TR200003859T2 - Amidino ve guanidino azetidinon triptaz önleyicileri - Google Patents

Amidino ve guanidino azetidinon triptaz önleyicileri

Info

Publication number
TR200003859T2
TR200003859T2 TR2000/03859T TR200003859T TR200003859T2 TR 200003859 T2 TR200003859 T2 TR 200003859T2 TR 2000/03859 T TR2000/03859 T TR 2000/03859T TR 200003859 T TR200003859 T TR 200003859T TR 200003859 T2 TR200003859 T2 TR 200003859T2
Authority
TR
Turkey
Prior art keywords
triptase
azetidinone
guanidino
amidino
inhibitors
Prior art date
Application number
TR2000/03859T
Other languages
English (en)
Inventor
Bisacchi Gregory
A. Slusarchyk William
Treuner Uwe
C. Sutton James
Zahler Robert
Seiler Steven
R. Kronenthal David
E. Randazzo Michael
Xu Zhongm�N
Shi Zhongping
D. Schwinden Mark
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of TR200003859T2 publication Critical patent/TR200003859T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/06—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D205/08—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with one oxygen atom directly attached in position 2, e.g. beta-lactams

Abstract

Formül (I), (II), (III)'e ait bilesikler.
TR2000/03859T 1998-06-25 1999-06-18 Amidino ve guanidino azetidinon triptaz önleyicileri TR200003859T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US9063698P 1998-06-25 1998-06-25

Publications (1)

Publication Number Publication Date
TR200003859T2 true TR200003859T2 (tr) 2001-07-23

Family

ID=22223632

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03859T TR200003859T2 (tr) 1998-06-25 1999-06-18 Amidino ve guanidino azetidinon triptaz önleyicileri

Country Status (24)

Country Link
EP (1) EP1089973B1 (tr)
JP (1) JP2002518478A (tr)
KR (1) KR20010053173A (tr)
CN (1) CN1202081C (tr)
AR (1) AR018945A1 (tr)
AT (1) ATE309211T1 (tr)
AU (1) AU752320B2 (tr)
BR (1) BR9911373A (tr)
CA (1) CA2336003A1 (tr)
DE (1) DE69928257T2 (tr)
ES (1) ES2249017T3 (tr)
HU (1) HUP0104308A3 (tr)
ID (1) ID27137A (tr)
IL (1) IL140414A0 (tr)
NO (1) NO20006380D0 (tr)
NZ (1) NZ507627A (tr)
PE (1) PE20000729A1 (tr)
PL (1) PL345067A1 (tr)
RU (1) RU2211832C2 (tr)
TR (1) TR200003859T2 (tr)
TW (1) TW548270B (tr)
UY (1) UY25580A1 (tr)
WO (1) WO1999067215A1 (tr)
ZA (1) ZA200006028B (tr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005063704A1 (ja) 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
WO2006062110A1 (ja) * 2004-12-06 2006-06-15 Banyu Pharmaceutical Co., Ltd. ピペラジン誘導体
US8772297B2 (en) * 2010-02-17 2014-07-08 Kyoto University TGF-β signal transduction inhibitor
CA2897924A1 (en) * 2013-03-20 2014-09-25 F. Hoffmann-La Roche Ag Urea derivatives and their use as fatty-acid binding protein (fabp) inhibitors
WO2014173855A1 (en) 2013-04-22 2014-10-30 Reuter Chemische Apparatebau Kg Process for preparing enantiomerically enriched 3-hydroxymethylpiperidine
EP3036219A4 (en) * 2013-06-04 2017-08-23 Temple University Of The Commonwealth System Of Higher Education Novel beta lactams as modulators of glutamate uptake and methods for use thereof
CN108892661B (zh) * 2014-02-07 2023-03-14 艾克赛特赫拉制药有限责任公司 治疗化合物和组合物
CA3089970A1 (en) 2018-02-07 2019-08-15 eXIthera Pharmaceuticals Inc. Therapeutic compounds and compositions
EP3778588A4 (en) * 2018-03-30 2021-04-28 Shanghai Meiyue Biotech Development Co., Ltd. QUATERNARY LACTAM COMPOUND AND ITS PHARMACEUTICAL USE
CN109988098A (zh) * 2019-05-23 2019-07-09 常州工程职业技术学院 一种(r)-n-叔丁氧羰基-3-羟甲基哌啶的合成方法
WO2020259366A1 (zh) * 2019-06-25 2020-12-30 广东东阳光药业有限公司 一种凝血因子XIa抑制剂的晶型及其制备方法
JP2023515735A (ja) 2019-11-08 2023-04-14 コエヴェ セラピューティクス 修飾されたアデノ随伴ウイルスベクターおよび中枢神経系へのその送達
EP4240837A1 (en) * 2020-11-06 2023-09-13 Coave Therapeutics Lactam-modified adeno-associated virus vectors

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250677A (en) * 1990-06-04 1993-10-05 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5037819A (en) * 1990-06-04 1991-08-06 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5175283A (en) * 1990-06-04 1992-12-29 Bristol-Myers Squibb Company Azetidin-2-one derivatives as serine protease inhibitors
US5110812A (en) * 1990-06-04 1992-05-05 Bristol-Myers Squibb Co. Azetidin-2-one derivatives as serine protease inhibitors
US5747485A (en) * 1995-04-13 1998-05-05 Merck & Co., Inc. Substituted azetidiones as anti-inflammatory and antidegenerative agents
DE69711926D1 (de) * 1996-09-23 2002-05-16 Naeja Pharmaceutical Inc 3,4-disubstituierte azetidin-2-on-derivate die als cystein-proteinase regulatoren nuetzlich sind

Also Published As

Publication number Publication date
RU2211832C2 (ru) 2003-09-10
BR9911373A (pt) 2001-09-18
EP1089973A1 (en) 2001-04-11
DE69928257D1 (de) 2005-12-15
ATE309211T1 (de) 2005-11-15
AR018945A1 (es) 2001-12-12
JP2002518478A (ja) 2002-06-25
ID27137A (id) 2001-03-01
ES2249017T3 (es) 2006-03-16
EP1089973B1 (en) 2005-11-09
PL345067A1 (en) 2001-12-03
PE20000729A1 (es) 2000-10-28
EP1089973A4 (en) 2001-12-12
WO1999067215A1 (en) 1999-12-29
AU752320B2 (en) 2002-09-12
CN1307560A (zh) 2001-08-08
CA2336003A1 (en) 1999-12-29
HUP0104308A2 (hu) 2002-04-29
HUP0104308A3 (en) 2002-06-28
ZA200006028B (en) 2002-09-25
CN1202081C (zh) 2005-05-18
KR20010053173A (ko) 2001-06-25
NZ507627A (en) 2003-12-19
TW548270B (en) 2003-08-21
NO20006380L (no) 2000-12-14
IL140414A0 (en) 2002-02-10
DE69928257T2 (de) 2006-08-03
NO20006380D0 (no) 2000-12-14
AU4695099A (en) 2000-01-10
UY25580A1 (es) 2001-08-27

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