SI2247558T1 - Nova kontrastna sredstva za zaznavanje nevroloških disfunkcij - Google Patents
Nova kontrastna sredstva za zaznavanje nevroloških disfunkcijInfo
- Publication number
- SI2247558T1 SI2247558T1 SI200932157T SI200932157T SI2247558T1 SI 2247558 T1 SI2247558 T1 SI 2247558T1 SI 200932157 T SI200932157 T SI 200932157T SI 200932157 T SI200932157 T SI 200932157T SI 2247558 T1 SI2247558 T1 SI 2247558T1
- Authority
- SI
- Slovenia
- Prior art keywords
- imaging agents
- neurological dysfunction
- novel imaging
- detecting neurological
- detecting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/002—Heterocyclic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US6610108P | 2008-02-14 | 2008-02-14 | |
PCT/US2009/000961 WO2009102498A1 (en) | 2008-02-14 | 2009-02-17 | Novel imaging agents for detecting neurological dysfunction |
EP09711194.2A EP2247558B1 (en) | 2008-02-14 | 2009-02-17 | Novel imaging agents for detecting neurological dysfunction |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2247558T1 true SI2247558T1 (sl) | 2022-07-29 |
Family
ID=40627498
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200932157T SI2247558T1 (sl) | 2008-02-14 | 2009-02-17 | Nova kontrastna sredstva za zaznavanje nevroloških disfunkcij |
Country Status (14)
Country | Link |
---|---|
US (2) | US20110046378A1 (sl) |
EP (2) | EP2599763A1 (sl) |
JP (1) | JP2011512354A (sl) |
KR (1) | KR20100135235A (sl) |
CA (1) | CA2715390A1 (sl) |
DK (1) | DK2247558T3 (sl) |
ES (1) | ES2907992T3 (sl) |
HR (1) | HRP20220401T3 (sl) |
HU (1) | HUE058352T2 (sl) |
LT (1) | LT2247558T (sl) |
PL (1) | PL2247558T3 (sl) |
PT (1) | PT2247558T (sl) |
SI (1) | SI2247558T1 (sl) |
WO (1) | WO2009102498A1 (sl) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2247558T3 (pl) | 2008-02-14 | 2022-05-02 | Eli Lilly And Company | Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych |
US8932557B2 (en) * | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
MX2011001070A (es) * | 2008-08-08 | 2011-03-25 | Neurosearch As | Nuevos derivados de difenil 1,2,3-triazol utiles como moduladores de los receptores de acetilcolina nicotinicos. |
JP5771525B2 (ja) * | 2008-09-18 | 2015-09-02 | セダーズ−シナイ メディカル センター | アルツハイマー病を検出するための光学的方法 |
US8691187B2 (en) * | 2009-03-23 | 2014-04-08 | Eli Lilly And Company | Imaging agents for detecting neurological disorders |
GB201016038D0 (en) | 2010-09-24 | 2010-11-10 | Ge Healthcare Ltd | In vivo imaging method |
DK2634177T3 (en) * | 2010-10-29 | 2016-08-15 | Clino Ltd | TAU IMAGE SOUND |
US20140275156A1 (en) * | 2011-08-11 | 2014-09-18 | Neuprotect Pty Ltd | Flavonoid compounds, and methods of use thereof |
US20130315825A1 (en) * | 2012-05-03 | 2013-11-28 | Washington University | Tricyclic heteroaromatic compounds as alpha-synuclein ligands |
EP2852572B1 (en) * | 2012-05-22 | 2020-04-01 | Eli Lilly and Company | Carboline and carbazole based imaging agents for detecting neurological dysfunction |
CA2894994C (en) | 2012-12-21 | 2019-11-12 | National Institute Of Radiological Sciences | Compounds for imaging tau proteins that accumulate in brain |
US20160115162A1 (en) | 2013-05-31 | 2016-04-28 | The General Hospital Corporation | Radiosynthesis of Tau Radiopharmaceuticals |
AR096721A1 (es) | 2013-06-25 | 2016-01-27 | Bristol Myers Squibb Co | Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos |
SG11201510028PA (en) | 2013-06-25 | 2016-01-28 | Bristol Myers Squibb Co | Carbazole carboxamide compounds useful as kinase inhibitors |
PE20160159A1 (es) * | 2013-10-08 | 2016-03-18 | Hoffmann La Roche | Derivados de diazacarbazol como ligandos de tau para pet |
TWI667233B (zh) | 2013-12-19 | 2019-08-01 | 德商拜耳製藥公司 | 新穎吲唑羧醯胺,其製備方法、含彼等之醫藥製劑及其製造醫藥之用途 |
US10662193B2 (en) | 2014-01-21 | 2020-05-26 | Ac Immune Sa | Carbazole and carboline compounds for use in the diagnosis, treatment, alleviation or prevention of disorders associated with amyloid or amyloid-like proteins |
RS61810B1 (sr) | 2014-05-13 | 2021-06-30 | Hoffmann La Roche | Deuterisana heterociklična jedinjenja i njihova upotreba kao sredstva za snimanje |
WO2016037106A1 (en) * | 2014-09-05 | 2016-03-10 | Allosteros Therapeutics, Inc | CaMKII INHIBITORS AND USES THEREOF |
KR20170052626A (ko) | 2014-09-05 | 2017-05-12 | 심바이오믹스 세러퓨틱스 엘엘씨 | 세균질증 치료에 사용하기 위한 세크니다졸 |
HUE048321T2 (hu) | 2014-10-24 | 2020-07-28 | Bristol Myers Squibb Co | Karabazol származékok |
SG10201903578VA (en) | 2014-10-24 | 2019-05-30 | Bristol Myers Squibb Co | Indole carboxamides compounds useful as kinase inhibitors |
EP3209652B1 (en) | 2014-10-24 | 2020-04-15 | Bristol-Myers Squibb Company | Tricyclic atropisomer compounds |
JP6579670B2 (ja) * | 2015-02-02 | 2019-09-25 | ユーシービー バイオファルマ エスピーアールエル | 9h−ピロロ−ジピリジン誘導体 |
CN105566269B (zh) * | 2015-03-27 | 2018-07-10 | 北京大学 | 香豆素衍生物的制备、药理作用及治疗瘙痒的应用 |
CN105524034B (zh) * | 2015-03-27 | 2018-08-17 | 北京大学 | 香豆素衍生物的制备、药理作用及治疗脑缺血的应用 |
US11253501B2 (en) | 2015-06-01 | 2022-02-22 | Lupin Inc. | Secnidazole formulations and use in treating bacterial vaginosis |
EP3118202A1 (en) | 2015-07-15 | 2017-01-18 | AC Immune S.A. | Dihydropyridopyrrole derivatives as tau-pet-ligands |
WO2017009454A1 (en) | 2015-07-15 | 2017-01-19 | Ac Immune S.A. | Novel imaging compounds |
ES2864825T3 (es) | 2015-11-13 | 2021-10-14 | Lilly Co Eli | Derivados de azetidina para la obtención de imágenes Tau |
EP3411083A1 (en) * | 2016-02-03 | 2018-12-12 | Janssen Pharmaceutica NV | Tau pet imaging ligands |
WO2018015546A1 (en) | 2016-07-22 | 2018-01-25 | Ac Immune S.A. | Compounds for imaging tau protein aggregates |
SG11201811311VA (en) * | 2016-07-22 | 2019-01-30 | Ac Immune Sa | Compounds for imaging tau protein aggregates |
WO2018024642A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
WO2018024643A1 (en) | 2016-08-02 | 2018-02-08 | Ucb Biopharma Sprl | 9h-pyrrolo-dipyridine derivatives |
SI3510031T1 (sl) | 2016-09-09 | 2021-03-31 | F. Hoffmann-La Roche Ag | Postopek za pripravo 2-(6-nitropiridin-3-il)-9H-dipirido(2,3-b;3',4'-d)pirola |
TW201906818A (zh) * | 2017-05-31 | 2019-02-16 | 美商511製藥公司 | 新穎氘取代之正子發射斷層掃描(pet)顯影劑及其藥理應用 |
EP3743423A1 (en) | 2018-01-24 | 2020-12-02 | AC Immune SA | Gamma-carboline compounds for the detection of tau aggregates |
WO2019145292A1 (en) | 2018-01-24 | 2019-08-01 | Ac Immune Sa | Azacarboline compounds for the detection of tau aggregates |
JPWO2019168170A1 (ja) * | 2018-03-02 | 2021-03-04 | 国立大学法人 長崎大学 | クロモン誘導体及びアミロイド関連疾患診断用組成物 |
EP4058065A4 (en) | 2019-11-13 | 2023-05-03 | Aprinoia Therapeutics Limited | COMPOUNDS FOR DEGRADING TAU PROTEIN AGGREGATES AND THEIR USES |
WO2023034346A1 (en) * | 2021-08-30 | 2023-03-09 | Pretzel Therapeutics, Inc. | Chromen-2-one modulators of polrmt |
WO2023034339A1 (en) * | 2021-08-30 | 2023-03-09 | Pretzel Therapeutics, Inc. | Hydroxy and alkoxy coumarins as modulators of polrmt |
US11938127B2 (en) | 2021-09-28 | 2024-03-26 | Wayne State University | Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders |
WO2023078252A1 (en) | 2021-11-02 | 2023-05-11 | Flare Therapeutics Inc. | Pparg inverse agonists and uses thereof |
WO2023204967A1 (en) * | 2022-04-21 | 2023-10-26 | Virginia Commonwealth University | Nlrp3 inflammasome inhibitors and compositions and uses thereof |
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NZ274063A (en) * | 1993-09-17 | 1997-11-24 | Smithkline Beecham Corp | Cytokine suppressive anti-inflammatory drug binding protein (csbp) and its use |
US6417178B1 (en) | 1994-07-19 | 2002-07-09 | University Of Pittsburgh | Amyloid binding nitrogen-linked compounds for the antemortem diagnosis of alzheimer's disease, in vivo imaging and prevention of amyloid deposits |
BR9611047A (pt) | 1995-10-17 | 2000-03-08 | Searle & Co | Processo de deteção de ciclo oxigenase-2 |
JPH09165378A (ja) * | 1995-12-15 | 1997-06-24 | Seitai Kinou Kenkyusho:Kk | N1−[18f]フルオロベンジル複素環化合物およびそれらの製造法 |
ZA989365B (en) | 1997-10-15 | 1999-04-15 | Boehringer Mannheim Pharm Corp | Preparation for treating alzheimer's disease |
JP2001048786A (ja) | 1999-08-05 | 2001-02-20 | Yamanouchi Pharmaceut Co Ltd | 三環式ヘテロアリール誘導体 |
US20020115717A1 (en) | 2000-07-25 | 2002-08-22 | Francine Gervais | Amyloid targeting imaging agents and uses thereof |
WO2002085903A2 (en) | 2001-04-23 | 2002-10-31 | The Trustees Of The University Of Pennsylvania | Amyloid plaque aggregation inhibitors and diagnostic imaging agents |
KR100947913B1 (ko) | 2001-08-27 | 2010-03-17 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 스틸벤 유도체 및 이것을 아밀로이드 플라크의 결합 및영상화에 사용하는 용도 |
MXPA04001153A (es) | 2001-08-31 | 2005-02-17 | Neurochem Int Ltd | Derivados de amidina para tratar la amiloidosis. |
EP1442039A1 (en) | 2001-10-31 | 2004-08-04 | Bayer HealthCare AG | Pyrimido (4,5-b) indole derivatives |
WO2003103598A2 (en) * | 2002-06-07 | 2003-12-18 | University Of North Carolina At Chapel Hill | Amidine derivatives for treating amyloidosis |
US20070060618A1 (en) | 2002-10-24 | 2007-03-15 | Merck & Co., Inc. | Alkyne derivatives as tracers for metabotropic glutamate receptor binding |
WO2004043496A1 (de) | 2002-11-11 | 2004-05-27 | Austria Wirtschaftsservice Gesellschaft M.B.H. | Fluor-18-markierte fluorchinolone |
GB0229686D0 (en) | 2002-12-20 | 2003-01-29 | Amersham Plc | Solid-phase fluorination of benzothiazoles |
WO2004058764A1 (en) | 2002-12-27 | 2004-07-15 | Bayer Healthcare Ag | 4-phenyl-pyrimido [4,5-b] indole derivatives |
WO2004113277A2 (en) | 2003-06-23 | 2004-12-29 | Neurochem (International) Limited | Methods and compositions for treating amyloid-related diseases |
CA2500358A1 (en) | 2003-08-13 | 2005-02-24 | Bf Research Institute, Inc. | Probes for diseases in which amyloid accumulates, agents for staining amyloid, drugs for treatment and prophylaxis of diseases with accumulated amyloid, and probes for diagnosis of neurofibrillary tangles and agents for staining neurofibrillary tangles |
JP2006100537A (ja) | 2004-09-29 | 2006-04-13 | Konica Minolta Holdings Inc | 有機エレクトロルミネッセンス素子、照明装置及び表示装置 |
US20060110787A1 (en) | 2004-11-19 | 2006-05-25 | The Board Trustees Of The University Of Arkansas | Use of fluorine-18-labeled fluoroquinolone antibiotics for diagnosing and monitoring bacterial infection |
JP4000353B2 (ja) * | 2004-11-26 | 2007-10-31 | 国立大学法人 長崎大学 | アミロイド関連疾患診断用組成物 |
JP2007084526A (ja) * | 2004-11-26 | 2007-04-05 | Nagasaki Univ | アミロイド関連疾患診断用組成物 |
SI2213652T1 (sl) * | 2004-12-17 | 2015-03-31 | The Trustees Of The University Of Pennsylvania | Derivati stilbena in njihova uporaba za vezavo in prikaz amiloidnih plakov |
FR2885905A1 (fr) | 2005-05-23 | 2006-11-24 | Trophos Sa | Nouveaux composes chimiques et leurs utilisations comme medicament |
WO2007002540A2 (en) * | 2005-06-24 | 2007-01-04 | Kung Hank F | Radiolabeled-pegylation of ligands for use as imaging agents |
CA2616397A1 (en) | 2005-08-03 | 2007-02-08 | Centre For Addiction And Mental Health | Diagnosis and treatment of mood disorders |
GB0523506D0 (en) * | 2005-11-18 | 2005-12-28 | Hammersmith Imanet Ltd | Novel in vivo imaging compounds |
CA2630562C (en) * | 2005-11-22 | 2013-12-31 | Merck & Co., Inc. | Tricyclic compounds useful as inhibitors of kinases |
US8022075B2 (en) | 2005-11-30 | 2011-09-20 | Fujifilm Ri Pharma Co., Ltd. | Diagnostic and remedy for disease caused by amyloid aggregation and/or deposition |
AR059356A1 (es) | 2006-02-14 | 2008-03-26 | Astrazeneca Ab | Nuevos radioligandos |
JP2007223952A (ja) | 2006-02-23 | 2007-09-06 | Tohoku Univ | アミロイドβ蛋白が蓄積する疾患の画像診断プローブ |
WO2008118122A2 (en) | 2006-05-08 | 2008-10-02 | Molecular Neuroimaging, Llc | Compounds and amyloid probes thereof for therapeutic and imaging uses |
US7678819B2 (en) | 2006-12-07 | 2010-03-16 | The Trustees Of The University Of Pennsylvania | Acetylene derivatives and their use for binding and imaging amyloid plaques |
ES2415863T3 (es) | 2006-12-22 | 2013-07-29 | Incyte Corporation | Heterociclos sustituidos como inhibidores de Janus Quinasas |
EP1944281A1 (en) | 2007-01-09 | 2008-07-16 | Technische Universität München | 18F-labeled compounds, method for the preparation and use thereof |
BRPI0702640A (pt) | 2007-01-10 | 2008-08-26 | Comissao Nac Energia Nuclear | processo de radiomarcação de flavonóides e sua aplicação em diagnóstico in vivo de disfunções cerebrais relacionadas aos sìtios receptores benzodiazepìnicos |
JP2010524857A (ja) | 2007-04-10 | 2010-07-22 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | フェン−ナフタレン及びフェン−キノリン誘導体、及びアミロイドプラークに結合させ、そして造影するための使用 |
EP2144507A4 (en) | 2007-04-19 | 2010-05-26 | Univ Pennsylvania | DIPHENYL-HETEROARYL DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLATES |
WO2008132454A1 (en) | 2007-04-26 | 2008-11-06 | Ge Healthcare Limited | Carbolines and their use as imaging agents |
US8942164B2 (en) | 2007-10-22 | 2015-01-27 | Texas Instruments Incorporated | Differential CQI for OFDMA systems |
JP5322180B2 (ja) | 2007-07-04 | 2013-10-23 | 国立大学法人東北大学 | フッ素およびヒドロキシ基で置換されたアルコキシ基を有するpetプローブ |
WO2009045535A2 (en) | 2007-10-04 | 2009-04-09 | Sloan-Kettering Institute For Cancer Research | Fluorine-18 derivative of dasatinib and uses thereof |
PL2247558T3 (pl) | 2008-02-14 | 2022-05-02 | Eli Lilly And Company | Nowe środki obrazujące do wykrywania czynnościowych zaburzeń neurologicznych |
KR20110046503A (ko) | 2008-07-24 | 2011-05-04 | 지멘스 메디컬 솔루션즈 유에스에이, 인크. | Ad 병인을 확인하기에 유용한 영상화제 |
JP2012051804A (ja) | 2008-12-26 | 2012-03-15 | Kyoto Univ | Eg5阻害剤 |
EP2218464A1 (en) | 2009-02-11 | 2010-08-18 | Technische Universität München | Compounds for non-invasive measurement of aggregates of amyloid peptides |
PE20160159A1 (es) | 2013-10-08 | 2016-03-18 | Hoffmann La Roche | Derivados de diazacarbazol como ligandos de tau para pet |
JP6579670B2 (ja) | 2015-02-02 | 2019-09-25 | ユーシービー バイオファルマ エスピーアールエル | 9h−ピロロ−ジピリジン誘導体 |
-
2009
- 2009-02-17 PL PL09711194T patent/PL2247558T3/pl unknown
- 2009-02-17 ES ES09711194T patent/ES2907992T3/es active Active
- 2009-02-17 JP JP2010546795A patent/JP2011512354A/ja active Pending
- 2009-02-17 HR HRP20220401TT patent/HRP20220401T3/hr unknown
- 2009-02-17 KR KR1020107020589A patent/KR20100135235A/ko not_active Application Discontinuation
- 2009-02-17 HU HUE09711194A patent/HUE058352T2/hu unknown
- 2009-02-17 EP EP20130157487 patent/EP2599763A1/en not_active Withdrawn
- 2009-02-17 US US12/867,502 patent/US20110046378A1/en not_active Abandoned
- 2009-02-17 PT PT97111942T patent/PT2247558T/pt unknown
- 2009-02-17 SI SI200932157T patent/SI2247558T1/sl unknown
- 2009-02-17 US US12/372,717 patent/US8318132B2/en active Active
- 2009-02-17 EP EP09711194.2A patent/EP2247558B1/en active Active
- 2009-02-17 DK DK09711194.2T patent/DK2247558T3/da active
- 2009-02-17 LT LTEPPCT/US2009/000961T patent/LT2247558T/lt unknown
- 2009-02-17 CA CA2715390A patent/CA2715390A1/en not_active Abandoned
- 2009-02-17 WO PCT/US2009/000961 patent/WO2009102498A1/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
LT2247558T (lt) | 2022-04-11 |
ES2907992T3 (es) | 2022-04-27 |
EP2599763A1 (en) | 2013-06-05 |
PL2247558T3 (pl) | 2022-05-02 |
KR20100135235A (ko) | 2010-12-24 |
US20110046378A1 (en) | 2011-02-24 |
JP2011512354A (ja) | 2011-04-21 |
CA2715390A1 (en) | 2009-08-20 |
EP2247558B1 (en) | 2022-02-02 |
HRP20220401T3 (hr) | 2022-05-27 |
US8318132B2 (en) | 2012-11-27 |
DK2247558T3 (da) | 2022-02-21 |
PT2247558T (pt) | 2022-03-21 |
EP2247558A1 (en) | 2010-11-10 |
WO2009102498A1 (en) | 2009-08-20 |
US20110091382A1 (en) | 2011-04-21 |
HUE058352T2 (hu) | 2022-07-28 |
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