TR201901929T4 - TGFBeta'ya antikorlar. - Google Patents
TGFBeta'ya antikorlar. Download PDFInfo
- Publication number
- TR201901929T4 TR201901929T4 TR2019/01929T TR201901929T TR201901929T4 TR 201901929 T4 TR201901929 T4 TR 201901929T4 TR 2019/01929 T TR2019/01929 T TR 2019/01929T TR 201901929 T TR201901929 T TR 201901929T TR 201901929 T4 TR201901929 T4 TR 201901929T4
- Authority
- TR
- Turkey
- Prior art keywords
- antibody molecules
- antibody
- igg4
- igg1
- bind
- Prior art date
Links
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 title abstract 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 abstract 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Abstract
Mevcut buluş, antikor molekülleri, özellikle Dönüştürücü Büyüme Faktörü beta'yı (TGFß) bağlayan antikor molekülleri ve bunların kullanımları ile ilgilidir. Daha özel olarak, buluş, "pan-spesifik" antikor moleküllerini denilen TGFß1, TGFß2 ve TGFß3'ü bağlayan ve tercih edildiği üzere bunları nötralize eden antikor molekülleri ve bu tür antikor moleküllerinin kullanımları ile ilgilidir. Mevcut buluş içerisinde tercih edilen düzenlemeler, antikorun tamamı (örneğin, IgGl veya IgG4 gibi IgG) veya antikor fragmanları (örneğin, scFv, Fab, dAb) olarak antikor molekülleridir.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65134305P | 2005-02-08 | 2005-02-08 |
Publications (1)
Publication Number | Publication Date |
---|---|
TR201901929T4 true TR201901929T4 (tr) | 2019-03-21 |
Family
ID=36793677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TR2019/01929T TR201901929T4 (tr) | 2005-02-08 | 2006-02-08 | TGFBeta'ya antikorlar. |
Country Status (20)
Country | Link |
---|---|
US (11) | US7723486B2 (tr) |
EP (2) | EP3520815B1 (tr) |
JP (5) | JP5174466B2 (tr) |
CN (3) | CN101163502A (tr) |
AU (1) | AU2006213875B2 (tr) |
BR (1) | BRPI0607639B1 (tr) |
CA (2) | CA2597098C (tr) |
CY (1) | CY1121424T1 (tr) |
DK (1) | DK1850873T3 (tr) |
ES (2) | ES2905923T3 (tr) |
HK (2) | HK1201859A1 (tr) |
HU (1) | HUE042689T2 (tr) |
IL (3) | IL184995A (tr) |
LT (1) | LT1850873T (tr) |
MX (1) | MX2007009545A (tr) |
PL (2) | PL1850873T3 (tr) |
PT (2) | PT3520815T (tr) |
SI (1) | SI1850873T1 (tr) |
TR (1) | TR201901929T4 (tr) |
WO (1) | WO2006086469A2 (tr) |
Families Citing this family (116)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7563874B2 (en) * | 1998-08-31 | 2009-07-21 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
RU2386638C2 (ru) * | 2004-03-31 | 2010-04-20 | Дженентек, Инк. | Гуманизированные анти-тфр-бета-антитела |
WO2006086469A2 (en) | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
DK2083863T3 (da) | 2006-10-03 | 2015-06-22 | Genzyme Corp | Antistoffer mod tgf-beta til anvendelse til behandling af spædbørn med risiko for udvikling af bronkopulmonal dysplasi |
EP2059534B1 (en) * | 2007-02-23 | 2012-04-25 | Schering Corporation | Engineered anti-il-23p19 antibodies |
SG178804A1 (en) | 2007-02-23 | 2012-03-29 | Schering Corp | Engineered anti-il-23p19 antibodies |
CA2680741A1 (en) | 2007-03-22 | 2009-01-15 | The Regents Of The University Of California | Therapeutic monoclonal antibodies that neutralize botulinum neurotoxins |
EP2313434A4 (en) | 2008-07-31 | 2013-03-27 | Univ California | NEUTRALIZING ANTIBODIES OF BOTULINIC NEUROTOXINS |
UA112050C2 (uk) * | 2008-08-04 | 2016-07-25 | БАЄР ХЕЛСКЕР ЛЛСі | Терапевтична композиція, що містить моноклональне антитіло проти інгібітора шляху тканинного фактора (tfpi) |
TWI614267B (zh) | 2009-05-13 | 2018-02-11 | 建新公司 | 抗人類cd52免疫球蛋白 |
SI3345615T1 (sl) | 2010-03-01 | 2020-03-31 | Bayer Healthcare Llc | Optimizirana monoklonska protitelesa proti zaviralcu poti tkivnega faktorja (TFPI) |
SI2835053T1 (sl) | 2010-03-12 | 2016-09-30 | Genzyme Corporation | Kombinirana terapija za zdravljenje raka dojke |
WO2012047427A2 (en) | 2010-08-31 | 2012-04-12 | The Regents Of The University Of California | Antibodies for botulinum neurotoxins |
SG187953A1 (en) * | 2010-09-01 | 2013-03-28 | Genzyme Corp | Treatment of myocardial infarction using tgf - beta antagonists |
RU2018102375A (ru) | 2010-11-18 | 2019-02-21 | Зе Дженерал Хоспитал Корпорейшен | Новые композиции и применения антигипертензивных средств для терапии рака |
PE20140633A1 (es) | 2010-11-19 | 2014-05-30 | Eisai Randd Man Co Ltd | Anticuerpos neutralizadores anti-ccl20 |
SI2714735T1 (sl) * | 2011-06-03 | 2021-12-31 | Xoma Technology Ltd. | Protitelesa, specifična za TGF-beta |
EP2737083A1 (en) | 2011-07-27 | 2014-06-04 | INSERM (Institut National de la Santé et de la Recherche Scientifique) | Methods for diagnosing and treating myhre syndrome |
AU2011379972B2 (en) | 2011-10-26 | 2016-05-12 | Seattle Children's Research Institute | Cysteamine in the treatment of fibrotic disease |
US9782452B2 (en) | 2011-11-22 | 2017-10-10 | Cornell University | Methods for stimulating hematopoietic recovery by inhibiting TGFβ signaling |
ES2694203T3 (es) | 2012-03-08 | 2018-12-19 | Ludwig Institute For Cancer Research Limited | Anticuerpos específicos del Tgf-1 y métodos y usos de los mismos |
BR112014022200A2 (pt) | 2012-03-08 | 2019-09-24 | Selig Sealing Products Inc | membro de vedação de recipiente com compodnente de segurança protegido e aba de remoção |
RU2681502C2 (ru) * | 2013-03-11 | 2019-03-06 | Джензим Корпорейшн | Сконструированные анти-tgf-бета антитела и антиген-связывающие фрагменты |
HUE057521T2 (hu) | 2013-03-14 | 2022-05-28 | Brigham & Womens Hospital Inc | Készítmények és eljárások epithelialis õssejtek szaporítására és tenyésztésére |
MY172324A (en) * | 2013-03-20 | 2019-11-21 | Genzyme Corp | Methods for treating osteogenesis imperfecta |
PL2981822T3 (pl) | 2013-05-06 | 2021-07-12 | Scholar Rock, Inc. | Kompozycje i sposoby modulacji czynnika wzrostu |
WO2015027082A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
ES2739203T3 (es) * | 2014-05-16 | 2020-01-29 | Wellhead Biological Tech Corp | Uso del ginsenósido M1 para la inhibición de la fibrosis renal |
EP3189134A1 (en) | 2014-09-03 | 2017-07-12 | The Brigham and Women's Hospital, Inc. | Compositions, systems, and methods for generating inner ear hair cells for treatment of hearing loss |
MA41044A (fr) | 2014-10-08 | 2017-08-15 | Novartis Ag | Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer |
AU2015333687B2 (en) | 2014-10-14 | 2021-03-18 | Dana-Farber Cancer Institute, Inc. | Antibody molecules to PD-L1 and uses thereof |
CA2971186A1 (en) | 2014-12-15 | 2016-06-23 | The Regents Of The University Of California | Cytotoxic molecules responsive to intracellular ligands for selective t cell mediated killing |
EP3240805A4 (en) | 2014-12-15 | 2018-05-09 | The Regents of the University of California | Bispecific or-gate chimeric antigen receptor responsive to cd19 and cd20 |
CN107530423B (zh) | 2015-01-14 | 2022-04-05 | 布里格姆及妇女医院股份有限公司 | 用抗lap单克隆抗体治疗癌症 |
EP3277716B1 (en) | 2015-04-03 | 2020-06-24 | XOMA Technology Ltd. | Treatment of cancer using inhibitors of tgf-beta and pd-1 |
EP3307772B1 (en) | 2015-06-12 | 2020-09-09 | Ludwig Institute For Cancer Research Limited | Tgf-beta 3 specific antibodies and methods and uses thereof |
TW201718010A (zh) * | 2015-06-19 | 2017-06-01 | 健臻公司 | 治療原發性局部節段性腎小球硬化症之方法 |
WO2017019897A1 (en) | 2015-07-29 | 2017-02-02 | Novartis Ag | Combination therapies comprising antibody molecules to tim-3 |
PT3317301T (pt) | 2015-07-29 | 2021-07-09 | Novartis Ag | Terapias de associação compreendendo moléculas de anticorpo contra lag-3 |
AU2016301380B2 (en) | 2015-08-04 | 2021-07-01 | Acceleron Pharma Inc. | Methods for treating myeloproliferative disorders |
WO2017075433A1 (en) * | 2015-10-30 | 2017-05-04 | The Regents Of The University Of California | Transforming growth factor-beta-responsive polypeptides and their methods for use |
CN108495651A (zh) | 2015-12-17 | 2018-09-04 | 诺华股份有限公司 | 抗pd-1的抗体分子及其用途 |
WO2017106630A1 (en) | 2015-12-18 | 2017-06-22 | The General Hospital Corporation | Polyacetal polymers, conjugates, particles and uses thereof |
EP3400286A1 (en) | 2016-01-08 | 2018-11-14 | Massachusetts Institute Of Technology | Production of differentiated enteroendocrine cells and insulin producing cells |
RU2018130106A (ru) * | 2016-01-21 | 2020-02-21 | Дзе Скриппс Рисерч Инститьют | Вакцина против синтетических опиоидов |
US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
ES2951648T3 (es) | 2016-03-11 | 2023-10-24 | Scholar Rock Inc | Inmunoglobulinas de unión a Tgfbeta1 y uso de las mismas |
MX2018014047A (es) | 2016-05-17 | 2019-06-20 | Genentech Inc | Firmas de genes estromales para el diagnóstico y uso en inmunoterapia. |
GB201610044D0 (en) * | 2016-06-08 | 2016-07-20 | Ucb Biopharma Sprl | Antibodies |
JP2019533003A (ja) * | 2016-08-11 | 2019-11-14 | プレシセラ,インコーポレイテッド | TGF−βアンタゴニストコンジュゲート |
KR20190057308A (ko) | 2016-09-02 | 2019-05-28 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 인터류킨-6 수용체 알파-결합 단일 사슬 가변 단편을 포함하는 방법 및 조성물 |
WO2018043734A1 (en) * | 2016-09-05 | 2018-03-08 | Chugai Seiyaku Kabushiki Kaisha | Anti-tgf-beta 1 antibodies and methods of use |
US10610104B2 (en) | 2016-12-07 | 2020-04-07 | Progenity, Inc. | Gastrointestinal tract detection methods, devices and systems |
CA3048220A1 (en) | 2016-12-30 | 2018-07-05 | Frequency Therapeutics, Inc. | 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
US20180207267A1 (en) | 2017-01-06 | 2018-07-26 | Scholar Rock, Inc. | Isoform-specific, context-permissive tgfb1 inhibitors and use thereof |
AR110755A1 (es) | 2017-01-20 | 2019-05-02 | Genzyme Corp | Anticuerpos dirigidos a hueso |
WO2018134681A1 (en) | 2017-01-20 | 2018-07-26 | Sanofi | Anti-tgf-beta antibodies and their use |
TW202313678A (zh) | 2017-01-20 | 2023-04-01 | 法商賽諾菲公司 | 抗TGF-β抗體及其用途 |
US11021527B2 (en) | 2017-05-04 | 2021-06-01 | Acceleron Pharma Inc. | Transforming growth factor beta receptor type II fusion polypeptides |
WO2018237157A1 (en) | 2017-06-22 | 2018-12-27 | Novartis Ag | CD73 BINDING ANTIBODY MOLECULES AND USES THEREOF |
EP3642240A1 (en) | 2017-06-22 | 2020-04-29 | Novartis AG | Antibody molecules to cd73 and uses thereof |
WO2019075090A1 (en) | 2017-10-10 | 2019-04-18 | Tilos Therapeutics, Inc. | ANTI-LAP ANTIBODIES AND USES THEREOF |
JP2021502066A (ja) | 2017-11-06 | 2021-01-28 | ジェネンテック, インコーポレイテッド | がんの診断及び療法 |
AU2018368731A1 (en) | 2017-11-16 | 2020-05-14 | Novartis Ag | Combination therapies |
US20200371091A1 (en) | 2017-11-30 | 2020-11-26 | Novartis Ag | Bcma-targeting chimeric antigen receptor, and uses thereof |
CA3093468A1 (en) | 2018-03-09 | 2019-09-12 | Agenus Inc. | Anti-cd73 antibodies and methods of use thereof |
US20210147547A1 (en) | 2018-04-13 | 2021-05-20 | Novartis Ag | Dosage Regimens For Anti-Pd-L1 Antibodies And Uses Thereof |
UY38247A (es) | 2018-05-30 | 2019-12-31 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
US20210214459A1 (en) | 2018-05-31 | 2021-07-15 | Novartis Ag | Antibody molecules to cd73 and uses thereof |
PE20210320A1 (es) | 2018-06-01 | 2021-02-16 | Novartis Ag | Moleculas de union contra bcma y usos de las mismas |
WO2019246317A1 (en) | 2018-06-20 | 2019-12-26 | Progenity, Inc. | Treatment of a disease or condition in a tissue originating from the endoderm |
AU2019301283A1 (en) * | 2018-07-10 | 2021-02-04 | Sanofi | Combination therapies against cancer targeting CD38 and TGF-beta |
AR116109A1 (es) | 2018-07-10 | 2021-03-31 | Novartis Ag | Derivados de 3-(5-amino-1-oxoisoindolin-2-il)piperidina-2,6-diona y usos de los mismos |
SI3677278T1 (sl) | 2018-07-11 | 2022-01-31 | Scholar Rock, Inc. | Izoformno selektivni zaviralci TGFBETA1 in uporaba le-teh |
TW202019957A (zh) | 2018-07-11 | 2020-06-01 | 美商供石公司 | TGFβ1抑制劑及其用途 |
US20210122814A1 (en) | 2018-07-11 | 2021-04-29 | Scholar Rock, Inc. | HIGH-AFFINITY, ISOFORM-SELECTIVE TGFß1 INHIBITORS AND USE THEREOF |
WO2020021465A1 (en) | 2018-07-25 | 2020-01-30 | Advanced Accelerator Applications (Italy) S.R.L. | Method of treatment of neuroendocrine tumors |
US11162071B2 (en) | 2018-08-17 | 2021-11-02 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating JAG-1 |
WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
CN113164780A (zh) | 2018-10-10 | 2021-07-23 | 泰洛斯治疗公司 | 抗lap抗体变体及其用途 |
CA3118186A1 (en) | 2018-11-05 | 2020-05-14 | Ludwig Institute For Cancer Research Ltd | Humanized and variant tgf-.beta.1 specific antibodies and methods and uses thereof |
WO2020095104A1 (en) | 2018-11-05 | 2020-05-14 | Ludwig Institute For Cancer Research Ltd. | HUMANIZED AND VARIANT TGF-β3 SPECIFIC ANTIBODIES AND METHODS AND USES THEREOF |
WO2020106750A1 (en) | 2018-11-19 | 2020-05-28 | Progenity, Inc. | Methods and devices for treating a disease with biotherapeutics |
BR112021011874A2 (pt) | 2018-12-20 | 2021-09-08 | Novartis Ag | Regime de dosagem e combinação farmacêutica compreendendo derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona |
EA202192130A1 (ru) | 2019-01-30 | 2021-12-28 | Сколар Рок, Инк. | Специфичные к ltbp-комплексу ингибиторы tgf и их применение |
KR20210129672A (ko) | 2019-02-15 | 2021-10-28 | 노파르티스 아게 | 치환된 3-(1-옥소이소인돌린-2-일)피페리딘-2,6-디온 유도체 및 이의 용도 |
MX2021009763A (es) | 2019-02-15 | 2021-09-08 | Novartis Ag | Derivados de 3-(1-oxo-5-(piperidin-4-il)isoindolin-2-il)piperidina -2,6-diona y usos de los mismos. |
WO2020201362A2 (en) | 2019-04-02 | 2020-10-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of predicting and preventing cancer in patients having premalignant lesions |
AU2020322474A1 (en) * | 2019-08-01 | 2022-03-10 | Vaccinex,Inc. | Combined inhibition of semaphorin-4D and TGFβ and compositions therefor |
TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
JP2022548881A (ja) | 2019-09-18 | 2022-11-22 | ノバルティス アーゲー | Entpd2抗体、組合せ療法並びに抗体及び組合せ療法を使用する方法 |
WO2021081258A1 (en) | 2019-10-23 | 2021-04-29 | Cue Biopharma, Inc. | TGF-β POLYPEPTIDES |
CN115666704A (zh) | 2019-12-13 | 2023-01-31 | 比奥拉治疗股份有限公司 | 用于将治疗剂递送至胃肠道的可摄取装置 |
CA3165399A1 (en) | 2019-12-20 | 2021-06-24 | Novartis Ag | Uses of anti-tgf-beta antibodies and checkpoint inhibitors for the treatment of proliferative diseases |
BR112022013733A2 (pt) | 2020-01-11 | 2022-11-01 | Scholar Rock Inc | Inibidores de tgfbeta e uso dos mesmos |
CN117551194A (zh) | 2020-03-19 | 2024-02-13 | 基因泰克公司 | 同种型选择性抗TGF-β抗体及使用方法 |
BR112022026202A2 (pt) | 2020-06-23 | 2023-01-17 | Novartis Ag | Regime de dosagem compreendendo derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona |
US20230321285A1 (en) | 2020-08-31 | 2023-10-12 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
US20230338587A1 (en) | 2020-08-31 | 2023-10-26 | Advanced Accelerator Applications International Sa | Method of treating psma-expressing cancers |
WO2022097060A1 (en) | 2020-11-06 | 2022-05-12 | Novartis Ag | Cd19 binding molecules and uses thereof |
AU2021388155A1 (en) | 2020-11-25 | 2023-06-15 | Catamaran Bio, Inc. | Cellular therapeutics engineered with signal modulators and methods of use thereof |
EP4284510A1 (en) | 2021-01-29 | 2023-12-06 | Novartis AG | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
CA3208365A1 (en) | 2021-02-15 | 2022-08-18 | Chantal KUHN | Cell therapy compositions and methods for modulating tgf-b signaling |
EP4294827A1 (en) | 2021-02-19 | 2023-12-27 | Theripion, Inc. | Paraoxonase fusion polypeptides and related compositions and methods |
TW202304979A (zh) | 2021-04-07 | 2023-02-01 | 瑞士商諾華公司 | 抗TGFβ抗體及其他治療劑用於治療增殖性疾病之用途 |
CN112940119B (zh) * | 2021-04-26 | 2022-05-20 | 北京芳渟阳生生物科技有限公司 | 一种单克隆抗体及其与间充质干细胞外泌体的联合应用 |
AR125874A1 (es) | 2021-05-18 | 2023-08-23 | Novartis Ag | Terapias de combinación |
WO2022256723A2 (en) | 2021-06-03 | 2022-12-08 | Scholar Rock, Inc. | Tgf-beta inhibitors and therapeutic use thereof |
IL310164A (en) | 2021-08-11 | 2024-03-01 | Hcw Biologics Inc | Multichain chimeric polypeptides and their use in the treatment of liver diseases |
WO2023080900A1 (en) | 2021-11-05 | 2023-05-11 | Genentech, Inc. | Methods and compositions for classifying and treating kidney cancer |
US20230372444A1 (en) | 2022-04-13 | 2023-11-23 | HCW Biologics, Inc. | Methods of reducing neuroinflammation |
WO2023201310A1 (en) | 2022-04-13 | 2023-10-19 | HCW Biologics, Inc. | Multi-chain chimeric polypeptide for use in the treatment of circardian clock gene disorder |
WO2024077166A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating lung cancer |
WO2024077095A1 (en) | 2022-10-05 | 2024-04-11 | Genentech, Inc. | Methods and compositions for classifying and treating bladder cancer |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2056642B (en) | 1979-08-08 | 1983-05-11 | Dawson Int | Radio frequency drying of textile material |
GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5571714A (en) * | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
EP0561921A1 (en) | 1990-12-10 | 1993-09-29 | Panama Engineering Pty Limited | Fork-lift attachment |
DE122004000008I1 (de) | 1991-06-14 | 2005-06-09 | Genentech Inc | Humanisierter Heregulin Antikörper. |
US5565332A (en) * | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
DK0605522T3 (da) | 1991-09-23 | 2000-01-17 | Medical Res Council | Fremgangsmåde til fremstilling af humaniserede antistoffer |
US5269388A (en) | 1991-11-12 | 1993-12-14 | Stress-Tek, Inc. | Weighing bed |
US5543143A (en) * | 1992-03-06 | 1996-08-06 | Corixa Corporation | Method for activating macrophages/monocytes |
EP0672142B1 (en) | 1992-12-04 | 2001-02-28 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
US5824655A (en) | 1995-02-15 | 1998-10-20 | The University Of Utah | Anti-transforming growth factor-β gene therapy |
GB9601081D0 (en) | 1995-10-06 | 1996-03-20 | Cambridge Antibody Tech | Specific binding members for human transforming growth factor beta;materials and methods |
WO1997029131A1 (en) | 1996-02-09 | 1997-08-14 | Basf Aktiengesellschaft | HUMAN ANTIBODIES THAT BIND HUMAN TNF$g(a) |
CN1330377C (zh) | 1996-03-10 | 2007-08-08 | 明治乳业株式会社 | 用于治疗***反应疾病的基于肽的免疫治疗剂 |
WO2000034784A1 (en) | 1998-12-10 | 2000-06-15 | Phylos, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
TR200503572T2 (tr) * | 1999-03-25 | 2006-04-21 | Knoll Gmbh & Co. Kg. | Beşeri IL-12'yi bağlayan beşeri antikorlar ve bunları üretmek için yöntemler. |
US6492497B1 (en) * | 1999-04-30 | 2002-12-10 | Cambridge Antibody Technology Limited | Specific binding members for TGFbeta1 |
US7323311B2 (en) | 2000-03-03 | 2008-01-29 | Cambridge Antibody Technology Limited | Methods of obtaining a specific binding member that binds eotaxin |
US20030224501A1 (en) * | 2000-03-17 | 2003-12-04 | Young Paul E. | Bone morphogenic protein polynucleotides, polypeptides, and antibodies |
CN1323716C (zh) * | 2000-12-06 | 2007-07-04 | 应用研究***Ars股份公司 | Sarp-1在治疗和/或预防硬皮病中的应用 |
US7560558B2 (en) * | 2002-08-23 | 2009-07-14 | Kirin Beer Kabushiki Kaisha | Compound having TGFβ inhibitory activity and medicinal composition containing the same |
US20060286105A1 (en) * | 2003-04-30 | 2006-12-21 | Steven Ledbetter | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
WO2005010049A2 (en) | 2003-07-09 | 2005-02-03 | Eli Lilly And Company | Tgf-beta1 ligands |
GB0407315D0 (en) * | 2003-07-15 | 2004-05-05 | Cambridge Antibody Tech | Human antibody molecules |
JP2005112812A (ja) * | 2003-10-09 | 2005-04-28 | Zeria Pharmaceut Co Ltd | リン酸化部位特異的抗体及びそれを用いたスクリーニング方法 |
JP4842834B2 (ja) | 2003-12-09 | 2011-12-21 | ノボザイムス,インコーポレイティド | 糸状菌株における遺伝子の発現を排除するか又は低めるための方法 |
RU2386638C2 (ru) * | 2004-03-31 | 2010-04-20 | Дженентек, Инк. | Гуманизированные анти-тфр-бета-антитела |
KR100749566B1 (ko) * | 2004-04-21 | 2007-08-16 | 이화여자대학교 산학협력단 | Alk5 및/또는 alk4 억제제로 유효한 2-피리딜이치환된 이미다졸 유도체 |
WO2006086469A2 (en) * | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
ITMI20110376A1 (it) | 2011-03-10 | 2012-09-11 | Wilic Sarl | Aerogeneratore raffreddato a fluido |
DE102011078333A1 (de) | 2011-06-29 | 2013-01-03 | Siemens Aktiengesellschaft | Überspannungsableiter |
-
2006
- 2006-02-08 WO PCT/US2006/004424 patent/WO2006086469A2/en active Application Filing
- 2006-02-08 MX MX2007009545A patent/MX2007009545A/es active IP Right Grant
- 2006-02-08 EP EP18208382.4A patent/EP3520815B1/en active Active
- 2006-02-08 PT PT182083824T patent/PT3520815T/pt unknown
- 2006-02-08 PT PT06734583T patent/PT1850873T/pt unknown
- 2006-02-08 CN CNA2006800088389A patent/CN101163502A/zh active Pending
- 2006-02-08 LT LTEP06734583.5T patent/LT1850873T/lt unknown
- 2006-02-08 ES ES18208382T patent/ES2905923T3/es active Active
- 2006-02-08 PL PL06734583T patent/PL1850873T3/pl unknown
- 2006-02-08 DK DK06734583.5T patent/DK1850873T3/en active
- 2006-02-08 CN CN201410331821.3A patent/CN104177497B/zh active Active
- 2006-02-08 CA CA2597098A patent/CA2597098C/en active Active
- 2006-02-08 CN CN201410332384.7A patent/CN104151427B/zh active Active
- 2006-02-08 PL PL18208382T patent/PL3520815T3/pl unknown
- 2006-02-08 JP JP2007554339A patent/JP5174466B2/ja active Active
- 2006-02-08 ES ES06734583T patent/ES2711213T3/es active Active
- 2006-02-08 HU HUE06734583A patent/HUE042689T2/hu unknown
- 2006-02-08 CA CA2930677A patent/CA2930677A1/en not_active Abandoned
- 2006-02-08 AU AU2006213875A patent/AU2006213875B2/en active Active
- 2006-02-08 TR TR2019/01929T patent/TR201901929T4/tr unknown
- 2006-02-08 SI SI200632315T patent/SI1850873T1/sl unknown
- 2006-02-08 BR BRPI0607639-4A patent/BRPI0607639B1/pt active IP Right Grant
- 2006-02-08 US US11/350,906 patent/US7723486B2/en active Active
- 2006-02-08 EP EP06734583.5A patent/EP1850873B1/en active Active
-
2007
- 2007-01-30 US US11/700,684 patent/US20070264255A1/en not_active Abandoned
- 2007-01-30 US US11/700,711 patent/US20070134246A1/en not_active Abandoned
- 2007-08-02 IL IL184995A patent/IL184995A/en active IP Right Grant
-
2010
- 2010-03-15 US US12/724,347 patent/US8383780B2/en active Active
-
2012
- 2012-08-16 JP JP2012180580A patent/JP5726140B2/ja active Active
- 2012-09-13 US US13/615,388 patent/US8591901B2/en active Active
-
2013
- 2013-04-14 IL IL225752A patent/IL225752A/en active IP Right Grant
- 2013-10-21 US US14/059,241 patent/US9090685B2/en active Active
-
2014
- 2014-09-22 JP JP2014192304A patent/JP6005703B2/ja active Active
-
2015
- 2015-03-10 HK HK15102452.0A patent/HK1201859A1/xx unknown
- 2015-03-10 HK HK15102453.9A patent/HK1201860A1/xx unknown
- 2015-04-09 US US14/682,975 patent/US9481726B2/en active Active
-
2016
- 2016-03-30 JP JP2016067713A patent/JP6341945B2/ja active Active
- 2016-09-28 US US15/278,819 patent/US10174108B2/en active Active
-
2017
- 2017-08-01 JP JP2017148818A patent/JP6463807B2/ja active Active
- 2017-10-16 IL IL255078A patent/IL255078B/en active IP Right Grant
-
2018
- 2018-11-21 US US16/197,802 patent/US10781252B2/en active Active
-
2019
- 2019-02-26 CY CY20191100235T patent/CY1121424T1/el unknown
-
2020
- 2020-08-19 US US16/997,365 patent/US20210061897A1/en not_active Abandoned
-
2022
- 2022-09-16 US US17/932,950 patent/US20230078449A1/en active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
TR201901929T4 (tr) | TGFBeta'ya antikorlar. | |
AU2018272852A8 (en) | Antibodies comprising modified heavy constant regions | |
WO2006089133A8 (en) | Anti-cd19 antibodies and uses in oncology | |
TW200738748A (en) | Human monoclonal antibody human CD134 (OX40) and methods of making and using same | |
HRP20191462T1 (hr) | Antitijela usmjerena protiv her-3 i njihove uporabe | |
WO2016081746A8 (en) | Antibodies comprising modified heavy constant regions | |
EA201070695A1 (ru) | Молекулы гуманизированных антител, специфичных к il-31 | |
CY1116632T1 (el) | Εξουδετερωτες αντισωματων του τελεστη διεγερσης αποικιων κοκκιοκυτταρων μακροφαγων ανθρωπου | |
CO6260104A2 (es) | Anticuerpos contra la il-25 | |
RS53760B1 (en) | HUMAN ANTIBODIES RELATING TO MESOTELINE AND THEIR USES | |
PE20091342A1 (es) | Inmunoglobulinas | |
PE20081899A1 (es) | Anticuerpos anti-ige | |
WO2005016969A3 (en) | Cd20-binding polypeptide compositions | |
DE602006013029D1 (de) | Anti-egfr-antikörper | |
WO2006121852A3 (en) | Anti-cd19 antibody therapy for autoimmune disease | |
CR20120587A (es) | Moléculas de unión al antígeno que fijan egfr, vectores que las codifican y uso de las mismas | |
GEP20104922B (en) | Antibodies to m-csf | |
EP2511301A3 (en) | Human antibodies to ERBB2 | |
UA92504C2 (en) | Anti-myostatin monoclonal antibody | |
WO2006071441A3 (en) | Antibodies directed to gpnmb and uses thereof | |
BRPI0607486A2 (pt) | anticorpo l243 humanizado, anticorpo biespecìfico ou fragmentos de ligação a antìgeno dos mesmos, composição farmacêutica, kit e uso dos referidos anticorpos | |
NZ597023A (en) | Monoclonal antibodies that bind to hGM-CSF and medical compositions comprising same | |
RS54271B1 (en) | HUMAN MONOCLONIC ANTIBODIES FOR LIGAND PROGRAMMED DEATH 1 (PD-L1) | |
SG196697A1 (en) | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof | |
WO2006133450A3 (en) | Anti-cd19 antibody therapy for the transplantation |