NO20080967L - Benzimidazoler nyttige som inhibitorer av proteinkinaser - Google Patents

Benzimidazoler nyttige som inhibitorer av proteinkinaser

Info

Publication number
NO20080967L
NO20080967L NO20080967A NO20080967A NO20080967L NO 20080967 L NO20080967 L NO 20080967L NO 20080967 A NO20080967 A NO 20080967A NO 20080967 A NO20080967 A NO 20080967A NO 20080967 L NO20080967 L NO 20080967L
Authority
NO
Norway
Prior art keywords
inhibitors
protein kinases
compounds
useful
benzimidazoles useful
Prior art date
Application number
NO20080967A
Other languages
English (en)
Inventor
Dean Stamos
Hayley Binch
Michael Mortimore
Daniel Robinson
Simon Everitt
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20080967L publication Critical patent/NO20080967L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/14—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Abstract

Foreliggende oppfinnelse vedrører forbindelser som er nyttige som inhibitorer av Aurora-, FLT-3- eller PDK1-proteinkinase. Oppfinnelsen tilveiebringer også farmasøytisk akseptable sammensetninger som omfatter nevnte forbindelser, og metoder for anvendelse av sammensetningene ved behandling av forskjellige sykdommer, tilstander eller forstyrrelser. Oppfinnelsen tilveiebringer også fremgangsmåter for å fremstille forbindelser ifølge oppfinnelsen.
NO20080967A 2005-07-26 2008-02-26 Benzimidazoler nyttige som inhibitorer av proteinkinaser NO20080967L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70239905P 2005-07-26 2005-07-26
PCT/US2006/028149 WO2007015923A2 (en) 2005-07-26 2006-07-21 Benzimidazoles useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
NO20080967L true NO20080967L (no) 2008-04-22

Family

ID=37680602

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20080967A NO20080967L (no) 2005-07-26 2008-02-26 Benzimidazoler nyttige som inhibitorer av proteinkinaser

Country Status (17)

Country Link
US (1) US8076343B2 (no)
EP (2) EP1937667B1 (no)
JP (2) JP5255438B2 (no)
KR (1) KR20080034483A (no)
CN (1) CN101291927A (no)
AT (1) ATE484501T1 (no)
AU (1) AU2006276088A1 (no)
CA (1) CA2616159A1 (no)
DE (1) DE602006017574D1 (no)
ES (1) ES2351357T3 (no)
IL (1) IL188942A0 (no)
NO (1) NO20080967L (no)
NZ (1) NZ566021A (no)
RU (1) RU2415853C2 (no)
TW (1) TW200745088A (no)
WO (1) WO2007015923A2 (no)
ZA (1) ZA200800992B (no)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7989465B2 (en) 2007-10-19 2011-08-02 Avila Therapeutics, Inc. 4,6-disubstituted pyrimidines useful as kinase inhibitors
EP2214486A4 (en) * 2007-10-19 2011-03-09 Avila Therapeutics Inc HETEROARYL COMPOUNDS AND ITS USES
US9273077B2 (en) 2008-05-21 2016-03-01 Ariad Pharmaceuticals, Inc. Phosphorus derivatives as kinase inhibitors
KR101956261B1 (ko) 2008-05-21 2019-03-08 어리어드 파마슈티칼스, 인코포레이티드 키나아제 억제제로서 포스포러스 유도체
JP5999177B2 (ja) 2011-05-04 2016-09-28 アリアド・ファーマシューティカルズ・インコーポレイテッド Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物
WO2013169401A1 (en) 2012-05-05 2013-11-14 Ariad Pharmaceuticals, Inc. Compounds for inhibiting cell proliferation in egfr-driven cancers
US9336046B2 (en) 2012-06-15 2016-05-10 International Business Machines Corporation Transaction abort processing
US9512136B2 (en) * 2012-11-26 2016-12-06 Universal Display Corporation Organic electroluminescent materials and devices
WO2014147203A1 (en) * 2013-03-21 2014-09-25 Bayer Pharma Aktiengesellschaft 3-heteroaryl substituted indazoles
US9611283B1 (en) 2013-04-10 2017-04-04 Ariad Pharmaceuticals, Inc. Methods for inhibiting cell proliferation in ALK-driven cancers
WO2014170421A1 (en) * 2013-04-19 2014-10-23 F. Hoffmann-La Roche Ag Serine/threonine kinase inhibitors
WO2019079369A1 (en) 2017-10-19 2019-04-25 Effector Therapeutics, Inc. BENZIMIDAZOLE INDOLE INHIBITORS OF MNK1 AND MNK2
CN112552287B (zh) * 2020-12-16 2021-11-30 北京华氏精恒医药科技有限公司 一种吲哚类衍生物药物制剂及其制备方法
WO2023116888A1 (zh) * 2021-12-23 2023-06-29 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4535350B2 (ja) * 1998-11-17 2010-09-01 クミアイ化学工業株式会社 ピリミジニルベンズイミダゾール誘導体及び農園芸用殺菌剤
WO2000029404A1 (fr) 1998-11-17 2000-05-25 Kumiai Chemical Industry Co., Ltd. Derives de pyrimidinylbenzimidazole et de triazinylbenzimidazole et bactericides agricoles/horticoles
ATE396978T1 (de) * 1999-10-07 2008-06-15 Amgen Inc Triazin-kinase-hemmer
AU3704101A (en) * 2000-02-17 2001-08-27 Amgen Inc Kinase inhibitors
KR100833371B1 (ko) * 2001-04-27 2008-05-28 젠야쿠코교가부시키가이샤 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제
NZ537156A (en) * 2002-05-23 2007-06-29 Cytopia Pty Ltd Kinase inhibitors
TWI335913B (en) * 2002-11-15 2011-01-11 Vertex Pharma Diaminotriazoles useful as inhibitors of protein kinases
UA80767C2 (en) * 2002-12-20 2007-10-25 Pfizer Prod Inc Pyrimidine derivatives for the treatment of abnormal cell growth
EP1704145B1 (en) * 2004-01-12 2012-06-13 YM BioSciences Australia Pty Ltd Selective kinase inhibitors

Also Published As

Publication number Publication date
ES2351357T3 (es) 2011-02-03
DE602006017574D1 (de) 2010-11-25
EP1937667A2 (en) 2008-07-02
ATE484501T1 (de) 2010-10-15
JP5255438B2 (ja) 2013-08-07
RU2008106949A (ru) 2009-09-10
US8076343B2 (en) 2011-12-13
NZ566021A (en) 2011-03-31
AU2006276088A1 (en) 2007-02-08
IL188942A0 (en) 2008-04-13
TW200745088A (en) 2007-12-16
KR20080034483A (ko) 2008-04-21
JP2009502921A (ja) 2009-01-29
EP2336122B1 (en) 2014-05-14
WO2007015923A8 (en) 2008-04-03
EP2336122A1 (en) 2011-06-22
WO2007015923A2 (en) 2007-02-08
JP2013082757A (ja) 2013-05-09
US20070099920A1 (en) 2007-05-03
EP1937667B1 (en) 2010-10-13
CN101291927A (zh) 2008-10-22
WO2007015923A3 (en) 2007-04-19
CA2616159A1 (en) 2007-02-08
RU2415853C2 (ru) 2011-04-10
ZA200800992B (en) 2009-09-30

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