SI2154967T1 - Derivati pirimidina - Google Patents

Derivati pirimidina

Info

Publication number
SI2154967T1
SI2154967T1 SI200831203T SI200831203T SI2154967T1 SI 2154967 T1 SI2154967 T1 SI 2154967T1 SI 200831203 T SI200831203 T SI 200831203T SI 200831203 T SI200831203 T SI 200831203T SI 2154967 T1 SI2154967 T1 SI 2154967T1
Authority
SI
Slovenia
Prior art keywords
pyrimidine derivatives
pyrimidine
derivatives
Prior art date
Application number
SI200831203T
Other languages
English (en)
Inventor
Wei-Guo Su
Hong Jia
Weihan Zhang
Yumin Cui
Xiaoqiang Yan
Yongxin Ren
Jifeng Duan
Yang Sai
Original Assignee
Hutchison Medipharma Enterprises Limited Offshore Group Chambers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchison Medipharma Enterprises Limited Offshore Group Chambers filed Critical Hutchison Medipharma Enterprises Limited Offshore Group Chambers
Publication of SI2154967T1 publication Critical patent/SI2154967T1/sl

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32One oxygen, sulfur or nitrogen atom
    • C07D239/42One nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
SI200831203T 2007-04-16 2008-04-15 Derivati pirimidina SI2154967T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91192107P 2007-04-16 2007-04-16
PCT/US2008/060366 WO2008128231A1 (en) 2007-04-16 2008-04-15 Pyrimidine derivatives
EP08745881.6A EP2154967B9 (en) 2007-04-16 2008-04-15 Pyrimidine derivatives

Publications (1)

Publication Number Publication Date
SI2154967T1 true SI2154967T1 (sl) 2014-06-30

Family

ID=39854302

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200831203T SI2154967T1 (sl) 2007-04-16 2008-04-15 Derivati pirimidina

Country Status (17)

Country Link
US (2) US8349859B2 (sl)
EP (1) EP2154967B9 (sl)
JP (1) JP5635398B2 (sl)
KR (1) KR101424847B1 (sl)
BR (1) BRPI0809715A2 (sl)
CA (1) CA2684470C (sl)
DK (1) DK2154967T5 (sl)
ES (1) ES2465673T3 (sl)
HR (1) HRP20140377T2 (sl)
MX (1) MX2009011199A (sl)
NZ (1) NZ580671A (sl)
PL (1) PL2154967T3 (sl)
PT (1) PT2154967E (sl)
RU (1) RU2455994C2 (sl)
SI (1) SI2154967T1 (sl)
TW (1) TWI484960B (sl)
WO (1) WO2008128231A1 (sl)

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TW201024281A (en) 2008-11-24 2010-07-01 Boehringer Ingelheim Int New compounds
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US8466155B2 (en) * 2009-10-02 2013-06-18 Boehringer Ingelheim International Gmbh Pyrimidines
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EP2395001A1 (en) 2010-05-21 2011-12-14 Chemilia AB Novel pyrimidine derivatives
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EP2621276B1 (en) * 2010-09-30 2017-12-27 Merck Sharp & Dohme Corp. 2-alkoxy pyrimidine pde10 inhibitors
EP2502924A1 (en) 2011-03-24 2012-09-26 Chemilia AB Novel pyrimidine derivatives
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EP2711364A1 (en) 2012-09-21 2014-03-26 Chemilia AB 4-(Indolyl or benzimidazolyl)amino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer
EP2711365A1 (en) 2012-09-21 2014-03-26 Chemilia AB 4-Indazolylamino-2-(2-(indol-3-yl)ethyl)aminopyrimidines useful for the treatment of cancer
AU2013337297A1 (en) 2012-11-05 2015-05-21 Nantbio, Inc. Substituted indol-5-ol derivatives and their therapeutical applications
CN105377261B (zh) 2013-03-15 2017-12-15 南特生物科学公司 取代的吲哚‑5‑酚衍生物和它们的治疗应用
CN105601573B (zh) * 2014-11-24 2021-07-02 中国科学院上海药物研究所 2-氨基嘧啶类化合物及其药物组合物和应用
CA2977764C (en) * 2015-02-27 2021-11-09 Nantbioscience, Inc. Pyrimidine derivatives as kinase inhibitors and their therapeutical applications
US10981899B2 (en) 2016-04-28 2021-04-20 Cornell University Inhibitors of soluble adenylyl cyclase
WO2020253862A1 (zh) * 2019-06-21 2020-12-24 上海翰森生物医药科技有限公司 含氮芳基磷氧化物类衍生物、其制备方法和应用
CN111004221B (zh) * 2019-12-13 2021-02-02 长治学院 一种嘧啶/苯并咪唑杂合物、制备方法及医药用途

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Also Published As

Publication number Publication date
EP2154967B1 (en) 2014-03-05
ES2465673T9 (es) 2014-11-14
JP2010524952A (ja) 2010-07-22
HRP20140377T1 (en) 2014-05-23
RU2009141982A (ru) 2011-05-27
CA2684470A1 (en) 2008-10-23
HRP20140377T2 (hr) 2015-01-16
BRPI0809715A2 (pt) 2019-11-05
US8349859B2 (en) 2013-01-08
EP2154967A4 (en) 2010-05-19
JP5635398B2 (ja) 2014-12-03
TWI484960B (zh) 2015-05-21
US8901143B2 (en) 2014-12-02
TW200848049A (en) 2008-12-16
DK2154967T5 (en) 2014-11-17
PL2154967T3 (pl) 2014-08-29
PT2154967E (pt) 2014-06-05
US20130065890A1 (en) 2013-03-14
KR20100016592A (ko) 2010-02-12
CA2684470C (en) 2016-02-09
NZ580671A (en) 2012-03-30
AU2008240084A1 (en) 2008-10-23
MX2009011199A (es) 2010-03-17
DK2154967T3 (da) 2014-04-07
EP2154967A1 (en) 2010-02-24
EP2154967B9 (en) 2014-07-23
ES2465673T3 (es) 2014-06-06
US20080255172A1 (en) 2008-10-16
RU2455994C2 (ru) 2012-07-20
KR101424847B1 (ko) 2016-07-08
WO2008128231A1 (en) 2008-10-23

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