TNSN99090A1 - Agonistes et antagonistes selectifs de il-2 - Google Patents
Agonistes et antagonistes selectifs de il-2Info
- Publication number
- TNSN99090A1 TNSN99090A1 TNTNSN99090A TNSN99090A TNSN99090A1 TN SN99090 A1 TNSN99090 A1 TN SN99090A1 TN TNSN99090 A TNTNSN99090 A TN TNSN99090A TN SN99090 A TNSN99090 A TN SN99090A TN SN99090 A1 TNSN99090 A1 TN SN99090A1
- Authority
- TN
- Tunisia
- Prior art keywords
- cells
- muteins
- human
- mutein
- agonists
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/55—IL-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
L'INVENTION CONCERNE UN POLYPEPTIDE COMPRENANT UNE MUTEINE DE IL-2 HUMAINE NUMEROTEE CONFORMEMENT A LA IL-2 DE TYPE SAUVAGE DANS LAQUELLE LADITE IL-2 HUMAINE EST SUBSTITUEE SUR AU MOINS L'UNE DES POSITIONS 20,88 ET 126 EN CONSEQUENCE DE QUOI LADITE MUTEINE ACTIVE DE FACON PREFERENTIELLE LES CELLULES T, PLUTOT QUE LES CELLULES TUEUSES NATURELLES. D20H ET I, N88G, I ET R, EN PARTICULIER, ONT UNE ACTIVITE DIFFERENTIELLE RELATIVE SUR LES CELLULES T BIEN SUPERIEURE A CELLE DE LA IL-2 NATIVE, AVEC UNE TOXICITE ASSOCIEE PREVUE REDUITE in vivo. L'INVENTION COMPREND AUSSI DES POLYNUCLEOTIDES CODANT LES MUTEINES DE L'INVENTION, DES VECTEURS CONTENANT LES POLYNUCLEOTIDES, DES CELLULES HOTES TRANSFORMEES, DES COMPOSITIONS PHARMACEUTIQUES COMPRENANT LES MUTEINES, ET DES PROCEDES THERAPEUTIQUES DE TRAITEMENT.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8008098A | 1998-05-15 | 1998-05-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
TNSN99090A1 true TNSN99090A1 (fr) | 2005-11-10 |
Family
ID=22155135
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TNTNSN99090A TNSN99090A1 (fr) | 1998-05-15 | 1999-05-13 | Agonistes et antagonistes selectifs de il-2 |
Country Status (39)
Country | Link |
---|---|
EP (1) | EP1076704B1 (fr) |
JP (1) | JP4276783B2 (fr) |
KR (1) | KR100607609B1 (fr) |
CN (2) | CN101319247B (fr) |
AR (1) | AR020322A1 (fr) |
AT (1) | ATE351907T1 (fr) |
AU (1) | AU759697B2 (fr) |
BG (1) | BG65139B1 (fr) |
BR (1) | BRPI9910504B1 (fr) |
CA (1) | CA2327349C (fr) |
CO (1) | CO5070701A1 (fr) |
CU (2) | CU23273B7 (fr) |
CY (1) | CY1107533T1 (fr) |
CZ (1) | CZ302071B6 (fr) |
DE (1) | DE69934881T2 (fr) |
DK (1) | DK1076704T3 (fr) |
DZ (1) | DZ2788A1 (fr) |
ES (1) | ES2281175T3 (fr) |
HK (1) | HK1039963B (fr) |
HN (1) | HN1999000075A (fr) |
HU (1) | HU226142B1 (fr) |
IL (2) | IL139136A0 (fr) |
MY (1) | MY130274A (fr) |
NO (1) | NO329235B1 (fr) |
NZ (1) | NZ508098A (fr) |
PA (1) | PA8472601A1 (fr) |
PE (1) | PE20000475A1 (fr) |
PL (1) | PL201675B1 (fr) |
PT (1) | PT1076704E (fr) |
RO (1) | RO122150B1 (fr) |
RU (1) | RU2235729C2 (fr) |
SI (1) | SI20643B (fr) |
SK (1) | SK288100B6 (fr) |
SV (1) | SV1999000061A (fr) |
TN (1) | TNSN99090A1 (fr) |
TR (1) | TR200003354T2 (fr) |
TW (1) | TWI223663B (fr) |
UA (1) | UA73719C2 (fr) |
WO (1) | WO1999060128A1 (fr) |
Families Citing this family (77)
Publication number | Priority date | Publication date | Assignee | Title |
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AU4057300A (en) * | 1999-03-30 | 2000-10-16 | Board Of Regents, The University Of Texas System | Compositions and methods for modifying toxic effects of proteinacious compounds |
EP1935431A3 (fr) | 2000-05-15 | 2008-08-13 | Health Research, Inc. | Traitements anti-cancéreux utilisant une combinaison d'anticorps contre le HER2 et l'interleukine-2 |
US6689353B1 (en) * | 2000-06-28 | 2004-02-10 | Bayer Pharmaceuticals Corporation | Stabilized interleukin 2 |
MY139948A (en) * | 2000-09-28 | 2009-11-30 | Bayer Corp | Enhanced transfection system |
US7723102B2 (en) * | 2000-09-28 | 2010-05-25 | Bayer Corporation | Enhanced transfection system |
WO2002079415A2 (fr) | 2001-03-30 | 2002-10-10 | Lexigen Pharmaceuticals Corp. | Reduction de l'immunogenicite de proteines de fusion |
AU2002357784B2 (en) | 2001-12-04 | 2008-07-31 | Merck Patent Gmbh | Immunocytokines with modulated selectivity |
WO2005007121A2 (fr) | 2003-07-18 | 2005-01-27 | Massachusetts Institute Of Technology | Polypeptides de l'interleukine-2(il-2) mutante |
DE602004031341D1 (de) | 2003-07-21 | 2011-03-24 | Transgene Sa | Multifunktionelle cytokine |
DK1944318T3 (da) | 2003-07-21 | 2011-06-14 | Transgene Sa | Multifunktionelle cytokiner |
ATE447412T1 (de) | 2003-11-04 | 2009-11-15 | Novartis Vaccines & Diagnostic | Antagonist-anti-cd40-monoklonale antikörper und anwendungsverfahren |
JP5744369B2 (ja) * | 2004-02-27 | 2015-07-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | IL15−Rα用IL−15結合部位およびアゴニスト/アンタゴニスト活性を有する特異的IL−15突然変異体 |
BRPI0508470A (pt) * | 2004-03-05 | 2007-07-31 | Chiron Corp | sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos |
WO2009061853A2 (fr) * | 2007-11-05 | 2009-05-14 | Massachusetts Institute Of Technology | Polypeptides d'interleukine-2 (il-2) mutants |
CN101244261B (zh) * | 2008-03-10 | 2010-09-15 | 山东大学 | 一种含未复性重组蛋白的生物制剂及其制备方法与应用 |
DE102008023820A1 (de) * | 2008-05-08 | 2009-11-12 | Aicuris Gmbh & Co. Kg | Mittel zur Behandlung und/oder Prophylaxe einer Autoimmunerkrankung und zur Bildung von Regulatorischen T-Zellen |
MX2011007647A (es) | 2009-01-21 | 2011-09-01 | Amgen Inc | Composiciones y metodos para el tratamiento de enfermedades inflamatorias y autoinmunes. |
CN102101885B (zh) * | 2010-09-01 | 2013-06-05 | 南京发士达生物科技有限公司 | 低诱导抑制性t细胞的人白细胞介素ⅱ突变体及其用途 |
CU23923B1 (es) * | 2010-11-12 | 2013-07-31 | Ct De Inmunología Molecular | Polipéptidos derivados de la il-2 con actividad agonista |
RS61854B1 (sr) | 2010-11-12 | 2021-06-30 | Nektar Therapeutics | Konjugati il-2 dela i polimera |
JP6093712B2 (ja) * | 2010-12-22 | 2017-03-08 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | インターロイキン2のスーパーアゴニストおよびアンタゴニスト |
SI2673294T1 (sl) | 2011-02-10 | 2016-08-31 | Roche Glycart Ag | Mutirani polipeptidi interlevkina-2 |
WO2012119093A1 (fr) * | 2011-03-03 | 2012-09-07 | Board Of Trustees Of The Leland Stanford Junior University | Superagonistes et antagonistes de l'interleukine-2 |
EA201892619A1 (ru) | 2011-04-29 | 2019-04-30 | Роше Гликарт Аг | Иммуноконъюгаты, содержащие мутантные полипептиды интерлейкина-2 |
US20140044675A1 (en) | 2012-08-10 | 2014-02-13 | Roche Glycart Ag | Interleukin-2 fusion proteins and uses thereof |
JP2016533167A (ja) | 2013-09-24 | 2016-10-27 | メディシナ セラピューティクス ピーティーイー リミテッド | インターロイキン−2融合タンパク質及びその使用 |
KR20190126205A (ko) | 2014-02-06 | 2019-11-08 | 에프. 호프만-라 로슈 아게 | 인터류킨-2 융합 단백질 및 이의 용도 |
GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
EP3134102B1 (fr) | 2014-04-24 | 2019-07-03 | The Board of Trustees of The Leland Stanford Junior University | Superagonistes, agonistes et antagonistes partiels de l'interleukine-2 |
JP6640834B2 (ja) * | 2014-08-11 | 2020-02-05 | デリニア, インコーポレイテッド | 自己免疫疾患の処置のために調節性t細胞を選択的に活性化させる改変il−2変異体 |
US20170204154A1 (en) | 2016-01-20 | 2017-07-20 | Delinia, Inc. | Molecules that selectively activate regulatory t cells for the treatment of autoimmune diseases |
WO2017201432A2 (fr) * | 2016-05-19 | 2017-11-23 | Jounaidi Youssef | Interleukine-2 liée à son récepteur il-2rbêta, plate-forme pour améliorer l'activité des cellules tueuses naturelles et des lymphocytes t régulateurs |
US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
WO2017220988A1 (fr) | 2016-06-20 | 2017-12-28 | Kymab Limited | Anticorps multispécifiques pour l'immuno-oncologie |
AU2017281469B2 (en) * | 2016-06-22 | 2023-08-31 | David Klatzmann | Genetically modified T lymphocytes |
US11779604B2 (en) | 2016-11-03 | 2023-10-10 | Kymab Limited | Antibodies, combinations comprising antibodies, biomarkers, uses and methods |
WO2018089420A1 (fr) | 2016-11-08 | 2018-05-17 | Delinia, Inc. | Variants d'il-2 pour le traitement de maladies auto-immunes |
US10472405B2 (en) * | 2016-12-13 | 2019-11-12 | Delinia, Inc. | Multivalent regulatory T cell modulators |
JP7165717B2 (ja) | 2017-03-15 | 2022-11-04 | パンディオン・オペレーションズ・インコーポレイテッド | 標的免疫寛容 |
JOP20190271A1 (ar) | 2017-05-24 | 2019-11-21 | Novartis Ag | بروتينات مطعّمة بسيتوكين- الجسم المضاد وطرق الاستخدام للاضطرابات المتعلقة بالمناعة |
BR112019024127A2 (pt) | 2017-05-24 | 2020-06-23 | Pandion Therapeutics, Inc. | Imunotolerância alvejada |
US12006354B2 (en) | 2017-05-24 | 2024-06-11 | Novartis Ag | Antibody-IL2 engrafted proteins and methods of use in the treatment of cancer |
US20200362058A1 (en) * | 2017-05-24 | 2020-11-19 | Novartis Ag | Antibody-cytokine engrafted proteins and methods of use |
CN111201035A (zh) | 2017-06-19 | 2020-05-26 | 梅迪塞纳医疗股份有限公司 | Il-2超激动剂、激动剂及其融合体的用途和方法 |
NZ761430A (en) * | 2017-08-03 | 2024-03-22 | Synthorx Inc | Cytokine conjugates for the treatment of proliferative and infectious diseases |
EP3713592A4 (fr) * | 2017-11-21 | 2022-01-12 | The Board of Trustees of the Leland Stanford Junior University | Agonistes partiels de l'interleukine-2 |
US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
US10174092B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
SG11202005732XA (en) | 2017-12-19 | 2020-07-29 | Xencor Inc | Engineered il-2 fc fusion proteins |
US11534479B2 (en) | 2018-02-16 | 2022-12-27 | Iltoo Pharma | Use of interleukin 2 for treating Sjögren's syndrome |
PE20210313A1 (es) | 2018-03-28 | 2021-02-12 | Bristol Myers Squibb Co | Proteinas de fusion interleucina-2/receptor alfa de interleucina-2 y metodos de uso |
CA3093722A1 (fr) | 2018-03-28 | 2019-10-03 | Ascendis Pharma Oncology Division A/S | Conjugues d'il-2 |
WO2020007937A1 (fr) | 2018-07-03 | 2020-01-09 | Iltoo Pharma | Utilisation de l'interleukine-2 pour le traitement de la sclérose systémique |
BR112021000811A8 (pt) * | 2018-07-24 | 2022-10-18 | Tron Translationale Onkologie An Der Univ Der Johannes Gutenberg Univ Mainz Gemeinnuetzige Gmbh | Agonistas de il2 |
EP3836954A1 (fr) | 2018-08-13 | 2021-06-23 | Iltoo Pharma | Combinaison d'interleukine 2 et d'un inhibiteur de l'interleukine 1, conjugués et utilisations thérapeutiques de celle-ci |
BR112020015030A2 (pt) * | 2018-09-17 | 2021-03-16 | Gi Innovation, Inc. | Proteína de fusão compreendendo a proteína il-2 e a proteína cd80 e uso da mesma |
KR20210107714A (ko) | 2018-12-21 | 2021-09-01 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 인간 인터류킨-2 변이체 또는 이의 유도체 |
JP2022533702A (ja) | 2019-05-20 | 2022-07-25 | パンディオン・オペレーションズ・インコーポレイテッド | MAdCAM標的化免疫寛容 |
TW202115105A (zh) * | 2019-06-24 | 2021-04-16 | 德商拜恩迪克Rna製藥有限公司 | Il2激動劑 |
CR20220111A (es) * | 2019-08-13 | 2022-05-04 | Amgen Inc | Muteínas de interleucina-2 para la expansión de células t reguladoras referencia cruzada a solicitudes relacionadas |
JP2023505590A (ja) | 2019-12-12 | 2023-02-09 | イルトゥー・ファルマ | インターロイキン2キメラ構築物 |
CN114867749A (zh) | 2019-12-17 | 2022-08-05 | 安进公司 | 用于疗法中的双重白介素-2/tnf受体激动剂 |
US11633488B2 (en) | 2020-01-10 | 2023-04-25 | Bright Peak Therapeutics Ag | Modified IL-2 polypeptides and uses thereof |
US11491205B2 (en) | 2020-01-14 | 2022-11-08 | Synthekine, Inc. | Biased IL2 muteins methods and compositions |
WO2021168079A1 (fr) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Immunotolérance ciblée sur un tissu avec un effecteur cd39 |
CN115698052A (zh) | 2020-03-19 | 2023-02-03 | 信达生物制药(苏州)有限公司 | 白介素2突变体及其用途 |
CA3169564A1 (fr) * | 2020-03-31 | 2021-10-07 | Hanmi Pharm. Co., Ltd. | Nouveaux analogues d'il-2 immunostimulants |
CA3178074A1 (fr) | 2020-06-03 | 2021-12-09 | Nina Gunnarsson | Sequences d'il-2 et leurs utilisations |
CN114507643A (zh) * | 2020-10-29 | 2022-05-17 | 未来智人再生医学研究院(广州)有限公司 | 一种表达il-2的多能干细胞衍生物及应用 |
CA3195260A1 (fr) | 2020-10-29 | 2022-05-05 | Bristol-Myers Squibb Company | Proteines de fusion pour le traitement d'une maladie |
CN113308477A (zh) * | 2021-04-08 | 2021-08-27 | 华南农业大学 | 一种鸭il-2基因真核表达重组质粒及其制备方法 |
WO2023045977A1 (fr) | 2021-09-22 | 2023-03-30 | 信达生物制药(苏州)有限公司 | Mutant de l'interleukine-2 et sa protéine de fusion |
AU2022360645A1 (en) | 2021-10-06 | 2024-05-02 | Assistance Publique - Hôpitaux De Paris | Interleukin 2 chimeric constructs with targeting specificity to inflamed tissues |
CN114875069B (zh) * | 2022-04-22 | 2023-09-15 | 四川大学 | 基因工程修饰的il2细胞因子的重组载体、宿主细胞及其用途 |
TW202413442A (zh) * | 2022-06-16 | 2024-04-01 | 美商希佛隆有限責任公司 | 抗pd-1抗體減弱之il-2免疫結合物及其用途 |
WO2024056154A1 (fr) | 2022-09-12 | 2024-03-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Interleukine-2 pour le traitement des troubles du spectre autistique |
FR3140287A1 (fr) | 2022-10-03 | 2024-04-05 | Arkema France | Procede de granulation de composes azoiques et granules obtenus |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5696234A (en) * | 1994-08-01 | 1997-12-09 | Schering Corporation | Muteins of mammalian cytokine interleukin-13 |
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1999
- 1999-05-12 DZ DZ990088A patent/DZ2788A1/fr active
- 1999-05-13 RO ROA200001123A patent/RO122150B1/ro unknown
- 1999-05-13 WO PCT/US1999/010643 patent/WO1999060128A1/fr active IP Right Grant
- 1999-05-13 ES ES99924232T patent/ES2281175T3/es not_active Expired - Lifetime
- 1999-05-13 BR BRPI9910504A patent/BRPI9910504B1/pt not_active IP Right Cessation
- 1999-05-13 CN CN2007101609093A patent/CN101319247B/zh not_active Expired - Lifetime
- 1999-05-13 PL PL344407A patent/PL201675B1/pl unknown
- 1999-05-13 TR TR2000/03354T patent/TR200003354T2/xx unknown
- 1999-05-13 KR KR1020007012747A patent/KR100607609B1/ko not_active IP Right Cessation
- 1999-05-13 CA CA2327349A patent/CA2327349C/fr not_active Expired - Lifetime
- 1999-05-13 SI SI9920034A patent/SI20643B/sl active Search and Examination
- 1999-05-13 IL IL13913699A patent/IL139136A0/xx unknown
- 1999-05-13 TN TNTNSN99090A patent/TNSN99090A1/fr unknown
- 1999-05-13 CZ CZ20004213A patent/CZ302071B6/cs not_active IP Right Cessation
- 1999-05-13 PE PE1999000399A patent/PE20000475A1/es not_active Application Discontinuation
- 1999-05-13 SK SK1724-2000A patent/SK288100B6/sk not_active IP Right Cessation
- 1999-05-13 AU AU40784/99A patent/AU759697B2/en not_active Expired
- 1999-05-13 CN CNB998086509A patent/CN100366742C/zh not_active Expired - Lifetime
- 1999-05-13 DE DE69934881T patent/DE69934881T2/de not_active Expired - Lifetime
- 1999-05-13 UA UA2000127206A patent/UA73719C2/uk unknown
- 1999-05-13 PA PA19998472601A patent/PA8472601A1/es unknown
- 1999-05-13 DK DK99924232T patent/DK1076704T3/da active
- 1999-05-13 EP EP99924232A patent/EP1076704B1/fr not_active Expired - Lifetime
- 1999-05-13 JP JP2000549735A patent/JP4276783B2/ja not_active Expired - Lifetime
- 1999-05-13 RU RU2000131593/04A patent/RU2235729C2/ru active
- 1999-05-13 NZ NZ508098A patent/NZ508098A/en not_active IP Right Cessation
- 1999-05-13 AR ARP990102269A patent/AR020322A1/es active IP Right Grant
- 1999-05-13 HU HU0101948A patent/HU226142B1/hu unknown
- 1999-05-13 AT AT99924232T patent/ATE351907T1/de active
- 1999-05-13 PT PT99924232T patent/PT1076704E/pt unknown
- 1999-05-14 MY MYPI99001912A patent/MY130274A/en unknown
- 1999-05-14 HN HN1999000075A patent/HN1999000075A/es unknown
- 1999-05-14 SV SV1999000061A patent/SV1999000061A/es active IP Right Grant
- 1999-05-14 CO CO99030158A patent/CO5070701A1/es unknown
- 1999-05-14 TW TW088107812A patent/TWI223663B/zh not_active IP Right Cessation
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2000
- 2000-10-18 IL IL139136A patent/IL139136A/en not_active IP Right Cessation
- 2000-11-08 BG BG104929A patent/BG65139B1/bg unknown
- 2000-11-14 NO NO20005762A patent/NO329235B1/no not_active IP Right Cessation
- 2000-11-15 CU CU20000257A patent/CU23273B7/es not_active IP Right Cessation
-
2002
- 2002-02-21 HK HK02101283.2A patent/HK1039963B/zh not_active IP Right Cessation
- 2002-06-19 CU CU20020125A patent/CU23272A1/es not_active IP Right Cessation
-
2007
- 2007-03-09 CY CY20071100330T patent/CY1107533T1/el unknown
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