja) * 1999-10-07 2003-03-25 アムジエン・インコーポレーテツド トリアジン系キナーゼ阻害薬
WO2001060816A1 (fr) * 2000-02-17 2001-08-23 Amgen Inc. Inhibiteurs de kinases
EP1389617B1 (fr) * 2001-04-27 2007-01-03 Zenyaku Kogyo Kabushiki Kaisha Compose heterocyclique et agent antitumoral contenant ce dernier en tant qu'ingredient actif
NZ537156A (en) * 2002-05-23 2007-06-29 Cytopia Pty Ltd Kinase inhibitors
AR042052A1 (es) * 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
CA2545427C (fr) * 2004-01-12 2012-08-21 Cytopia Research Pty Ltd Inhibiteurs selectifs de kinases

Also Published As

Publication number Publication date
RU2008106949A (ru) 2009-09-10
ATE484501T1 (de) 2010-10-15
EP2336122A1 (fr) 2011-06-22
AU2006276088A1 (en) 2007-02-08
IL188942A0 (en) 2008-04-13
WO2007015923A2 (fr) 2007-02-08
DE602006017574D1 (de) 2010-11-25
JP2013082757A (ja) 2013-05-09
JP2009502921A (ja) 2009-01-29
CA2616159A1 (fr) 2007-02-08
JP5255438B2 (ja) 2013-08-07
WO2007015923A8 (fr) 2008-04-03
ZA200800992B (en) 2009-09-30
RU2415853C2 (ru) 2011-04-10
CN101291927A (zh) 2008-10-22
EP1937667A2 (fr) 2008-07-02
US8076343B2 (en) 2011-12-13
EP1937667B1 (fr) 2010-10-13
KR20080034483A (ko) 2008-04-21
EP2336122B1 (fr) 2014-05-14
WO2007015923A3 (fr) 2007-04-19
ES2351357T3 (es) 2011-02-03
NZ566021A (en) 2011-03-31
NO20080967L (no) 2008-04-22
US20070099920A1 (en) 2007-05-03

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