TR200200082T2 - MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi. - Google Patents

MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.

Info

Publication number: TR200200082T2
Authority: TR; Turkey
Prior art keywords: chronic pain; treating chronic; mek inhibitors; formula; mek
Prior art date: 1999-07-16

Application number

TR2002/00082T

Other languages

English (en)

Turkish (tr)

Inventor

Dixon Alistair

Lee Kevin

Denham Pinnock Robert

Original Assignee

Warner-Lambert Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-16

Filing date

2000-07-05

Publication date

2002-04-22

2000-07-05 Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company

2002-04-22 Publication of TR200200082T2 publication Critical patent/TR200200082T2/xx

Links

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4

TR2002/00082T 1999-07-16 2000-07-05 MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi. TR200200082T2 (tr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US14429299P	1999-07-16	1999-07-16

Publications (1)

Publication Number	Publication Date
TR200200082T2 true TR200200082T2 (tr)	2002-04-22

Family

ID=22507940

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
TR2002/00082T TR200200082T2 (tr)	1999-07-16	2000-07-05	MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.

Country Status (16)

Country	Link
EP (1)	EP1202726A2 (zh)
JP (1)	JP2003504400A (zh)
KR (1)	KR20020012315A (zh)
CN (1)	CN1373660A (zh)
AR (1)	AR024732A1 (zh)
AU (1)	AU5786000A (zh)
CA (1)	CA2374052A1 (zh)
CO (1)	CO5300398A1 (zh)
HU (1)	HUP0202623A3 (zh)
IL (1)	IL147619A0 (zh)
NZ (1)	NZ515567A (zh)
PE (1)	PE20010545A1 (zh)
PL (1)	PL352684A1 (zh)
TR (1)	TR200200082T2 (zh)
WO (1)	WO2001005392A2 (zh)
ZA (1)	ZA200109907B (zh)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1219753C (zh)	2000-07-19	2005-09-21	沃尼尔·朗伯公司	4－碘苯氨基苯氧肟酸的氧合酯
NZ518726A (en)	2001-05-09	2004-06-25	Warner Lambert Co	Method of treating or inhibiting neutrophil chemotaxis by administering a mek inhibitor
US7235537B2 (en)	2002-03-13	2007-06-26	Array Biopharma, Inc.	N3 alkylated benzimidazole derivatives as MEK inhibitors
PT3000810T (pt)	2002-03-13	2017-10-25	Array Biopharma Inc	Derivados de benzimidazole alquilado n3 como inibidores de mek
US7632866B2 (en)	2002-10-21	2009-12-15	Ramot At Tel Aviv University	Derivatives of N-phenylanthranilic acid and 2-benzimidazolone as potassium channel and/or neuron activity modulators
DE602004023207D1 (de)	2003-07-24	2009-10-29	Warner Lambert Co	Benzimidazol-derivate als mek-hemmer
US7144907B2 (en)	2003-09-03	2006-12-05	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
US7538120B2 (en)	2003-09-03	2009-05-26	Array Biopharma Inc.	Method of treating inflammatory diseases
BRPI0415018A (pt) *	2003-10-08	2006-11-28	Teijin Pharma Ltd	métodos para a produção de derivados de aminopirrolidina e de antranilamida, e, composto
CA2542210A1 (en)	2003-10-21	2005-05-06	Warner-Lambert Company Llc	Polymorphic form of n-[(r)-2,3-dihydroxy-propoxy]-3,4-difluoro-2-(2-fluoro-4-iodophenylamino)-benzamide
US7517994B2 (en)	2003-11-19	2009-04-14	Array Biopharma Inc.	Heterocyclic inhibitors of MEK and methods of use thereof
US7732616B2 (en)	2003-11-19	2010-06-08	Array Biopharma Inc.	Dihydropyridine and dihydropyridazine derivatives as inhibitors of MEK and methods of use thereof
JP4768628B2 (ja)	2003-11-19	2011-09-07	アレイバイオファーマ、インコーポレイテッド	Ｍｅｋの二環系阻害剤及びその使用方法
AU2004293026B2 (en)	2003-11-21	2012-01-19	Array Biopharma Inc.	AKT protein kinase inhibitors
MY144232A (en) *	2004-07-26	2011-08-15	Chugai Pharmaceutical Co Ltd	5-substituted-2-phenylamino benzamides as mek inhibitors
SG177981A1 (en)	2005-05-18	2012-02-28	Array Biopharma Inc	4-(phenylamino)-6-oxo-1, 6-dihydropyridazine-3-carboxamide derivatives as mek inhibitors for the treatment of hyperproliferative diseases
PL1934174T3 (pl)	2005-10-07	2011-09-30	Exelixis Inc	Azetydyny jako inhibitory w leczeniu chorób proliferacyjnych
WO2008006039A1 (en)	2006-07-06	2008-01-10	Array Biopharma Inc.	Dihydrothieno pyrimidines as akt protein kinase inhibitors
DE602007011628D1 (de)	2006-07-06	2011-02-10	Array Biopharma Inc	Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren
US8063050B2 (en)	2006-07-06	2011-11-22	Array Biopharma Inc.	Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors
UA99597C2 (ru)	2006-07-06	2012-09-10	Еррей Біофарма Інк.	Пиримидилциклопентаны как ингибиторы акт протеинкиназ
CN101605540A (zh)	2006-12-14	2009-12-16	埃克塞利希斯股份有限公司	使用mek抑制剂的方法
EP2173723B3 (en)	2007-07-05	2014-11-19	Array Biopharma Inc.	Pyrimidyl cyclopentanes as akt protein kinase inhibitors
US8846683B2 (en)	2007-07-05	2014-09-30	Array Biopharma, Inc.	Pyrimidyl cyclopentanes as Akt protein kinase inhibitors
US9409886B2 (en)	2007-07-05	2016-08-09	Array Biopharma Inc.	Pyrimidyl cyclopentanes as AKT protein kinase inhibitors
CA2692502C (en)	2007-07-05	2016-03-01	Array Biopharma Inc.	Pyrimidyl cyclopentanes as akt protein kinase inhibitors
WO2009037707A2 (en)	2007-09-20	2009-03-26	Ramot At Tel Aviv University Ltd.	N-phenyl anthranilic acid derivatives and uses thereof
NZ586418A (en)	2007-12-19	2012-09-28	Cancer Rec Tech Ltd	Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
WO2009089459A1 (en)	2008-01-09	2009-07-16	Array Biopharma Inc.	Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors
KR101624752B1 (ko)	2008-01-09	2016-05-26	어레이 바이오파마 인크.	Ａｋｔ 단백질 키나제 저해물질로써의 수산화된 피리미딜 시클로펜탄
WO2010051933A2 (en)	2008-11-10	2010-05-14	Bayer Schering Pharma Aktiengesellschaft	Substituted sulphonamido phenoxybenzamides
CA2777430A1 (en)	2009-10-21	2011-04-28	Bayer Pharma Aktiengesellschaft	Substituted benzosulphonamides
WO2011047796A1 (en)	2009-10-21	2011-04-28	Bayer Schering Pharma Aktiengesellschaft	Substituted halophenoxybenzamide derivatives
EP2491015A1 (en)	2009-10-21	2012-08-29	Bayer Pharma Aktiengesellschaft	Substituted benzosulphonamides
BR112012018415A2 (pt)	2010-02-01	2020-08-04	Cancer Research Technology Limited	composto, composição, métodos de preparar uma composição e de tratamento, e, uso de um composto.
JP2013542214A (ja)	2010-10-29	2013-11-21	バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング	置換フェノキシピリジン類
TR201815685T4 (tr)	2011-04-01	2018-11-21	Genentech Inc	Kanser tedavisi için akt ve mek inhibe edici bileşiklerin kombinasyonları.
CA2844699C (en)	2011-04-01	2019-05-07	Genentech, Inc.	Combinations of akt inhibitor compounds and abiraterone, and methods of use
NZ706723A (en)	2012-10-12	2018-07-27	Exelixis Inc	Novel process for making compounds for use in the treatment of cancer
WO2015038743A1 (en)	2013-09-11	2015-03-19	The Administrators Of The Tulane Educational Fund	Novel anthranilic amides and the use thereof
GB201320732D0 (en)	2013-11-25	2014-01-08	Cancer Rec Tech Ltd	Methods of chemical synthesis
GB201320729D0 (en)	2013-11-25	2014-01-08	Cancer Rec Tech Ltd	Therapeutic compounds and their use
CA3001879A1 (en)	2015-10-27	2017-05-04	Acetylon Pharmaceuticals, Inc.	Hdac inhibitors for the treatment of diabetic peripheral neuropathy
WO2019076947A1 (en) *	2017-10-17	2019-04-25	Atriva Therapeutics Gmbh	NEW MEK INHIBITOR FOR THE TREATMENT OF VIRAL AND BACTERIAL INFECTIONS
CN114008013A (zh) *	2019-06-28	2022-02-01	哥本哈根大学	伴有睡眠障碍的cns病症的治疗

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU5610398A (en) *	1997-02-28	1998-09-18	Warner-Lambert Company	Method of treating or preventing septic shock by administering a mek inhibitor
WO1999001421A1 (en) *	1997-07-01	1999-01-14	Warner-Lambert Company	2-(4-bromo or 4-iodo phenylamino) benzoic acid derivatives and their use as mek inhibitors
ATE277895T1 (de) *	1997-07-01	2004-10-15	Warner Lambert Co	4-brom or 4-iod-phenylamino- benzhydroxamsäurederivate und ihre anwendung als mek-inhibitoren
IL143236A0 (en) *	1998-12-16	2002-04-21	Warner Lambert Co	Treatment of arthritis with mek inhibitors

2000
- 2000-07-05 AU AU57860/00A patent/AU5786000A/en not_active Abandoned
- 2000-07-05 IL IL14761900A patent/IL147619A0/xx unknown
- 2000-07-05 JP JP2001510449A patent/JP2003504400A/ja active Pending
- 2000-07-05 NZ NZ515567A patent/NZ515567A/xx unknown
- 2000-07-05 KR KR1020027000609A patent/KR20020012315A/ko not_active Application Discontinuation
- 2000-07-05 EP EP00943383A patent/EP1202726A2/en not_active Withdrawn
- 2000-07-05 TR TR2002/00082T patent/TR200200082T2/xx unknown
- 2000-07-05 PL PL00352684A patent/PL352684A1/xx not_active Application Discontinuation
- 2000-07-05 HU HU0202623A patent/HUP0202623A3/hu unknown
- 2000-07-05 CN CN00809801A patent/CN1373660A/zh active Pending
- 2000-07-05 CA CA002374052A patent/CA2374052A1/en not_active Abandoned
- 2000-07-05 WO PCT/US2000/018347 patent/WO2001005392A2/en not_active Application Discontinuation
- 2000-07-13 AR ARP000103604A patent/AR024732A1/es unknown
- 2000-07-14 PE PE2000000705A patent/PE20010545A1/es not_active Application Discontinuation
- 2000-07-14 CO CO00053304A patent/CO5300398A1/es not_active Application Discontinuation
2001
- 2001-11-30 ZA ZA200109907A patent/ZA200109907B/en unknown

Also Published As

Publication number	Publication date
CN1373660A (zh)	2002-10-09
CA2374052A1 (en)	2001-01-25
NZ515567A (en)	2004-03-26
HUP0202623A3 (en)	2003-03-28
EP1202726A2 (en)	2002-05-08
KR20020012315A (ko)	2002-02-15
ZA200109907B (en)	2003-02-28
PE20010545A1 (es)	2001-06-04
AR024732A1 (es)	2002-10-23
AU5786000A (en)	2001-02-05
WO2001005392A2 (en)	2001-01-25
CO5300398A1 (es)	2003-07-31
WO2001005392A3 (en)	2001-07-19
HUP0202623A2 (hu)	2002-11-28
JP2003504400A (ja)	2003-02-04
PL352684A1 (en)	2003-09-08
IL147619A0 (en)	2002-08-14

Publication	Publication Date	Title
TR200200082T2 (tr)	2002-04-22	MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi.
TR200200205T2 (tr)	2002-06-21	MEK inhibitörleri kullanılarak kronik ağrının tedavi edilmesi
WO2001005390A3 (en)	2001-05-17	Method for treating chronic pain using mek inhibitors
BR0208105A (pt)	2004-03-09	Inibidores de metaloproteinase
BR9806752A (pt)	2000-03-14	Ftalazinonas.
ATE228111T1 (de)	2002-12-15	M-amidinophenyl-analoga als faktor-xa-inhibitoren
TR199801255T2 (xx)	1998-10-21	Vitronektin resept�r antagonistleri.
ID27838A (id)	2001-04-26	Inhibitor 1,2,3,4-tetrahidrokinolin tersubstitusi 2-tersubstitusi 4-amino sebagai inhibitor cetp
ATE297898T1 (de)	2005-07-15	4-carboxamino-2-subsitutierte-1,2,3,4- tetrahydrochinoline als cetp inhibitoren
ATE277906T1 (de)	2004-10-15	4-carboxamino-2-methyl-1,2,3,4- tetrahydrochinoline als cetp inhibitoren
DE69729583D1 (de)	2004-07-22	N-(amidinophenyl)-n'-(subst.)-3h-2,4-benzodiazepin-3-on derivative als faktor xa inhibitoren
DK0840732T3 (da)	2001-04-17	Substituerede benzolactamforbindelser som substans P-antagonister
ID18142A (id)	1998-03-05	Inhibitor metaloprotease 1,4-heterosiklik
ID18141A (id)	1998-03-05	Inhibitor metaloprotease 1,3-diheterosiklik
ATE248161T1 (de)	2003-09-15	2-aminopyridin enthaltende kondensierte zyklische systeme als nos hemme
PT1037886E (pt)	2003-09-30	Inibidores de angiogenese de triazina
BR9810459A (pt)	2006-10-03	sais nìtricos dos inibidores de ace
FI974618A (fi)	1997-12-23	Kahden- ja kolmenarvoiset pienimolekyyliset selektiininestäjät
CO5261493A1 (es)	2003-03-31	Procedimiento y compuestos para la inhibicion de la mrp1
DE69812634D1 (de)	2003-04-30	Metalloproteinase-inhibitoren
DE69625230T2 (de)	2003-09-04	Thrombininhibitoren
TR200003859T2 (tr)	2001-07-23	Amidino ve guanidino azetidinon triptaz önleyicileri
ATE211719T1 (de)	2002-01-15	Korrosionsinhibitoren enthaltender injektionszement
TR200102514T2 (tr)	2002-04-22	COPD tedavisi için metod
TR200001819T2 (tr)	2000-11-21	COPD tedavi yöntemi.