SG11202005732XA - Engineered il-2 fc fusion proteins - Google Patents

Engineered il-2 fc fusion proteins

Info

Publication number
SG11202005732XA
SG11202005732XA SG11202005732XA SG11202005732XA SG11202005732XA SG 11202005732X A SG11202005732X A SG 11202005732XA SG 11202005732X A SG11202005732X A SG 11202005732XA SG 11202005732X A SG11202005732X A SG 11202005732XA SG 11202005732X A SG11202005732X A SG 11202005732XA
Authority
SG
Singapore
Prior art keywords
engineered
fusion proteins
fusion
proteins
Prior art date
Application number
SG11202005732XA
Inventor
Matthew Bernett
John Desjarlais
Rajat Varma
Rumana Rashid
Suzanne Schubbert
Original Assignee
Xencor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xencor Inc filed Critical Xencor Inc
Publication of SG11202005732XA publication Critical patent/SG11202005732XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70535—Fc-receptors, e.g. CD16, CD32, CD64 (CD2314/705F)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
SG11202005732XA 2017-12-19 2018-11-30 Engineered il-2 fc fusion proteins SG11202005732XA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762607850P 2017-12-19 2017-12-19
US201862675070P 2018-05-22 2018-05-22
PCT/US2018/063443 WO2019125732A1 (en) 2017-12-19 2018-11-30 Engineered il-2 fc fusion proteins

Publications (1)

Publication Number Publication Date
SG11202005732XA true SG11202005732XA (en) 2020-07-29

Family

ID=65009801

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202005732XA SG11202005732XA (en) 2017-12-19 2018-11-30 Engineered il-2 fc fusion proteins

Country Status (12)

Country Link
US (1) US11319355B2 (en)
EP (1) EP3728302A1 (en)
JP (2) JP2021506291A (en)
KR (1) KR20200100098A (en)
CN (1) CN111655718A (en)
AU (2) AU2018390418B2 (en)
CA (1) CA3086199A1 (en)
IL (1) IL275426A (en)
MA (1) MA51291A (en)
MX (1) MX2020006322A (en)
SG (1) SG11202005732XA (en)
WO (1) WO2019125732A1 (en)

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US10174092B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
CN114679909A (en) 2019-05-20 2022-06-28 潘迪恩运营公司 MAdCAM-targeted immune tolerance
US20220324932A1 (en) * 2019-06-20 2022-10-13 CSPC Megalith Biopharmaceutical Co., Ltd. Modified il-2 proteins, peg conjugates, and uses thereof
US20220289806A1 (en) * 2019-08-15 2022-09-15 Cytimm Therapeutics, Inc. Modified Interleukin 2 (IL-2) Polypeptides, Conjugates and Uses Thereof
KR20220066276A (en) * 2019-08-22 2022-05-24 시다라 세라퓨틱스, 인코포레이티드 Variant FC domains and uses thereof
TW202128961A (en) 2019-11-20 2021-08-01 美商安維塔生物科學股份有限公司 Cytokine fusion proteins, and their pharmaceutical compositions and therapeutic applications
KR20220116513A (en) 2019-12-20 2022-08-23 리제너론 파아마슈티컬스, 인크. Novel IL2 agonists and methods of use thereof
CN115315436A (en) * 2020-01-10 2022-11-08 明峰治疗股份公司 Modified IL-2 polypeptides and uses thereof
CA3175580A1 (en) 2020-04-15 2021-10-21 Heather C. Losey Immunostimulatory agents in combination with angiogenesis inhibitors
IL297329A (en) 2020-04-22 2022-12-01 Merck Sharp & Dohme Llc Human interleukin-2 conjugates biased for the interleukin-2 receptor beta gammac dimer and conjugated to a nonpeptidic, water-soluble polymer
WO2021222150A2 (en) 2020-04-28 2021-11-04 Anwita Biosciences, Inc. Interleukin-2 polypeptides and fusion proteins thereof, and their pharmaceutical compositions and therapeutic applications
JP2023534793A (en) * 2020-07-09 2023-08-14 ユーティレックス カンパニー リミテッド IL-2 variant
TWI815194B (en) 2020-10-22 2023-09-11 美商基利科學股份有限公司 INTERLEUKIN-2-Fc FUSION PROTEINS AND METHODS OF USE
AR124463A1 (en) * 2020-12-23 2023-03-29 Merck Sharp & Dohme Llc IL-2 MUTEINS FOR THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
WO2023281480A1 (en) * 2021-07-09 2023-01-12 Bright Peak Therapeutics Ag Conjugates of checkpoint inhibitors with il-2, and uses thereof
US20230303649A1 (en) * 2021-07-09 2023-09-28 Bright Peak Therapeutics Ag Modified il-2 polypeptides for treatment of inflammatory and autoimmune diseases
WO2023001987A2 (en) * 2021-07-22 2023-01-26 University Of Dundee Therapeutic muteins
WO2023045977A1 (en) * 2021-09-22 2023-03-30 信达生物制药(苏州)有限公司 Interleukin-2 mutant and fusion protein thereof
WO2024043643A1 (en) * 2022-08-23 2024-02-29 머스트바이오 주식회사 Il2 variant and protein complex comprising same
WO2024054868A1 (en) * 2022-09-07 2024-03-14 Xencor, Inc. An il-2 fc fusion protein for use in methods for the treatment of plaque psoriasis and atopic dermatitis
CN116041539B (en) * 2022-10-31 2023-07-21 山东博安生物技术股份有限公司 IL-2 mutant immunoconjugates

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