SK282699B6 - Spôsob štiepenia racemického 2-(o-chlórfenyl)-2-metylaminocyklohexanónu - Google Patents
Spôsob štiepenia racemického 2-(o-chlórfenyl)-2-metylaminocyklohexanónu Download PDFInfo
- Publication number
- SK282699B6 SK282699B6 SK1529-98A SK152998A SK282699B6 SK 282699 B6 SK282699 B6 SK 282699B6 SK 152998 A SK152998 A SK 152998A SK 282699 B6 SK282699 B6 SK 282699B6
- Authority
- SK
- Slovakia
- Prior art keywords
- water
- chlorophenyl
- methylaminocyclohexanone
- mixture
- tartaric acid
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C221/00—Preparation of compounds containing amino groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Indole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19619665A DE19619665C2 (de) | 1996-05-15 | 1996-05-15 | Racemattrennung von Ketamin |
PCT/EP1997/002360 WO1997043244A1 (de) | 1996-05-15 | 1997-05-07 | Racemattrennung von ketamin |
Publications (2)
Publication Number | Publication Date |
---|---|
SK152998A3 SK152998A3 (en) | 1999-07-12 |
SK282699B6 true SK282699B6 (sk) | 2002-11-06 |
Family
ID=7794445
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1529-98A SK282699B6 (sk) | 1996-05-15 | 1997-05-07 | Spôsob štiepenia racemického 2-(o-chlórfenyl)-2-metylaminocyklohexanónu |
Country Status (20)
Country | Link |
---|---|
US (1) | US6040479A (ja) |
EP (1) | EP0918744B1 (ja) |
JP (1) | JP4151988B2 (ja) |
AT (1) | ATE272606T1 (ja) |
AU (1) | AU727528B2 (ja) |
CA (1) | CA2253575C (ja) |
CZ (1) | CZ293546B6 (ja) |
DE (2) | DE19619665C2 (ja) |
DK (1) | DK0918744T3 (ja) |
EE (1) | EE03436B1 (ja) |
ES (1) | ES2224247T3 (ja) |
HU (1) | HU225773B1 (ja) |
IL (1) | IL127026A (ja) |
NO (1) | NO311565B1 (ja) |
PL (1) | PL187625B1 (ja) |
PT (1) | PT918744E (ja) |
SK (1) | SK282699B6 (ja) |
TR (1) | TR199802317T2 (ja) |
WO (1) | WO1997043244A1 (ja) |
ZA (1) | ZA974216B (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0002693B8 (pt) * | 2000-06-19 | 2021-05-25 | Cristalia Produtos Quim Farmaceuticos Ltda | processo de obtenção dos enantiômeros da cetamina e seus sais farmaceuticamente aceitáveis |
SG11201507347QA (en) | 2013-03-15 | 2015-10-29 | Janssen Pharmaceutica Nv | Pharmaceutical composition of s-ketamine hydrochloride |
EP3964203A1 (en) | 2013-09-13 | 2022-03-09 | National University Corporation Chiba University | Application of r-ketamine and salt thereof as pharmaceuticals |
US10098854B2 (en) | 2014-08-13 | 2018-10-16 | Janssen Pharmaceutica Nv | Method for the treatment of depression |
EP3725307A1 (en) | 2014-09-15 | 2020-10-21 | Janssen Pharmaceutica NV | Val66met (snp rs6265) genotype specific dosing regimens and methods for the treatment of depression |
US20160332962A1 (en) * | 2015-05-13 | 2016-11-17 | Janssen Pharmaceutica Nv | (s)-csa salt of s-ketamine, (r)-csa salt of s-ketamine and processes for the preparation of s-ketamine |
CN110167541A (zh) | 2016-10-27 | 2019-08-23 | 国立大学法人千叶大学 | (s)-去甲***及其盐作为药物的应用 |
US20200009081A1 (en) | 2017-09-13 | 2020-01-09 | Janssen Pharmaceutica N.V. | Delivery Of Esketamine For The Treatment Of Depression |
TW201919595A (zh) | 2017-09-27 | 2019-06-01 | 國立大學法人千葉大學 | 作為神經變性疾病或認知機能障礙之預防或治療劑之r-***及其衍生物 |
MX2020006650A (es) | 2017-12-22 | 2020-11-06 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
CN111936127A (zh) | 2018-02-15 | 2020-11-13 | 国立大学法人千叶大学 | 炎症性疾病或骨病的预防或治疗剂及医药组合物 |
WO2019213551A1 (en) | 2018-05-04 | 2019-11-07 | Perception Neuroscience, Inc. | Methods of treating substance abuse |
JP7483630B2 (ja) | 2018-12-27 | 2024-05-15 | 国立大学法人千葉大学 | 神経発達障害の予防または治療剤としてのr-ケタミンおよびその誘導体 |
MX2021010683A (es) | 2019-03-05 | 2021-12-10 | Janssen Pharmaceuticals Inc | Esketamina para el tratamiento de la depresión. |
US20220220062A1 (en) * | 2019-04-16 | 2022-07-14 | Janssen Pharmaceutica Nv | Synthetic methods of preparing esketamine |
CN112125816A (zh) * | 2020-03-17 | 2020-12-25 | 国药集团工业有限公司 | 一种***、其衍生物或其盐的消旋化方法 |
CN112409195A (zh) * | 2020-03-17 | 2021-02-26 | 国药集团工业有限公司 | 一种(s)-***盐酸盐的制备方法及其中间体、其晶型 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH535201A (de) * | 1969-12-19 | 1973-03-31 | Bristol Myers Co | Verfahren zur Spaltung von racemischen 2-(o-Chlorphenyl)-2-methylaminocyclohexanon in die optisch-aktiven Isomeren |
-
1996
- 1996-05-15 DE DE19619665A patent/DE19619665C2/de not_active Expired - Lifetime
-
1997
- 1997-05-07 DK DK97923022T patent/DK0918744T3/da active
- 1997-05-07 IL IL12702697A patent/IL127026A/en not_active IP Right Cessation
- 1997-05-07 EP EP97923022A patent/EP0918744B1/de not_active Expired - Lifetime
- 1997-05-07 AT AT97923022T patent/ATE272606T1/de active
- 1997-05-07 US US09/180,530 patent/US6040479A/en not_active Expired - Lifetime
- 1997-05-07 AU AU28943/97A patent/AU727528B2/en not_active Expired
- 1997-05-07 DE DE59711834T patent/DE59711834D1/de not_active Expired - Lifetime
- 1997-05-07 PL PL97329743A patent/PL187625B1/pl unknown
- 1997-05-07 PT PT97923022T patent/PT918744E/pt unknown
- 1997-05-07 JP JP54048797A patent/JP4151988B2/ja not_active Expired - Lifetime
- 1997-05-07 EE EE9800394A patent/EE03436B1/xx unknown
- 1997-05-07 HU HU9903085A patent/HU225773B1/hu unknown
- 1997-05-07 SK SK1529-98A patent/SK282699B6/sk not_active IP Right Cessation
- 1997-05-07 CA CA002253575A patent/CA2253575C/en not_active Expired - Lifetime
- 1997-05-07 TR TR1998/02317T patent/TR199802317T2/xx unknown
- 1997-05-07 ES ES97923022T patent/ES2224247T3/es not_active Expired - Lifetime
- 1997-05-07 CZ CZ19983558A patent/CZ293546B6/cs not_active IP Right Cessation
- 1997-05-07 WO PCT/EP1997/002360 patent/WO1997043244A1/de active IP Right Grant
- 1997-05-15 ZA ZA9704216A patent/ZA974216B/xx unknown
-
1998
- 1998-11-13 NO NO19985300A patent/NO311565B1/no not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EE03436B1 (et) | 2001-06-15 |
EP0918744A1 (de) | 1999-06-02 |
CZ293546B6 (cs) | 2004-06-16 |
HU225773B1 (en) | 2007-08-28 |
DK0918744T3 (da) | 2004-12-06 |
JP2000510135A (ja) | 2000-08-08 |
PT918744E (pt) | 2004-10-29 |
TR199802317T2 (xx) | 1999-02-22 |
NO985300L (no) | 1998-11-13 |
NO311565B1 (no) | 2001-12-10 |
DE19619665C2 (de) | 2001-03-08 |
EE9800394A (et) | 1999-06-15 |
DE19619665A1 (de) | 1997-11-20 |
ES2224247T3 (es) | 2005-03-01 |
AU2894397A (en) | 1997-12-05 |
HUP9903085A3 (en) | 2000-05-29 |
JP4151988B2 (ja) | 2008-09-17 |
IL127026A (en) | 2004-02-19 |
ATE272606T1 (de) | 2004-08-15 |
SK152998A3 (en) | 1999-07-12 |
ZA974216B (en) | 1997-12-10 |
NO985300D0 (no) | 1998-11-13 |
EP0918744B1 (de) | 2004-08-04 |
CA2253575A1 (en) | 1997-11-20 |
AU727528B2 (en) | 2000-12-14 |
PL187625B1 (pl) | 2004-08-31 |
WO1997043244A1 (de) | 1997-11-20 |
US6040479A (en) | 2000-03-21 |
PL329743A1 (en) | 1999-04-12 |
IL127026A0 (en) | 1999-09-22 |
DE59711834D1 (de) | 2004-09-09 |
CA2253575C (en) | 2005-11-29 |
CZ355898A3 (cs) | 1999-04-14 |
HUP9903085A1 (hu) | 2000-04-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SK282699B6 (sk) | Spôsob štiepenia racemického 2-(o-chlórfenyl)-2-metylaminocyklohexanónu | |
JP2009521402A (ja) | プロパルギル化アミノインダンの分離のための方法 | |
CZ292579B6 (cs) | Způsob přípravy enantiomerně čistých esterů kyseliny tropové | |
JP2022553230A (ja) | ジアステレオマー酒石酸エステルによるラセミ体の分割により2-シアノエチル(4s)-4-(4-シアノ-2-メトキシフェニル)-5-エトキシ-2,8-ジメチル-1,4-ジヒドロ-1,6-ナフチリジン-3-カルボキシレートを調製する方法 | |
CA2634133A1 (en) | An improved process for the preparation of armodafinil | |
JP2011503122A (ja) | 4,5−ジメトキシ−1−(メチルアミノメチル)−ベンゾシクロブタンの分離 | |
US4968837A (en) | Resolution of racemic mixtures | |
PL212886B1 (pl) | Sposób przemyslowej syntezy chlorowodorku 11-amino-3-chloro-6,11-dihydro-5,5-diokso-6-metylodibenzo[c,f][1,2]tiazepiny | |
SK151297A3 (en) | New process for the preparation of ropivacaine hydrochloride monohydrate | |
JPH02306947A (ja) | キラルβ―アミノ酸の製造方法 | |
EP0481118B1 (en) | A method for producing butyl 3'-(1H-tetrazol-5-yl) oxanilate | |
WO2014009964A1 (en) | Process for enantiomeric enrichment of 2 ', 6 ' - pipecoloxylidide | |
JP2001521498A (ja) | O−(3−アミノ−2−ヒドロキシ−プロピル)−ヒドロキシミック酸ハロゲン化物の製造方法 | |
WO2016046833A2 (en) | Improved processes for the preparation of agomelatine using novel intermediates | |
GB2036744A (en) | Eburnane derivatives | |
JPH06340595A (ja) | 光学的に純粋なアミノアルコールの製造方法 | |
FR2510575A1 (fr) | Nouveaux composes bicycliques, leur procede de preparation et composition pharmaceutique les renfermant | |
JPH08176108A (ja) | (−)−n−メチル−n−[4−(4−フェニル−4−アセチルアミノピペリジン−1−イル)−2−(3,4−ジクロロフェニル)ブチル]ベンズアミドおよびその薬学的に許容しうる塩の製造方法 | |
JP2852023B2 (ja) | 2−フルオロシクロプロピルアミンスルホン酸塩及びその化学的化合物2−フルオロシクロプロピルイソシアネートの製造法 | |
JP3655311B2 (ja) | フタリド化合物の製造方法 | |
JP2003508359A (ja) | 接触脱水素反応によるジベンゾスベレノン誘導体の製造 | |
EP1484315A1 (en) | Process for production of optically active beta-phenylalanine | |
CA2409614C (en) | Separation of the enantiomers of piperidone derivatives with simultaneous racemisation in situ of the unwanted enantiomer | |
JPH10182578A (ja) | 不斉な含フッ素一級アミンの製造法 | |
FR2753968A1 (fr) | Nouvelles heteroaryloxyethylamines, leur procede de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
MK4A | Expiry of patent |
Expiry date: 20170507 |