TR200101858T2 - JNK protein kinaz inhibitörleri olarak 4-ariloksindoller - Google Patents

JNK protein kinaz inhibitörleri olarak 4-ariloksindoller

Info

Publication number
TR200101858T2
TR200101858T2 TR2001/01858T TR200101858T TR200101858T2 TR 200101858 T2 TR200101858 T2 TR 200101858T2 TR 2001/01858 T TR2001/01858 T TR 2001/01858T TR 200101858 T TR200101858 T TR 200101858T TR 200101858 T2 TR200101858 T2 TR 200101858T2
Authority
TR
Turkey
Prior art keywords
aryloxindoles
protein kinase
kinase inhibitors
jnk protein
jnk
Prior art date
Application number
TR2001/01858T
Other languages
English (en)
Inventor
Lea Corbett Wendy
Luk Kin-Chun
E. Mahaney Paige
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR200101858T2 publication Critical patent/TR200101858T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

Bu bulus yeni formül (I)4-ariloksindolleri ile ilgilidir ki burada R2,R3 X ve A tarifnamede belirtildigi gibidir ve bunlar protein kinazlari, özellikle de JNK protein kinazlari inhibe eder ya da hafifletir ve bu nedenle iltihaba karsi maddeler olarak ve özellikle romatizmal artirit tedavisinde kullanislidirlar.
TR2001/01858T 1998-12-17 1999-12-09 JNK protein kinaz inhibitörleri olarak 4-ariloksindoller TR200101858T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11259098P 1998-12-17 1998-12-17
US14902899P 1999-08-16 1999-08-16

Publications (1)

Publication Number Publication Date
TR200101858T2 true TR200101858T2 (tr) 2001-12-21

Family

ID=26810127

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01858T TR200101858T2 (tr) 1998-12-17 1999-12-09 JNK protein kinaz inhibitörleri olarak 4-ariloksindoller

Country Status (10)

Country Link
US (1) US6307056B1 (tr)
EP (1) EP1149093A1 (tr)
JP (1) JP2002532493A (tr)
KR (1) KR20010101266A (tr)
CN (1) CN1136217C (tr)
AU (1) AU760039B2 (tr)
BR (1) BR9916223A (tr)
CA (1) CA2354591A1 (tr)
TR (1) TR200101858T2 (tr)
WO (1) WO2000035909A1 (tr)

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CN103356710A (zh) 2007-02-12 2013-10-23 人类起源公司 利用胎盘干细胞治疗炎性疾病
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Also Published As

Publication number Publication date
CA2354591A1 (en) 2000-06-22
EP1149093A1 (en) 2001-10-31
AU760039B2 (en) 2003-05-08
KR20010101266A (ko) 2001-11-14
JP2002532493A (ja) 2002-10-02
BR9916223A (pt) 2001-09-04
CN1136217C (zh) 2004-01-28
US6307056B1 (en) 2001-10-23
WO2000035909A1 (en) 2000-06-22
CN1330648A (zh) 2002-01-09
AU2281500A (en) 2000-07-03

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