SI20642A - Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh - Google Patents

Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh Download PDF

Info

Publication number
SI20642A
SI20642A SI200020017A SI200020017A SI20642A SI 20642 A SI20642 A SI 20642A SI 200020017 A SI200020017 A SI 200020017A SI 200020017 A SI200020017 A SI 200020017A SI 20642 A SI20642 A SI 20642A
Authority
SI
Slovenia
Prior art keywords
butyl
tert
chloro
polypeptide
expression vector
Prior art date
Application number
SI200020017A
Other languages
English (en)
Slovenian (sl)
Inventor
Noriyuki Kizaki
Yukio Yamada
Yoshihiko Yasohara
Junzo Hasegawa
Original Assignee
Kaneka Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kaneka Corporation filed Critical Kaneka Corporation
Publication of SI20642A publication Critical patent/SI20642A/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/40—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Candida
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/002—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by oxidation/reduction reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI200020017A 1999-12-03 2000-11-24 Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh SI20642A (sl)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP34554199 1999-12-03
PCT/JP2000/008321 WO2001040450A1 (fr) 1999-12-03 2000-11-24 Nouvelle carbonyl reductase, son gene et son procede d'utilisation

Publications (1)

Publication Number Publication Date
SI20642A true SI20642A (sl) 2002-02-28

Family

ID=18377296

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200020017A SI20642A (sl) 1999-12-03 2000-11-24 Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh

Country Status (15)

Country Link
US (1) US6645746B1 (fr)
EP (1) EP1152054B1 (fr)
JP (1) JP4510351B2 (fr)
KR (1) KR100512080B1 (fr)
AT (1) ATE291616T1 (fr)
AU (1) AU1551701A (fr)
CA (1) CA2360376C (fr)
CZ (1) CZ20012792A3 (fr)
DE (1) DE60018909T2 (fr)
ES (1) ES2240205T3 (fr)
HU (1) HUP0105331A3 (fr)
MX (1) MXPA01007858A (fr)
NO (1) NO20013801L (fr)
SI (1) SI20642A (fr)
WO (1) WO2001040450A1 (fr)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1537222B1 (fr) * 2002-08-09 2011-03-09 Codexis, Inc. Production par voie enzymatique de derives de 3-acide hydroxybutyrique substitues en position 4
AU2003289229A1 (en) * 2002-12-06 2004-06-30 Kaneka Corporation Process for producing optically active 3-hydroxypropionic ester derivative
BRPI0413501A (pt) 2003-08-11 2006-10-10 Codexis Inc polipetìdeo, polinucleotìdeo isolado ou recombinante, vetor de expressão, célula hospedeira, e, método de preparar um polipetìdeo de hhdh
US7588928B2 (en) * 2003-08-11 2009-09-15 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
EP1654354A1 (fr) * 2003-08-11 2006-05-10 Codexis, Inc. Polypeptides cetoreductase ameliores et polynucleotides associes
MXPA06001719A (es) * 2003-08-11 2006-05-19 Codexis Inc Polipeptidos de glucosa deshidrogenasa mejorados, y polinucleotidos relacionados.
US7541171B2 (en) * 2003-08-11 2009-06-02 Codexis, Inc. Halohydrin dehalogenases and related polynucleotides
JP2007502111A (ja) * 2003-08-11 2007-02-08 コデクシス， インコーポレイテッド ４−置換３−ヒドロキシ酪酸誘導体およびビシナルなシアノ，ヒドロキシ置換カルボン酸エステルの生成のための酵素的プロセス
DE10345772A1 (de) * 2003-10-01 2005-04-21 Basf Ag Verfahren zur Herstellung von 3-Methylamino-1-(thien-2-yl)-propan-1-ol
EP1811021A4 (fr) * 2004-10-27 2008-05-28 Kaneka Corp Nouvelle carbonyle reductase, gene codant pour ladite enzyme et applications de ladite enzyme
DE102005044736A1 (de) * 2005-09-19 2007-03-22 Basf Ag Neue Dehydrogenasen, deren Derivate und ein Verfahren zur Herstellung von optisch aktiven Alkanolen
AT503017B1 (de) * 2005-12-19 2007-07-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von hydroxyketoverbindungen
JP5261172B2 (ja) 2006-03-31 2013-08-14 株式会社カネカ エリスロ又はスレオ−２−アミノ−３−ヒドロキシプロピオン酸エステルの製造方法、新規カルボニル還元酵素、その遺伝子、ベクター、形質転換体、およびそれらを利用した光学活性アルコールの製造方法
CN101528917B (zh) 2006-10-02 2015-07-29 科德克希思公司 用于制备立体异构纯的他汀类及其合成中间体的组合物和方法
AT504542B1 (de) * 2006-12-07 2008-09-15 Iep Gmbh Verfahren zur enantioselektiven enzymatischen reduktion von secodionderivaten
JP2010517574A (ja) * 2007-02-08 2010-05-27 コデクシス， インコーポレイテッド ケトレダクターゼおよびその使用
JP2010536385A (ja) 2007-08-24 2010-12-02 コデクシス， インコーポレイテッド （ｒ）−３−ヒドロキシチオランの立体選択的生成のための改善されたケトレダクターゼポリペプチド
JP5973131B2 (ja) 2007-09-13 2016-08-23 コデクシス， インコーポレイテッド アセトフェノンの還元のためのケトレダクターゼポリペプチド
TWI601825B (zh) * 2007-09-27 2017-10-11 Ｉｅｐ有限公司 對映異構選擇性酶催化還原中間產物之方法
KR20100061571A (ko) 2007-09-28 2010-06-07 코덱시스, 인코포레이티드 케토리덕타제 폴리펩티드 및 이의 용도
WO2009046153A1 (fr) 2007-10-01 2009-04-09 Codexis, Inc. Polypeptides de cétoréductase pour la production d'azétidinone
SI2329013T1 (sl) 2008-08-27 2016-03-31 Codexis, Inc. Polipeptidi ketoreduktaze za proizvodnjo 3-aril-3-hidroksipropanamina iz 3-aril-3-ketopropanamina
US8288141B2 (en) 2008-08-27 2012-10-16 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2010027710A2 (fr) 2008-08-27 2010-03-11 Codexis, Inc. Polypeptides de cétoréductase et leurs utilisations
US8273554B2 (en) 2008-08-29 2012-09-25 Codexis, Inc. Ketoreductase polypeptides for the stereoselective production of (4S)-3-[(5S)-5-(4-fluorophenyl)-5-hydroxypentanoyl]-4-phenyl-1,3-oxazolidin-2-one
SG172231A1 (en) 2008-12-18 2011-07-28 Codexis Inc Recombinant halohydrin dehalogenase polypeptides
EP2226386A1 (fr) 2009-03-05 2010-09-08 IEP GmbH Procédé de réduction stéréosélective enzymatique de composés cétoniques
CN102803233B (zh) * 2009-06-22 2017-03-01 爱思开生物制药株式会社 制备氨基甲酸(r)‑1‑芳基‑2‑四唑基‑乙酯的方法
CN102482648B (zh) 2009-06-22 2014-12-10 科德克希思公司 酮还原酶介导的产生α氯代醇的立体选择性途径
EP2467473B1 (fr) 2009-08-19 2016-03-23 Codexis, Inc. Polypeptides de kétoréductase pour la préparation de phényléphrine
US8404461B2 (en) 2009-10-15 2013-03-26 SK Biopharmaceutical Co. Ltd. Method for preparation of carbamic acid (R)-1-aryl-2-tetrazolyl-ethyl ester
WO2011100265A2 (fr) 2010-02-10 2011-08-18 Codexis, Inc. Procédés utilisant des acide aminé déshydrogénases et un système de régénération de cofacteur à base de cétoréductase
EP2566497B1 (fr) 2010-05-04 2015-07-29 Codexis, Inc. Biocatalyseurs pour la synthèse d'ézétimibe
JP5941410B2 (ja) 2010-11-09 2016-06-29 株式会社カネカ ハロゲン化インデノン類及びそれを用いた光学活性インダノン類又は光学活性インダノール類の製造方法
CN102676596A (zh) * 2011-03-16 2012-09-19 苏州国镝医药科技有限公司 生物酶手性合成立普妥中间体ats-7
US9139819B2 (en) 2011-11-18 2015-09-22 Codexis, Inc. Biocatalysts for the preparation of hydroxy substituted carbamates
TW201343623A (zh) 2012-02-07 2013-11-01 Annikki Gmbh 使氧化還原輔因子經酶催化再生之方法
JP6189334B2 (ja) 2012-02-07 2017-08-30 アニッキ ゲーエムベーハーＡｎｎｉｋｋｉ Ｇｍｂｈ グルコースからのフラン誘導体の製造方法。
WO2013117251A1 (fr) 2012-02-07 2013-08-15 Annikki Gmbh Procédé de régénération enzymatique de cofacteurs redox
DE102012017026A1 (de) 2012-08-28 2014-03-06 Forschungszentrum Jülich GmbH Sensor für NADP(H) und Entwicklung von Alkoholdehydrogenasen
KR101446551B1 (ko) 2013-02-26 2014-10-06 주식회사 아미노로직스 (2rs)-아미노-(3s)-히드록시-부티르산 또는 이의 유도체의 제조방법
CN105102626B (zh) 2013-03-27 2019-01-01 安尼基有限责任公司 葡萄糖异构化的方法
ES2686695T3 (es) 2014-04-22 2018-10-19 C-Lecta Gmbh Cetorreductasas
CN104328148A (zh) * 2014-11-04 2015-02-04 尚科生物医药（上海）有限公司 酶法制备(3r,5s)-6-氯-3,5-二羟基己酸叔丁酯
ES2830725T3 (es) 2015-02-10 2021-06-04 Codexis Inc Polipéptidos cetoreductasa para la síntesis de compuestos quirales
CN104830921B (zh) * 2015-04-27 2019-07-02 上海工业生物技术研发中心 一种酶法制备他汀类化合物中间体的方法
CN105087685A (zh) * 2015-09-16 2015-11-25 连云港宏业化工有限公司 一种合成（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的方法
CN105087684A (zh) * 2015-09-16 2015-11-25 连云港宏业化工有限公司 一种（3r，5s）-6-氯-3,5-二羟基己酸叔丁酯的制备方法
CN106011092A (zh) * 2016-06-20 2016-10-12 苏州汉酶生物技术有限公司 一种工程化酮还原酶多肽及其用于制备孟鲁斯特中间体的方法
CN106011095B (zh) * 2016-07-27 2021-02-26 苏州汉酶生物技术有限公司 工程化酮还原酶多肽及使用其制备依替米贝中间体的方法
CN110831618B (zh) 2017-04-27 2023-08-25 科德克希思公司 酮还原酶多肽及多核苷酸
CN110914446B (zh) 2017-07-14 2024-02-06 C-乐克塔股份有限公司 酮还原酶
CN108441523A (zh) * 2018-03-22 2018-08-24 南京工业大学 （3r,5s）-6-氯-3,5,-二羟基己酸叔丁酯的制备方法
CN110387359B (zh) * 2018-04-17 2021-04-20 湖州颐盛生物科技有限公司 羰基还原酶突变体及其应用
EP3587393B1 (fr) 2018-06-21 2024-01-17 F.I.S.- Fabbrica Italiana Sintetici S.p.A. Procédé enzymatique pour la préparation de la droxidopa
TW202304921A (zh) 2021-04-02 2023-02-01 美商建南德克公司 製造雙環酮化合物之方法
CN114875081A (zh) * 2022-06-07 2022-08-09 湖北迅达药业股份有限公司 一种瑞舒伐他汀关键中间体的绿色工业化生产方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5278313A (en) * 1992-03-27 1994-01-11 E. R. Squibb & Sons, Inc. Process for the preparation of 1,3-dioxane derivatives useful in the preparation of HMG-COA reductase inhibitors
GB9512837D0 (en) 1995-06-23 1995-08-23 Zeneca Ltd reduction of ketone groups
DE69910562T2 (de) * 1998-04-30 2004-06-17 Kaneka Corp. Verfahren zur herstellung von derivaten der 6-cyanomethyl-1,3-dioxan-4-essigsäure
PT1619191E (pt) 1998-08-05 2010-12-21 Kaneka Corp Processo de produção de derivados opticamente activos do ácido 2-[6-(hidroximetil)-1,3-dioxan-4-il]acético
DE19857302C2 (de) 1998-12-14 2000-10-26 Forschungszentrum Juelich Gmbh Verfahren zur enantioselektiven Reduktion von 3,5-Dioxocarbonsäuren, deren Salze und Ester
EP1194582A1 (fr) * 1999-07-09 2002-04-10 Forschungszentrum Jülich Gmbh Procede de reduction d'acides cetocarboxyliques et de leurs esters

Also Published As

Publication number Publication date
EP1152054B1 (fr) 2005-03-23
CA2360376C (fr) 2005-04-26
KR20020008116A (ko) 2002-01-29
DE60018909T2 (de) 2006-03-30
DE60018909D1 (de) 2005-04-28
NO20013801L (no) 2001-10-03
HUP0105331A2 (hu) 2002-05-29
ATE291616T1 (de) 2005-04-15
WO2001040450A1 (fr) 2001-06-07
CA2360376A1 (fr) 2001-06-07
US6645746B1 (en) 2003-11-11
HUP0105331A3 (en) 2005-10-28
KR100512080B1 (ko) 2005-09-02
EP1152054A4 (fr) 2002-11-20
AU1551701A (en) 2001-06-12
NO20013801D0 (no) 2001-08-02
MXPA01007858A (es) 2003-07-14
EP1152054A1 (fr) 2001-11-07
ES2240205T3 (es) 2005-10-16
JP4510351B2 (ja) 2010-07-21
CZ20012792A3 (cs) 2002-03-13

Similar Documents

Publication Publication Date Title
SI20642A (sl) Nova karbonil-reduktaza, gen le-te in postopek za uporabo le-teh
KR100506134B1 (ko) 신규한 카르보닐 환원효소 및 이것을 코딩하는 유전자 및 이러한 환원효소 및 유전자 이용방법
JP5261172B2 (ja) エリスロ又はスレオ−２−アミノ−３−ヒドロキシプロピオン酸エステルの製造方法、新規カルボニル還元酵素、その遺伝子、ベクター、形質転換体、およびそれらを利用した光学活性アルコールの製造方法
JP5516664B2 (ja) Ｎ−アセチル−（Ｒ，Ｓ）−β−アミノ酸アシラーゼ遺伝子
JP3941998B2 (ja) コエンザイムｑ１０の製造法
EP2128258B1 (fr) Nouvelle amidase, gène pour celle-ci, vecteur, transformant et procédé de fabrication d'un amide d'acide carboxylique optiquement actif et d'un acide carboxylique optiquement actif à l'aide de l'un quelconque de ces éléments
JP4880859B2 (ja) 新規カルボニル還元酵素、その遺伝子、およびその利用法
JP5761641B2 (ja) （ｒ）−３−キヌクリジノールの製造方法
JP2003502021A (ja) アスペルギルス起源のエポキシドヒドロラーゼ
JP5119783B2 (ja) Ｎ−アセチル−（Ｒ，Ｓ）−β−アミノ酸アシラーゼ遺伝子
WO2005123921A1 (fr) Nouvelle glycerol déhydrogènase, gène relatif et procédé de leur utilisation
EP1408107B1 (fr) Gène de l'hydrolase asymétrique pour chlorhydrine et ester d'acide hydroxycarboxylique
JP6088973B2 (ja) 新規アミダーゼ
JPWO2006043555A1 (ja) 生体高分子生成のための還元酵素変異体
JPH0556787A (ja) エステル不斉加水分解酵素遺伝子
JP2006115729A (ja) 光学活性β−ヒドロキシアミノ酸の晶析方法
JP2002320491A (ja) 新規なｄ−アミノアシラーゼをコードするｄｎａおよびそれを用いたｄ−アミノ酸の製造方法
MXPA99007259A (en) Novel carbonyl reductase, gene that encodes the same, and method of utilizing these

Legal Events

Date Code Title Description
IF Valid on the event date
KO00 Lapse of patent

Effective date: 20060731